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Protein

Kanamycin nucleotidyltransferase

Gene

knt

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Kanamycin nucleotidyltransferase (EC:2.7.7.-)
Short name:
Neo(R)
Gene namesi
Name:knt
Synonyms:kan
Encoded oniPlasmid pUB1100 Publication
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Pathology & Biotechi

Chemistry databases

DrugBankiDB01172. Kanamycin.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000685681 – 253Kanamycin nucleotidyltransferaseAdd BLAST253

Proteomic databases

PaxDbiP05057.
PRIDEiP05057.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi158878.SAV0035.

Structurei

Secondary structure

1253
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 27Combined sources19
Helixi28 – 30Combined sources3
Beta strandi31 – 37Combined sources7
Helixi38 – 42Combined sources5
Beta strandi51 – 59Combined sources9
Beta strandi63 – 69Combined sources7
Beta strandi74 – 81Combined sources8
Helixi82 – 89Combined sources8
Helixi96 – 99Combined sources4
Helixi100 – 103Combined sources4
Beta strandi107 – 114Combined sources8
Helixi115 – 124Combined sources10
Helixi128 – 141Combined sources14
Helixi143 – 156Combined sources14
Helixi159 – 161Combined sources3
Helixi162 – 181Combined sources20
Beta strandi186 – 190Combined sources5
Helixi191 – 195Combined sources5
Beta strandi198 – 200Combined sources3
Helixi205 – 214Combined sources10
Helixi220 – 241Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KANX-ray3.00A/B1-253[»]
1KNYX-ray2.50A/B1-253[»]
ProteinModelPortaliP05057.
SMRiP05057.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05057.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108S3A. Bacteria.
ENOG4111GRA. LUCA.
KOiK17882.

Family and domain databases

InterProiIPR012481. KNTase_C.
[Graphical view]
PfamiPF07827. KNTase_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGPIIMTRE ERMKIVHEIK ERILDKYGDD VKAIGVYGSL GRQTDGPYSD
60 70 80 90 100
IEMMCVMSTE EAEFSHEWTT GEWKVEVNFD SEEILLDYAS QVESDWPLTH
110 120 130 140 150
GQFFSILPIY DSGGYLEKVY QTAKSVEAQT FHDAICALIV EELFEYAGKW
160 170 180 190 200
RNIRVQGPTT FLPSLTVQVA MAGAMLIGLH HRICYTTSAS VLTEAVKQSD
210 220 230 240 250
LPSGYDHLCQ FVMSGQLSDS EKLLESLENF WNGIQEWTER HGYIVDVSKR

IPF
Length:253
Mass (Da):28,798
Last modified:August 13, 1987 - v1
Checksum:i9CB3D60E72A45DC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03408 Genomic DNA. Translation: CAA27142.1.
M37273 Genomic DNA. Translation: AAA98214.1.
M19465 Genomic DNA. Translation: AAA88361.1.
RefSeqiNP_040433.1. NC_001384.1.
WP_001014230.1. NG_047373.1.
YP_006937662.1. NC_013320.1.
YP_006938491.1. NC_013342.1.

Genome annotation databases

GeneIDi13874812.
13875662.
3284089.
KEGGiag:AAA88361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03408 Genomic DNA. Translation: CAA27142.1.
M37273 Genomic DNA. Translation: AAA98214.1.
M19465 Genomic DNA. Translation: AAA88361.1.
RefSeqiNP_040433.1. NC_001384.1.
WP_001014230.1. NG_047373.1.
YP_006937662.1. NC_013320.1.
YP_006938491.1. NC_013342.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KANX-ray3.00A/B1-253[»]
1KNYX-ray2.50A/B1-253[»]
ProteinModelPortaliP05057.
SMRiP05057.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV0035.

Chemistry databases

DrugBankiDB01172. Kanamycin.

Proteomic databases

PaxDbiP05057.
PRIDEiP05057.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13874812.
13875662.
3284089.
KEGGiag:AAA88361.

Phylogenomic databases

eggNOGiENOG4108S3A. Bacteria.
ENOG4111GRA. LUCA.
KOiK17882.

Miscellaneous databases

EvolutionaryTraceiP05057.

Family and domain databases

InterProiIPR012481. KNTase_C.
[Graphical view]
PfamiPF07827. KNTase_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKANU_STAAU
AccessioniPrimary (citable) accession number: P05057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.