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Protein

Serine protease snake

Gene

snk

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei235Charge relay systemBy similarity1
Active sitei283Charge relay systemBy similarity1
Active sitei381Charge relay systemBy similarity1

GO - Molecular functioni

  • peptidase activity Source: FlyBase
  • serine-type endopeptidase activity Source: FlyBase
  • serine-type peptidase activity Source: FlyBase

GO - Biological processi

  • dorsal/ventral axis specification Source: FlyBase
  • maternal specification of dorsal/ventral axis, oocyte, germ-line encoded Source: FlyBase
  • protein processing Source: FlyBase
  • proteolysis Source: FlyBase
  • Toll signaling pathway Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-DME-209442 Formation of the trans-membrane 'signalling complex'

Protein family/group databases

MEROPSiS01.200

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease snake (EC:3.4.21.-)
Gene namesi
Name:snk
ORF Names:CG7996
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003450 snk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000002813228 – 435Serine protease snakeAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi93 ↔ 137By similarity
Disulfide bondi104 ↔ 127By similarity
Disulfide bondi110 ↔ 138By similarity
Disulfide bondi179 ↔ 303By similarity
Disulfide bondi220 ↔ 236PROSITE-ProRule annotation
Disulfide bondi346 ↔ 366PROSITE-ProRule annotation
Disulfide bondi377 ↔ 408PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP05049
PRIDEiP05049

Expressioni

Gene expression databases

BgeeiFBgn0003450
ExpressionAtlasiP05049 differential
GenevisibleiP05049 DM

Interactioni

Protein-protein interaction databases

BioGridi66694, 3 interactors
STRINGi7227.FBpp0111746

Structurei

3D structure databases

ProteinModelPortaliP05049
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 139CLIPSequence analysisAdd BLAST47
Domaini186 – 432Peptidase S1PROSITE-ProRule annotationAdd BLAST247

Domaini

The CLIP domain consists of 37-55 residues which are "knitted" together usually by 3 conserved disulfide bonds forming a clip-like compact structure.Curated

Sequence similaritiesi

Belongs to the peptidase S1 family. CLIP subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00840000130336
InParanoidiP05049
OMAiCQEYNSA
OrthoDBiEOG091G0DF7
PhylomeDBiP05049

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR022700 CLIP
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00680 CLIP, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIILWSLIVH LQLTCLHLIL QTPNLEALDA LEIINYQTTK YTIPEVWKEQ
60 70 80 90 100
PVATIGEDVD DQDTEDEESY LKFGDDAEVR TSVSEGLHEG AFCRRSFDGR
110 120 130 140 150
SGYCILAYQC LHVIREYRVH GTRIDICTHR NNVPVICCPL ADKHVLAQRI
160 170 180 190 200
SATKCQEYNA AARRLHLTDT GRTFSGKQCV PSVPLIVGGT PTRHGLFPHM
210 220 230 240 250
AALGWTQGSG SKDQDIKWGC GGALVSELYV LTAAHCATSG SKPPDMVRLG
260 270 280 290 300
ARQLNETSAT QQDIKILIIV LHPKYRSSAY YHDIALLKLT RRVKFSEQVR
310 320 330 340 350
PACLWQLPEL QIPTVVAAGW GRTEFLGAKS NALRQVDLDV VPQMTCKQIY
360 370 380 390 400
RKERRLPRGI IEGQFCAGYL PGGRDTCQGD SGGPIHALLP EYNCVAFVVG
410 420 430
ITSFGKFCAA PNAPGVYTRL YSYLDWIEKI AFKQH
Length:435
Mass (Da):48,458
Last modified:May 10, 2004 - v2
Checksum:i6ECEA32D3CE41B32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53 – 54AT → QA in CAA28197 (PubMed:11486795).Curated2
Sequence conflicti91A → R in CAA28197 (PubMed:11486795).Curated1
Sequence conflicti96S → T in CAA28197 (PubMed:11486795).Curated1
Sequence conflicti104 – 123CILAY…VHGTR → ASWPISGSTSSESIGCMA in CAA28197 (PubMed:11486795).CuratedAdd BLAST20
Sequence conflicti171G → V in CAA28197 (PubMed:11486795).Curated1
Sequence conflicti241 – 252SKPPD…RLGAR → ANHRTWFAWRP in CAA28197 (PubMed:11486795).CuratedAdd BLAST12
Sequence conflicti307 – 313LPELQIP → CGAPHT in CAA28197 (PubMed:11486795).Curated7
Sequence conflicti341V → S in CAA28197 (PubMed:11486795).Curated1
Sequence conflicti371 – 376PGGRDT → QAQGH in CAA28197 (PubMed:11486795).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04513 mRNA Translation: CAA28197.1
AE014297 Genomic DNA Translation: AAF54897.1
BT024420 mRNA Translation: ABC86482.1
PIRiA24702
RefSeqiNP_001097766.1, NM_001104296.2
NP_524338.2, NM_079614.3
UniGeneiDm.2435

Genome annotation databases

EnsemblMetazoaiFBtr0082716; FBpp0082184; FBgn0003450
FBtr0112833; FBpp0111746; FBgn0003450
GeneIDi41607
KEGGidme:Dmel_CG7996
UCSCiCG7996-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiSNAK_DROME
AccessioniPrimary (citable) accession number: P05049
Secondary accession number(s): Q29QH0, Q9VFZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: May 10, 2004
Last modified: May 23, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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