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Protein

Seed lectin subunit I

Gene
N/A
Organism
Vigna unguiculata subsp. cylindrica (Horse gram) (Dolichos biflorus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metalloglycoprotein, containing Ca, Mg, Mn, and Zn and the carbohydrates galactose, glucosamine, mannose, and fucose. It agglutinates erythrocytes of blood group A1. Has a high preference for GalNAc over Gal.

GO - Molecular functioni

Keywordsi

LigandCalcium, Lectin, Mannose-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Seed lectin subunit I
Short name:
SL
Cleaved into the following chain:
OrganismiVigna unguiculata subsp. cylindrica (Horse gram) (Dolichos biflorus)
Taxonomic identifieri3840 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna

Pathology & Biotechi

Protein family/group databases

Allergomei3011 Dol b Agglutinin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000001761123 – 275Seed lectin subunit IAdd BLAST253
ChainiPRO_000001761223 – 265Seed lectin subunit IIAdd BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Subunit II may arise from subunit I by proteolytic cleavage at the C-terminal end.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei265 – 266Cleavage2

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 32Combined sources9
Helixi35 – 37Combined sources3
Beta strandi38 – 42Combined sources5
Beta strandi45 – 47Combined sources3
Beta strandi50 – 52Combined sources3
Beta strandi67 – 74Combined sources8
Turni81 – 84Combined sources4
Beta strandi88 – 96Combined sources9
Beta strandi107 – 115Combined sources9
Helixi124 – 126Combined sources3
Turni127 – 129Combined sources3
Helixi137 – 139Combined sources3
Beta strandi142 – 147Combined sources6
Turni152 – 154Combined sources3
Beta strandi160 – 169Combined sources10
Beta strandi171 – 175Combined sources5
Beta strandi184 – 191Combined sources8
Turni192 – 195Combined sources4
Beta strandi196 – 202Combined sources7
Helixi204 – 206Combined sources3
Beta strandi209 – 215Combined sources7
Helixi218 – 221Combined sources4
Beta strandi224 – 234Combined sources11
Beta strandi245 – 255Combined sources11
Beta strandi257 – 259Combined sources3
Helixi266 – 273Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BJQX-ray2.65A/B/C/D/E/F/G/H23-275[»]
1LU1X-ray2.60A23-275[»]
1LU2X-ray2.80A/B23-275[»]
ProteinModelPortaliP05045
SMRiP05045
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05045

Family & Domainsi

Sequence similaritiesi

Belongs to the leguminous lectin family.Curated

Keywords - Domaini

Signal

Family and domain databases

CDDicd06899 lectin_legume_LecRK_Arcelin_Co, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR016363 L-lectin
IPR000985 Lectin_LegA_CS
IPR019825 Lectin_legB_Mn/Ca_BS
IPR001220 Legume_lectin_dom
PfamiView protein in Pfam
PF00139 Lectin_legB, 1 hit
PIRSFiPIRSF002690 L-type_lectin_plant, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00308 LECTIN_LEGUME_ALPHA, 1 hit
PS00307 LECTIN_LEGUME_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTVSVVL SLFLLLLTQA NSANIQSFSF KNFNSPSFIL QGDATVSSGK
60 70 80 90 100
LQLTKVKENG IPTPSSLGRA FYSSPIQIYD KSTGAVASWA TSFTVKISAP
110 120 130 140 150
SKASFADGIA FALVPVGSEP RRNGGYLGVF DSDVYNNSAQ TVAVEFDTFS
160 170 180 190 200
NSGWDPSMKH IGIDVNSIKS IATVSWDLAN GENAEILITY NAATSLLVAS
210 220 230 240 250
LVHPSRRTSY ILSERVDITN ELPEYVSVGF SATTGLSEGY IETHDVLSWS
260 270
FASKLPDDST AEPLDLASYL VRNVL
Length:275
Mass (Da):29,406
Last modified:July 15, 1999 - v2
Checksum:iD313D73860661A83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61 – 67IPTPSSL → FPLRFPS in AAA33141 (PubMed:3584113).Curated7
Sequence conflicti82S → F in AAA33141 (PubMed:3584113).Curated1
Sequence conflicti149F → L in AAA33141 (PubMed:3584113).Curated1
Sequence conflicti199A → V in AAA33141 (PubMed:3584113).Curated1
Sequence conflicti227S → G in AAA33141 (PubMed:3584113).Curated1
Sequence conflicti254K → R in AAA33141 (PubMed:3584113).Curated1
Sequence conflicti268S → R in AAA33141 (PubMed:3584113).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02721 mRNA Translation: AAA33141.1
M34270 Genomic DNA Translation: AAA33143.1
PIRiA29572

Similar proteinsi

Entry informationi

Entry nameiLEC1_VIGUC
AccessioniPrimary (citable) accession number: P05045
Secondary accession number(s): Q39666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: July 15, 1999
Last modified: May 23, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure
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Main funding by: National Institutes of Health