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Protein

Sorcin

Gene

SRI

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the sarcoplasmic reticulum in the heart. Modulates the activity of RYR2 calcium channels.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi83 – 941Add BLAST12
Calcium bindingi113 – 1242Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: BHF-UCL
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorcin
Alternative name(s):
22 kDa protein
CP-22
V19
Gene namesi
Name:SRI
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

GO - Cellular componenti

  • membrane Source: BHF-UCL
  • sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi99W → G: No significant effect. 1 Publication1
Mutagenesisi105W → G: Reduced affinity for calcium, resulting in reduced interaction with ANXA7 and strongly reduced modulation of RYR2 channel activity. 1 Publication1
Mutagenesisi124E → A: Strongly reduced modulation of RYR2 channel activity. 1 Publication1
Mutagenesisi178S → D: Increases calcium-sensitivity and promotes interaction with sarcoplasmic reticulum membranes. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737241 – 198SorcinAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated; partially.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP05044.

PTM databases

iPTMnetiP05044.

Expressioni

Tissue specificityi

Detected in myocardium.1 Publication

Interactioni

Subunit structurei

Homodimer. Interacts with GCA and RYR2 (By similarity). Interacts with ANXA7.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Anxa7Q070762EBI-10816377,EBI-10824194From a different organism.

Protein-protein interaction databases

IntActiP05044. 2 interactors.

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 42Combined sources7
Helixi51 – 61Combined sources11
Helixi72 – 82Combined sources11
Helixi92 – 112Combined sources21
Beta strandi118 – 120Combined sources3
Helixi122 – 130Combined sources9
Turni131 – 133Combined sources3
Helixi138 – 147Combined sources10
Beta strandi153 – 155Combined sources3
Helixi156 – 176Combined sources21
Beta strandi182 – 187Combined sources6
Helixi188 – 196Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GJYX-ray2.20A/B/C/D33-198[»]
ProteinModelPortaliP05044.
SMRiP05044.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05044.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 64EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini70 – 103EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini100 – 135EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini134 – 169EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG004492.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYPGHPGAG GGYYPGGYGG APGGPSFPGQ TQDPLYGYFA SVAGQDGQID
60 70 80 90 100
ADELQRCLTQ SGIAGGYKPF NLETCRLMVS MLDRDMSGTM GFNEFKELWA
110 120 130 140 150
VLNGWRQHFI SFDSDRSGTV DPQELQKALT TMGFRLNPQT VNSIAKRYST
160 170 180 190
SGKITFDDYI ACCVKLRALT DSFRRRDSAQ QGMVNFSYDD FIQCVMTV
Length:198
Mass (Da):21,746
Last modified:August 13, 1987 - v1
Checksum:iDA2AF8A9707561C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04656 mRNA. Translation: CAA28354.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04656 mRNA. Translation: CAA28354.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GJYX-ray2.20A/B/C/D33-198[»]
ProteinModelPortaliP05044.
SMRiP05044.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP05044. 2 interactors.

PTM databases

iPTMnetiP05044.

Proteomic databases

PRIDEiP05044.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004492.

Miscellaneous databases

EvolutionaryTraceiP05044.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSORCN_CRIGR
AccessioniPrimary (citable) accession number: P05044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is encoded by an amplified gene in multidrug-resistant cells.
This protein has been shown to bind calcium with high affinity.

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.