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P05035

- PYRF_NEUCR

UniProt

P05035 - PYRF_NEUCR

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyr-4

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei48 – 481SubstrateBy similarity
    Active sitei107 – 1071Proton donorPROSITE-ProRule annotation
    Binding sitei347 – 3471SubstrateBy similarity
    Binding sitei366 – 3661SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:pyr-4
    ORF Names:B23H20.130, NCU03488
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 6, Linkage Group II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Orotidine 5'-phosphate decarboxylasePRO_0000134665Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU03488.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP05035.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni70 – 723Substrate bindingBy similarity
    Regioni105 – 11410Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000213905.
    KOiK13421.
    OMAiMGQQYRT.
    OrthoDBiEOG7CVQ76.

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    InterProiIPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 2 hits.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P05035-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTSQETQPH WSLKQSFAER VESSTHPLTS YLFRLMEVKQ SNLCLSADVE    50
    HARDLLALAD KVGPSIVVLK THYDLITGWD YHPHTGTGAK LAALARKHGF 100
    LIFEDRKFVD IGSTVQKQYT AGTARIVEWA HITNADIHAG EAMVSAMAQA 150
    AQKWRERIPY EVKTSVSVGT PVADQFADEE AEDQVEELRK VVTRETSTTT 200
    KDTDGRKSSI VSITTVTQTY EPADSPRLVK TISEDDEMVF PGIEEAPLDR 250
    GLLILAQMSS KGCLMDGKYT WECVKAARKN KGFVMGYVAQ QNLNGITKEA 300
    LAPSYEDGES TTEEEAQADN FIHMTPGCKL PPPGEEAPQG DGLGQQYNTP 350
    DNLVNIKGTD IAIVGRGIIT AADPPAEAER YRRKAWKAYQ DRRERLA 397
    Length:397
    Mass (Da):43,903
    Last modified:August 13, 1987 - v1
    Checksum:iC9A39CDA33A3FCD9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13448 Genomic DNA. Translation: AAA33611.1.
    X05993 Genomic DNA. Translation: CAA29411.1.
    AL669988 Genomic DNA. Translation: CAD21085.1.
    CM002237 Genomic DNA. Translation: EAA26639.1.
    PIRiA24398. DCNCOP.
    RefSeqiXP_955875.1. XM_950782.2.
    UniGeneiNcr.14497.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000002693; EFNCRP00000002693; EFNCRG00000002690.
    GeneIDi3872022.
    KEGGincr:NCU03488.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13448 Genomic DNA. Translation: AAA33611.1 .
    X05993 Genomic DNA. Translation: CAA29411.1 .
    AL669988 Genomic DNA. Translation: CAD21085.1 .
    CM002237 Genomic DNA. Translation: EAA26639.1 .
    PIRi A24398. DCNCOP.
    RefSeqi XP_955875.1. XM_950782.2.
    UniGenei Ncr.14497.

    3D structure databases

    ProteinModelPortali P05035.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU03488.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000002693 ; EFNCRP00000002693 ; EFNCRG00000002690 .
    GeneIDi 3872022.
    KEGGi ncr:NCU03488.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000213905.
    KOi K13421.
    OMAi MGQQYRT.
    OrthoDBi EOG7CVQ76.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    InterProi IPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 2 hits.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the pyr-4 (orotidine 5'-P decarboxylase) gene of Neurospora crassa."
      Newbury S.F., Glazebrook J.A., Radford A.
      Gene 43:51-58(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular genetic analysis of the pyr-4 gene of Neurospora crassa."
      Glazebrook J.A., Mitchell K., Radford A.
      Mol. Gen. Genet. 209:399-402(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
      Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
      Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    4. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiPYRF_NEUCR
    AccessioniPrimary (citable) accession number: P05035
    Secondary accession number(s): Q7RV44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3