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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyr-4

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481SubstrateBy similarity
Active sitei107 – 1071Proton donorPROSITE-ProRule annotation
Binding sitei347 – 3471SubstrateBy similarity
Binding sitei366 – 3661SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:pyr-4
ORF Names:B23H20.130, NCU03488
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 6, Linkage Group II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Orotidine 5'-phosphate decarboxylasePRO_0000134665Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU03488.1.

Structurei

3D structure databases

ProteinModelPortaliP05035.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 723Substrate bindingBy similarity
Regioni105 – 11410Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000213905.
InParanoidiP05035.
KOiK13421.
OMAiMGQQYRT.
OrthoDBiEOG7CVQ76.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSQETQPH WSLKQSFAER VESSTHPLTS YLFRLMEVKQ SNLCLSADVE
60 70 80 90 100
HARDLLALAD KVGPSIVVLK THYDLITGWD YHPHTGTGAK LAALARKHGF
110 120 130 140 150
LIFEDRKFVD IGSTVQKQYT AGTARIVEWA HITNADIHAG EAMVSAMAQA
160 170 180 190 200
AQKWRERIPY EVKTSVSVGT PVADQFADEE AEDQVEELRK VVTRETSTTT
210 220 230 240 250
KDTDGRKSSI VSITTVTQTY EPADSPRLVK TISEDDEMVF PGIEEAPLDR
260 270 280 290 300
GLLILAQMSS KGCLMDGKYT WECVKAARKN KGFVMGYVAQ QNLNGITKEA
310 320 330 340 350
LAPSYEDGES TTEEEAQADN FIHMTPGCKL PPPGEEAPQG DGLGQQYNTP
360 370 380 390
DNLVNIKGTD IAIVGRGIIT AADPPAEAER YRRKAWKAYQ DRRERLA
Length:397
Mass (Da):43,903
Last modified:August 13, 1987 - v1
Checksum:iC9A39CDA33A3FCD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13448 Genomic DNA. Translation: AAA33611.1.
X05993 Genomic DNA. Translation: CAA29411.1.
AL669988 Genomic DNA. Translation: CAD21085.1.
CM002237 Genomic DNA. Translation: EAA26639.1.
PIRiA24398. DCNCOP.
RefSeqiXP_955875.1. XM_950782.2.
UniGeneiNcr.14497.

Genome annotation databases

EnsemblFungiiEFNCRT00000002693; EFNCRP00000002693; EFNCRG00000002690.
GeneIDi3872022.
KEGGincr:NCU03488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13448 Genomic DNA. Translation: AAA33611.1.
X05993 Genomic DNA. Translation: CAA29411.1.
AL669988 Genomic DNA. Translation: CAD21085.1.
CM002237 Genomic DNA. Translation: EAA26639.1.
PIRiA24398. DCNCOP.
RefSeqiXP_955875.1. XM_950782.2.
UniGeneiNcr.14497.

3D structure databases

ProteinModelPortaliP05035.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5141.NCU03488.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000002693; EFNCRP00000002693; EFNCRG00000002690.
GeneIDi3872022.
KEGGincr:NCU03488.

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000213905.
InParanoidiP05035.
KOiK13421.
OMAiMGQQYRT.
OrthoDBiEOG7CVQ76.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the pyr-4 (orotidine 5'-P decarboxylase) gene of Neurospora crassa."
    Newbury S.F., Glazebrook J.A., Radford A.
    Gene 43:51-58(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular genetic analysis of the pyr-4 gene of Neurospora crassa."
    Glazebrook J.A., Mitchell K., Radford A.
    Mol. Gen. Genet. 209:399-402(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  4. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiPYRF_NEUCR
AccessioniPrimary (citable) accession number: P05035
Secondary accession number(s): Q7RV44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: January 7, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.