Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P05035 (PYRF_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:pyr-4
ORF Names:B23H20.130, NCU03488
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Orotidine 5'-phosphate decarboxylase
PRO_0000134665

Regions

Region70 – 723Substrate binding By similarity
Region105 – 11410Substrate binding By similarity

Sites

Active site1071Proton donor By similarity
Binding site481Substrate By similarity
Binding site3471Substrate By similarity
Binding site3661Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P05035 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: C9A39CDA33A3FCD9

FASTA39743,903
        10         20         30         40         50         60 
MSTSQETQPH WSLKQSFAER VESSTHPLTS YLFRLMEVKQ SNLCLSADVE HARDLLALAD 

        70         80         90        100        110        120 
KVGPSIVVLK THYDLITGWD YHPHTGTGAK LAALARKHGF LIFEDRKFVD IGSTVQKQYT 

       130        140        150        160        170        180 
AGTARIVEWA HITNADIHAG EAMVSAMAQA AQKWRERIPY EVKTSVSVGT PVADQFADEE 

       190        200        210        220        230        240 
AEDQVEELRK VVTRETSTTT KDTDGRKSSI VSITTVTQTY EPADSPRLVK TISEDDEMVF 

       250        260        270        280        290        300 
PGIEEAPLDR GLLILAQMSS KGCLMDGKYT WECVKAARKN KGFVMGYVAQ QNLNGITKEA 

       310        320        330        340        350        360 
LAPSYEDGES TTEEEAQADN FIHMTPGCKL PPPGEEAPQG DGLGQQYNTP DNLVNIKGTD 

       370        380        390 
IAIVGRGIIT AADPPAEAER YRRKAWKAYQ DRRERLA 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the pyr-4 (orotidine 5'-P decarboxylase) gene of Neurospora crassa."
Newbury S.F., Glazebrook J.A., Radford A.
Gene 43:51-58(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular genetic analysis of the pyr-4 gene of Neurospora crassa."
Glazebrook J.A., Mitchell K., Radford A.
Mol. Gen. Genet. 209:399-402(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[4]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M13448 Genomic DNA. Translation: AAA33611.1.
X05993 Genomic DNA. Translation: CAA29411.1.
AL669988 Genomic DNA. Translation: CAD21085.1.
CM002237 Genomic DNA. Translation: EAA26639.1.
PIRDCNCOP. A24398.
RefSeqXP_955875.1. XM_950782.2.
UniGeneNcr.14497.

3D structure databases

ProteinModelPortalP05035.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU03488.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000002693; EFNCRP00000002693; EFNCRG00000002690.
GeneID3872022.
KEGGncr:NCU03488.

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000213905.
KOK13421.
OMAMGQQYRT.
OrthoDBEOG7CVQ76.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 2 hits.
InterProIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 2 hits.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_NEUCR
AccessionPrimary (citable) accession number: P05035
Secondary accession number(s): Q7RV44
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: February 19, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways