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Protein

Sodium/potassium-transporting ATPase subunit beta-1

Gene

ATP1B1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Involved in cell adhesion and establishing epithelial cell polarity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-1
Gene namesi
Name:ATP1B1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 12

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434CytoplasmicSequence analysisAdd
BLAST
Transmembranei35 – 6228Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini63 – 303241ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Sodium/potassium-transporting ATPase subunit beta-1PRO_0000219101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111PhosphoserineBy similarity
Modified residuei101 – 1011PhosphotyrosineBy similarity
Disulfide bondi126 ↔ 149By similarity
Glycosylationi158 – 1581N-linked (GlcNAc...)By similarity
Disulfide bondi159 ↔ 175By similarity
Glycosylationi193 – 1931N-linked (GlcNAc...)By similarity
Disulfide bondi213 ↔ 276By similarity
Glycosylationi265 – 2651N-linked (GlcNAc...)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma. Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM. Interacts with KIRREL3 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP05028.
SMRiP05028. Positions 28-73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni191 – 303113immunoglobulin-likeBy similarityAdd
BLAST

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074530.
HOVERGENiHBG050603.
KOiK01540.
OMAiRGEFNNE.
OrthoDBiEOG091G0DJ4.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
IPR015565. Na/K_ATPase_sub_beta_chordates.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PTHR11523:SF10. PTHR11523:SF10. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF
60 70 80 90 100
IGTIQVMLLT ISEFKPTYQD RVAPPGLTQI PQIQKTEIAF RPNDPKSYMT
110 120 130 140 150
YVDNIDNFLK KYRDSAQKDD MIFEDCGNVP SELKDRGEFN NEQGERKVCR
160 170 180 190 200
FKLEWLGNCS GINDETYGYK EGKPCVIIKL NRVLGFKPKP PKNESLETYP
210 220 230 240 250
VMKYNPYVLP VQCTGKRDED KEKVGSIEYF GLGGYPGFPL QYYPYYGKLL
260 270 280 290 300
QPKYLQPLLA VQFTNLTMDT EIRIECKAYG ENIGYSEKDR FQGRFDVKIE

VKS
Length:303
Mass (Da):35,071
Last modified:August 13, 1987 - v1
Checksum:i0038B8EA355A3540
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03883 mRNA. Translation: CAA27515.1.
PIRiA25768.
RefSeqiNP_001009796.1. NM_001009796.1.
UniGeneiOar.421.

Genome annotation databases

EnsembliENSOART00000010200; ENSOARP00000010054; ENSOARG00000009371.
GeneIDi443384.
KEGGioas:443384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03883 mRNA. Translation: CAA27515.1.
PIRiA25768.
RefSeqiNP_001009796.1. NM_001009796.1.
UniGeneiOar.421.

3D structure databases

ProteinModelPortaliP05028.
SMRiP05028. Positions 28-73.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000010200; ENSOARP00000010054; ENSOARG00000009371.
GeneIDi443384.
KEGGioas:443384.

Organism-specific databases

CTDi481.

Phylogenomic databases

GeneTreeiENSGT00550000074530.
HOVERGENiHBG050603.
KOiK01540.
OMAiRGEFNNE.
OrthoDBiEOG091G0DJ4.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
IPR015565. Na/K_ATPase_sub_beta_chordates.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PTHR11523:SF10. PTHR11523:SF10. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1B1_SHEEP
AccessioniPrimary (citable) accession number: P05028
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.