P05028 (AT1B1_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1

Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-1

Gene names

Name:

ATP1B1

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma. Interacts with NKAIN1, NKAIN2 and NKAIN4 By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein.
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Potassium Sodium
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sodium:potassium-exchanging ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Sodium/potassium-transporting ATPase subunit beta-1		PRO_0000219101
Regions
	Topological domain	1 – 34	34	Cytoplasmic Potential
	Transmembrane	35 – 62	28	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	63 – 303	241	Extracellular Potential
Amino acid modifications
	Modified residue	101	1	Phosphotyrosine By similarity
	Glycosylation	158	1	N-linked (GlcNAc...) By similarity
	Glycosylation	193	1	N-linked (GlcNAc...) By similarity
	Glycosylation	265	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	126 ↔ 149		By similarity
	Disulfide bond	159 ↔ 175		By similarity
	Disulfide bond	213 ↔ 276		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P05028 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 0038B8EA355A3540	FASTA	303	35,071
	10 20 30 40 50 60 MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF IGTIQVMLLT 70 80 90 100 110 120 ISEFKPTYQD RVAPPGLTQI PQIQKTEIAF RPNDPKSYMT YVDNIDNFLK KYRDSAQKDD 130 140 150 160 170 180 MIFEDCGNVP SELKDRGEFN NEQGERKVCR FKLEWLGNCS GINDETYGYK EGKPCVIIKL 190 200 210 220 230 240 NRVLGFKPKP PKNESLETYP VMKYNPYVLP VQCTGKRDED KEKVGSIEYF GLGGYPGFPL 250 260 270 280 290 300 QYYPYYGKLL QPKYLQPLLA VQFTNLTMDT EIRIECKAYG ENIGYSEKDR FQGRFDVKIE VKS

References

[1]	"Amino-acid sequence of the beta-subunit of the (Na+ + K+)ATPase deduced from a cDNA." Shull G.E., Lane L.K., Lingrel J.B. Nature 321:429-431(1986) [PubMed: 3012356] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of antigenic sites on the Na+/K(+)-ATPase beta-subunit: their sequences and the effects of thiol reduction upon their structure." Sun Y., Ball W.J. Jr. Biochim. Biophys. Acta 1207:236-248(1994) [PubMed: 7521214] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X03883 mRNA. Translation: CAA27515.1.
PIR	A25768.
RefSeq	NP_001009796.1. NM_001009796.1.
UniGene	Oar.421.
3D structure databases
ProteinModelPortal	P05028.
SMR	P05028. Positions 28-73.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	443384.
Organism-specific databases
CTD	481.
Phylogenomic databases
HOVERGEN	HBG050603.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. IPR015565. ATPase_P-typ_Na/K-dep_b1su. [Graphical view]
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit. PTHR11523:SF10. Na/K_ATPaseBeta1. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. PS00391. ATPASE_NA_K_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AT1B1_SHEEP

Accession

Primary (citable) accession number: P05028

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	June 28, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program