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P05026

- AT1B1_HUMAN

UniProt

P05026 - AT1B1_HUMAN

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Protein

Sodium/potassium-transporting ATPase subunit beta-1

Gene

ATP1B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.1 Publication
Involved in cell adhesion and establishing epithelial cell polarity.1 Publication

GO - Molecular functioni

  1. ATPase activator activity Source: BHF-UCL
  2. ATPase binding Source: BHF-UCL
  3. MHC class II protein complex binding Source: UniProt
  4. sodium:potassium-exchanging ATPase activity Source: Ensembl

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. cardiac muscle contraction Source: BHF-UCL
  3. cell adhesion Source: UniProtKB-KW
  4. cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  5. cellular calcium ion homeostasis Source: BHF-UCL
  6. cellular potassium ion homeostasis Source: BHF-UCL
  7. cellular sodium ion homeostasis Source: BHF-UCL
  8. ion transmembrane transport Source: Reactome
  9. leukocyte migration Source: Reactome
  10. membrane repolarization Source: BHF-UCL
  11. membrane repolarization during cardiac muscle cell action potential Source: BHF-UCL
  12. positive regulation of ATPase activity Source: BHF-UCL
  13. positive regulation of ATP catabolic process Source: BHF-UCL
  14. positive regulation of calcium:sodium antiporter activity Source: BHF-UCL
  15. positive regulation of potassium ion import Source: BHF-UCL
  16. positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
  17. positive regulation of sodium ion export from cell Source: BHF-UCL
  18. potassium ion import Source: BHF-UCL
  19. protein localization to plasma membrane Source: BHF-UCL
  20. protein stabilization Source: BHF-UCL
  21. protein transport into plasma membrane raft Source: BHF-UCL
  22. regulation of cardiac muscle contraction by calcium ion signaling Source: BHF-UCL
  23. regulation of gene expression Source: BHF-UCL
  24. relaxation of cardiac muscle Source: BHF-UCL
  25. response to hypoxia Source: Ensembl
  26. sodium ion export from cell Source: BHF-UCL
  27. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Enzyme and pathway databases

ReactomeiREACT_12560. Basigin interactions.
REACT_25149. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.1.1. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-1
Gene namesi
Name:ATP1B1
Synonyms:ATP1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:804. ATP1B1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei35 – 6228Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini63 – 303241ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. caveola Source: Ensembl
  4. extracellular vesicular exosome Source: UniProtKB
  5. intercalated disc Source: BHF-UCL
  6. plasma membrane Source: BHF-UCL
  7. sarcolemma Source: BHF-UCL
  8. sodium:potassium-exchanging ATPase complex Source: BHF-UCL
  9. vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA66.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Sodium/potassium-transporting ATPase subunit beta-1PRO_0000219097Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei101 – 1011PhosphotyrosineBy similarity
Disulfide bondi126 ↔ 149By similarity
Glycosylationi158 – 1581N-linked (GlcNAc...)2 Publications
Disulfide bondi159 ↔ 175By similarity
Glycosylationi193 – 1931N-linked (GlcNAc...)2 Publications
Disulfide bondi213 ↔ 276By similarity
Glycosylationi265 – 2651N-linked (GlcNAc...)3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP05026.
PaxDbiP05026.
PRIDEiP05026.

PTM databases

PhosphoSiteiP05026.

Expressioni

Tissue specificityi

Found in most tissues.

Gene expression databases

BgeeiP05026.
CleanExiHS_ATP1B1.
ExpressionAtlasiP05026. baseline and differential.
GenevestigatoriP05026.

Organism-specific databases

HPAiHPA012911.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma. Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM.By similarity1 Publication

Protein-protein interaction databases

BioGridi106971. 25 interactions.
IntActiP05026. 10 interactions.
MINTiMINT-5000887.
STRINGi9606.ENSP00000356789.

Structurei

3D structure databases

ProteinModelPortaliP05026.
SMRiP05026. Positions 1-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni191 – 303113immunoglobulin-likeAdd
BLAST

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313139.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP05026.
KOiK01540.
OMAiGFKPKPP.
OrthoDBiEOG7M6D85.
PhylomeDBiP05026.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
IPR015565. Na/K_ATPase_sub_beta_chordates.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PTHR11523:SF10. PTHR11523:SF10. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P05026-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF
60 70 80 90 100
IGTIQVMLLT ISEFKPTYQD RVAPPGLTQI PQIQKTEISF RPNDPKSYEA
110 120 130 140 150
YVLNIVRFLE KYKDSAQRDD MIFEDCGDVP SEPKERGDFN HERGERKVCR
160 170 180 190 200
FKLEWLGNCS GLNDETYGYK EGKPCIIIKL NRVLGFKPKP PKNESLETYP
210 220 230 240 250
VMKYNPNVLP VQCTGKRDED KDKVGNVEYF GLGNSPGFPL QYYPYYGKLL
260 270 280 290 300
QPKYLQPLLA VQFTNLTMDT EIRIECKAYG ENIGYSEKDR FQGRFDVKIE

VKS
Length:303
Mass (Da):35,061
Last modified:August 13, 1987 - v1
Checksum:i107D3C04394F2D11
GO
Isoform 2 (identifier: P05026-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-303: EVKS → KF

Show »
Length:301
Mass (Da):34,893
Checksum:i670C194F2D114F67
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei300 – 3034EVKS → KF in isoform 2. 1 PublicationVSP_000349

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03747 mRNA. Translation: CAA27385.1.
M25160, M25161 Genomic DNA. Translation: AAA36352.1.
U16799 mRNA. Translation: AAC50132.1.
BT009787 mRNA. Translation: AAP88789.1.
AL031726 Genomic DNA. Translation: CAI18888.1.
BC000006 mRNA. Translation: AAH00006.1.
X17161 Genomic DNA. Translation: CAA35040.1.
CCDSiCCDS1276.1. [P05026-1]
PIRiA23764. PWHUNB.
RefSeqiNP_001668.1. NM_001677.3. [P05026-1]
UniGeneiHs.291196.

Genome annotation databases

EnsembliENST00000367815; ENSP00000356789; ENSG00000143153. [P05026-1]
ENST00000367816; ENSP00000356790; ENSG00000143153. [P05026-1]
GeneIDi481.
KEGGihsa:481.
UCSCiuc001gfr.1. human. [P05026-1]

Polymorphism databases

DMDMi114392.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03747 mRNA. Translation: CAA27385.1 .
M25160 , M25161 Genomic DNA. Translation: AAA36352.1 .
U16799 mRNA. Translation: AAC50132.1 .
BT009787 mRNA. Translation: AAP88789.1 .
AL031726 Genomic DNA. Translation: CAI18888.1 .
BC000006 mRNA. Translation: AAH00006.1 .
X17161 Genomic DNA. Translation: CAA35040.1 .
CCDSi CCDS1276.1. [P05026-1 ]
PIRi A23764. PWHUNB.
RefSeqi NP_001668.1. NM_001677.3. [P05026-1 ]
UniGenei Hs.291196.

3D structure databases

ProteinModelPortali P05026.
SMRi P05026. Positions 1-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106971. 25 interactions.
IntActi P05026. 10 interactions.
MINTi MINT-5000887.
STRINGi 9606.ENSP00000356789.

Chemistry

ChEMBLi CHEMBL2095186.

Protein family/group databases

TCDBi 3.A.3.1.1. the p-type atpase (p-atpase) superfamily.

PTM databases

PhosphoSitei P05026.

Polymorphism databases

DMDMi 114392.

Proteomic databases

MaxQBi P05026.
PaxDbi P05026.
PRIDEi P05026.

Protocols and materials databases

DNASUi 481.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367815 ; ENSP00000356789 ; ENSG00000143153 . [P05026-1 ]
ENST00000367816 ; ENSP00000356790 ; ENSG00000143153 . [P05026-1 ]
GeneIDi 481.
KEGGi hsa:481.
UCSCi uc001gfr.1. human. [P05026-1 ]

Organism-specific databases

CTDi 481.
GeneCardsi GC01P169074.
H-InvDB HIX0001311.
HGNCi HGNC:804. ATP1B1.
HPAi HPA012911.
MIMi 182330. gene.
neXtProti NX_P05026.
PharmGKBi PA66.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313139.
GeneTreei ENSGT00550000074530.
HOGENOMi HOG000039248.
HOVERGENi HBG050603.
InParanoidi P05026.
KOi K01540.
OMAi GFKPKPP.
OrthoDBi EOG7M6D85.
PhylomeDBi P05026.
TreeFami TF314618.

Enzyme and pathway databases

Reactomei REACT_12560. Basigin interactions.
REACT_25149. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSi ATP1B1. human.
GeneWikii ATP1B1.
GenomeRNAii 481.
NextBioi 1995.
PROi P05026.
SOURCEi Search...

Gene expression databases

Bgeei P05026.
CleanExi HS_ATP1B1.
ExpressionAtlasi P05026. baseline and differential.
Genevestigatori P05026.

Family and domain databases

InterProi IPR000402. Na/K_ATPase_sub_beta.
IPR015565. Na/K_ATPase_sub_beta_chordates.
[Graphical view ]
PANTHERi PTHR11523. PTHR11523. 1 hit.
PTHR11523:SF10. PTHR11523:SF10. 1 hit.
Pfami PF00287. Na_K-ATPase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEi PS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequence analysis of human Na,K-ATPase beta-subunit."
    Kawakami K., Nojima H., Ohta T., Nagano K.
    Nucleic Acids Res. 14:2833-2844(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Characterization of two genes for the human Na,K-ATPase beta subunit."
    Lane L.K., Shull M.M., Whitmer K.R., Lingrel J.B.
    Genomics 5:445-453(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium."
    Ruiz A., Bhat S.P., Bok D.
    Gene 155:179-184(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Retinal pigment epithelium.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  7. "Human Na(+), K(+)-ATPase genes. Beta subunit gene family contains at least one gene and one pseudogene."
    Ushkaryov Y.A., Monastyrskaya G.S., Broude N.E., Nikiforova N.N., Bessarab B.A., Orlova M.Y., Petrukhin K.E., Modyanov N.N., Sverdlov E.D.
    FEBS Lett. 257:439-442(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-72.
    Tissue: Sperm.
  8. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
    Zhang H., Li X.-J., Martin D.B., Aebersold R.
    Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-158; ASN-193 AND ASN-265.
  9. "A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules."
    Bab-Dinitz E., Albeck S., Peleg Y., Brumfeld V., Gottschalk K.E., Karlish S.J.
    Biochemistry 48:8684-8691(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ADHESION, DOMAIN IMMUNOGLOBULIN-LIKE.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-158; ASN-193 AND ASN-265.
    Tissue: Liver.
  11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-265.
    Tissue: Leukemic T-cell.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations."
    Lanciotti A., Brignone M.S., Molinari P., Visentin S., De Nuccio C., Macchia G., Aiello C., Bertini E., Aloisi F., Petrucci T.C., Ambrosini E.
    Hum. Mol. Genet. 21:2166-2180(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MLC1.

Entry informationi

Entry nameiAT1B1_HUMAN
AccessioniPrimary (citable) accession number: P05026
Secondary accession number(s): Q5TGZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 26, 2014
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3