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P05026

- AT1B1_HUMAN

UniProt

P05026 - AT1B1_HUMAN

Protein

Sodium/potassium-transporting ATPase subunit beta-1

Gene

ATP1B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 155 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.1 Publication
    Involved in cell adhesion and establishing epithelial cell polarity.1 Publication

    GO - Molecular functioni

    1. MHC class II protein complex binding Source: UniProt
    2. protein binding Source: UniProtKB
    3. sodium:potassium-exchanging ATPase activity Source: ProtInc

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. cell adhesion Source: UniProtKB-KW
    3. ion transmembrane transport Source: Reactome
    4. leukocyte migration Source: Reactome
    5. response to hypoxia Source: Ensembl
    6. sodium ion transmembrane transport Source: GOC
    7. transmembrane transport Source: Reactome
    8. transport Source: ProtInc

    Keywords - Biological processi

    Cell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    Potassium, Sodium

    Enzyme and pathway databases

    ReactomeiREACT_12560. Basigin interactions.
    REACT_25149. Ion transport by P-type ATPases.

    Protein family/group databases

    TCDBi3.A.3.1.1. the p-type atpase (p-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-1
    Alternative name(s):
    Sodium/potassium-dependent ATPase subunit beta-1
    Gene namesi
    Name:ATP1B1
    Synonyms:ATP1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:804. ATP1B1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. caveola Source: Ensembl
    4. extracellular vesicular exosome Source: UniProt
    5. plasma membrane Source: Reactome
    6. sodium:potassium-exchanging ATPase complex Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA66.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Sodium/potassium-transporting ATPase subunit beta-1PRO_0000219097Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei101 – 1011PhosphotyrosineBy similarity
    Disulfide bondi126 ↔ 149By similarity
    Glycosylationi158 – 1581N-linked (GlcNAc...)2 Publications
    Disulfide bondi159 ↔ 175By similarity
    Glycosylationi193 – 1931N-linked (GlcNAc...)2 Publications
    Disulfide bondi213 ↔ 276By similarity
    Glycosylationi265 – 2651N-linked (GlcNAc...)3 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP05026.
    PaxDbiP05026.
    PRIDEiP05026.

    PTM databases

    PhosphoSiteiP05026.

    Expressioni

    Tissue specificityi

    Found in most tissues.

    Gene expression databases

    ArrayExpressiP05026.
    BgeeiP05026.
    CleanExiHS_ATP1B1.
    GenevestigatoriP05026.

    Organism-specific databases

    HPAiHPA012911.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma. Interacts with NKAIN1, NKAIN2 and NKAIN4 By similarity. Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi106971. 24 interactions.
    IntActiP05026. 10 interactions.
    MINTiMINT-5000887.
    STRINGi9606.ENSP00000356789.

    Structurei

    3D structure databases

    ProteinModelPortaliP05026.
    SMRiP05026. Positions 1-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini63 – 303241ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 6228Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni191 – 303113immunoglobulin-likeAdd
    BLAST

    Domaini

    The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG313139.
    HOGENOMiHOG000039248.
    HOVERGENiHBG050603.
    InParanoidiP05026.
    KOiK01540.
    OMAiGFKPKPP.
    OrthoDBiEOG7M6D85.
    PhylomeDBiP05026.
    TreeFamiTF314618.

    Family and domain databases

    InterProiIPR000402. Na/K_ATPase_sub_beta.
    IPR015565. Na/K_ATPase_sub_beta_chordates.
    [Graphical view]
    PANTHERiPTHR11523. PTHR11523. 1 hit.
    PTHR11523:SF10. PTHR11523:SF10. 1 hit.
    PfamiPF00287. Na_K-ATPase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
    PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
    PS00391. ATPASE_NA_K_BETA_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P05026-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF    50
    IGTIQVMLLT ISEFKPTYQD RVAPPGLTQI PQIQKTEISF RPNDPKSYEA 100
    YVLNIVRFLE KYKDSAQRDD MIFEDCGDVP SEPKERGDFN HERGERKVCR 150
    FKLEWLGNCS GLNDETYGYK EGKPCIIIKL NRVLGFKPKP PKNESLETYP 200
    VMKYNPNVLP VQCTGKRDED KDKVGNVEYF GLGNSPGFPL QYYPYYGKLL 250
    QPKYLQPLLA VQFTNLTMDT EIRIECKAYG ENIGYSEKDR FQGRFDVKIE 300
    VKS 303
    Length:303
    Mass (Da):35,061
    Last modified:August 13, 1987 - v1
    Checksum:i107D3C04394F2D11
    GO
    Isoform 2 (identifier: P05026-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         300-303: EVKS → KF

    Show »
    Length:301
    Mass (Da):34,893
    Checksum:i670C194F2D114F67
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei300 – 3034EVKS → KF in isoform 2. 1 PublicationVSP_000349

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03747 mRNA. Translation: CAA27385.1.
    M25160, M25161 Genomic DNA. Translation: AAA36352.1.
    U16799 mRNA. Translation: AAC50132.1.
    BT009787 mRNA. Translation: AAP88789.1.
    AL031726 Genomic DNA. Translation: CAI18888.1.
    BC000006 mRNA. Translation: AAH00006.1.
    X17161 Genomic DNA. Translation: CAA35040.1.
    CCDSiCCDS1276.1. [P05026-1]
    PIRiA23764. PWHUNB.
    RefSeqiNP_001668.1. NM_001677.3. [P05026-1]
    UniGeneiHs.291196.

    Genome annotation databases

    EnsembliENST00000367815; ENSP00000356789; ENSG00000143153. [P05026-1]
    ENST00000367816; ENSP00000356790; ENSG00000143153. [P05026-1]
    GeneIDi481.
    KEGGihsa:481.
    UCSCiuc001gfr.1. human. [P05026-1]

    Polymorphism databases

    DMDMi114392.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03747 mRNA. Translation: CAA27385.1 .
    M25160 , M25161 Genomic DNA. Translation: AAA36352.1 .
    U16799 mRNA. Translation: AAC50132.1 .
    BT009787 mRNA. Translation: AAP88789.1 .
    AL031726 Genomic DNA. Translation: CAI18888.1 .
    BC000006 mRNA. Translation: AAH00006.1 .
    X17161 Genomic DNA. Translation: CAA35040.1 .
    CCDSi CCDS1276.1. [P05026-1 ]
    PIRi A23764. PWHUNB.
    RefSeqi NP_001668.1. NM_001677.3. [P05026-1 ]
    UniGenei Hs.291196.

    3D structure databases

    ProteinModelPortali P05026.
    SMRi P05026. Positions 1-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106971. 24 interactions.
    IntActi P05026. 10 interactions.
    MINTi MINT-5000887.
    STRINGi 9606.ENSP00000356789.

    Chemistry

    BindingDBi P05026.
    ChEMBLi CHEMBL2095186.

    Protein family/group databases

    TCDBi 3.A.3.1.1. the p-type atpase (p-atpase) superfamily.

    PTM databases

    PhosphoSitei P05026.

    Polymorphism databases

    DMDMi 114392.

    Proteomic databases

    MaxQBi P05026.
    PaxDbi P05026.
    PRIDEi P05026.

    Protocols and materials databases

    DNASUi 481.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367815 ; ENSP00000356789 ; ENSG00000143153 . [P05026-1 ]
    ENST00000367816 ; ENSP00000356790 ; ENSG00000143153 . [P05026-1 ]
    GeneIDi 481.
    KEGGi hsa:481.
    UCSCi uc001gfr.1. human. [P05026-1 ]

    Organism-specific databases

    CTDi 481.
    GeneCardsi GC01P169074.
    H-InvDB HIX0001311.
    HGNCi HGNC:804. ATP1B1.
    HPAi HPA012911.
    MIMi 182330. gene.
    neXtProti NX_P05026.
    PharmGKBi PA66.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313139.
    HOGENOMi HOG000039248.
    HOVERGENi HBG050603.
    InParanoidi P05026.
    KOi K01540.
    OMAi GFKPKPP.
    OrthoDBi EOG7M6D85.
    PhylomeDBi P05026.
    TreeFami TF314618.

    Enzyme and pathway databases

    Reactomei REACT_12560. Basigin interactions.
    REACT_25149. Ion transport by P-type ATPases.

    Miscellaneous databases

    ChiTaRSi ATP1B1. human.
    GeneWikii ATP1B1.
    GenomeRNAii 481.
    NextBioi 1995.
    PROi P05026.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P05026.
    Bgeei P05026.
    CleanExi HS_ATP1B1.
    Genevestigatori P05026.

    Family and domain databases

    InterProi IPR000402. Na/K_ATPase_sub_beta.
    IPR015565. Na/K_ATPase_sub_beta_chordates.
    [Graphical view ]
    PANTHERi PTHR11523. PTHR11523. 1 hit.
    PTHR11523:SF10. PTHR11523:SF10. 1 hit.
    Pfami PF00287. Na_K-ATPase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01107. Na_K_ATPase_bet. 1 hit.
    PROSITEi PS00390. ATPASE_NA_K_BETA_1. 1 hit.
    PS00391. ATPASE_NA_K_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequence analysis of human Na,K-ATPase beta-subunit."
      Kawakami K., Nojima H., Ohta T., Nagano K.
      Nucleic Acids Res. 14:2833-2844(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Characterization of two genes for the human Na,K-ATPase beta subunit."
      Lane L.K., Shull M.M., Whitmer K.R., Lingrel J.B.
      Genomics 5:445-453(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium."
      Ruiz A., Bhat S.P., Bok D.
      Gene 155:179-184(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Retinal pigment epithelium.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    7. "Human Na(+), K(+)-ATPase genes. Beta subunit gene family contains at least one gene and one pseudogene."
      Ushkaryov Y.A., Monastyrskaya G.S., Broude N.E., Nikiforova N.N., Bessarab B.A., Orlova M.Y., Petrukhin K.E., Modyanov N.N., Sverdlov E.D.
      FEBS Lett. 257:439-442(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-72.
      Tissue: Sperm.
    8. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-158; ASN-193 AND ASN-265.
    9. "A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules."
      Bab-Dinitz E., Albeck S., Peleg Y., Brumfeld V., Gottschalk K.E., Karlish S.J.
      Biochemistry 48:8684-8691(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ADHESION, DOMAIN IMMUNOGLOBULIN-LIKE.
    10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-158; ASN-193 AND ASN-265.
      Tissue: Liver.
    11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-265.
      Tissue: Leukemic T-cell.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations."
      Lanciotti A., Brignone M.S., Molinari P., Visentin S., De Nuccio C., Macchia G., Aiello C., Bertini E., Aloisi F., Petrucci T.C., Ambrosini E.
      Hum. Mol. Genet. 21:2166-2180(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MLC1.

    Entry informationi

    Entry nameiAT1B1_HUMAN
    AccessioniPrimary (citable) accession number: P05026
    Secondary accession number(s): Q5TGZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 155 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3