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P05025

- AT1A_TORCA

UniProt

P05025 - AT1A_TORCA

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Protein
Sodium/potassium-transporting ATPase subunit alpha
Gene
N/A
Organism
Torpedo californica (Pacific electric ray)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei376 – 37614-aspartylphosphate intermediate By similarity
Metal bindingi716 – 7161Magnesium By similarity
Metal bindingi720 – 7201Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha subunit
Alternative name(s):
Sodium pump subunit alpha
OrganismiTorpedo californica (Pacific electric ray)
Taxonomic identifieri7787 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaTorpediniformesTorpedinidaeTorpedo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini6 – 8782Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Topological domaini109 – 13123Lumenal Reviewed prediction
Add
BLAST
Transmembranei132 – 15221Helical; Reviewed prediction
Add
BLAST
Topological domaini153 – 288136Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei289 – 30820Helical; Reviewed prediction
Add
BLAST
Topological domaini309 – 32012Lumenal Reviewed prediction
Add
BLAST
Transmembranei321 – 33818Helical; Reviewed prediction
Add
BLAST
Topological domaini339 – 771433Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei772 – 79120Helical; Reviewed prediction
Add
BLAST
Topological domaini792 – 80110Lumenal Reviewed prediction
Transmembranei802 – 82221Helical; Reviewed prediction
Add
BLAST
Topological domaini823 – 84220Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei843 – 86523Helical; Reviewed prediction
Add
BLAST
Topological domaini866 – 91752Lumenal Reviewed prediction
Add
BLAST
Transmembranei918 – 93720Helical; Reviewed prediction
Add
BLAST
Topological domaini938 – 95013Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei951 – 96919Helical; Reviewed prediction
Add
BLAST
Topological domaini970 – 98415Lumenal Reviewed prediction
Add
BLAST
Transmembranei985 – 100521Helical; Reviewed prediction
Add
BLAST
Topological domaini1006 – 102217Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 55
PRO_0000002509
Chaini6 – 10221017Sodium/potassium-transporting ATPase subunit alpha
PRO_0000002510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine; by PKC By similarity
Modified residuei942 – 9421Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP05025.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP05025.
SMRiP05025. Positions 28-1022.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 843Interaction with phosphoinositide-3 kinase By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05025-1 [UniParc]FASTAAdd to Basket

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MGKGAASEKY QPAATSENAK NSKKSKSKTT DLDELKKEVS LDDHKLNLDE     50
LHQKYGTDLT QGLTPARAKE ILARDGPNAL TPPPTTPEWI KFCRQLFGGF 100
SILLWTGAIL CFLAYGIQVA TVDNPANDNL YLGVVLSTVV IITGCFSYYQ 150
EAKSSKIMDS FKNMVPQQAL VIRDGEKSSI NAEQVVVGDL VEVKGGDRIP 200
ADLRIISACS CKVDNSSLTG ESEPQSRSPE YSSENPLETK NIAFFSTNCV 250
EGTARGIVIN IGDHTVMGRI ATLASGLEVG QTPIAAEIEH FIHIITGVAV 300
FLGVSFFILS LILGYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR 350
MARKNCLVKN LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA 400
DTTENQSGIS FDKTSLSWNA LSRIAALCNR AVFQAGQDSV PILKRSVAGD 450
ASESALLKCI ELCCGSVSQM RDRNPKIVEI PFNSTNKYQL SIHENDKADS 500
RYLLVMKGAP ERILDRCSTI LLNGEDKPLN EEMKEAFQNA YLELGGLGER 550
VLGFCHLKLS TSKFPEGYPF DVEEPNFPIT DLCFVGLMSM IDPPRAAVPD 600
AVGKCRSAGI KVIMVTGDHP ITAKAIAKGV GIISEGNETV EDIAARLNIP 650
VNQVNPRDAK ACVVHGTDLK DLSHENLDDI LHYHTEIVFA RTSPQQKLII 700
VEGCQRQGAI VAVTGDGVND SPALKKADIG VAMGIAGSDV SKQAADMILL 750
DDNFASIVTG VEEGRLIFDN LKKSIAYTLT SNIPEITPFL VFIIANVPLP 800
LGTVTILCID LGTDMVPAIS LAYERAESDI MKRQPRNPKT DKLVNERLIS 850
MAYGQIGMIQ ALGGFFSYFV ILAENGFLPI DLIGIREKWD ELWTQDLEDS 900
YGQQWTYEQR KIVEYTCHTS FFVSIVIVQW ADLIICKTRR NSIFQQGMKN 950
KILIFGLFEE TALAAFLSYT PGTDIALRMY PLKPSWWFCA FPYSLIIFLY 1000
DEARRFILRR NPGGWVEQET YY 1022
Length:1,022
Mass (Da):112,430
Last modified:August 13, 1987 - v1
Checksum:iD92FE737847D73C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02810 mRNA. Translation: CAA26578.1.
PIRiS00503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02810 mRNA. Translation: CAA26578.1 .
PIRi S00503.

3D structure databases

ProteinModelPortali P05025.
SMRi P05025. Positions 28-1022.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P05025.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004298.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of the alpha-subunit of Torpedo californica (Na+ + K+)ATPase deduced from cDNA sequence."
    Kawakami K., Noguchi S., Noda M., Takahashi H., Ohta T., Kawamura M., Nojima H., Nagano K., Hirose T., Inayama S., Hayashida H., Miyata T., Numa S.
    Nature 316:733-736(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "The active site structure of Na+/K+-transporting ATPase: location of the 5'-(p-fluorosulfonyl)benzoyladenosine binding site and soluble peptides released by trypsin."
    Ohta T., Nagano K., Yoshida M.
    Proc. Natl. Acad. Sci. U.S.A. 83:2071-2075(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 386-402; 502-512; 671-689 AND 887-906.

Entry informationi

Entry nameiAT1A_TORCA
AccessioniPrimary (citable) accession number: P05025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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