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Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

ATP1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3764-aspartylphosphate intermediateBy similarity1
Binding sitei487ATPBy similarity1
Metal bindingi717MagnesiumBy similarity1
Metal bindingi721MagnesiumBy similarity1

GO - Molecular functioni

  • ADP binding Source: Ensembl
  • ATP binding Source: BHF-UCL
  • chaperone binding Source: BHF-UCL
  • phosphatase activity Source: Ensembl
  • potassium ion binding Source: BHF-UCL
  • sodium:potassium-exchanging ATPase activity Source: UniProtKB
  • sodium ion binding Source: BHF-UCL
  • steroid hormone binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Enzyme and pathway databases

BioCyciZFISH:HS08843-MONOMER.
ReactomeiR-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.1.1. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:ATP1A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:799. ATP1A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini6 – 87CytoplasmicSequence analysisAdd BLAST82
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 131ExtracellularSequence analysisAdd BLAST23
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 288CytoplasmicSequence analysisAdd BLAST136
Transmembranei289 – 308HelicalSequence analysisAdd BLAST20
Topological domaini309 – 320ExtracellularSequence analysisAdd BLAST12
Transmembranei321 – 338HelicalSequence analysisAdd BLAST18
Topological domaini339 – 772CytoplasmicSequence analysisAdd BLAST434
Transmembranei773 – 792HelicalSequence analysisAdd BLAST20
Topological domaini793 – 802ExtracellularSequence analysis10
Transmembranei803 – 823HelicalSequence analysisAdd BLAST21
Topological domaini824 – 843CytoplasmicSequence analysisAdd BLAST20
Transmembranei844 – 866HelicalSequence analysisAdd BLAST23
Topological domaini867 – 918ExtracellularSequence analysisAdd BLAST52
Transmembranei919 – 938HelicalSequence analysisAdd BLAST20
Topological domaini939 – 951CytoplasmicSequence analysisAdd BLAST13
Transmembranei952 – 970HelicalSequence analysisAdd BLAST19
Topological domaini971 – 985ExtracellularSequence analysisAdd BLAST15
Transmembranei986 – 1006HelicalSequence analysisAdd BLAST21
Topological domaini1007 – 1023CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • basolateral plasma membrane Source: Ensembl
  • caveola Source: Ensembl
  • endoplasmic reticulum Source: BHF-UCL
  • endosome Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular vesicle Source: UniProtKB
  • Golgi apparatus Source: BHF-UCL
  • integral component of membrane Source: UniProtKB
  • intercalated disc Source: Ensembl
  • intracellular membrane-bounded organelle Source: GO_Central
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: ProtInc
  • myelin sheath Source: Ensembl
  • plasma membrane Source: UniProtKB
  • postsynaptic density Source: Ensembl
  • protein complex Source: MGI
  • sarcolemma Source: BHF-UCL
  • sodium:potassium-exchanging ATPase complex Source: BHF-UCL
  • T-tubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi476.
OpenTargetsiENSG00000163399.
Orphaneti85142. Aldosterone-producing adenoma.
PharmGKBiPA62.

Chemistry databases

ChEMBLiCHEMBL1807.
DrugBankiDB00511. Acetyldigitoxin.
DB01430. Almitrine.
DB01370. Aluminium.
DB01244. Bepridil.
DB01158. Bretylium.
DB01188. Ciclopirox.
DB01078. Deslanoside.
DB01119. Diazoxide.
DB01396. Digitoxin.
DB00390. Digoxin.
DB00903. Ethacrynic acid.
DB00774. Hydroflumethiazide.
DB01092. Ouabain.
DB01345. Potassium.
DB01021. Trichlormethiazide.

Polymorphism and mutation databases

BioMutaiATP1A1.
DMDMi114374.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000024831 – 55
ChainiPRO_00000024846 – 1023Sodium/potassium-transporting ATPase subunit alpha-1Add BLAST1018

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei10PhosphotyrosineBy similarity1
Modified residuei16PhosphoserineCombined sources1
Modified residuei21N6-acetyllysineBy similarity1
Modified residuei40PhosphoserineBy similarity1
Modified residuei47PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei260PhosphotyrosineBy similarity1
Modified residuei452PhosphoserineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei542PhosphotyrosineCombined sources1
Modified residuei661N6-succinyllysineBy similarity1
Modified residuei668PhosphoserineBy similarity1
Modified residuei675PhosphoserineBy similarity1
Modified residuei943Phosphoserine; by PKABy similarity1

Post-translational modificationi

Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP05023.
MaxQBiP05023.
PaxDbiP05023.
PeptideAtlasiP05023.
PRIDEiP05023.

PTM databases

iPTMnetiP05023.
PhosphoSitePlusiP05023.
SwissPalmiP05023.

Expressioni

Gene expression databases

BgeeiENSG00000163399.
CleanExiHS_ATP1A1.
ExpressionAtlasiP05023. baseline and differential.
GenevisibleiP05023. HS.

Organism-specific databases

HPAiCAB018702.

Interactioni

Subunit structurei

Interacts with SIK1 (By similarity). Composed of three subunits: alpha (catalytic), beta and gamma. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SLC35G1 and STIM1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TPT1P136935EBI-358778,EBI-1783169

GO - Molecular functioni

  • chaperone binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi106966. 120 interactors.
DIPiDIP-38196N.
IntActiP05023. 58 interactors.
MINTiMINT-4998863.
STRINGi9606.ENSP00000295598.

Structurei

3D structure databases

ProteinModelPortaliP05023.
SMRiP05023.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 84Phosphoinositide-3 kinase bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00850000132256.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP05023.
KOiK01539.
OMAiPVENLCF.
OrthoDBiEOG091G01BB.
PhylomeDBiP05023.
TreeFamiTF312838.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P05023-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKGVGRDKY EPAAVSEQGD KKGKKGKKDR DMDELKKEVS MDDHKLSLDE
60 70 80 90 100
LHRKYGTDLS RGLTSARAAE ILARDGPNAL TPPPTTPEWI KFCRQLFGGF
110 120 130 140 150
SMLLWIGAIL CFLAYSIQAA TEEEPQNDNL YLGVVLSAVV IITGCFSYYQ
160 170 180 190 200
EAKSSKIMES FKNMVPQQAL VIRNGEKMSI NAEEVVVGDL VEVKGGDRIP
210 220 230 240 250
ADLRIISANG CKVDNSSLTG ESEPQTRSPD FTNENPLETR NIAFFSTNCV
260 270 280 290 300
EGTARGIVVY TGDRTVMGRI ATLASGLEGG QTPIAAEIEH FIHIITGVAV
310 320 330 340 350
FLGVSFFILS LILEYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR
360 370 380 390 400
MARKNCLVKN LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA
410 420 430 440 450
DTTENQSGVS FDKTSATWLA LSRIAGLCNR AVFQANQENL PILKRAVAGD
460 470 480 490 500
ASESALLKCI ELCCGSVKEM RERYAKIVEI PFNSTNKYQL SIHKNPNTSE
510 520 530 540 550
PQHLLVMKGA PERILDRCSS ILLHGKEQPL DEELKDAFQN AYLELGGLGE
560 570 580 590 600
RVLGFCHLFL PDEQFPEGFQ FDTDDVNFPI DNLCFVGLIS MIDPPRAAVP
610 620 630 640 650
DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI
660 670 680 690 700
PVSQVNPRDA KACVVHGSDL KDMTSEQLDD ILKYHTEIVF ARTSPQQKLI
710 720 730 740 750
IVEGCQRQGA IVAVTGDGVN DSPALKKADI GVAMGIAGSD VSKQAADMIL
760 770 780 790 800
LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEITPF LIFIIANIPL
810 820 830 840 850
PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK TDKLVNERLI
860 870 880 890 900
SMAYGQIGMI QALGGFFTYF VILAENGFLP IHLLGLRVDW DDRWINDVED
910 920 930 940 950
SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR RNSVFQQGMK
960 970 980 990 1000
NKILIFGLFE ETALAAFLSY CPGMGVALRM YPLKPTWWFC AFPYSLLIFV
1010 1020
YDEVRKLIIR RRPGGWVEKE TYY
Length:1,023
Mass (Da):112,896
Last modified:August 13, 1987 - v1
Checksum:iF3C6FDE04FB3F667
GO
Isoform 2 (identifier: P05023-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     638-681: NETVEDIAAR...DMTSEQLDDI → SGPMSRGKSW...PGGIRSSSRG
     682-1023: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:681
Mass (Da):74,140
Checksum:iB74A8E7E31E975AD
GO
Isoform 3 (identifier: P05023-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:992
Mass (Da):109,550
Checksum:i6F607167FD03A23B
GO
Isoform 4 (identifier: P05023-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-4: GKG → AFK

Show »
Length:1,023
Mass (Da):113,000
Checksum:iB5B35DE0B0650011
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti248N → S in BAG37313 (PubMed:14702039).Curated1
Sequence conflicti323F → L in BAH11971 (PubMed:14702039).Curated1
Sequence conflicti475A → T in CAA27390 (Ref. 13) Curated1
Sequence conflicti499S → A in CAA27390 (Ref. 13) Curated1
Sequence conflicti502Q → R in CAA27390 (Ref. 13) Curated1
Sequence conflicti523L → I in CAA27390 (Ref. 13) Curated1
Sequence conflicti892D → G in BAH11971 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04837447S → I.Corresponds to variant rs12564026dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442421 – 31Missing in isoform 3. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0473092 – 4GKG → AFK in isoform 4. 1 Publication3
Alternative sequenceiVSP_000415638 – 681NETVE…QLDDI → SGPMSRGKSWSSPATQPSSS VSWWCSGPTWSSVRPGGIRS SSRG in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_000416682 – 1023Missing in isoform 2. 1 PublicationAdd BLAST342

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00099 mRNA. Translation: BAA00061.1.
X04297 mRNA. Translation: CAA27840.1.
U16798 mRNA. Translation: AAC50131.1.
AK295095 mRNA. Translation: BAH11971.1.
AK296362 mRNA. Translation: BAH12332.1.
AK314777 mRNA. Translation: BAG37313.1.
AL136376 Genomic DNA. No translation available.
CH471122 Genomic DNA. Translation: EAW56644.1.
BC003077 mRNA. Translation: AAH03077.1.
BC001330 mRNA. Translation: AAH01330.1.
BC050359 mRNA. Translation: AAH50359.1.
M30310, M30309 Genomic DNA. Translation: AAA51801.1.
L76938 Genomic DNA. Translation: AAA92713.1.
M16793 mRNA. Translation: AAD56251.1.
M16794 mRNA. Translation: AAD56252.1.
J03007 mRNA. Translation: AAA51803.1.
M27572 Genomic DNA. Translation: AAA35573.1.
M27579 Genomic DNA. Translation: AAA35574.2.
X03757 mRNA. Translation: CAA27390.1.
CCDSiCCDS53351.1. [P05023-4]
CCDS53352.1. [P05023-3]
CCDS887.1. [P05023-1]
PIRiA24414.
RefSeqiNP_000692.2. NM_000701.7. [P05023-1]
NP_001153705.1. NM_001160233.1. [P05023-4]
NP_001153706.1. NM_001160234.1. [P05023-3]
XP_016856849.1. XM_017001360.1. [P05023-3]
XP_016856850.1. XM_017001361.1. [P05023-3]
UniGeneiHs.371889.

Genome annotation databases

EnsembliENST00000295598; ENSP00000295598; ENSG00000163399. [P05023-1]
ENST00000369496; ENSP00000358508; ENSG00000163399. [P05023-3]
ENST00000537345; ENSP00000445306; ENSG00000163399. [P05023-4]
GeneIDi476.
KEGGihsa:476.
UCSCiuc001ege.5. human. [P05023-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00099 mRNA. Translation: BAA00061.1.
X04297 mRNA. Translation: CAA27840.1.
U16798 mRNA. Translation: AAC50131.1.
AK295095 mRNA. Translation: BAH11971.1.
AK296362 mRNA. Translation: BAH12332.1.
AK314777 mRNA. Translation: BAG37313.1.
AL136376 Genomic DNA. No translation available.
CH471122 Genomic DNA. Translation: EAW56644.1.
BC003077 mRNA. Translation: AAH03077.1.
BC001330 mRNA. Translation: AAH01330.1.
BC050359 mRNA. Translation: AAH50359.1.
M30310, M30309 Genomic DNA. Translation: AAA51801.1.
L76938 Genomic DNA. Translation: AAA92713.1.
M16793 mRNA. Translation: AAD56251.1.
M16794 mRNA. Translation: AAD56252.1.
J03007 mRNA. Translation: AAA51803.1.
M27572 Genomic DNA. Translation: AAA35573.1.
M27579 Genomic DNA. Translation: AAA35574.2.
X03757 mRNA. Translation: CAA27390.1.
CCDSiCCDS53351.1. [P05023-4]
CCDS53352.1. [P05023-3]
CCDS887.1. [P05023-1]
PIRiA24414.
RefSeqiNP_000692.2. NM_000701.7. [P05023-1]
NP_001153705.1. NM_001160233.1. [P05023-4]
NP_001153706.1. NM_001160234.1. [P05023-3]
XP_016856849.1. XM_017001360.1. [P05023-3]
XP_016856850.1. XM_017001361.1. [P05023-3]
UniGeneiHs.371889.

3D structure databases

ProteinModelPortaliP05023.
SMRiP05023.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106966. 120 interactors.
DIPiDIP-38196N.
IntActiP05023. 58 interactors.
MINTiMINT-4998863.
STRINGi9606.ENSP00000295598.

Chemistry databases

ChEMBLiCHEMBL1807.
DrugBankiDB00511. Acetyldigitoxin.
DB01430. Almitrine.
DB01370. Aluminium.
DB01244. Bepridil.
DB01158. Bretylium.
DB01188. Ciclopirox.
DB01078. Deslanoside.
DB01119. Diazoxide.
DB01396. Digitoxin.
DB00390. Digoxin.
DB00903. Ethacrynic acid.
DB00774. Hydroflumethiazide.
DB01092. Ouabain.
DB01345. Potassium.
DB01021. Trichlormethiazide.

Protein family/group databases

TCDBi3.A.3.1.1. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiP05023.
PhosphoSitePlusiP05023.
SwissPalmiP05023.

Polymorphism and mutation databases

BioMutaiATP1A1.
DMDMi114374.

Proteomic databases

EPDiP05023.
MaxQBiP05023.
PaxDbiP05023.
PeptideAtlasiP05023.
PRIDEiP05023.

Protocols and materials databases

DNASUi476.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295598; ENSP00000295598; ENSG00000163399. [P05023-1]
ENST00000369496; ENSP00000358508; ENSG00000163399. [P05023-3]
ENST00000537345; ENSP00000445306; ENSG00000163399. [P05023-4]
GeneIDi476.
KEGGihsa:476.
UCSCiuc001ege.5. human. [P05023-1]

Organism-specific databases

CTDi476.
DisGeNETi476.
GeneCardsiATP1A1.
HGNCiHGNC:799. ATP1A1.
HPAiCAB018702.
MIMi182310. gene.
neXtProtiNX_P05023.
OpenTargetsiENSG00000163399.
Orphaneti85142. Aldosterone-producing adenoma.
PharmGKBiPA62.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00850000132256.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP05023.
KOiK01539.
OMAiPVENLCF.
OrthoDBiEOG091G01BB.
PhylomeDBiP05023.
TreeFamiTF312838.

Enzyme and pathway databases

BioCyciZFISH:HS08843-MONOMER.
ReactomeiR-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiATP1A1. human.
GeneWikiiATPase,_Na%2B/K%2B_transporting,_alpha_1.
GenomeRNAii476.
PROiP05023.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163399.
CleanExiHS_ATP1A1.
ExpressionAtlasiP05023. baseline and differential.
GenevisibleiP05023. HS.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1A1_HUMAN
AccessioniPrimary (citable) accession number: P05023
Secondary accession number(s): B2RBR6
, B7Z2T5, B7Z3U6, F5H3A1, Q16689, Q6LDM4, Q9UCN1, Q9UJ20, Q9UJ21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 202 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.