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Protein

Insulin-like growth factor I

Gene

IGF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309).By similarity6 Publications

GO - Molecular functioni

  • hormone activity Source: BHF-UCL
  • insulin-like growth factor receptor binding Source: UniProtKB
  • insulin receptor binding Source: BHF-UCL
  • integrin binding Source: UniProtKB

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • activation of protein kinase B activity Source: UniProtKB
  • bone mineralization involved in bone maturation Source: BHF-UCL
  • cell activation Source: MGI
  • cell proliferation Source: AgBase
  • cellular protein metabolic process Source: Reactome
  • DNA replication Source: ProtInc
  • ERK1 and ERK2 cascade Source: AgBase
  • glycolate metabolic process Source: ProtInc
  • insulin-like growth factor receptor signaling pathway Source: UniProtKB
  • movement of cell or subcellular component Source: ProtInc
  • muscle hypertrophy Source: BHF-UCL
  • muscle organ development Source: ProtInc
  • myoblast differentiation Source: BHF-UCL
  • myoblast proliferation Source: BHF-UCL
  • myotube cell development Source: BHF-UCL
  • negative regulation of apoptotic process Source: AgBase
  • negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  • negative regulation of oocyte development Source: AgBase
  • negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
  • negative regulation of smooth muscle cell apoptotic process Source: BHF-UCL
  • phosphatidylinositol 3-kinase signaling Source: AgBase
  • phosphatidylinositol-mediated signaling Source: BHF-UCL
  • platelet degranulation Source: Reactome
  • positive regulation of activated T cell proliferation Source: BHF-UCL
  • positive regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
  • positive regulation of cardiac muscle hypertrophy Source: UniProtKB
  • positive regulation of cell growth involved in cardiac muscle cell development Source: BHF-UCL
  • positive regulation of cell migration Source: AgBase
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of DNA binding Source: UniProtKB
  • positive regulation of DNA replication Source: BHF-UCL
  • positive regulation of epithelial cell proliferation Source: BHF-UCL
  • positive regulation of fibroblast proliferation Source: BHF-UCL
  • positive regulation of glucose import Source: UniProtKB
  • positive regulation of glycogen biosynthetic process Source: UniProtKB
  • positive regulation of glycolytic process Source: BHF-UCL
  • positive regulation of glycoprotein biosynthetic process Source: AgBase
  • positive regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
  • positive regulation of MAPK cascade Source: UniProtKB
  • positive regulation of mitotic nuclear division Source: UniProtKB
  • positive regulation of osteoblast differentiation Source: BHF-UCL
  • positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
  • positive regulation of protein import into nucleus, translocation Source: UniProtKB
  • positive regulation of protein secretion Source: AgBase
  • positive regulation of Ras protein signal transduction Source: BHF-UCL
  • positive regulation of smooth muscle cell migration Source: BHF-UCL
  • positive regulation of smooth muscle cell proliferation Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of transcription regulatory region DNA binding Source: AgBase
  • positive regulation of trophectodermal cell proliferation Source: AgBase
  • positive regulation of tyrosine phosphorylation of Stat5 protein Source: BHF-UCL
  • protein kinase B signaling Source: AgBase
  • protein stabilization Source: AgBase
  • proteoglycan biosynthetic process Source: BHF-UCL
  • Ras protein signal transduction Source: ProtInc
  • regulation of gene expression Source: AgBase
  • regulation of multicellular organism growth Source: BHF-UCL
  • response to heat Source: AgBase
  • signal transduction Source: ProtInc
  • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: BHF-UCL
  • skeletal system development Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000017427-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-HSA-2428928. IRS-related events triggered by IGF1R.
R-HSA-2428933. SHC-related events triggered by IGF1R.
R-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-HSA-422085. Synthesis, secretion, and deacylation of Ghrelin.
SABIO-RKP05019.
SignaLinkiP05019.
SIGNORiP05019.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor I
Short name:
IGF-I
Alternative name(s):
Mechano growth factor
Short name:
MGF
Somatomedin-C
Gene namesi
Name:IGF1
Synonyms:IBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:5464. IGF1.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • alphav-beta3 integrin-IGF-1-IGF1R complex Source: UniProtKB
  • exocytic vesicle Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: AgBase
  • insulin-like growth factor binding protein complex Source: BHF-UCL
  • insulin-like growth factor ternary complex Source: BHF-UCL
  • plasma membrane Source: Reactome
  • platelet alpha granule lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Insulin-like growth factor I deficiency (IGF1 deficiency)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
See also OMIM:608747

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi84R → E: Dominant-negative mutant, no effect on IGFR1-binding, defective in integrin-binding and the formation of ternary complex with integrins and IGFR1, defective in inducing IGF1 signaling and cell proliferation, and suppresses activation of IGF1R by insulin and tumorigenesis in vivo; when associated with E-85. 4 Publications1
Mutagenesisi85R → E: Dominant-negative mutant, no effect on IGFR1-binding, defective in integrin-binding and the formation of ternary complex with integrins and IGFR1, defective in inducing IGF1 signaling and cell proliferation, and suppresses activation of IGF1R by insulin and tumorigenesis in vivo; when associated with E-84. 4 Publications1

Keywords - Diseasei

Deafness

Organism-specific databases

DisGeNETi3479.
MalaCardsiIGF1.
MIMi608747. phenotype.
OpenTargetsiENSG00000017427.
Orphaneti73272. Growth delay due to insulin-like growth factor type 1 deficiency.
PharmGKBiPA29697.

Protein family/group databases

Allergomei11751. Hom s IGF-1.

Chemistry databases

ChEMBLiCHEMBL3217394.

Polymorphism and mutation databases

BioMutaiIGF1.
DMDMi124263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000001566322 – 48Add BLAST27
ChainiPRO_000001566449 – 118Insulin-like growth factor IAdd BLAST70
PropeptideiPRO_0000015665119 – 195E peptideAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 961 Publication
Disulfide bondi66 ↔ 1091 Publication
Disulfide bondi95 ↔ 1001 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP05019.
PeptideAtlasiP05019.
PRIDEiP05019.

PTM databases

iPTMnetiP05019.
PhosphoSitePlusiP05019.

Miscellaneous databases

PMAP-CutDBP01343.

Expressioni

Gene expression databases

BgeeiENSG00000017427.
CleanExiHS_IGF1.
ExpressionAtlasiP05019. baseline and differential.
GenevisibleiP05019. HS.

Organism-specific databases

HPAiHPA048946.

Interactioni

Subunit structurei

Forms a ternary complex with IGFR1 and ITGAV:ITGB3 (PubMed:19578119). Forms a ternary complex with IGFR1 and ITGA6:ITGB4 (PubMed:22351760, PubMed:23696648).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IGF1RP080695EBI-7902275,EBI-475981
INSRP062134EBI-7902275,EBI-475899

GO - Molecular functioni

  • hormone activity Source: BHF-UCL
  • insulin-like growth factor receptor binding Source: UniProtKB
  • insulin receptor binding Source: BHF-UCL
  • integrin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109700. 13 interactors.
DIPiDIP-41933N.
DIP-6021N.
IntActiP05019. 2 interactors.
MINTiMINT-204184.
STRINGi9606.ENSP00000302665.

Structurei

Secondary structure

1195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi52 – 66Combined sources15
Helixi67 – 69Combined sources3
Beta strandi71 – 73Combined sources3
Beta strandi79 – 81Combined sources3
Beta strandi82 – 85Combined sources4
Helixi90 – 95Combined sources6
Beta strandi96 – 98Combined sources3
Helixi102 – 108Combined sources7
Beta strandi109 – 111Combined sources3
Beta strandi112 – 116Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B9GNMR-A49-118[»]
1BQTNMR-A49-118[»]
1GF1model-A49-118[»]
1GZRX-ray2.00B49-118[»]
1GZYX-ray2.54B49-118[»]
1GZZX-ray2.30B49-118[»]
1H02X-ray2.00B49-118[»]
1H59X-ray2.10A49-118[»]
1IMXX-ray1.82A49-118[»]
1PMXNMR-A49-118[»]
1TGRX-ray1.42A/B49-77[»]
A/B90-110[»]
1WQJX-ray1.60I49-118[»]
2DSPX-ray2.50I49-118[»]
2DSQX-ray2.80C/I49-118[»]
2DSRX-ray2.10I49-118[»]
2GF1NMR-A49-118[»]
3GF1NMR-A49-118[»]
3LRINMR-A49-118[»]
4XSSX-ray3.00B49-118[»]
ProteinModelPortaliP05019.
SMRiP05019.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05019.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 77BAdd BLAST29
Regioni78 – 89CAdd BLAST12
Regioni90 – 110AAdd BLAST21
Regioni111 – 118D8

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP05019.
KOiK05459.
OMAiHTVSYIH.
OrthoDBiEOG091G0H56.
PhylomeDBiP05019.
TreeFamiTF332820.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P05019-1) [UniParc]FASTAAdd to basket
Also known as: IGF-IB

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKISSLPTQ LFKCCFCDFL KVKMHTMSSS HLFYLALCLL TFTSSATAGP
60 70 80 90 100
ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC
110 120 130 140 150
DLRRLEMYCA PLKPAKSARS VRAQRHTDMP KTQKYQPPST NKNTKSQRRK
160 170 180 190
GWPKTHPGGE QKEGTEASLQ IRGKKKEQRR EIGSRNAECR GKKGK
Length:195
Mass (Da):21,841
Last modified:August 13, 1987 - v1
Checksum:iE88A8CFBD1CD1873
GO
Isoform 2 (identifier: P05019-2) [UniParc]FASTAAdd to basket
Also known as: IGF-IA

The sequence of this isoform differs from the canonical sequence as follows:
     135-195: YQPPSTNKNT...NAECRGKKGK → EVHLKNASRGSAGNKNYRM

Show »
Length:153
Mass (Da):17,026
Checksum:iC6ECD92DCA9B37BC
GO
Isoform 3 (identifier: P05019-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MGKISSLPTQLFKCCFCDFLK → MITPT
     135-195: YQPPSTNKNT...NAECRGKKGK → EVHLKNASRGSAGNKNYRM

Note: Expressed in liver.
Show »
Length:137
Mass (Da):15,177
Checksum:iBFCC0D11E32AB75D
GO
Isoform 4 (identifier: P05019-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-195: WPKTHPGGEQKEGTEASLQIRGKKKEQRREIGSRNAECRGKKGK → STFEERK

Note: Gene prediction based on EST data.
Show »
Length:158
Mass (Da):17,762
Checksum:i59DB4A0437679B6A
GO

Sequence cautioni

The sequence CAA27250 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07582598R → W Found in a patient with primordial dwarfism; unknown pathological significance. 1 PublicationCorresponds to variant rs587779350dbSNPEnsembl.1
Natural variantiVAR_056113115A → T.Corresponds to variant rs17884626dbSNPEnsembl.1
Natural variantiVAR_013945187A → D.1 PublicationCorresponds to variant rs6213dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0433171 – 21MGKIS…CDFLK → MITPT in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_039637135 – 195YQPPS…GKKGK → EVHLKNASRGSAGNKNYRM in isoform 2 and isoform 3. 5 PublicationsAdd BLAST61
Alternative sequenceiVSP_047399152 – 195WPKTH…GKKGK → STFEERK in isoform 4. CuratedAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00173 mRNA. Translation: CAA24998.1.
X03420 Genomic DNA. Translation: CAA27152.1.
X03421 Genomic DNA. Translation: CAA27153.1.
X03422 Genomic DNA. Translation: CAA27154.1.
M27544 mRNA. Translation: AAA52787.1.
M14155
, M12659, M14153, M14154 Genomic DNA. Translation: AAA52537.1.
M14156
, M12659, M14153, M14154 Genomic DNA. Translation: AAA52538.1.
M11568 mRNA. Translation: AAA52539.1.
M37484 mRNA. Translation: AAA52789.1.
X57025 mRNA. Translation: CAA40342.1.
X56773 mRNA. Translation: CAA40092.1.
X56774 mRNA. Translation: CAA40093.1.
AY260957 Genomic DNA. Translation: AAO74829.1.
AC010202 Genomic DNA. No translation available.
AC068648 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97696.1.
CH471054 Genomic DNA. Translation: EAW97697.1.
BC148266 mRNA. Translation: AAI48267.1.
X03563 Genomic DNA. Translation: CAA27250.1. Sequence problems.
CCDSiCCDS44960.1. [P05019-3]
CCDS44961.1. [P05019-4]
CCDS9091.1. [P05019-2]
PIRiA01611. IGHU1B.
A92581. IGHU1.
RefSeqiNP_000609.1. NM_000618.4. [P05019-2]
NP_001104754.1. NM_001111284.1. [P05019-3]
NP_001104755.1. NM_001111285.2.
UniGeneiHs.160562.

Genome annotation databases

EnsembliENST00000307046; ENSP00000302665; ENSG00000017427. [P05019-1]
ENST00000337514; ENSP00000337612; ENSG00000017427. [P05019-2]
ENST00000392904; ENSP00000376637; ENSG00000017427. [P05019-4]
ENST00000424202; ENSP00000416811; ENSG00000017427. [P05019-3]
ENST00000456098; ENSP00000394999; ENSG00000017427. [P05019-4]
GeneIDi3479.
KEGGihsa:3479.
UCSCiuc001tjm.2. human. [P05019-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

NIEHS-SNPs
Wikipedia

Insulin-like growth factor 1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00173 mRNA. Translation: CAA24998.1.
X03420 Genomic DNA. Translation: CAA27152.1.
X03421 Genomic DNA. Translation: CAA27153.1.
X03422 Genomic DNA. Translation: CAA27154.1.
M27544 mRNA. Translation: AAA52787.1.
M14155
, M12659, M14153, M14154 Genomic DNA. Translation: AAA52537.1.
M14156
, M12659, M14153, M14154 Genomic DNA. Translation: AAA52538.1.
M11568 mRNA. Translation: AAA52539.1.
M37484 mRNA. Translation: AAA52789.1.
X57025 mRNA. Translation: CAA40342.1.
X56773 mRNA. Translation: CAA40092.1.
X56774 mRNA. Translation: CAA40093.1.
AY260957 Genomic DNA. Translation: AAO74829.1.
AC010202 Genomic DNA. No translation available.
AC068648 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97696.1.
CH471054 Genomic DNA. Translation: EAW97697.1.
BC148266 mRNA. Translation: AAI48267.1.
X03563 Genomic DNA. Translation: CAA27250.1. Sequence problems.
CCDSiCCDS44960.1. [P05019-3]
CCDS44961.1. [P05019-4]
CCDS9091.1. [P05019-2]
PIRiA01611. IGHU1B.
A92581. IGHU1.
RefSeqiNP_000609.1. NM_000618.4. [P05019-2]
NP_001104754.1. NM_001111284.1. [P05019-3]
NP_001104755.1. NM_001111285.2.
UniGeneiHs.160562.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B9GNMR-A49-118[»]
1BQTNMR-A49-118[»]
1GF1model-A49-118[»]
1GZRX-ray2.00B49-118[»]
1GZYX-ray2.54B49-118[»]
1GZZX-ray2.30B49-118[»]
1H02X-ray2.00B49-118[»]
1H59X-ray2.10A49-118[»]
1IMXX-ray1.82A49-118[»]
1PMXNMR-A49-118[»]
1TGRX-ray1.42A/B49-77[»]
A/B90-110[»]
1WQJX-ray1.60I49-118[»]
2DSPX-ray2.50I49-118[»]
2DSQX-ray2.80C/I49-118[»]
2DSRX-ray2.10I49-118[»]
2GF1NMR-A49-118[»]
3GF1NMR-A49-118[»]
3LRINMR-A49-118[»]
4XSSX-ray3.00B49-118[»]
ProteinModelPortaliP05019.
SMRiP05019.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109700. 13 interactors.
DIPiDIP-41933N.
DIP-6021N.
IntActiP05019. 2 interactors.
MINTiMINT-204184.
STRINGi9606.ENSP00000302665.

Chemistry databases

ChEMBLiCHEMBL3217394.

Protein family/group databases

Allergomei11751. Hom s IGF-1.

PTM databases

iPTMnetiP05019.
PhosphoSitePlusiP05019.

Polymorphism and mutation databases

BioMutaiIGF1.
DMDMi124263.

Proteomic databases

PaxDbiP05019.
PeptideAtlasiP05019.
PRIDEiP05019.

Protocols and materials databases

DNASUi3479.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307046; ENSP00000302665; ENSG00000017427. [P05019-1]
ENST00000337514; ENSP00000337612; ENSG00000017427. [P05019-2]
ENST00000392904; ENSP00000376637; ENSG00000017427. [P05019-4]
ENST00000424202; ENSP00000416811; ENSG00000017427. [P05019-3]
ENST00000456098; ENSP00000394999; ENSG00000017427. [P05019-4]
GeneIDi3479.
KEGGihsa:3479.
UCSCiuc001tjm.2. human. [P05019-1]

Organism-specific databases

CTDi3479.
DisGeNETi3479.
GeneCardsiIGF1.
HGNCiHGNC:5464. IGF1.
HPAiHPA048946.
MalaCardsiIGF1.
MIMi147440. gene.
608747. phenotype.
neXtProtiNX_P05019.
OpenTargetsiENSG00000017427.
Orphaneti73272. Growth delay due to insulin-like growth factor type 1 deficiency.
PharmGKBiPA29697.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP05019.
KOiK05459.
OMAiHTVSYIH.
OrthoDBiEOG091G0H56.
PhylomeDBiP05019.
TreeFamiTF332820.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000017427-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-HSA-2428928. IRS-related events triggered by IGF1R.
R-HSA-2428933. SHC-related events triggered by IGF1R.
R-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-HSA-422085. Synthesis, secretion, and deacylation of Ghrelin.
SABIO-RKP05019.
SignaLinkiP05019.
SIGNORiP05019.

Miscellaneous databases

ChiTaRSiIGF1. human.
EvolutionaryTraceiP05019.
GeneWikiiInsulin-like_growth_factor_1.
GenomeRNAii3479.
PMAP-CutDBP01343.
PROiP05019.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000017427.
CleanExiHS_IGF1.
ExpressionAtlasiP05019. baseline and differential.
GenevisibleiP05019. HS.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGF1_HUMAN
AccessioniPrimary (citable) accession number: P05019
Secondary accession number(s): B2RWM7
, E9PD02, P01343, Q14620
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 201 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.