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P05017

- IGF1_MOUSE

UniProt

P05017 - IGF1_MOUSE

Protein

Insulin-like growth factor I

Gene

Igf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation By similarity.By similarity

    GO - Molecular functioni

    1. insulin-like growth factor receptor binding Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. blood vessel remodeling Source: MGI
    2. branching morphogenesis of an epithelial tube Source: MGI
    3. cell activation Source: MGI
    4. cell development Source: MGI
    5. chondroitin sulfate proteoglycan biosynthetic process Source: MGI
    6. circadian rhythm Source: UniProtKB
    7. exocrine pancreas development Source: MGI
    8. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    9. glial cell differentiation Source: MGI
    10. inner ear development Source: MGI
    11. insulin-like growth factor receptor signaling pathway Source: MGI
    12. lung alveolus development Source: MGI
    13. lung development Source: MGI
    14. lung lobe morphogenesis Source: MGI
    15. lung vasculature development Source: MGI
    16. mammary gland development Source: MGI
    17. multicellular organism growth Source: MGI
    18. negative regulation of androgen receptor signaling pathway Source: MGI
    19. negative regulation of apoptotic process Source: UniProtKB
    20. negative regulation of cell proliferation Source: MGI
    21. negative regulation of ERK1 and ERK2 cascade Source: MGI
    22. negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
    23. nervous system development Source: MGI
    24. osteoblast differentiation Source: BHF-UCL
    25. positive regulation of cell proliferation Source: MGI
    26. positive regulation of cerebellar granule cell precursor proliferation Source: MGI
    27. positive regulation of glucose import Source: UniProtKB
    28. positive regulation of glycogen biosynthetic process Source: UniProtKB
    29. positive regulation of myoblast proliferation Source: MGI
    30. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
    31. positive regulation of protein kinase B signaling Source: MGI
    32. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    33. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
    34. prostate gland epithelium morphogenesis Source: MGI
    35. prostate gland growth Source: MGI
    36. prostate gland stromal morphogenesis Source: MGI
    37. regulation of establishment or maintenance of cell polarity Source: MGI
    38. regulation of protein metabolic process Source: MGI
    39. regulation of protein phosphorylation Source: MGI
    40. Type II pneumocyte differentiation Source: MGI
    41. Type I pneumocyte differentiation Source: MGI
    42. water homeostasis Source: MGI

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_188215. IRS-related events triggered by IGF1R.
    REACT_188219. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
    REACT_188220. SHC-related events triggered by IGF1R.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor I
    Short name:
    IGF-I
    Alternative name(s):
    Somatomedin
    Gene namesi
    Name:Igf1
    Synonyms:Igf-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:96432. Igf1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei? – 48By similarityPRO_0000015666
    Signal peptidei1 – ?Sequence Analysis
    Chaini49 – 11870Insulin-like growth factor IPRO_0000015667Add
    BLAST
    Propeptidei119 – 15335E peptidePRO_0000015668Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 96By similarity
    Disulfide bondi66 ↔ 109By similarity
    Disulfide bondi95 ↔ 100By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP05017.
    PRIDEiP05017.

    PTM databases

    PhosphoSiteiP05017.

    Expressioni

    Inductioni

    Expression in the bone oscillates in a circadian manner and its expression is negatively regulated by CCRN4L/NOC.1 Publication

    Gene expression databases

    ArrayExpressiP05017.
    BgeeiP05017.
    CleanExiMM_IGF1.
    GenevestigatoriP05017.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-266530.
    STRINGi10090.ENSMUSP00000056668.

    Structurei

    3D structure databases

    ProteinModelPortaliP05017.
    SMRiP05017. Positions 50-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni49 – 7729BAdd
    BLAST
    Regioni78 – 8912CAdd
    BLAST
    Regioni90 – 11021AAdd
    BLAST
    Regioni111 – 1188D

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39886.
    HOGENOMiHOG000233362.
    HOVERGENiHBG006137.
    KOiK05459.
    OrthoDBiEOG7TF7CG.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022341. IGF-I.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF00049. Insulin. 2 hits.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02005. INSLNLIKEGF1.
    PR00276. INSULINFAMLY.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform IGF-IA (identifier: P05017-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGKISSLPTQ LFKICLCDFL KIKIHIMSSS HLFYLALCLL TFTSSTTAGP    50
    ETLCGAELVD ALQFVCGPRG FYFNKPTGYG SSIRRAPQTG IVDECCFRSC 100
    DLRRLEMYCA PLKPTKAARS IRAQRHTDMP KTQKEVHLKN TSRGSAGNKT 150
    YRM 153
    Length:153
    Mass (Da):17,093
    Last modified:December 7, 2004 - v2
    Checksum:i967596AEAC0CA387
    GO
    Isoform IGF-IB (identifier: P05017-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         135-153: EVHLKNTSRGSAGNKTYRM → SPSLSTNKKTKLQRRRKGSTFEE

    Show »
    Length:157
    Mass (Da):17,623
    Checksum:i153C6311A323ACA4
    GO

    Sequence cautioni

    The sequence AAH12409.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei135 – 15319EVHLK…KTYRM → SPSLSTNKKTKLQRRRKGST FEE in isoform IGF-IB. 2 PublicationsVSP_012165Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK081019 mRNA. Translation: BAC38117.1.
    BC012409 mRNA. Translation: AAH12409.1. Different initiation.
    X04480 mRNA. Translation: CAA28168.1.
    X04482 mRNA. Translation: CAA28170.1.
    M28139 Genomic DNA. Translation: AAA74553.1.
    M14983 Genomic DNA. Translation: AAA37925.1.
    CCDSiCCDS48661.1. [P05017-1]
    PIRiA25540.
    RefSeqiNP_001104745.1. NM_001111275.1. [P05017-1]
    NP_034642.2. NM_010512.4.
    XP_006513326.1. XM_006513263.1. [P05017-1]
    XP_006513329.1. XM_006513266.1.
    UniGeneiMm.268521.

    Genome annotation databases

    EnsembliENSMUST00000095360; ENSMUSP00000093005; ENSMUSG00000020053. [P05017-1]
    ENSMUST00000122386; ENSMUSP00000113905; ENSMUSG00000020053. [P05017-1]
    GeneIDi16000.
    KEGGimmu:16000.
    UCSCiuc007gqw.2. mouse. [P05017-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK081019 mRNA. Translation: BAC38117.1 .
    BC012409 mRNA. Translation: AAH12409.1 . Different initiation.
    X04480 mRNA. Translation: CAA28168.1 .
    X04482 mRNA. Translation: CAA28170.1 .
    M28139 Genomic DNA. Translation: AAA74553.1 .
    M14983 Genomic DNA. Translation: AAA37925.1 .
    CCDSi CCDS48661.1. [P05017-1 ]
    PIRi A25540.
    RefSeqi NP_001104745.1. NM_001111275.1. [P05017-1 ]
    NP_034642.2. NM_010512.4.
    XP_006513326.1. XM_006513263.1. [P05017-1 ]
    XP_006513329.1. XM_006513266.1.
    UniGenei Mm.268521.

    3D structure databases

    ProteinModelPortali P05017.
    SMRi P05017. Positions 50-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-266530.
    STRINGi 10090.ENSMUSP00000056668.

    PTM databases

    PhosphoSitei P05017.

    Proteomic databases

    PaxDbi P05017.
    PRIDEi P05017.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095360 ; ENSMUSP00000093005 ; ENSMUSG00000020053 . [P05017-1 ]
    ENSMUST00000122386 ; ENSMUSP00000113905 ; ENSMUSG00000020053 . [P05017-1 ]
    GeneIDi 16000.
    KEGGi mmu:16000.
    UCSCi uc007gqw.2. mouse. [P05017-1 ]

    Organism-specific databases

    CTDi 3479.
    MGIi MGI:96432. Igf1.

    Phylogenomic databases

    eggNOGi NOG39886.
    HOGENOMi HOG000233362.
    HOVERGENi HBG006137.
    KOi K05459.
    OrthoDBi EOG7TF7CG.

    Enzyme and pathway databases

    Reactomei REACT_188215. IRS-related events triggered by IGF1R.
    REACT_188219. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
    REACT_188220. SHC-related events triggered by IGF1R.

    Miscellaneous databases

    ChiTaRSi IGF1. mouse.
    NextBioi 288784.
    PROi P05017.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P05017.
    Bgeei P05017.
    CleanExi MM_IGF1.
    Genevestigatori P05017.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022341. IGF-I.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF00049. Insulin. 2 hits.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02005. INSLNLIKEGF1.
    PR00276. INSULINFAMLY.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IGF-IA).
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-153 (ISOFORM IGF-IB).
      Strain: FVB/N.
      Tissue: Liver.
    3. "Sequences of liver cDNAs encoding two different mouse insulin-like growth factor I precursors."
      Bell G.I., Stempien M.M., Fong N.M., Rall L.B.
      Nucleic Acids Res. 14:7873-7882(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-153 (ISOFORMS IGF-IA AND IGF-IB).
      Tissue: Liver.
    4. "Insulin-like growth factors (IGF) in muscle development. Expression of IGF-I, the IGF-I receptor, and an IGF binding protein during myoblast differentiation."
      Tollefsen S.E., Lajara R., McCusker R.H., Clemmons D.R., Rotwein P.
      J. Biol. Chem. 264:13810-13817(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 75-134.
    5. "Regulation of insulin-like growth factor I gene expression by growth hormone."
      Mathews L.S., Norstedt G., Palmiter R.D.
      Proc. Natl. Acad. Sci. U.S.A. 83:9343-9347(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 75-134.
    6. "Nocturnin suppresses igf1 expression in bone by targeting the 3' untranslated region of igf1 mRNA."
      Kawai M., Delany A.M., Green C.B., Adamo M.L., Rosen C.J.
      Endocrinology 151:4861-4870(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiIGF1_MOUSE
    AccessioniPrimary (citable) accession number: P05017
    Secondary accession number(s): P05018, Q6LDP4, Q8C4U6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3