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P05017

- IGF1_MOUSE

UniProt

P05017 - IGF1_MOUSE

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Protein
Insulin-like growth factor I
Gene
Igf1, Igf-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation By similarity.

GO - Molecular functioni

  1. insulin-like growth factor receptor binding Source: MGI
  2. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. Type I pneumocyte differentiation Source: MGI
  2. Type II pneumocyte differentiation Source: MGI
  3. blood vessel remodeling Source: MGI
  4. branching morphogenesis of an epithelial tube Source: MGI
  5. cell activation Source: MGI
  6. cell development Source: MGI
  7. chondroitin sulfate proteoglycan biosynthetic process Source: MGI
  8. circadian rhythm Source: UniProtKB
  9. exocrine pancreas development Source: MGI
  10. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  11. glial cell differentiation Source: MGI
  12. inner ear development Source: MGI
  13. insulin-like growth factor receptor signaling pathway Source: MGI
  14. lung alveolus development Source: MGI
  15. lung development Source: MGI
  16. lung lobe morphogenesis Source: MGI
  17. lung vasculature development Source: MGI
  18. mammary gland development Source: MGI
  19. multicellular organism growth Source: MGI
  20. negative regulation of ERK1 and ERK2 cascade Source: MGI
  21. negative regulation of androgen receptor signaling pathway Source: MGI
  22. negative regulation of apoptotic process Source: UniProtKB
  23. negative regulation of cell proliferation Source: MGI
  24. negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
  25. nervous system development Source: MGI
  26. osteoblast differentiation Source: BHF-UCL
  27. positive regulation of cell proliferation Source: MGI
  28. positive regulation of cerebellar granule cell precursor proliferation Source: MGI
  29. positive regulation of glucose import Source: UniProtKB
  30. positive regulation of glycogen biosynthetic process Source: UniProtKB
  31. positive regulation of myoblast proliferation Source: MGI
  32. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  33. positive regulation of protein kinase B signaling Source: MGI
  34. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  35. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
  36. prostate gland epithelium morphogenesis Source: MGI
  37. prostate gland growth Source: MGI
  38. prostate gland stromal morphogenesis Source: MGI
  39. regulation of establishment or maintenance of cell polarity Source: MGI
  40. regulation of protein metabolic process Source: MGI
  41. regulation of protein phosphorylation Source: MGI
  42. water homeostasis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_188215. IRS-related events triggered by IGF1R.
REACT_188219. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
REACT_188220. SHC-related events triggered by IGF1R.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor I
Short name:
IGF-I
Alternative name(s):
Somatomedin
Gene namesi
Name:Igf1
Synonyms:Igf-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:96432. Igf1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 48 By similarityPRO_0000015666
Signal peptidei1 – ? Reviewed prediction
Chaini49 – 11870Insulin-like growth factor I
PRO_0000015667Add
BLAST
Propeptidei119 – 15335E peptide
PRO_0000015668Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 96 By similarity
Disulfide bondi66 ↔ 109 By similarity
Disulfide bondi95 ↔ 100 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP05017.
PRIDEiP05017.

PTM databases

PhosphoSiteiP05017.

Expressioni

Inductioni

Expression in the bone oscillates in a circadian manner and its expression is negatively regulated by CCRN4L/NOC.1 Publication

Gene expression databases

ArrayExpressiP05017.
BgeeiP05017.
CleanExiMM_IGF1.
GenevestigatoriP05017.

Interactioni

Protein-protein interaction databases

MINTiMINT-266530.
STRINGi10090.ENSMUSP00000056668.

Structurei

3D structure databases

ProteinModelPortaliP05017.
SMRiP05017. Positions 50-111.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 7729B
Add
BLAST
Regioni78 – 8912C
Add
BLAST
Regioni90 – 11021A
Add
BLAST
Regioni111 – 1188D

Sequence similaritiesi

Belongs to the insulin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39886.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
KOiK05459.
OrthoDBiEOG7TF7CG.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform IGF-IA (identifier: P05017-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGKISSLPTQ LFKICLCDFL KIKIHIMSSS HLFYLALCLL TFTSSTTAGP    50
ETLCGAELVD ALQFVCGPRG FYFNKPTGYG SSIRRAPQTG IVDECCFRSC 100
DLRRLEMYCA PLKPTKAARS IRAQRHTDMP KTQKEVHLKN TSRGSAGNKT 150
YRM 153
Length:153
Mass (Da):17,093
Last modified:December 7, 2004 - v2
Checksum:i967596AEAC0CA387
GO
Isoform IGF-IB (identifier: P05017-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-153: EVHLKNTSRGSAGNKTYRM → SPSLSTNKKTKLQRRRKGSTFEE

Show »
Length:157
Mass (Da):17,623
Checksum:i153C6311A323ACA4
GO

Sequence cautioni

The sequence AAH12409.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei135 – 15319EVHLK…KTYRM → SPSLSTNKKTKLQRRRKGST FEE in isoform IGF-IB.
VSP_012165Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK081019 mRNA. Translation: BAC38117.1.
BC012409 mRNA. Translation: AAH12409.1. Different initiation.
X04480 mRNA. Translation: CAA28168.1.
X04482 mRNA. Translation: CAA28170.1.
M28139 Genomic DNA. Translation: AAA74553.1.
M14983 Genomic DNA. Translation: AAA37925.1.
CCDSiCCDS48661.1. [P05017-1]
PIRiA25540.
RefSeqiNP_001104745.1. NM_001111275.1. [P05017-1]
NP_034642.2. NM_010512.4.
XP_006513326.1. XM_006513263.1. [P05017-1]
XP_006513329.1. XM_006513266.1.
UniGeneiMm.268521.

Genome annotation databases

EnsembliENSMUST00000095360; ENSMUSP00000093005; ENSMUSG00000020053. [P05017-1]
ENSMUST00000122386; ENSMUSP00000113905; ENSMUSG00000020053. [P05017-1]
GeneIDi16000.
KEGGimmu:16000.
UCSCiuc007gqw.2. mouse. [P05017-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK081019 mRNA. Translation: BAC38117.1 .
BC012409 mRNA. Translation: AAH12409.1 . Different initiation.
X04480 mRNA. Translation: CAA28168.1 .
X04482 mRNA. Translation: CAA28170.1 .
M28139 Genomic DNA. Translation: AAA74553.1 .
M14983 Genomic DNA. Translation: AAA37925.1 .
CCDSi CCDS48661.1. [P05017-1 ]
PIRi A25540.
RefSeqi NP_001104745.1. NM_001111275.1. [P05017-1 ]
NP_034642.2. NM_010512.4.
XP_006513326.1. XM_006513263.1. [P05017-1 ]
XP_006513329.1. XM_006513266.1.
UniGenei Mm.268521.

3D structure databases

ProteinModelPortali P05017.
SMRi P05017. Positions 50-111.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-266530.
STRINGi 10090.ENSMUSP00000056668.

PTM databases

PhosphoSitei P05017.

Proteomic databases

PaxDbi P05017.
PRIDEi P05017.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095360 ; ENSMUSP00000093005 ; ENSMUSG00000020053 . [P05017-1 ]
ENSMUST00000122386 ; ENSMUSP00000113905 ; ENSMUSG00000020053 . [P05017-1 ]
GeneIDi 16000.
KEGGi mmu:16000.
UCSCi uc007gqw.2. mouse. [P05017-1 ]

Organism-specific databases

CTDi 3479.
MGIi MGI:96432. Igf1.

Phylogenomic databases

eggNOGi NOG39886.
HOGENOMi HOG000233362.
HOVERGENi HBG006137.
KOi K05459.
OrthoDBi EOG7TF7CG.

Enzyme and pathway databases

Reactomei REACT_188215. IRS-related events triggered by IGF1R.
REACT_188219. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
REACT_188220. SHC-related events triggered by IGF1R.

Miscellaneous databases

ChiTaRSi IGF1. mouse.
NextBioi 288784.
PROi P05017.
SOURCEi Search...

Gene expression databases

ArrayExpressi P05017.
Bgeei P05017.
CleanExi MM_IGF1.
Genevestigatori P05017.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF00049. Insulin. 2 hits.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IGF-IA).
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-153 (ISOFORM IGF-IB).
    Strain: FVB/N.
    Tissue: Liver.
  3. "Sequences of liver cDNAs encoding two different mouse insulin-like growth factor I precursors."
    Bell G.I., Stempien M.M., Fong N.M., Rall L.B.
    Nucleic Acids Res. 14:7873-7882(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-153 (ISOFORMS IGF-IA AND IGF-IB).
    Tissue: Liver.
  4. "Insulin-like growth factors (IGF) in muscle development. Expression of IGF-I, the IGF-I receptor, and an IGF binding protein during myoblast differentiation."
    Tollefsen S.E., Lajara R., McCusker R.H., Clemmons D.R., Rotwein P.
    J. Biol. Chem. 264:13810-13817(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 75-134.
  5. "Regulation of insulin-like growth factor I gene expression by growth hormone."
    Mathews L.S., Norstedt G., Palmiter R.D.
    Proc. Natl. Acad. Sci. U.S.A. 83:9343-9347(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 75-134.
  6. "Nocturnin suppresses igf1 expression in bone by targeting the 3' untranslated region of igf1 mRNA."
    Kawai M., Delany A.M., Green C.B., Adamo M.L., Rosen C.J.
    Endocrinology 151:4861-4870(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiIGF1_MOUSE
AccessioniPrimary (citable) accession number: P05017
Secondary accession number(s): P05018, Q6LDP4, Q8C4U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi