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Protein

Interleukin-2

Gene

IL2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:IL2
Synonyms:IL-2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 155135Interleukin-2PRO_0000015474Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231O-linked (GalNAc...)By similarity
Disulfide bondi79 ↔ 127By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05016.
PRIDEiP05016.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027819.

Structurei

3D structure databases

ProteinModelPortaliP05016.
SMRiP05016. Positions 21-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.
InParanoidiP05016.
KOiK05429.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKIQLLSCI ALTLALVANG APTSSSTGNT MKEVKSLLLD LQLLLEKVKN
60 70 80 90 100
PENLKLSRMH TFDFYVPKVN ATELKHLKCL LEELKLLEEV LNLAPSKNLN
110 120 130 140 150
PREIKDSMDN IKRIVLELQG SETRFTCEYD DATVNAVEFL NKWITFCQSI

YSTMT
Length:155
Mass (Da):17,628
Last modified:August 13, 1987 - v1
Checksum:i816667DFEA052EDF
GO

Sequence cautioni

The sequence AAA21143.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661V → A in AAA21143 (PubMed:3486415).Curated
Sequence conflicti66 – 661V → G in AAN76508 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12791 mRNA. Translation: AAA30586.1.
M13204 mRNA. Translation: AAA21143.1. Different initiation.
AF535144 Genomic DNA. Translation: AAQ10670.1.
AF348423 mRNA. Translation: AAN76508.1.
EF056472 Genomic DNA. Translation: ABK41607.1.
EU276068 mRNA. Translation: ABX72066.1.
X52687 Genomic DNA. Translation: CAA36912.1.
X17201 Genomic DNA. Translation: CAA35062.1.
PIRiI45913.
RefSeqiNP_851340.2. NM_180997.2.
UniGeneiBt.341.

Genome annotation databases

GeneIDi280822.
KEGGibta:280822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12791 mRNA. Translation: AAA30586.1.
M13204 mRNA. Translation: AAA21143.1. Different initiation.
AF535144 Genomic DNA. Translation: AAQ10670.1.
AF348423 mRNA. Translation: AAN76508.1.
EF056472 Genomic DNA. Translation: ABK41607.1.
EU276068 mRNA. Translation: ABX72066.1.
X52687 Genomic DNA. Translation: CAA36912.1.
X17201 Genomic DNA. Translation: CAA35062.1.
PIRiI45913.
RefSeqiNP_851340.2. NM_180997.2.
UniGeneiBt.341.

3D structure databases

ProteinModelPortaliP05016.
SMRiP05016. Positions 21-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027819.

Proteomic databases

PaxDbiP05016.
PRIDEiP05016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280822.
KEGGibta:280822.

Organism-specific databases

CTDi3558.

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.
InParanoidiP05016.
KOiK05429.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Functional analysis of a single nucleotide polymorphism in a potential binding site for GATA transcription factors in the ovine interleukin 2 gene."
    Luhken G., Stamm I., Menge C., Erhardt G.
    Vet. Immunol. Immunopathol. 107:51-56(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Ahn J.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Molecular characterization of Bos taurus IL2."
    Luehken G., Erhardt G.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
    U.S. Veterinary Immune Reagent Network
    Hudgens T., Tompkins D., Baldwin C.L.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Belted Galloway.
    Tissue: Peripheral blood.
  7. Anikeeva N.N., Vinogradova T.V., Votoshin O.N.
    Submitted (DEC-1989) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
    Tissue: Thymus.

Entry informationi

Entry nameiIL2_BOVIN
AccessioniPrimary (citable) accession number: P05016
Secondary accession number(s): A0MZP6
, A9QWQ6, Q5QT38, Q8HYR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.