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Protein

Interferon alpha-16

Gene

IFNA16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-16
Short name:
IFN-alpha-16
Alternative name(s):
Interferon alpha-WA
Gene namesi
Name:IFNA16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:5421. IFNA16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29660.

Polymorphism and mutation databases

BioMutaiIFNA16.
DMDMi124463.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 189166Interferon alpha-16PRO_0000016368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP05015.
PRIDEiP05015.

PTM databases

PhosphoSiteiP05015.

Expressioni

Gene expression databases

CleanExiHS_IFNA16.
GenevisibleiP05015. HS.

Organism-specific databases

HPAiHPA047557.

Interactioni

Protein-protein interaction databases

BioGridi109672. 1 interaction.
IntActiP05015. 1 interaction.
MINTiMINT-8201769.
STRINGi9606.ENSP00000369564.

Structurei

3D structure databases

ProteinModelPortaliP05015.
SMRiP05015. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG71630.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05015.
KOiK05414.
OMAiISAFHEM.
OrthoDBiEOG7BW0KT.
PhylomeDBiP05015.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF
60 70 80 90 100
SCLKDRYDFG FPQEVFDGNQ FQKAQAISAF HEMIQQTFNL FSTKDSSAAW
110 120 130 140 150
DETLLDKFYI ELFQQLNDLE ACVTQEVGVE EIALMNEDSI LAVRKYFQRI
160 170 180
TLYLMGKKYS PCAWEVVRAE IMRSFSFSTN LQKGLRRKD
Length:189
Mass (Da):21,711
Last modified:August 13, 1987 - v1
Checksum:iFC8822F787F1585F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02957 Genomic DNA. Translation: CAA26703.1.
K02055 Genomic DNA. Translation: AAA52727.1.
M28585 mRNA. Translation: AAA36042.1.
AL512606 Genomic DNA. Translation: CAH71193.1.
CH471071 Genomic DNA. Translation: EAW58618.1.
CCDSiCCDS34996.1.
PIRiG23753. IVHU16.
RefSeqiNP_002164.1. NM_002173.2.
UniGeneiHs.56303.

Genome annotation databases

EnsembliENST00000380216; ENSP00000369564; ENSG00000147885.
GeneIDi3449.
KEGGihsa:3449.
UCSCiuc003zor.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02957 Genomic DNA. Translation: CAA26703.1.
K02055 Genomic DNA. Translation: AAA52727.1.
M28585 mRNA. Translation: AAA36042.1.
AL512606 Genomic DNA. Translation: CAH71193.1.
CH471071 Genomic DNA. Translation: EAW58618.1.
CCDSiCCDS34996.1.
PIRiG23753. IVHU16.
RefSeqiNP_002164.1. NM_002173.2.
UniGeneiHs.56303.

3D structure databases

ProteinModelPortaliP05015.
SMRiP05015. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109672. 1 interaction.
IntActiP05015. 1 interaction.
MINTiMINT-8201769.
STRINGi9606.ENSP00000369564.

PTM databases

PhosphoSiteiP05015.

Polymorphism and mutation databases

BioMutaiIFNA16.
DMDMi124463.

Proteomic databases

PaxDbiP05015.
PRIDEiP05015.

Protocols and materials databases

DNASUi3449.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380216; ENSP00000369564; ENSG00000147885.
GeneIDi3449.
KEGGihsa:3449.
UCSCiuc003zor.1. human.

Organism-specific databases

CTDi3449.
GeneCardsiGC09M021216.
HGNCiHGNC:5421. IFNA16.
HPAiHPA047557.
MIMi147580. gene.
neXtProtiNX_P05015.
PharmGKBiPA29660.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG71630.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05015.
KOiK05414.
OMAiISAFHEM.
OrthoDBiEOG7BW0KT.
PhylomeDBiP05015.
TreeFamiTF336177.

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Miscellaneous databases

GeneWikiiIFNA16.
GenomeRNAii3449.
NextBioi13592.
PROiP05015.
SOURCEiSearch...

Gene expression databases

CleanExiHS_IFNA16.
GenevisibleiP05015. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human genomic library screened with 17-base oligonucleotide probes yields a novel interferon gene."
    Torczynski R.M., Fuke M., Bollon A.P.
    Proc. Natl. Acad. Sci. U.S.A. 81:6451-6455(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes."
    Gren E., Berzin V.M., Jansone I., Tsimanis A., Vishnevsky Y., Apsalons U.
    J. Interferon Res. 4:609-617(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiIFN16_HUMAN
AccessioniPrimary (citable) accession number: P05015
Secondary accession number(s): Q5VV12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 22, 2015
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.