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P05015

- IFN16_HUMAN

UniProt

P05015 - IFN16_HUMAN

Protein

Interferon alpha-16

Gene

IFNA16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome
    2. type I interferon receptor binding Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. blood coagulation Source: Reactome
    5. cytokine-mediated signaling pathway Source: RefGenome
    6. defense response to virus Source: UniProtKB-KW
    7. humoral immune response Source: RefGenome
    8. innate immune response Source: RefGenome
    9. natural killer cell activation involved in immune response Source: RefGenome
    10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    11. regulation of MHC class I biosynthetic process Source: RefGenome
    12. regulation of type I interferon-mediated signaling pathway Source: Reactome
    13. response to exogenous dsRNA Source: RefGenome
    14. T cell activation involved in immune response Source: RefGenome
    15. type I interferon signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon alpha-16
    Short name:
    IFN-alpha-16
    Alternative name(s):
    Interferon alpha-WA
    Gene namesi
    Name:IFNA16
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:5421. IFNA16.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29660.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Add
    BLAST
    Chaini24 – 189166Interferon alpha-16PRO_0000016368Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 122By similarity
    Disulfide bondi52 ↔ 162By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP05015.
    PRIDEiP05015.

    PTM databases

    PhosphoSiteiP05015.

    Expressioni

    Gene expression databases

    CleanExiHS_IFNA16.
    GenevestigatoriP05015.

    Organism-specific databases

    HPAiHPA047557.

    Interactioni

    Protein-protein interaction databases

    BioGridi109672. 1 interaction.
    IntActiP05015. 1 interaction.
    MINTiMINT-8201769.
    STRINGi9606.ENSP00000369564.

    Structurei

    3D structure databases

    ProteinModelPortaliP05015.
    SMRiP05015. Positions 24-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG71630.
    HOGENOMiHOG000230500.
    HOVERGENiHBG052086.
    InParanoidiP05015.
    KOiK05414.
    OMAiISAFHEM.
    OrthoDBiEOG7BW0KT.
    PhylomeDBiP05015.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05015-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF    50
    SCLKDRYDFG FPQEVFDGNQ FQKAQAISAF HEMIQQTFNL FSTKDSSAAW 100
    DETLLDKFYI ELFQQLNDLE ACVTQEVGVE EIALMNEDSI LAVRKYFQRI 150
    TLYLMGKKYS PCAWEVVRAE IMRSFSFSTN LQKGLRRKD 189
    Length:189
    Mass (Da):21,711
    Last modified:August 13, 1987 - v1
    Checksum:iFC8822F787F1585F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02957 Genomic DNA. Translation: CAA26703.1.
    K02055 Genomic DNA. Translation: AAA52727.1.
    M28585 mRNA. Translation: AAA36042.1.
    AL512606 Genomic DNA. Translation: CAH71193.1.
    CH471071 Genomic DNA. Translation: EAW58618.1.
    CCDSiCCDS34996.1.
    PIRiG23753. IVHU16.
    RefSeqiNP_002164.1. NM_002173.2.
    UniGeneiHs.56303.

    Genome annotation databases

    EnsembliENST00000380216; ENSP00000369564; ENSG00000147885.
    GeneIDi3449.
    KEGGihsa:3449.
    UCSCiuc003zor.1. human.

    Polymorphism databases

    DMDMi124463.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02957 Genomic DNA. Translation: CAA26703.1 .
    K02055 Genomic DNA. Translation: AAA52727.1 .
    M28585 mRNA. Translation: AAA36042.1 .
    AL512606 Genomic DNA. Translation: CAH71193.1 .
    CH471071 Genomic DNA. Translation: EAW58618.1 .
    CCDSi CCDS34996.1.
    PIRi G23753. IVHU16.
    RefSeqi NP_002164.1. NM_002173.2.
    UniGenei Hs.56303.

    3D structure databases

    ProteinModelPortali P05015.
    SMRi P05015. Positions 24-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109672. 1 interaction.
    IntActi P05015. 1 interaction.
    MINTi MINT-8201769.
    STRINGi 9606.ENSP00000369564.

    PTM databases

    PhosphoSitei P05015.

    Polymorphism databases

    DMDMi 124463.

    Proteomic databases

    PaxDbi P05015.
    PRIDEi P05015.

    Protocols and materials databases

    DNASUi 3449.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380216 ; ENSP00000369564 ; ENSG00000147885 .
    GeneIDi 3449.
    KEGGi hsa:3449.
    UCSCi uc003zor.1. human.

    Organism-specific databases

    CTDi 3449.
    GeneCardsi GC09M021216.
    HGNCi HGNC:5421. IFNA16.
    HPAi HPA047557.
    MIMi 147580. gene.
    neXtProti NX_P05015.
    PharmGKBi PA29660.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG71630.
    HOGENOMi HOG000230500.
    HOVERGENi HBG052086.
    InParanoidi P05015.
    KOi K05414.
    OMAi ISAFHEM.
    OrthoDBi EOG7BW0KT.
    PhylomeDBi P05015.
    TreeFami TF336177.

    Enzyme and pathway databases

    Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Miscellaneous databases

    GeneWikii IFNA16.
    GenomeRNAii 3449.
    NextBioi 13592.
    PROi P05015.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_IFNA16.
    Genevestigatori P05015.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human genomic library screened with 17-base oligonucleotide probes yields a novel interferon gene."
      Torczynski R.M., Fuke M., Bollon A.P.
      Proc. Natl. Acad. Sci. U.S.A. 81:6451-6455(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes."
      Gren E., Berzin V.M., Jansone I., Tsimanis A., Vishnevsky Y., Apsalons U.
      J. Interferon Res. 4:609-617(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiIFN16_HUMAN
    AccessioniPrimary (citable) accession number: P05015
    Secondary accession number(s): Q5VV12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3