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P05015

- IFN16_HUMAN

UniProt

P05015 - IFN16_HUMAN

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Protein

Interferon alpha-16

Gene

IFNA16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  1. cytokine activity Source: RefGenome
  2. type I interferon receptor binding Source: RefGenome

GO - Biological processi

  1. adaptive immune response Source: RefGenome
  2. B cell differentiation Source: RefGenome
  3. B cell proliferation Source: RefGenome
  4. blood coagulation Source: Reactome
  5. cytokine-mediated signaling pathway Source: RefGenome
  6. defense response to virus Source: UniProtKB-KW
  7. humoral immune response Source: RefGenome
  8. innate immune response Source: RefGenome
  9. natural killer cell activation involved in immune response Source: RefGenome
  10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
  11. regulation of MHC class I biosynthetic process Source: RefGenome
  12. regulation of type I interferon-mediated signaling pathway Source: Reactome
  13. response to exogenous dsRNA Source: RefGenome
  14. T cell activation involved in immune response Source: RefGenome
  15. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-16
Short name:
IFN-alpha-16
Alternative name(s):
Interferon alpha-WA
Gene namesi
Name:IFNA16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:5421. IFNA16.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29660.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 189166Interferon alpha-16PRO_0000016368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP05015.
PRIDEiP05015.

PTM databases

PhosphoSiteiP05015.

Expressioni

Gene expression databases

CleanExiHS_IFNA16.
GenevestigatoriP05015.

Organism-specific databases

HPAiHPA047557.

Interactioni

Protein-protein interaction databases

BioGridi109672. 1 interaction.
IntActiP05015. 1 interaction.
MINTiMINT-8201769.
STRINGi9606.ENSP00000369564.

Structurei

3D structure databases

ProteinModelPortaliP05015.
SMRiP05015. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG71630.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05015.
KOiK05414.
OMAiISAFHEM.
OrthoDBiEOG7BW0KT.
PhylomeDBiP05015.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05015-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF
60 70 80 90 100
SCLKDRYDFG FPQEVFDGNQ FQKAQAISAF HEMIQQTFNL FSTKDSSAAW
110 120 130 140 150
DETLLDKFYI ELFQQLNDLE ACVTQEVGVE EIALMNEDSI LAVRKYFQRI
160 170 180
TLYLMGKKYS PCAWEVVRAE IMRSFSFSTN LQKGLRRKD
Length:189
Mass (Da):21,711
Last modified:August 13, 1987 - v1
Checksum:iFC8822F787F1585F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02957 Genomic DNA. Translation: CAA26703.1.
K02055 Genomic DNA. Translation: AAA52727.1.
M28585 mRNA. Translation: AAA36042.1.
AL512606 Genomic DNA. Translation: CAH71193.1.
CH471071 Genomic DNA. Translation: EAW58618.1.
CCDSiCCDS34996.1.
PIRiG23753. IVHU16.
RefSeqiNP_002164.1. NM_002173.2.
UniGeneiHs.56303.

Genome annotation databases

EnsembliENST00000380216; ENSP00000369564; ENSG00000147885.
GeneIDi3449.
KEGGihsa:3449.
UCSCiuc003zor.1. human.

Polymorphism databases

DMDMi124463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02957 Genomic DNA. Translation: CAA26703.1 .
K02055 Genomic DNA. Translation: AAA52727.1 .
M28585 mRNA. Translation: AAA36042.1 .
AL512606 Genomic DNA. Translation: CAH71193.1 .
CH471071 Genomic DNA. Translation: EAW58618.1 .
CCDSi CCDS34996.1.
PIRi G23753. IVHU16.
RefSeqi NP_002164.1. NM_002173.2.
UniGenei Hs.56303.

3D structure databases

ProteinModelPortali P05015.
SMRi P05015. Positions 24-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109672. 1 interaction.
IntActi P05015. 1 interaction.
MINTi MINT-8201769.
STRINGi 9606.ENSP00000369564.

PTM databases

PhosphoSitei P05015.

Polymorphism databases

DMDMi 124463.

Proteomic databases

PaxDbi P05015.
PRIDEi P05015.

Protocols and materials databases

DNASUi 3449.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380216 ; ENSP00000369564 ; ENSG00000147885 .
GeneIDi 3449.
KEGGi hsa:3449.
UCSCi uc003zor.1. human.

Organism-specific databases

CTDi 3449.
GeneCardsi GC09M021216.
HGNCi HGNC:5421. IFNA16.
HPAi HPA047557.
MIMi 147580. gene.
neXtProti NX_P05015.
PharmGKBi PA29660.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG71630.
GeneTreei ENSGT00760000119150.
HOGENOMi HOG000230500.
HOVERGENi HBG052086.
InParanoidi P05015.
KOi K05414.
OMAi ISAFHEM.
OrthoDBi EOG7BW0KT.
PhylomeDBi P05015.
TreeFami TF336177.

Enzyme and pathway databases

Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Miscellaneous databases

GeneWikii IFNA16.
GenomeRNAii 3449.
NextBioi 13592.
PROi P05015.
SOURCEi Search...

Gene expression databases

CleanExi HS_IFNA16.
Genevestigatori P05015.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view ]
PANTHERi PTHR11691. PTHR11691. 1 hit.
Pfami PF00143. Interferon. 1 hit.
[Graphical view ]
PRINTSi PR00266. INTERFERONAB.
SMARTi SM00076. IFabd. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human genomic library screened with 17-base oligonucleotide probes yields a novel interferon gene."
    Torczynski R.M., Fuke M., Bollon A.P.
    Proc. Natl. Acad. Sci. U.S.A. 81:6451-6455(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes."
    Gren E., Berzin V.M., Jansone I., Tsimanis A., Vishnevsky Y., Apsalons U.
    J. Interferon Res. 4:609-617(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiIFN16_HUMAN
AccessioniPrimary (citable) accession number: P05015
Secondary accession number(s): Q5VV12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 29, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3