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P05014

- IFNA4_HUMAN

UniProt

P05014 - IFNA4_HUMAN

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Protein
Interferon alpha-4
Gene
IFNA4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  1. cytokine activity Source: RefGenome
  2. type I interferon receptor binding Source: RefGenome

GO - Biological processi

  1. B cell differentiation Source: RefGenome
  2. B cell proliferation Source: RefGenome
  3. T cell activation involved in immune response Source: RefGenome
  4. adaptive immune response Source: RefGenome
  5. blood coagulation Source: Reactome
  6. cytokine-mediated signaling pathway Source: RefGenome
  7. defense response to virus Source: UniProtKB-KW
  8. humoral immune response Source: RefGenome
  9. innate immune response Source: RefGenome
  10. natural killer cell activation involved in immune response Source: RefGenome
  11. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
  12. regulation of MHC class I biosynthetic process Source: RefGenome
  13. regulation of type I interferon-mediated signaling pathway Source: Reactome
  14. response to exogenous dsRNA Source: RefGenome
  15. response to virus Source: ProtInc
  16. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-4
Short name:
IFN-alpha-4
Alternative name(s):
Interferon alpha-4B
Interferon alpha-76
Interferon alpha-M1
Gene namesi
Name:IFNA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:5425. IFNA4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 Publication
Add
BLAST
Chaini24 – 189166Interferon alpha-4
PRO_0000016361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122 By similarity
Disulfide bondi52 ↔ 162 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP05014.
PRIDEiP05014.

PTM databases

PhosphoSiteiP05014.

Expressioni

Gene expression databases

CleanExiHS_IFNA4.
GenevestigatoriP05014.

Organism-specific databases

HPAiHPA047557.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000412897.

Structurei

3D structure databases

ProteinModelPortaliP05014.
SMRiP05014. Positions 24-189.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG119628.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05014.
KOiK05414.
OMAiPVLMHED.
OrthoDBiEOG7M98HV.
PhylomeDBiP05014.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05014-1 [UniParc]FASTAAdd to Basket

« Hide

MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF    50
SCLKDRHDFG FPEEEFDGHQ FQKAQAISVL HEMIQQTFNL FSTEDSSAAW 100
EQSLLEKFST ELYQQLNDLE ACVIQEVGVE ETPLMNEDSI LAVRKYFQRI 150
TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN LQKRLRRKD 189
Length:189
Mass (Da):21,808
Last modified:May 10, 2005 - v2
Checksum:i828DF9C33ABC337F
GO

Polymorphismi

Two forms exist; alpha-4a (shown here) and alpha-4b. They seem to be equally abundant.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491H → P.
Corresponds to variant rs3203573 [ dbSNP | Ensembl ].
VAR_034010
Natural varianti74 – 741A → T in alpha-4B. 3 Publications
Corresponds to variant rs1062571 [ dbSNP | Ensembl ].
VAR_013002
Natural varianti137 – 1371E → V in alpha-4B. 1 Publication
Corresponds to variant rs3750480 [ dbSNP | Ensembl ].
VAR_013003

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27318 mRNA. Translation: AAA52726.1.
X02955 Genomic DNA. Translation: CAA26701.1.
AL512606 Genomic DNA. Translation: CAH71188.1.
CH471071 Genomic DNA. Translation: EAW58621.1.
BC074965 mRNA. Translation: AAH74965.1.
BC074966 mRNA. Translation: AAH74966.1.
BC113640 mRNA. Translation: AAI13641.1.
BC113642 mRNA. Translation: AAI13643.1.
CCDSiCCDS6498.1.
PIRiE23753. IVHU4B.
I52347.
RefSeqiNP_066546.1. NM_021068.2.
UniGeneiHs.1510.

Genome annotation databases

EnsembliENST00000421715; ENSP00000412897; ENSG00000236637.
GeneIDi3441.
KEGGihsa:3441.
UCSCiuc003zon.2. human.

Polymorphism databases

DMDMi84029375.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27318 mRNA. Translation: AAA52726.1 .
X02955 Genomic DNA. Translation: CAA26701.1 .
AL512606 Genomic DNA. Translation: CAH71188.1 .
CH471071 Genomic DNA. Translation: EAW58621.1 .
BC074965 mRNA. Translation: AAH74965.1 .
BC074966 mRNA. Translation: AAH74966.1 .
BC113640 mRNA. Translation: AAI13641.1 .
BC113642 mRNA. Translation: AAI13643.1 .
CCDSi CCDS6498.1.
PIRi E23753. IVHU4B.
I52347.
RefSeqi NP_066546.1. NM_021068.2.
UniGenei Hs.1510.

3D structure databases

ProteinModelPortali P05014.
SMRi P05014. Positions 24-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000412897.

PTM databases

PhosphoSitei P05014.

Polymorphism databases

DMDMi 84029375.

Proteomic databases

PaxDbi P05014.
PRIDEi P05014.

Protocols and materials databases

DNASUi 3441.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000421715 ; ENSP00000412897 ; ENSG00000236637 .
GeneIDi 3441.
KEGGi hsa:3441.
UCSCi uc003zon.2. human.

Organism-specific databases

CTDi 3441.
GeneCardsi GC09M021186.
HGNCi HGNC:5425. IFNA4.
HPAi HPA047557.
MIMi 147564. gene.
neXtProti NX_P05014.
PharmGKBi PA29664.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG119628.
HOGENOMi HOG000230500.
HOVERGENi HBG052086.
InParanoidi P05014.
KOi K05414.
OMAi PVLMHED.
OrthoDBi EOG7M98HV.
PhylomeDBi P05014.
TreeFami TF336177.

Enzyme and pathway databases

Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Miscellaneous databases

GeneWikii IFNA4.
GenomeRNAii 3441.
NextBioi 13560.
PROi P05014.
SOURCEi Search...

Gene expression databases

CleanExi HS_IFNA4.
Genevestigatori P05014.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view ]
PANTHERi PTHR11691. PTHR11691. 1 hit.
Pfami PF00143. Interferon. 1 hit.
[Graphical view ]
PRINTSi PR00266. INTERFERONAB.
SMARTi SM00076. IFabd. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides."
    Linnane A.W., Beilharz M.W., McMullen G.L., Macreadie I.G., Murphy M., Nisbet I.T., Novitski C.E., Woodrow G.C.
    Biochem. Int. 8:725-732(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALPHA-4B THR-74 AND VAL-137.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-74.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-74.
    Tissue: Brain.
  6. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
    Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
    Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-56.
  7. "Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population."
    Hussain M., Gill D.S., Liao M.-J.
    J. Interferon Cytokine Res. 17:559-566(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM.

Entry informationi

Entry nameiIFNA4_HUMAN
AccessioniPrimary (citable) accession number: P05014
Secondary accession number(s): P13358, Q14CS4, Q5VV15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: May 10, 2005
Last modified: September 3, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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