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P05014

- IFNA4_HUMAN

UniProt

P05014 - IFNA4_HUMAN

Protein

Interferon alpha-4

Gene

IFNA4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (10 May 2005)
      Previous versions | rss
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    Functioni

    Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome
    2. type I interferon receptor binding Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. blood coagulation Source: Reactome
    5. cytokine-mediated signaling pathway Source: RefGenome
    6. defense response to virus Source: UniProtKB-KW
    7. humoral immune response Source: RefGenome
    8. innate immune response Source: RefGenome
    9. natural killer cell activation involved in immune response Source: RefGenome
    10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    11. regulation of MHC class I biosynthetic process Source: RefGenome
    12. regulation of type I interferon-mediated signaling pathway Source: Reactome
    13. response to exogenous dsRNA Source: RefGenome
    14. response to virus Source: ProtInc
    15. T cell activation involved in immune response Source: RefGenome
    16. type I interferon signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon alpha-4
    Short name:
    IFN-alpha-4
    Alternative name(s):
    Interferon alpha-4B
    Interferon alpha-76
    Interferon alpha-M1
    Gene namesi
    Name:IFNA4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:5425. IFNA4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29664.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 189166Interferon alpha-4PRO_0000016361Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 122By similarity
    Disulfide bondi52 ↔ 162By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP05014.
    PRIDEiP05014.

    PTM databases

    PhosphoSiteiP05014.

    Expressioni

    Gene expression databases

    CleanExiHS_IFNA4.
    GenevestigatoriP05014.

    Organism-specific databases

    HPAiHPA047557.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000412897.

    Structurei

    3D structure databases

    ProteinModelPortaliP05014.
    SMRiP05014. Positions 24-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG119628.
    HOGENOMiHOG000230500.
    HOVERGENiHBG052086.
    InParanoidiP05014.
    KOiK05414.
    OMAiPVLMHED.
    OrthoDBiEOG7M98HV.
    PhylomeDBiP05014.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05014-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF    50
    SCLKDRHDFG FPEEEFDGHQ FQKAQAISVL HEMIQQTFNL FSTEDSSAAW 100
    EQSLLEKFST ELYQQLNDLE ACVIQEVGVE ETPLMNEDSI LAVRKYFQRI 150
    TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN LQKRLRRKD 189
    Length:189
    Mass (Da):21,808
    Last modified:May 10, 2005 - v2
    Checksum:i828DF9C33ABC337F
    GO

    Polymorphismi

    Two forms exist; alpha-4a (shown here) and alpha-4b. They seem to be equally abundant.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti49 – 491H → P.
    Corresponds to variant rs3203573 [ dbSNP | Ensembl ].
    VAR_034010
    Natural varianti74 – 741A → T in alpha-4B. 3 Publications
    Corresponds to variant rs1062571 [ dbSNP | Ensembl ].
    VAR_013002
    Natural varianti137 – 1371E → V in alpha-4B. 1 Publication
    Corresponds to variant rs3750480 [ dbSNP | Ensembl ].
    VAR_013003

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27318 mRNA. Translation: AAA52726.1.
    X02955 Genomic DNA. Translation: CAA26701.1.
    AL512606 Genomic DNA. Translation: CAH71188.1.
    CH471071 Genomic DNA. Translation: EAW58621.1.
    BC074965 mRNA. Translation: AAH74965.1.
    BC074966 mRNA. Translation: AAH74966.1.
    BC113640 mRNA. Translation: AAI13641.1.
    BC113642 mRNA. Translation: AAI13643.1.
    CCDSiCCDS6498.1.
    PIRiE23753. IVHU4B.
    I52347.
    RefSeqiNP_066546.1. NM_021068.2.
    UniGeneiHs.1510.

    Genome annotation databases

    EnsembliENST00000421715; ENSP00000412897; ENSG00000236637.
    GeneIDi3441.
    KEGGihsa:3441.
    UCSCiuc003zon.2. human.

    Polymorphism databases

    DMDMi84029375.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27318 mRNA. Translation: AAA52726.1 .
    X02955 Genomic DNA. Translation: CAA26701.1 .
    AL512606 Genomic DNA. Translation: CAH71188.1 .
    CH471071 Genomic DNA. Translation: EAW58621.1 .
    BC074965 mRNA. Translation: AAH74965.1 .
    BC074966 mRNA. Translation: AAH74966.1 .
    BC113640 mRNA. Translation: AAI13641.1 .
    BC113642 mRNA. Translation: AAI13643.1 .
    CCDSi CCDS6498.1.
    PIRi E23753. IVHU4B.
    I52347.
    RefSeqi NP_066546.1. NM_021068.2.
    UniGenei Hs.1510.

    3D structure databases

    ProteinModelPortali P05014.
    SMRi P05014. Positions 24-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000412897.

    PTM databases

    PhosphoSitei P05014.

    Polymorphism databases

    DMDMi 84029375.

    Proteomic databases

    PaxDbi P05014.
    PRIDEi P05014.

    Protocols and materials databases

    DNASUi 3441.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000421715 ; ENSP00000412897 ; ENSG00000236637 .
    GeneIDi 3441.
    KEGGi hsa:3441.
    UCSCi uc003zon.2. human.

    Organism-specific databases

    CTDi 3441.
    GeneCardsi GC09M021186.
    HGNCi HGNC:5425. IFNA4.
    HPAi HPA047557.
    MIMi 147564. gene.
    neXtProti NX_P05014.
    PharmGKBi PA29664.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG119628.
    HOGENOMi HOG000230500.
    HOVERGENi HBG052086.
    InParanoidi P05014.
    KOi K05414.
    OMAi PVLMHED.
    OrthoDBi EOG7M98HV.
    PhylomeDBi P05014.
    TreeFami TF336177.

    Enzyme and pathway databases

    Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Miscellaneous databases

    GeneWikii IFNA4.
    GenomeRNAii 3441.
    NextBioi 13560.
    PROi P05014.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_IFNA4.
    Genevestigatori P05014.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides."
      Linnane A.W., Beilharz M.W., McMullen G.L., Macreadie I.G., Murphy M., Nisbet I.T., Novitski C.E., Woodrow G.C.
      Biochem. Int. 8:725-732(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALPHA-4B THR-74 AND VAL-137.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-74.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-74.
      Tissue: Brain.
    6. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
      Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
      Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-56.
    7. "Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population."
      Hussain M., Gill D.S., Liao M.-J.
      J. Interferon Cytokine Res. 17:559-566(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYMORPHISM.

    Entry informationi

    Entry nameiIFNA4_HUMAN
    AccessioniPrimary (citable) accession number: P05014
    Secondary accession number(s): P13358, Q14CS4, Q5VV15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3