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Protein

Interferon alpha-4

Gene

IFNA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-4
Short name:
IFN-alpha-4
Alternative name(s):
Interferon alpha-4B
Interferon alpha-76
Interferon alpha-M1
Gene namesi
Name:IFNA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:5425. IFNA4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29664.

Polymorphism and mutation databases

BioMutaiIFNA4.
DMDMi84029375.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 189166Interferon alpha-4PRO_0000016361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP05014.
PRIDEiP05014.

PTM databases

PhosphoSiteiP05014.

Expressioni

Gene expression databases

CleanExiHS_IFNA4.
GenevisibleiP05014. HS.

Organism-specific databases

HPAiHPA047557.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALDOAP04075-23EBI-10194381,EBI-10194102

Protein-protein interaction databases

BioGridi109664. 11 interactions.
IntActiP05014. 1 interaction.
STRINGi9606.ENSP00000412897.

Structurei

3D structure databases

ProteinModelPortaliP05014.
SMRiP05014. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG119628.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05014.
KOiK05414.
OMAiTNSSATW.
OrthoDBiEOG7M98HV.
PhylomeDBiP05014.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISHF
60 70 80 90 100
SCLKDRHDFG FPEEEFDGHQ FQKAQAISVL HEMIQQTFNL FSTEDSSAAW
110 120 130 140 150
EQSLLEKFST ELYQQLNDLE ACVIQEVGVE ETPLMNEDSI LAVRKYFQRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSLSFSTN LQKRLRRKD
Length:189
Mass (Da):21,808
Last modified:May 10, 2005 - v2
Checksum:i828DF9C33ABC337F
GO

Polymorphismi

Two forms exist; alpha-4a (shown here) and alpha-4b. They seem to be equally abundant.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491H → P.
Corresponds to variant rs3203573 [ dbSNP | Ensembl ].
VAR_034010
Natural varianti74 – 741A → T in alpha-4B. 3 Publications
Corresponds to variant rs1062571 [ dbSNP | Ensembl ].
VAR_013002
Natural varianti137 – 1371E → V in alpha-4B. 1 Publication
Corresponds to variant rs3750480 [ dbSNP | Ensembl ].
VAR_013003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27318 mRNA. Translation: AAA52726.1.
X02955 Genomic DNA. Translation: CAA26701.1.
AL512606 Genomic DNA. Translation: CAH71188.1.
CH471071 Genomic DNA. Translation: EAW58621.1.
BC074965 mRNA. Translation: AAH74965.1.
BC074966 mRNA. Translation: AAH74966.1.
BC113640 mRNA. Translation: AAI13641.1.
BC113642 mRNA. Translation: AAI13643.1.
CCDSiCCDS6498.1.
PIRiE23753. IVHU4B.
I52347.
RefSeqiNP_066546.1. NM_021068.2.
UniGeneiHs.1510.

Genome annotation databases

EnsembliENST00000421715; ENSP00000412897; ENSG00000236637.
GeneIDi3441.
KEGGihsa:3441.
UCSCiuc003zon.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27318 mRNA. Translation: AAA52726.1.
X02955 Genomic DNA. Translation: CAA26701.1.
AL512606 Genomic DNA. Translation: CAH71188.1.
CH471071 Genomic DNA. Translation: EAW58621.1.
BC074965 mRNA. Translation: AAH74965.1.
BC074966 mRNA. Translation: AAH74966.1.
BC113640 mRNA. Translation: AAI13641.1.
BC113642 mRNA. Translation: AAI13643.1.
CCDSiCCDS6498.1.
PIRiE23753. IVHU4B.
I52347.
RefSeqiNP_066546.1. NM_021068.2.
UniGeneiHs.1510.

3D structure databases

ProteinModelPortaliP05014.
SMRiP05014. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109664. 11 interactions.
IntActiP05014. 1 interaction.
STRINGi9606.ENSP00000412897.

PTM databases

PhosphoSiteiP05014.

Polymorphism and mutation databases

BioMutaiIFNA4.
DMDMi84029375.

Proteomic databases

PaxDbiP05014.
PRIDEiP05014.

Protocols and materials databases

DNASUi3441.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421715; ENSP00000412897; ENSG00000236637.
GeneIDi3441.
KEGGihsa:3441.
UCSCiuc003zon.2. human.

Organism-specific databases

CTDi3441.
GeneCardsiGC09M021186.
HGNCiHGNC:5425. IFNA4.
HPAiHPA047557.
MIMi147564. gene.
neXtProtiNX_P05014.
PharmGKBiPA29664.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG119628.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05014.
KOiK05414.
OMAiTNSSATW.
OrthoDBiEOG7M98HV.
PhylomeDBiP05014.
TreeFamiTF336177.

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Miscellaneous databases

GeneWikiiIFNA4.
GenomeRNAii3441.
NextBioi13560.
PROiP05014.
SOURCEiSearch...

Gene expression databases

CleanExiHS_IFNA4.
GenevisibleiP05014. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides."
    Linnane A.W., Beilharz M.W., McMullen G.L., Macreadie I.G., Murphy M., Nisbet I.T., Novitski C.E., Woodrow G.C.
    Biochem. Int. 8:725-732(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALPHA-4B THR-74 AND VAL-137.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-74.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-74.
    Tissue: Brain.
  6. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
    Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
    Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-56.
  7. "Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population."
    Hussain M., Gill D.S., Liao M.-J.
    J. Interferon Cytokine Res. 17:559-566(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM.

Entry informationi

Entry nameiIFNA4_HUMAN
AccessioniPrimary (citable) accession number: P05014
Secondary accession number(s): P13358, Q14CS4, Q5VV15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: May 10, 2005
Last modified: July 22, 2015
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.