ID   IFNA6_HUMAN             Reviewed;         189 AA.
AC   P05013; Q5VYQ1;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   27-MAR-2024, entry version 192.
DE   RecName: Full=Interferon alpha-6;
DE            Short=IFN-alpha-6;
DE   AltName: Full=Interferon alpha-54;
DE   AltName: Full=Interferon alpha-K;
DE            Short=LeIF K;
DE   Flags: Precursor;
GN   Name=IFNA6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=4057246; DOI=10.1016/0022-2836(85)90401-2;
RA   Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J.,
RA   Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M.,
RA   Nagata S., Weissmann C.;
RT   "Structural relationship of human interferon alpha genes and pseudogenes.";
RL   J. Mol. Biol. 185:227-260(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PROTEIN SEQUENCE OF 21-35.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally verified
RT   cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC       Interferon stimulates the production of two enzymes: a protein kinase
CC       and an oligoadenylate synthetase.
CC   -!- INTERACTION:
CC       P05013; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-14133376, EBI-16439278;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X02958; CAA26704.1; -; Genomic_DNA.
DR   EMBL; AL353732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471071; EAW58613.1; -; Genomic_DNA.
DR   EMBL; BC069471; AAH69471.1; -; mRNA.
DR   EMBL; BC096697; AAH96697.1; -; mRNA.
DR   EMBL; BC096710; AAH96710.1; -; mRNA.
DR   EMBL; BC096730; AAH96730.1; -; mRNA.
DR   EMBL; BC098357; AAH98357.1; -; mRNA.
DR   CCDS; CCDS6504.1; -.
DR   PIR; A23753; IVHUI6.
DR   RefSeq; NP_066282.1; NM_021002.2.
DR   AlphaFoldDB; P05013; -.
DR   SMR; P05013; -.
DR   BioGRID; 109666; 7.
DR   ComplexPortal; CPX-6000; Interferon alpha receptor-ligand complex, IFNA6 variant.
DR   IntAct; P05013; 5.
DR   STRING; 9606.ENSP00000369558; -.
DR   ChEMBL; CHEMBL3856161; -.
DR   iPTMnet; P05013; -.
DR   PhosphoSitePlus; P05013; -.
DR   BioMuta; IFNA6; -.
DR   DMDM; 124460; -.
DR   jPOST; P05013; -.
DR   MassIVE; P05013; -.
DR   PaxDb; 9606-ENSP00000369558; -.
DR   PeptideAtlas; P05013; -.
DR   ABCD; P05013; 6 sequenced antibodies.
DR   Antibodypedia; 24870; 196 antibodies from 24 providers.
DR   DNASU; 3443; -.
DR   Ensembl; ENST00000380210.2; ENSP00000369558.1; ENSG00000120235.5.
DR   GeneID; 3443; -.
DR   KEGG; hsa:3443; -.
DR   MANE-Select; ENST00000380210.2; ENSP00000369558.1; NM_021002.2; NP_066282.1.
DR   UCSC; uc011lni.3; human.
DR   AGR; HGNC:5427; -.
DR   CTD; 3443; -.
DR   DisGeNET; 3443; -.
DR   GeneCards; IFNA6; -.
DR   HGNC; HGNC:5427; IFNA6.
DR   HPA; ENSG00000120235; Not detected.
DR   MIM; 147566; gene.
DR   neXtProt; NX_P05013; -.
DR   OpenTargets; ENSG00000120235; -.
DR   PharmGKB; PA29666; -.
DR   VEuPathDB; HostDB:ENSG00000120235; -.
DR   eggNOG; ENOG502SQAC; Eukaryota.
DR   GeneTree; ENSGT01000000214430; -.
DR   InParanoid; P05013; -.
DR   OMA; RYDFRFP; -.
DR   OrthoDB; 5358931at2759; -.
DR   PhylomeDB; P05013; -.
DR   TreeFam; TF336177; -.
DR   PathwayCommons; P05013; -.
DR   Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR   Reactome; R-HSA-912694; Regulation of IFNA/IFNB signaling.
DR   Reactome; R-HSA-933541; TRAF6 mediated IRF7 activation.
DR   Reactome; R-HSA-9705671; SARS-CoV-2 activates/modulates innate and adaptive immune responses.
DR   Reactome; R-HSA-983231; Factors involved in megakaryocyte development and platelet production.
DR   SignaLink; P05013; -.
DR   BioGRID-ORCS; 3443; 7 hits in 1064 CRISPR screens.
DR   GeneWiki; IFNA6; -.
DR   GenomeRNAi; 3443; -.
DR   Pharos; P05013; Tbio.
DR   PRO; PR:P05013; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; P05013; Protein.
DR   Bgee; ENSG00000120235; Expressed in putamen and 20 other cell types or tissues.
DR   ExpressionAtlas; P05013; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0098586; P:cellular response to virus; NAS:ComplexPortal.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; NAS:ComplexPortal.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691:SF27; INTERFERON ALPHA-6; 1.
DR   PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
DR   Genevisible; P05013; HS.
PE   1: Evidence at protein level;
KW   Antiviral defense; Cytokine; Direct protein sequencing; Disulfide bond;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000269|PubMed:15340161"
FT   CHAIN           21..189
FT                   /note="Interferon alpha-6"
FT                   /id="PRO_0000016363"
FT   DISULFID        24..122
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..162
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   189 AA;  22141 MW;  8C7F3F90F12C562E CRC64;
     MALPFALLMA LVVLSCKSSC SLDCDLPQTH SLGHRRTMML LAQMRRISLF SCLKDRHDFR
     FPQEEFDGNQ FQKAEAISVL HEVIQQTFNL FSTKDSSVAW DERLLDKLYT ELYQQLNDLE
     ACVMQEVWVG GTPLMNEDSI LAVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSFSSSRN
     LQERLRRKE
//