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Protein

Interferon alpha-6

Gene

IFNA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733. Interferon alpha/beta signaling.
R-HSA-912694. Regulation of IFNA signaling.
R-HSA-933541. TRAF6 mediated IRF7 activation.
R-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-6
Short name:
IFN-alpha-6
Alternative name(s):
Interferon alpha-54
Interferon alpha-K
Short name:
LeIF K
Gene namesi
Name:IFNA6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000120235.4.
HGNCiHGNC:5427. IFNA6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3443.
OpenTargetsiENSG00000120235.
PharmGKBiPA29666.

Polymorphism and mutation databases

BioMutaiIFNA6.
DMDMi124460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001636321 – 189Interferon alpha-6Add BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP05013.
PRIDEiP05013.

PTM databases

iPTMnetiP05013.
PhosphoSitePlusiP05013.

Expressioni

Gene expression databases

BgeeiENSG00000120235.
CleanExiHS_IFNA6.
ExpressionAtlasiP05013. baseline and differential.
GenevisibleiP05013. HS.

Organism-specific databases

HPAiHPA047557.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109666. 4 interactors.
IntActiP05013. 1 interactor.
STRINGi9606.ENSP00000369558.

Structurei

3D structure databases

ProteinModelPortaliP05013.
SMRiP05013.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735. Eukaryota.
ENOG410ZH91. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05013.
KOiK05414.
OMAiHRRTMML.
PhylomeDBiP05013.
TreeFamiTF336177.

Family and domain databases

CDDicd00095. IFab. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000471. Interferon_alpha/beta/delta.
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiView protein in Pfam
PF00143. Interferon. 1 hit.
PRINTSiPR00266. INTERFERONAB.
SMARTiView protein in SMART
SM00076. IFabd. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00252. INTERFERON_A_B_D. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPFALLMA LVVLSCKSSC SLDCDLPQTH SLGHRRTMML LAQMRRISLF
60 70 80 90 100
SCLKDRHDFR FPQEEFDGNQ FQKAEAISVL HEVIQQTFNL FSTKDSSVAW
110 120 130 140 150
DERLLDKLYT ELYQQLNDLE ACVMQEVWVG GTPLMNEDSI LAVRKYFQRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSFSSSRN LQERLRRKE
Length:189
Mass (Da):22,141
Last modified:August 13, 1987 - v1
Checksum:i8C7F3F90F12C562E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02958 Genomic DNA. Translation: CAA26704.1.
AL353732 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58613.1.
BC069471 mRNA. Translation: AAH69471.1.
BC096697 mRNA. Translation: AAH96697.1.
BC096710 mRNA. Translation: AAH96710.1.
BC096730 mRNA. Translation: AAH96730.1.
BC098357 mRNA. Translation: AAH98357.1.
CCDSiCCDS6504.1.
PIRiA23753. IVHUI6.
RefSeqiNP_066282.1. NM_021002.2.
UniGeneiHs.533470.

Genome annotation databases

EnsembliENST00000380210; ENSP00000369558; ENSG00000120235.
GeneIDi3443.
KEGGihsa:3443.
UCSCiuc011lni.3. human.

Similar proteinsi

Entry informationi

Entry nameiIFNA6_HUMAN
AccessioniPrimary (citable) accession number: P05013
Secondary accession number(s): Q5VYQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 27, 2017
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families