P05013 (IFNA6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon alpha-6
Short name=IFN-alpha-6

Alternative name(s):
Interferon alpha-54
Interferon alpha-K
Short name=LeIF K

Gene names

Name:

IFNA6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Subcellular location	Secreted.
Sequence similarities	Belongs to the alpha/beta interferon family.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Traceable author statement. Source: Reactome defense response to virus Inferred from electronic annotation. Source: UniProtKB-KW regulation of type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome response to virus Non-traceable author statement. Source: UniProtKB type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular_component	extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine receptor binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Ref.5
	Chain	21 – 189	169	Interferon alpha-6		PRO_0000016363
Amino acid modifications
	Disulfide bond	24 ↔ 122		By similarity
	Disulfide bond	52 ↔ 162		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P05013 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 8C7F3F90F12C562E	FASTA	189	22,141
	10 20 30 40 50 60 MALPFALLMA LVVLSCKSSC SLDCDLPQTH SLGHRRTMML LAQMRRISLF SCLKDRHDFR 70 80 90 100 110 120 FPQEEFDGNQ FQKAEAISVL HEVIQQTFNL FSTKDSSVAW DERLLDKLYT ELYQQLNDLE 130 140 150 160 170 180 ACVMQEVWVG GTPLMNEDSI LAVRKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSFSSSRN LQERLRRKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural relationship of human interferon alpha genes and pseudogenes." Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J., Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M., Nagata S., Weissmann C. J. Mol. Biol. 185:227-260(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-35.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X02958 Genomic DNA. Translation: CAA26704.1. AL353732 Genomic DNA. Translation: CAH72903.1. CH471071 Genomic DNA. Translation: EAW58613.1. BC069471 mRNA. Translation: AAH69471.1. BC096697 mRNA. Translation: AAH96697.1. BC096710 mRNA. Translation: AAH96710.1. BC096730 mRNA. Translation: AAH96730.1. BC098357 mRNA. Translation: AAH98357.1.
IPI	IPI00006454.
PIR	IVHUI6. A23753.
RefSeq	NP_066282.1. NM_021002.2.
UniGene	Hs.533470.
3D structure databases
ProteinModelPortal	P05013.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000369558.
PTM databases
PhosphoSite	P05013.
Polymorphism databases
DMDM	124460.
Proteomic databases
PaxDb	P05013.
PRIDE	P05013.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380210; ENSP00000369558; ENSG00000120235.
GeneID	3443.
KEGG	hsa:3443.
UCSC	uc011lni.2. human.
Organism-specific databases
CTD	3443.
GeneCards	GC09M021340.
HGNC	HGNC:5427. IFNA6.
HPA	HPA047557.
MIM	147566. gene.
neXtProt	NX_P05013.
PharmGKB	PA29666.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG281600.
HOGENOM	HOG000230500.
HOVERGEN	HBG052086.
InParanoid	P05013.
KO	K05414.
OMA	GHRRTMM.
OrthoDB	EOG4J3WJ5.
PhylomeDB	P05013.
Enzyme and pathway databases
Pathway_Interaction_DB	cd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells.
Reactome	REACT_604. Hemostasis. REACT_6900. Immune System.
Gene expression databases
Bgee	P05013.
CleanEx	HS_IFNA6.
Genevestigator	P05013.
GermOnline	ENSG00000120235. Homo sapiens.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR015589. Interferon_alpha. IPR000471. Interferon_alpha/beta/delta. [Graphical view]
PANTHER	PTHR11691. PTHR11691. 1 hit. PTHR11691:SF9. PTHR11691:SF9. 1 hit.
Pfam	PF00143. Interferon. 1 hit. [Graphical view]
PRINTS	PR00266. INTERFERONAB.
SMART	SM00076. IFabd. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3443.
NextBio	13568.
SOURCE	Search...

Entry information

Entry name

IFNA6_HUMAN

Accession

Primary (citable) accession number: P05013
Secondary accession number(s): Q5VYQ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	May 1, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.