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Protein

Interferon alpha-1

Gene

Ifna1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-1
Gene namesi
Name:Ifna1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359312. Ifna1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 192169Interferon alpha-1PRO_0000016383Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity
Glycosylationi190 – 1901N-linked (GlcNAc...)Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05011.
PRIDEiP05011.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051043.

Structurei

3D structure databases

ProteinModelPortaliP05011.
SMRiP05011. Positions 24-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735. Eukaryota.
ENOG410ZH91. LUCA.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05011.
KOiK05414.
PhylomeDBiP05011.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLCAFLMS LVVVSYWSAC CLGCDLPHTH NLRNKRVFTL LAQMRRLSPV
60 70 80 90 100
SCLKDRKYFG FPLEKVDGQQ IQKAQAIPVL HELTQQILSL FTSKESSTAW
110 120 130 140 150
DATLLDSFCN DLQQQLSGLQ ACLMQQVGVQ ESPLTQEDSL LAVREYFHRI
160 170 180 190
TVYLRENKHS PCAWEVVKAE VWRALSSSAN LMGRLREERN ES
Length:192
Mass (Da):21,935
Last modified:August 13, 1987 - v1
Checksum:i9FD1ECE8554AE604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00336 Genomic DNA. Translation: CAA25091.1.
PIRiA23179. IVRTA1.
RefSeqiNP_001014786.1. NM_001014786.1.
UniGeneiRn.196548.

Genome annotation databases

GeneIDi298210.
KEGGirno:298210.
UCSCiRGD:1359312. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00336 Genomic DNA. Translation: CAA25091.1.
PIRiA23179. IVRTA1.
RefSeqiNP_001014786.1. NM_001014786.1.
UniGeneiRn.196548.

3D structure databases

ProteinModelPortaliP05011.
SMRiP05011. Positions 24-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051043.

Proteomic databases

PaxDbiP05011.
PRIDEiP05011.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi298210.
KEGGirno:298210.
UCSCiRGD:1359312. rat.

Organism-specific databases

CTDi3439.
RGDi1359312. Ifna1.

Phylogenomic databases

eggNOGiENOG410J735. Eukaryota.
ENOG410ZH91. LUCA.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05011.
KOiK05414.
PhylomeDBiP05011.

Miscellaneous databases

PROiP05011.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFNA1_RAT
AccessioniPrimary (citable) accession number: P05011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There appear to be at least 12 rat interferon-alpha-1 genes.
The antiviral activity of this interferon appears to be independent of glycosylation.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.