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Protein

Interferon alpha-1

Gene
N/A
Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-1
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 23

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 184161Interferon alpha-1PRO_0000016371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP05003.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000000882.

Structurei

3D structure databases

ProteinModelPortaliP05003.
SMRiP05003. Positions 24-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735. Eukaryota.
ENOG410ZH91. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05003.
KOiK05414.
OMAiIMRSLYY.
OrthoDBiEOG7M98HV.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPVSLLMA LVVLSCHSIC SLGCDLPHTH SLGNTRVLML LGQMRRISPF
60 70 80 90 100
SCLKDRNDFG FPQEVFDGNQ FRKPQAISAV HETIQQIFHL FSTDGSSAAW
110 120 130 140 150
DESLLDKLYT GLYQQLTELE ACLSQEVGVE ETPLMNEDSL LAVRRYFQRI
160 170 180
ALYLQEKKYS PCAWEIVRAE IMRSFSSSTN LPQS
Length:184
Mass (Da):20,808
Last modified:August 13, 1987 - v1
Checksum:i9E860B8CD05C83E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14540 Genomic DNA. Translation: AAA30953.1.
PIRiA24912. IVHOA1.
RefSeqiXP_003364009.1. XM_003363961.2.
UniGeneiEca.16088.

Genome annotation databases

EnsembliENSECAT00000001107; ENSECAP00000000882; ENSECAG00000001136.
GeneIDi100629951.
KEGGiecb:100629951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14540 Genomic DNA. Translation: AAA30953.1.
PIRiA24912. IVHOA1.
RefSeqiXP_003364009.1. XM_003363961.2.
UniGeneiEca.16088.

3D structure databases

ProteinModelPortaliP05003.
SMRiP05003. Positions 24-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000000882.

Proteomic databases

PaxDbiP05003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000001107; ENSECAP00000000882; ENSECAG00000001136.
GeneIDi100629951.
KEGGiecb:100629951.

Phylogenomic databases

eggNOGiENOG410J735. Eukaryota.
ENOG410ZH91. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05003.
KOiK05414.
OMAiIMRSLYY.
OrthoDBiEOG7M98HV.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression in Escherichia coli of equine type I interferons."
    Himmler A., Hauptmann R., Adolf G.R., Swetly P.
    DNA 5:345-356(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiIFNA1_HORSE
AccessioniPrimary (citable) accession number: P05003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.