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Reviewed, UniProtKB/Swiss-Prot P05000 (IFNW1_HUMAN)

Last modified July 22, 2008. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Interferon omega-1
Alternative name(s):
    Interferon alpha-II-1
Gene names
Name: IFNW1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Subcellular location

Secreted.

Sequence similarities

Belongs to the alpha/beta interferon family.

Ontologies

Keywords

   Biological processAntiviral defense
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
   Technical termDirect protein sequencing

Gene Ontology (GO)

   Biological processcell cycle arrest

Traceable author statement. Source: ProtInc

response to virus Ref.2

Traceable author statement. Source: ProtInc

   Molecular functionhematopoietin/interferon-class (D200-domain) cytokine receptor binding Ref.2

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 2121Or 23 in some molecules
Chain22 – 195174Interferon omega-1

Amino acid modifications

Glycosylation1011N-linked (GlcNAc...)
Disulfide bond24 ↔ 122 By similarity
Disulfide bond52 ↔ 162 By similarity

Natural variations

Natural variant951R → S: dbSNP rs2230055.

Experimental info

Sequence conflict22 – 232LG → EF in AAA70091. Ref.7
Sequence conflict421H → M AA sequence Ref.8
Sequence conflict791V → A in AAA70091. Ref.7
Sequence conflict1111G → E in AAA52724. Ref.1
Sequence conflict1671V → D in AAA70091. Ref.7

Sequences

Sequence LengthMass (Da)Tools
P05000-1 [UniParc].

Last modified July 1, 1993. Version 2.
Checksum: 1E4306F3487987FA

FASTA19522,319
        10         20         30         40         50         60 
MALLFPLLAA LVMTSYSPVG SLGCDLPQNH GLLSRNTLVL LHQMRRISPF LCLKDRRDFR 

        70         80         90        100        110        120 
FPQEMVKGSQ LQKAHVMSVL HEMLQQIFSL FHTERSSAAW NMTLLDQLHT GLHQQLQHLE 

       130        140        150        160        170        180 
TCLLQVVGEG ESAGAISSPA LTLRRYFQGI RVYLKEKKYS DCAWEVVRME IMKSLFLSTN 

       190 
MQERLRSKDR DLGSS 

« Hide

References

« Hide 'large scale' references
[1]"Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides."
Capon D.J., Shepard H.M., Goeddel D.V.
Mol. Cell. Biol. 5:768-779(1985) [PubMed: 2985969] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein."
Adolf G.R., Fruehbeis B., Hauptmann R., Kalsner I., Maurer-Fogy I., Ostermann E., Patzelt E., Schwendenwein R., Sommergruber W., Zoephel A.
Biochim. Biophys. Acta 1089:167-174(1991) [PubMed: 1647209] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Leukocyte.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed: 15164053] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"A novel class of human type I interferons."
Hauptmann R., Swetly P.
Nucleic Acids Res. 13:4739-4749(1985) [PubMed: 3895159] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-195.
[7]"Cloning, sequencing and expression in E. coli of interferon-omega 1 gene."
Li M.F., Zeng Q., Zhou Y., Guo H.Y., Hou Y.D.
Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 36:1361-1366(1993) [PubMed: 8142025] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-195.
[8]"Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes."
Shirono H., Koga J., Uemura H., Matsuo A.
Biosci. Biotechnol. Biochem. 58:1714-1715(1994) [PubMed: 7765487] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-55.
[9]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-36.
[10]"Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase."
Adolf G.R., Maurer-Fogy I., Kalsner I., Cantell K.
J. Biol. Chem. 265:9290-9295(1990) [PubMed: 1693148] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-33, GLYCOSYLATION AT ASN-101.
[11]"Human IFN-omega 1 gene isolated from embryonic hepar."
Yang R.Y., Yang Z.F., Zhu Y.T., Feng L.L., Liu N., Zhao F., Zhang F.X., Fu L.C.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-195.
Tissue: Liver.

Cross-references

Sequence databases

M11003 Genomic DNA. Translation: AAA52724.1.
X58822 Genomic DNA. Translation: CAA41626.1.
AL390882 Genomic DNA. Translation: CAH70158.1.
CH471071 Genomic DNA. Translation: EAW58624.1.
BC069095 mRNA. Translation: AAH69095.1.
BC117290 mRNA. Translation: AAI17291.1.
BC117292 mRNA. Translation: AAI17293.1.
X02669 mRNA. Translation: CAA26501.1.
A12140 Unassigned RNA. Translation: CAA01011.1.
U25670 Genomic DNA. Translation: AAA70091.1.
AY780805 mRNA. Translation: AAV49320.1.
PIRIVHUII. A93070.
PC2204.
PC2205.
RefSeqNP_002168.1.
UniGeneHs.73010

3D structure databases

HSSPHSSP built from PDB template 1ITF based on UniProtKB P01563.
ModBaseSearch...

PTM databases

GlycoSuiteDBP05000.

Genome annotation databases

EnsemblENSG00000177047. Homo sapiens. [Contig view]
GeneID3467.
KEGGhsa:3467.

Organism-specific databases

H-InvDBHIX0034819.
HGNCHGNC:5448. IFNW1.
MIM147553. gene.
PharmGKBPA29683.
GenAtlasSearch...
GeneCardsSearch...
GeneLynxSearch...

Phylogenomic databases

HOGENOMP05000.
HOVERGENP05000.

Gene expression databases

ArrayExpressP05000.
CleanExHS_IFNW1.
GermOnlineENSG00000177047. Homo sapiens.

Family and domain databases

InterProIPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_abd.
[Graphical view]
Gene3DG3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.
PANTHERPTHR11691. Interferon_abd. 1 hit.
PfamPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSPR00266. INTERFERONAB.
ProDomPD000550. Interferon_abd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00076. IFabd. 1 hit.
[Graphical view]
PROSITEPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

LinkHubP05000.
SOURCESearch...
ProtoNetSearch...

Entry information

Entry nameIFNW1_HUMAN
AccessionPrimary (citable) accession number: P05000
Secondary accession number(s): Q13168 expand/collapse secondary AC list , Q5U802, Q5VWD0, Q7M4P5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: July 1, 1993
Last modified: July 22, 2008
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents