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Protein

Interferon omega-1

Gene

IFNW1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cytokine activity Source: GO_Central
  2. cytokine receptor binding Source: ProtInc
  3. type I interferon receptor binding Source: GO_Central

GO - Biological processi

  1. adaptive immune response Source: GO_Central
  2. B cell differentiation Source: GO_Central
  3. B cell proliferation Source: GO_Central
  4. cell cycle arrest Source: ProtInc
  5. cytokine-mediated signaling pathway Source: GO_Central
  6. defense response to virus Source: UniProtKB-KW
  7. humoral immune response Source: GO_Central
  8. innate immune response Source: GO_Central
  9. natural killer cell activation involved in immune response Source: GO_Central
  10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
  11. regulation of MHC class I biosynthetic process Source: GO_Central
  12. response to exogenous dsRNA Source: GO_Central
  13. response to virus Source: ProtInc
  14. T cell activation involved in immune response Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon omega-1
Alternative name(s):
Interferon alpha-II-1
Gene namesi
Name:IFNW1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:5448. IFNW1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29683.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Or 23 in some molecules3 PublicationsAdd
BLAST
Chaini22 – 195174Interferon omega-1PRO_0000016408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 1621 Publication
Glycosylationi101 – 1011N-linked (GlcNAc...)1 PublicationCAR_000050

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05000.
PRIDEiP05000.

PTM databases

PhosphoSiteiP05000.
UniCarbKBiP05000.

Expressioni

Gene expression databases

BgeeiP05000.
CleanExiHS_IFNW1.
GenevestigatoriP05000.

Interactioni

Protein-protein interaction databases

BioGridi109689. 1 interaction.
IntActiP05000. 2 interactions.
STRINGi9606.ENSP00000369578.

Structurei

Secondary structure

1
195
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi31 – 4313
Helixi49 – 524
Helixi73 – 9119
Helixi96 – 983
Helixi102 – 11918
Helixi139 – 15719
Helixi161 – 17818

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SE4X-ray3.50B22-195[»]
ProteinModelPortaliP05000.
SMRiP05000. Positions 23-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG71630.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05000.
KOiK05440.
OMAiRISPFLC.
OrthoDBiEOG7WMCKW.
PhylomeDBiP05000.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05000-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALLFPLLAA LVMTSYSPVG SLGCDLPQNH GLLSRNTLVL LHQMRRISPF
60 70 80 90 100
LCLKDRRDFR FPQEMVKGSQ LQKAHVMSVL HEMLQQIFSL FHTERSSAAW
110 120 130 140 150
NMTLLDQLHT GLHQQLQHLE TCLLQVVGEG ESAGAISSPA LTLRRYFQGI
160 170 180 190
RVYLKEKKYS DCAWEVVRME IMKSLFLSTN MQERLRSKDR DLGSS
Length:195
Mass (Da):22,319
Last modified:July 1, 1993 - v2
Checksum:i1E4306F3487987FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 232LG → EF in AAA70091. (PubMed:8142025)Curated
Sequence conflicti42 – 421H → M AA sequence (PubMed:7765487)Curated
Sequence conflicti79 – 791V → A in AAA70091. (PubMed:8142025)Curated
Sequence conflicti111 – 1111G → E in AAA52724. (PubMed:2985969)Curated
Sequence conflicti167 – 1671V → D in AAA70091. (PubMed:8142025)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951R → S.
Corresponds to variant rs2230055 [ dbSNP | Ensembl ].
VAR_020028

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11003 Genomic DNA. Translation: AAA52724.1.
X58822 Genomic DNA. Translation: CAA41626.1.
AL390882 Genomic DNA. Translation: CAH70158.1.
CH471071 Genomic DNA. Translation: EAW58624.1.
BC069095 mRNA. Translation: AAH69095.1.
BC117290 mRNA. Translation: AAI17291.1.
BC117292 mRNA. Translation: AAI17293.1.
X02669 mRNA. Translation: CAA26501.1.
U25670 Genomic DNA. Translation: AAA70091.1.
AY780805 mRNA. Translation: AAV49320.1.
CCDSiCCDS6496.1.
PIRiA93070. IVHUII.
PC2204.
PC2205.
RefSeqiNP_002168.1. NM_002177.1.
UniGeneiHs.73010.

Genome annotation databases

EnsembliENST00000380229; ENSP00000369578; ENSG00000177047.
GeneIDi3467.
KEGGihsa:3467.
UCSCiuc003zol.1. human.

Polymorphism databases

DMDMi400061.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11003 Genomic DNA. Translation: AAA52724.1.
X58822 Genomic DNA. Translation: CAA41626.1.
AL390882 Genomic DNA. Translation: CAH70158.1.
CH471071 Genomic DNA. Translation: EAW58624.1.
BC069095 mRNA. Translation: AAH69095.1.
BC117290 mRNA. Translation: AAI17291.1.
BC117292 mRNA. Translation: AAI17293.1.
X02669 mRNA. Translation: CAA26501.1.
U25670 Genomic DNA. Translation: AAA70091.1.
AY780805 mRNA. Translation: AAV49320.1.
CCDSiCCDS6496.1.
PIRiA93070. IVHUII.
PC2204.
PC2205.
RefSeqiNP_002168.1. NM_002177.1.
UniGeneiHs.73010.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SE4X-ray3.50B22-195[»]
ProteinModelPortaliP05000.
SMRiP05000. Positions 23-182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109689. 1 interaction.
IntActiP05000. 2 interactions.
STRINGi9606.ENSP00000369578.

PTM databases

PhosphoSiteiP05000.
UniCarbKBiP05000.

Polymorphism databases

DMDMi400061.

Proteomic databases

PaxDbiP05000.
PRIDEiP05000.

Protocols and materials databases

DNASUi3467.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380229; ENSP00000369578; ENSG00000177047.
GeneIDi3467.
KEGGihsa:3467.
UCSCiuc003zol.1. human.

Organism-specific databases

CTDi3467.
GeneCardsiGC09M021103.
HGNCiHGNC:5448. IFNW1.
MIMi147553. gene.
neXtProtiNX_P05000.
PharmGKBiPA29683.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG71630.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05000.
KOiK05440.
OMAiRISPFLC.
OrthoDBiEOG7WMCKW.
PhylomeDBiP05000.
TreeFamiTF336177.

Miscellaneous databases

GeneWikiiIFNW1.
GenomeRNAii3467.
NextBioi13648.
PROiP05000.
SOURCEiSearch...

Gene expression databases

BgeeiP05000.
CleanExiHS_IFNW1.
GenevestigatoriP05000.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides."
    Capon D.J., Shepard H.M., Goeddel D.V.
    Mol. Cell. Biol. 5:768-779(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein."
    Adolf G.R., Fruehbeis B., Hauptmann R., Kalsner I., Maurer-Fogy I., Ostermann E., Patzelt E., Schwendenwein R., Sommergruber W., Zoephel A.
    Biochim. Biophys. Acta 1089:167-174(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leukocyte.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "A novel class of human type I interferons."
    Hauptmann R., Swetly P.
    Nucleic Acids Res. 13:4739-4749(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-195.
  7. "Cloning, sequencing and expression in E. coli of interferon-omega 1 gene."
    Li M.F., Zeng Q., Zhou Y., Guo H.Y., Hou Y.D.
    Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 36:1361-1366(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-195.
  8. "Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes."
    Shirono H., Koga J., Uemura H., Matsuo A.
    Biosci. Biotechnol. Biochem. 58:1714-1715(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-55.
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.
  10. "Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase."
    Adolf G.R., Maurer-Fogy I., Kalsner I., Cantell K.
    J. Biol. Chem. 265:9290-9295(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-33, GLYCOSYLATION AT ASN-101.
  11. "Human IFN-omega 1 gene isolated from embryonic hepar."
    Yang R.Y., Yang Z.F., Zhu Y.T., Feng L.L., Liu N., Zhao F., Zhang F.X., Fu L.C.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-195.
    Tissue: Liver.
  12. "Structural linkage between ligand discrimination and receptor activation by type I interferons."
    Thomas C., Moraga I., Levin D., Krutzik P.O., Podoplelova Y., Trejo A., Lee C., Yarden G., Vleck S.E., Glenn J.S., Nolan G.P., Piehler J., Schreiber G., Garcia K.C.
    Cell 146:621-632(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 22-195 IN COMPLEX WITH IFNAR1 AND IFNAR2, DISULFIDE BOND.

Entry informationi

Entry nameiIFNW1_HUMAN
AccessioniPrimary (citable) accession number: P05000
Secondary accession number(s): Q13168
, Q5U802, Q5VWD0, Q7M4P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: July 1, 1993
Last modified: February 4, 2015
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.