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P05000 (IFNW1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon omega-1
Alternative name(s):
Interferon alpha-II-1
Gene names
Name:IFNW1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted.

Sequence similarities

Belongs to the alpha/beta interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processB cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

B cell proliferation

Inferred from Biological aspect of Ancestor. Source: RefGenome

T cell activation involved in immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

adaptive immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell cycle arrest

Traceable author statement PubMed 10835682. Source: ProtInc

cytokine-mediated signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

defense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

humoral immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

innate immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

natural killer cell activation involved in immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of MHC class I biosynthetic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to exogenous dsRNA

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to virus

Traceable author statement Ref.2. Source: ProtInc

   Cellular_componentextracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functioncytokine activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytokine receptor binding

Traceable author statement Ref.2. Source: ProtInc

type I interferon receptor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121Or 23 in some molecules Ref.8 Ref.9 Ref.10
Chain22 – 195174Interferon omega-1
PRO_0000016408

Amino acid modifications

Glycosylation1011N-linked (GlcNAc...) Ref.10
CAR_000050
Disulfide bond24 ↔ 122 By similarity
Disulfide bond52 ↔ 162 Ref.12

Natural variations

Natural variant951R → S.
Corresponds to variant rs2230055 [ dbSNP | Ensembl ].
VAR_020028

Experimental info

Sequence conflict22 – 232LG → EF in AAA70091. Ref.7
Sequence conflict421H → M AA sequence Ref.8
Sequence conflict791V → A in AAA70091. Ref.7
Sequence conflict1111G → E in AAA52724. Ref.1
Sequence conflict1671V → D in AAA70091. Ref.7

Secondary structure

............... 195
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P05000 [UniParc].

Last modified July 1, 1993. Version 2.
Checksum: 1E4306F3487987FA

FASTA19522,319
        10         20         30         40         50         60 
MALLFPLLAA LVMTSYSPVG SLGCDLPQNH GLLSRNTLVL LHQMRRISPF LCLKDRRDFR 

        70         80         90        100        110        120 
FPQEMVKGSQ LQKAHVMSVL HEMLQQIFSL FHTERSSAAW NMTLLDQLHT GLHQQLQHLE 

       130        140        150        160        170        180 
TCLLQVVGEG ESAGAISSPA LTLRRYFQGI RVYLKEKKYS DCAWEVVRME IMKSLFLSTN 

       190 
MQERLRSKDR DLGSS 

« Hide

References

« Hide 'large scale' references
[1]"Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides."
Capon D.J., Shepard H.M., Goeddel D.V.
Mol. Cell. Biol. 5:768-779(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein."
Adolf G.R., Fruehbeis B., Hauptmann R., Kalsner I., Maurer-Fogy I., Ostermann E., Patzelt E., Schwendenwein R., Sommergruber W., Zoephel A.
Biochim. Biophys. Acta 1089:167-174(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Leukocyte.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"A novel class of human type I interferons."
Hauptmann R., Swetly P.
Nucleic Acids Res. 13:4739-4749(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-195.
[7]"Cloning, sequencing and expression in E. coli of interferon-omega 1 gene."
Li M.F., Zeng Q., Zhou Y., Guo H.Y., Hou Y.D.
Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 36:1361-1366(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-195.
[8]"Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes."
Shirono H., Koga J., Uemura H., Matsuo A.
Biosci. Biotechnol. Biochem. 58:1714-1715(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-55.
[9]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-36.
[10]"Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase."
Adolf G.R., Maurer-Fogy I., Kalsner I., Cantell K.
J. Biol. Chem. 265:9290-9295(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-33, GLYCOSYLATION AT ASN-101.
[11]"Human IFN-omega 1 gene isolated from embryonic hepar."
Yang R.Y., Yang Z.F., Zhu Y.T., Feng L.L., Liu N., Zhao F., Zhang F.X., Fu L.C.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-195.
Tissue: Liver.
[12]"Structural linkage between ligand discrimination and receptor activation by type I interferons."
Thomas C., Moraga I., Levin D., Krutzik P.O., Podoplelova Y., Trejo A., Lee C., Yarden G., Vleck S.E., Glenn J.S., Nolan G.P., Piehler J., Schreiber G., Garcia K.C.
Cell 146:621-632(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 22-195 IN COMPLEX WITH IFNAR1 AND IFNAR2, DISULFIDE BOND.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M11003 Genomic DNA. Translation: AAA52724.1.
X58822 Genomic DNA. Translation: CAA41626.1.
AL390882 Genomic DNA. Translation: CAH70158.1.
CH471071 Genomic DNA. Translation: EAW58624.1.
BC069095 mRNA. Translation: AAH69095.1.
BC117290 mRNA. Translation: AAI17291.1.
BC117292 mRNA. Translation: AAI17293.1.
X02669 mRNA. Translation: CAA26501.1.
U25670 Genomic DNA. Translation: AAA70091.1.
AY780805 mRNA. Translation: AAV49320.1.
PIRIVHUII. A93070.
PC2204.
PC2205.
RefSeqNP_002168.1. NM_002177.1.
UniGeneHs.73010.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3SE4X-ray3.50B22-195[»]
ProteinModelPortalP05000.
SMRP05000. Positions 23-182.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109689. 1 interaction.
IntActP05000. 2 interactions.
STRING9606.ENSP00000369578.

PTM databases

PhosphoSiteP05000.
UniCarbKBP05000.

Polymorphism databases

DMDM400061.

Proteomic databases

PaxDbP05000.
PRIDEP05000.

Protocols and materials databases

DNASU3467.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380229; ENSP00000369578; ENSG00000177047.
GeneID3467.
KEGGhsa:3467.
UCSCuc003zol.1. human.

Organism-specific databases

CTD3467.
GeneCardsGC09M021103.
HGNCHGNC:5448. IFNW1.
MIM147553. gene.
neXtProtNX_P05000.
PharmGKBPA29683.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG71630.
HOGENOMHOG000230500.
HOVERGENHBG052086.
InParanoidP05000.
KOK05440.
OMARISPFLC.
OrthoDBEOG7WMCKW.
PhylomeDBP05000.
TreeFamTF336177.

Gene expression databases

BgeeP05000.
CleanExHS_IFNW1.
GenevestigatorP05000.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERPTHR11691. PTHR11691. 1 hit.
PfamPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSPR00266. INTERFERONAB.
SMARTSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIFNW1.
GenomeRNAi3467.
NextBio13648.
PROP05000.
SOURCESearch...

Entry information

Entry nameIFNW1_HUMAN
AccessionPrimary (citable) accession number: P05000
Secondary accession number(s): Q13168 expand/collapse secondary AC list , Q5U802, Q5VWD0, Q7M4P5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM