Reviewed, UniProtKB/Swiss-Prot P05000 (IFNW1_HUMAN)

Names and origin

Protein names

Recommended name:
    Interferon omega-1
Alternative name(s):
    Interferon alpha-II-1

Gene names

Name:

IFNW1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted.
Sequence similarities	Belongs to the alpha/beta interferon family.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell cycle arrest Traceable author statement. Source: ProtInc response to virus Ref.2 Traceable author statement. Source: ProtInc
Molecular function	hematopoietin/interferon-class (D200-domain) cytokine receptor binding Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 21	21	Or 23 in some molecules
	Chain	22 – 195	174	Interferon omega-1
Amino acid modifications
	Glycosylation	101	1	N-linked (GlcNAc...)
	Disulfide bond	24 ↔ 122		By similarity
	Disulfide bond	52 ↔ 162		By similarity
Natural variations
	Natural variant	95	1	R → S: dbSNP rs2230055.
Experimental info
	Sequence conflict	22 – 23	2	LG → EF in AAA70091. Ref.7
	Sequence conflict	42	1	H → M AA sequence Ref.8
	Sequence conflict	79	1	V → A in AAA70091. Ref.7
	Sequence conflict	111	1	G → E in AAA52724. Ref.1
	Sequence conflict	167	1	V → D in AAA70091. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	P05000-1 [UniParc]. Last modified July 1, 1993. Version 2. Checksum: 1E4306F3487987FA	FASTA	195	22,319
	10 20 30 40 50 60 MALLFPLLAA LVMTSYSPVG SLGCDLPQNH GLLSRNTLVL LHQMRRISPF LCLKDRRDFR 70 80 90 100 110 120 FPQEMVKGSQ LQKAHVMSVL HEMLQQIFSL FHTERSSAAW NMTLLDQLHT GLHQQLQHLE 130 140 150 160 170 180 TCLLQVVGEG ESAGAISSPA LTLRRYFQGI RVYLKEKKYS DCAWEVVRME IMKSLFLSTN 190 MQERLRSKDR DLGSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides." Capon D.J., Shepard H.M., Goeddel D.V. Mol. Cell. Biol. 5:768-779(1985) [PubMed: 2985969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein." Adolf G.R., Fruehbeis B., Hauptmann R., Kalsner I., Maurer-Fogy I., Ostermann E., Patzelt E., Schwendenwein R., Sommergruber W., Zoephel A. Biochim. Biophys. Acta 1089:167-174(1991) [PubMed: 1647209] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Leukocyte.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"A novel class of human type I interferons." Hauptmann R., Swetly P. Nucleic Acids Res. 13:4739-4749(1985) [PubMed: 3895159] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-195.
[7]	"Cloning, sequencing and expression in E. coli of interferon-omega 1 gene." Li M.F., Zeng Q., Zhou Y., Guo H.Y., Hou Y.D. Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 36:1361-1366(1993) [PubMed: 8142025] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-195.
[8]	"Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes." Shirono H., Koga J., Uemura H., Matsuo A. Biosci. Biotechnol. Biochem. 58:1714-1715(1994) [PubMed: 7765487] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-55.
[9]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-36.
[10]	"Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase." Adolf G.R., Maurer-Fogy I., Kalsner I., Cantell K. J. Biol. Chem. 265:9290-9295(1990) [PubMed: 1693148] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-33, GLYCOSYLATION AT ASN-101.
[11]	"Human IFN-omega 1 gene isolated from embryonic hepar." Yang R.Y., Yang Z.F., Zhu Y.T., Feng L.L., Liu N., Zhao F., Zhang F.X., Fu L.C. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-195. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M11003 Genomic DNA. Translation: AAA52724.1. X58822 Genomic DNA. Translation: CAA41626.1. AL390882 Genomic DNA. Translation: CAH70158.1. CH471071 Genomic DNA. Translation: EAW58624.1. BC069095 mRNA. Translation: AAH69095.1. BC117290 mRNA. Translation: AAI17291.1. BC117292 mRNA. Translation: AAI17293.1. X02669 mRNA. Translation: CAA26501.1. A12140 Unassigned RNA. Translation: CAA01011.1. U25670 Genomic DNA. Translation: AAA70091.1. AY780805 mRNA. Translation: AAV49320.1.
PIR	IVHUII. A93070. PC2204. PC2205.
RefSeq	NP_002168.1.
UniGene	Hs.73010
3D structure databases
HSSP	HSSP built from PDB template 1ITF based on UniProtKB P01563.
ModBase	Search...
PTM databases
GlycoSuiteDB	P05000.
Genome annotation databases
Ensembl	ENSG00000177047. Homo sapiens. [Contig view]
GeneID	3467.
KEGG	hsa:3467.
Organism-specific databases
H-InvDB	HIX0034819.
HGNC	HGNC:5448. IFNW1.
MIM	147553. gene.
PharmGKB	PA29683.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	P05000.
HOVERGEN	P05000.
Gene expression databases
ArrayExpress	P05000.
CleanEx	HS_IFNW1.
GermOnline	ENSG00000177047. Homo sapiens.
Family and domain databases
InterPro	IPR012351. 4_helix_cytokine_core. IPR000471. Interferon_abd. [Graphical view]
Gene3D	G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.
PANTHER	PTHR11691. Interferon_abd. 1 hit.
Pfam	PF00143. Interferon. 1 hit. [Graphical view]
PRINTS	PR00266. INTERFERONAB.
ProDom	PD000550. Interferon_abd. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00076. IFabd. 1 hit. [Graphical view]
PROSITE	PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
LinkHub	P05000.
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

IFNW1_HUMAN

Accession

Primary (citable) accession number: P05000
Secondary accession number(s): Q13168 , Q5U802, Q5VWD0, Q7M4P5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	July 1, 1993
Last modified:	July 22, 2008
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)