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Protein

Interferon omega-1

Gene

IFNW1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

SIGNORiP05000.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon omega-1
Alternative name(s):
Interferon alpha-II-1
Gene namesi
Name:IFNW1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:5448. IFNW1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3467.
OpenTargetsiENSG00000177047.
PharmGKBiPA29683.

Polymorphism and mutation databases

BioMutaiIFNW1.
DMDMi400061.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Or 23 in some molecules3 PublicationsAdd BLAST21
ChainiPRO_000001640822 – 195Interferon omega-1Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 1621 Publication
GlycosylationiCAR_000050101N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05000.
PeptideAtlasiP05000.
PRIDEiP05000.

PTM databases

UniCarbKBiP05000.

Expressioni

Gene expression databases

BgeeiENSG00000177047.
CleanExiHS_IFNW1.
GenevisibleiP05000. HS.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109689. 2 interactors.
IntActiP05000. 2 interactors.
STRINGi9606.ENSP00000369578.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SE4X-ray3.50B22-195[»]
ProteinModelPortaliP05000.
SMRiP05000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J975. Eukaryota.
ENOG4111675. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05000.
KOiK05440.
OMAiRISPFLC.
OrthoDBiEOG091G0TRU.
PhylomeDBiP05000.
TreeFamiTF336177.

Family and domain databases

CDDicd00095. IFab. 1 hit.
Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLFPLLAA LVMTSYSPVG SLGCDLPQNH GLLSRNTLVL LHQMRRISPF
60 70 80 90 100
LCLKDRRDFR FPQEMVKGSQ LQKAHVMSVL HEMLQQIFSL FHTERSSAAW
110 120 130 140 150
NMTLLDQLHT GLHQQLQHLE TCLLQVVGEG ESAGAISSPA LTLRRYFQGI
160 170 180 190
RVYLKEKKYS DCAWEVVRME IMKSLFLSTN MQERLRSKDR DLGSS
Length:195
Mass (Da):22,319
Last modified:July 1, 1993 - v2
Checksum:i1E4306F3487987FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 23LG → EF in AAA70091 (PubMed:8142025).Curated2
Sequence conflicti42H → M AA sequence (PubMed:7765487).Curated1
Sequence conflicti79V → A in AAA70091 (PubMed:8142025).Curated1
Sequence conflicti111G → E in AAA52724 (PubMed:2985969).Curated1
Sequence conflicti167V → D in AAA70091 (PubMed:8142025).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02002895R → S.Corresponds to variant rs2230055dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11003 Genomic DNA. Translation: AAA52724.1.
X58822 Genomic DNA. Translation: CAA41626.1.
AL390882 Genomic DNA. Translation: CAH70158.1.
CH471071 Genomic DNA. Translation: EAW58624.1.
BC069095 mRNA. Translation: AAH69095.1.
BC117290 mRNA. Translation: AAI17291.1.
BC117292 mRNA. Translation: AAI17293.1.
X02669 mRNA. Translation: CAA26501.1.
U25670 Genomic DNA. Translation: AAA70091.1.
AY780805 mRNA. Translation: AAV49320.1.
CCDSiCCDS6496.1.
PIRiA93070. IVHUII.
PC2204.
PC2205.
RefSeqiNP_002168.1. NM_002177.2.
UniGeneiHs.73010.

Genome annotation databases

EnsembliENST00000380229; ENSP00000369578; ENSG00000177047.
GeneIDi3467.
KEGGihsa:3467.
UCSCiuc003zol.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11003 Genomic DNA. Translation: AAA52724.1.
X58822 Genomic DNA. Translation: CAA41626.1.
AL390882 Genomic DNA. Translation: CAH70158.1.
CH471071 Genomic DNA. Translation: EAW58624.1.
BC069095 mRNA. Translation: AAH69095.1.
BC117290 mRNA. Translation: AAI17291.1.
BC117292 mRNA. Translation: AAI17293.1.
X02669 mRNA. Translation: CAA26501.1.
U25670 Genomic DNA. Translation: AAA70091.1.
AY780805 mRNA. Translation: AAV49320.1.
CCDSiCCDS6496.1.
PIRiA93070. IVHUII.
PC2204.
PC2205.
RefSeqiNP_002168.1. NM_002177.2.
UniGeneiHs.73010.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SE4X-ray3.50B22-195[»]
ProteinModelPortaliP05000.
SMRiP05000.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109689. 2 interactors.
IntActiP05000. 2 interactors.
STRINGi9606.ENSP00000369578.

PTM databases

UniCarbKBiP05000.

Polymorphism and mutation databases

BioMutaiIFNW1.
DMDMi400061.

Proteomic databases

PaxDbiP05000.
PeptideAtlasiP05000.
PRIDEiP05000.

Protocols and materials databases

DNASUi3467.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380229; ENSP00000369578; ENSG00000177047.
GeneIDi3467.
KEGGihsa:3467.
UCSCiuc003zol.2. human.

Organism-specific databases

CTDi3467.
DisGeNETi3467.
GeneCardsiIFNW1.
HGNCiHGNC:5448. IFNW1.
MIMi147553. gene.
neXtProtiNX_P05000.
OpenTargetsiENSG00000177047.
PharmGKBiPA29683.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J975. Eukaryota.
ENOG4111675. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP05000.
KOiK05440.
OMAiRISPFLC.
OrthoDBiEOG091G0TRU.
PhylomeDBiP05000.
TreeFamiTF336177.

Enzyme and pathway databases

SIGNORiP05000.

Miscellaneous databases

GeneWikiiIFNW1.
GenomeRNAii3467.
PROiP05000.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177047.
CleanExiHS_IFNW1.
GenevisibleiP05000. HS.

Family and domain databases

CDDicd00095. IFab. 1 hit.
Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFNW1_HUMAN
AccessioniPrimary (citable) accession number: P05000
Secondary accession number(s): Q13168
, Q5U802, Q5VWD0, Q7M4P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.