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P05000

- IFNW1_HUMAN

UniProt

P05000 - IFNW1_HUMAN

Protein

Interferon omega-1

Gene

IFNW1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 2 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome
    2. cytokine receptor binding Source: ProtInc
    3. type I interferon receptor binding Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. cell cycle arrest Source: ProtInc
    5. cytokine-mediated signaling pathway Source: RefGenome
    6. defense response to virus Source: UniProtKB-KW
    7. humoral immune response Source: RefGenome
    8. innate immune response Source: RefGenome
    9. natural killer cell activation involved in immune response Source: RefGenome
    10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    11. regulation of MHC class I biosynthetic process Source: RefGenome
    12. response to exogenous dsRNA Source: RefGenome
    13. response to virus Source: ProtInc
    14. T cell activation involved in immune response Source: RefGenome

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon omega-1
    Alternative name(s):
    Interferon alpha-II-1
    Gene namesi
    Name:IFNW1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:5448. IFNW1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29683.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Or 23 in some molecules3 PublicationsAdd
    BLAST
    Chaini22 – 195174Interferon omega-1PRO_0000016408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 122By similarity
    Disulfide bondi52 ↔ 1621 Publication
    Glycosylationi101 – 1011N-linked (GlcNAc...)1 PublicationCAR_000050

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP05000.
    PRIDEiP05000.

    PTM databases

    PhosphoSiteiP05000.
    UniCarbKBiP05000.

    Expressioni

    Gene expression databases

    BgeeiP05000.
    CleanExiHS_IFNW1.
    GenevestigatoriP05000.

    Interactioni

    Protein-protein interaction databases

    BioGridi109689. 1 interaction.
    IntActiP05000. 2 interactions.
    STRINGi9606.ENSP00000369578.

    Structurei

    Secondary structure

    1
    195
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi31 – 4313
    Helixi49 – 524
    Helixi73 – 9119
    Helixi96 – 983
    Helixi102 – 11918
    Helixi139 – 15719
    Helixi161 – 17818

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3SE4X-ray3.50B22-195[»]
    ProteinModelPortaliP05000.
    SMRiP05000. Positions 23-182.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG71630.
    HOGENOMiHOG000230500.
    HOVERGENiHBG052086.
    InParanoidiP05000.
    KOiK05440.
    OMAiRISPFLC.
    OrthoDBiEOG7WMCKW.
    PhylomeDBiP05000.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05000-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLFPLLAA LVMTSYSPVG SLGCDLPQNH GLLSRNTLVL LHQMRRISPF    50
    LCLKDRRDFR FPQEMVKGSQ LQKAHVMSVL HEMLQQIFSL FHTERSSAAW 100
    NMTLLDQLHT GLHQQLQHLE TCLLQVVGEG ESAGAISSPA LTLRRYFQGI 150
    RVYLKEKKYS DCAWEVVRME IMKSLFLSTN MQERLRSKDR DLGSS 195
    Length:195
    Mass (Da):22,319
    Last modified:July 1, 1993 - v2
    Checksum:i1E4306F3487987FA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 232LG → EF in AAA70091. (PubMed:8142025)Curated
    Sequence conflicti42 – 421H → M AA sequence (PubMed:7765487)Curated
    Sequence conflicti79 – 791V → A in AAA70091. (PubMed:8142025)Curated
    Sequence conflicti111 – 1111G → E in AAA52724. (PubMed:2985969)Curated
    Sequence conflicti167 – 1671V → D in AAA70091. (PubMed:8142025)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti95 – 951R → S.
    Corresponds to variant rs2230055 [ dbSNP | Ensembl ].
    VAR_020028

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11003 Genomic DNA. Translation: AAA52724.1.
    X58822 Genomic DNA. Translation: CAA41626.1.
    AL390882 Genomic DNA. Translation: CAH70158.1.
    CH471071 Genomic DNA. Translation: EAW58624.1.
    BC069095 mRNA. Translation: AAH69095.1.
    BC117290 mRNA. Translation: AAI17291.1.
    BC117292 mRNA. Translation: AAI17293.1.
    X02669 mRNA. Translation: CAA26501.1.
    U25670 Genomic DNA. Translation: AAA70091.1.
    AY780805 mRNA. Translation: AAV49320.1.
    CCDSiCCDS6496.1.
    PIRiA93070. IVHUII.
    PC2204.
    PC2205.
    RefSeqiNP_002168.1. NM_002177.1.
    UniGeneiHs.73010.

    Genome annotation databases

    EnsembliENST00000380229; ENSP00000369578; ENSG00000177047.
    GeneIDi3467.
    KEGGihsa:3467.
    UCSCiuc003zol.1. human.

    Polymorphism databases

    DMDMi400061.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11003 Genomic DNA. Translation: AAA52724.1 .
    X58822 Genomic DNA. Translation: CAA41626.1 .
    AL390882 Genomic DNA. Translation: CAH70158.1 .
    CH471071 Genomic DNA. Translation: EAW58624.1 .
    BC069095 mRNA. Translation: AAH69095.1 .
    BC117290 mRNA. Translation: AAI17291.1 .
    BC117292 mRNA. Translation: AAI17293.1 .
    X02669 mRNA. Translation: CAA26501.1 .
    U25670 Genomic DNA. Translation: AAA70091.1 .
    AY780805 mRNA. Translation: AAV49320.1 .
    CCDSi CCDS6496.1.
    PIRi A93070. IVHUII.
    PC2204.
    PC2205.
    RefSeqi NP_002168.1. NM_002177.1.
    UniGenei Hs.73010.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3SE4 X-ray 3.50 B 22-195 [» ]
    ProteinModelPortali P05000.
    SMRi P05000. Positions 23-182.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109689. 1 interaction.
    IntActi P05000. 2 interactions.
    STRINGi 9606.ENSP00000369578.

    PTM databases

    PhosphoSitei P05000.
    UniCarbKBi P05000.

    Polymorphism databases

    DMDMi 400061.

    Proteomic databases

    PaxDbi P05000.
    PRIDEi P05000.

    Protocols and materials databases

    DNASUi 3467.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380229 ; ENSP00000369578 ; ENSG00000177047 .
    GeneIDi 3467.
    KEGGi hsa:3467.
    UCSCi uc003zol.1. human.

    Organism-specific databases

    CTDi 3467.
    GeneCardsi GC09M021103.
    HGNCi HGNC:5448. IFNW1.
    MIMi 147553. gene.
    neXtProti NX_P05000.
    PharmGKBi PA29683.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG71630.
    HOGENOMi HOG000230500.
    HOVERGENi HBG052086.
    InParanoidi P05000.
    KOi K05440.
    OMAi RISPFLC.
    OrthoDBi EOG7WMCKW.
    PhylomeDBi P05000.
    TreeFami TF336177.

    Miscellaneous databases

    GeneWikii IFNW1.
    GenomeRNAii 3467.
    NextBioi 13648.
    PROi P05000.
    SOURCEi Search...

    Gene expression databases

    Bgeei P05000.
    CleanExi HS_IFNW1.
    Genevestigatori P05000.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides."
      Capon D.J., Shepard H.M., Goeddel D.V.
      Mol. Cell. Biol. 5:768-779(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein."
      Adolf G.R., Fruehbeis B., Hauptmann R., Kalsner I., Maurer-Fogy I., Ostermann E., Patzelt E., Schwendenwein R., Sommergruber W., Zoephel A.
      Biochim. Biophys. Acta 1089:167-174(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Leukocyte.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "A novel class of human type I interferons."
      Hauptmann R., Swetly P.
      Nucleic Acids Res. 13:4739-4749(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-195.
    7. "Cloning, sequencing and expression in E. coli of interferon-omega 1 gene."
      Li M.F., Zeng Q., Zhou Y., Guo H.Y., Hou Y.D.
      Sci. China, Ser. B, Chem. Life Sci. Earth Sci. 36:1361-1366(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-195.
    8. "Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes."
      Shirono H., Koga J., Uemura H., Matsuo A.
      Biosci. Biotechnol. Biochem. 58:1714-1715(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-55.
    9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-36.
    10. "Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase."
      Adolf G.R., Maurer-Fogy I., Kalsner I., Cantell K.
      J. Biol. Chem. 265:9290-9295(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-33, GLYCOSYLATION AT ASN-101.
    11. "Human IFN-omega 1 gene isolated from embryonic hepar."
      Yang R.Y., Yang Z.F., Zhu Y.T., Feng L.L., Liu N., Zhao F., Zhang F.X., Fu L.C.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-195.
      Tissue: Liver.
    12. "Structural linkage between ligand discrimination and receptor activation by type I interferons."
      Thomas C., Moraga I., Levin D., Krutzik P.O., Podoplelova Y., Trejo A., Lee C., Yarden G., Vleck S.E., Glenn J.S., Nolan G.P., Piehler J., Schreiber G., Garcia K.C.
      Cell 146:621-632(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 22-195 IN COMPLEX WITH IFNAR1 AND IFNAR2, DISULFIDE BOND.

    Entry informationi

    Entry nameiIFNW1_HUMAN
    AccessioniPrimary (citable) accession number: P05000
    Secondary accession number(s): Q13168
    , Q5U802, Q5VWD0, Q7M4P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 146 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3