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Protein

Threonine synthase

Gene

thrC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pathwayi: L-threonine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase 3 (yclM), Aspartokinase 2 (lysC), Aspartokinase 1 (dapG)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (hom)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85Pyridoxal phosphateBy similarity1
Binding sitei314Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBSUB:BSU32250-MONOMER.
UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:BSU32250
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001856261 – 352Threonine synthaseAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP04990.
PRIDEiP04990.

Interactioni

Protein-protein interaction databases

IntActiP04990. 1 interactor.
MINTiMINT-8366482.
STRINGi224308.Bsubs1_010100017501.

Structurei

3D structure databases

ProteinModelPortaliP04990.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni185 – 189Pyridoxal phosphate bindingBy similarity5

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiENOG4108IYI. Bacteria.
COG0498. LUCA.
HOGENOMiHOG000076503.
InParanoidiP04990.
KOiK01733.
OMAiSAWYAPF.
PhylomeDBiP04990.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR004450. Thr_synthase-like.
IPR026260. Thr_Synthase_bac/arc.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF038945. Thr_synthase. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKGLIHQYK EFLPVTDQTP ALTLHEGNTP LIHLPKLSEQ LGIELHVKTE
60 70 80 90 100
GVNPTGSFKD RGMVMAVAKA KEEGNDTIMC ASTGNTSAAA AAYAARANMK
110 120 130 140 150
CIVIIPNGKI AFGKLAQAVM YGAEIIAIDG NFDDALKIVR SICEKSPIAL
160 170 180 190 200
VNSVNPYRIE GQKTAAFEVC EQLGEAPDVL AIPVGNAGNI TAYWKGFKEY
210 220 230 240 250
HEKNGTGLPK MRGFEAEGAA AIVRNEVIEN PETIATAIRI GNPASWDKAV
260 270 280 290 300
KAAEESNGKI DEVTDDEILH AYQLIARVEG VFAEPGSCAS IAGVLKQVKS
310 320 330 340 350
GEIPKGSKVV AVLTGNGLKD PNTAVDISEI KPVTLPTDED SILEYVKGAA

RV
Length:352
Mass (Da):37,464
Last modified:August 13, 1987 - v1
Checksum:iF478003AA330C6A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04603 Genomic DNA. Translation: CAA28270.1.
AL009126 Genomic DNA. Translation: CAB15215.1.
M23217 Genomic DNA. Translation: AAA50610.1.
PIRiA25364.
RefSeqiNP_391105.1. NC_000964.3.
WP_003228697.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15215; CAB15215; BSU32250.
GeneIDi936660.
KEGGibsu:BSU32250.
PATRICi18978422. VBIBacSub10457_3374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04603 Genomic DNA. Translation: CAA28270.1.
AL009126 Genomic DNA. Translation: CAB15215.1.
M23217 Genomic DNA. Translation: AAA50610.1.
PIRiA25364.
RefSeqiNP_391105.1. NC_000964.3.
WP_003228697.1. NZ_JNCM01000033.1.

3D structure databases

ProteinModelPortaliP04990.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04990. 1 interactor.
MINTiMINT-8366482.
STRINGi224308.Bsubs1_010100017501.

Proteomic databases

PaxDbiP04990.
PRIDEiP04990.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15215; CAB15215; BSU32250.
GeneIDi936660.
KEGGibsu:BSU32250.
PATRICi18978422. VBIBacSub10457_3374.

Phylogenomic databases

eggNOGiENOG4108IYI. Bacteria.
COG0498. LUCA.
HOGENOMiHOG000076503.
InParanoidiP04990.
KOiK01733.
OMAiSAWYAPF.
PhylomeDBiP04990.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.
BioCyciBSUB:BSU32250-MONOMER.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR004450. Thr_synthase-like.
IPR026260. Thr_Synthase_bac/arc.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF038945. Thr_synthase. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHRC_BACSU
AccessioniPrimary (citable) accession number: P04990
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 5, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.