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Protein

Cysteine proteinase 1

Gene

cprA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cysteine proteinases 1 and 2 are believed to participate in the breakdown of protein during differentiation of Dictyostelium as a response to starvation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142By similarity1
Active sitei286By similarity1
Active sitei311By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-DDI-2132295 MHC class II antigen presentation

Protein family/group databases

MEROPSiC01.022

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine proteinase 1 (EC:3.4.22.-)
Gene namesi
Name:cprA
Synonyms:CP1
ORF Names:DDB_G0290957
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290957 cprA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000002635819 – 117Activation peptideAdd BLAST99
ChainiPRO_0000026359118 – 343Cysteine proteinase 1Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi139 ↔ 190By similarity
Disulfide bondi173 ↔ 224By similarity
Disulfide bondi279 ↔ 332By similarity

Post-translational modificationi

Phosphoglycosylated, contains GlcNAc-alpha-1-P-Ser residues.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

PaxDbiP04988

2D gel databases

SWISS-2DPAGEP04988

PTM databases

GlyConnecti118
UniCarbKBiP04988

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0201647

Structurei

3D structure databases

ProteinModelPortaliP04988
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1542 Eukaryota
COG4870 LUCA
InParanoidiP04988
KOiK01373
OMAiERSHDVT
PhylomeDBiP04988

Family and domain databases

InterProiView protein in InterPro
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVILLFVLA VFTVFVSSRG IPLEEQSQFL EFQDKFNKKY SHEEYLERFE
60 70 80 90 100
IFKSNLGKIE ELNLIAINHK ADTKFGVNKF ADLSSDEFKN YYLNNKEAIF
110 120 130 140 150
TDDLPVADYL DDEFINSIPT AFDWRTRGAV TPVKNQGQCG SCWSFSTTGN
160 170 180 190 200
VEGQHFISQN KLVSLSEQNL VDCDHECMEY EGEQACDEGC NGGLQPNAYN
210 220 230 240 250
YIIKNGGIQT ESSYPYTAET GTQCNFNSAN IGAKISNFTM IPKNETVMAG
260 270 280 290 300
YIVSTGPLAI AADAVEWQFY IGGVFDIPCN PNSLDHGILI VGYSAKNTIF
310 320 330 340
RKNMPYWIVK NSWGADWGEQ GYIYLRRGKN TCGVSNFVST SII
Length:343
Mass (Da):38,510
Last modified:December 4, 2007 - v2
Checksum:i8F70D4907C891021
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23L → P in CAA26255 (PubMed:2990918).Curated1
Sequence conflicti184Q → E in CAA26255 (PubMed:2990918).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02407 mRNA Translation: CAA26255.1
AAFI02000174 Genomic DNA Translation: EAL61909.1
PIRiA22827 KHDO
RefSeqiXP_635417.1, XM_630325.1

Genome annotation databases

EnsemblProtistsiEAL61909; EAL61909; DDB_G0290957
GeneIDi8627918
KEGGiddi:DDB_G0290957

Similar proteinsi

Entry informationi

Entry nameiCYSP1_DICDI
AccessioniPrimary (citable) accession number: P04988
Secondary accession number(s): Q54FC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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