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Protein

Clathrin light chain B

Gene

CLTB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-BTA-190873. Gap junction degradation.
R-BTA-196025. Formation of annular gap junctions.
R-BTA-432720. Lysosome Vesicle Biogenesis.
R-BTA-5099900. WNT5A-dependent internalization of FZD4.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain B
Short name:
Lcb
Gene namesi
Name:CLTB
Synonyms:CLTLB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Clathrin light chain BPRO_0000205770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11Blocked amino end (Met)
Modified residuei11 – 111Phosphoserine1 Publication
Modified residuei13 – 131Phosphoserine1 Publication
Modified residuei186 – 1861PhosphothreonineBy similarity
Disulfide bondi198 ↔ 2081 Publication
Modified residuei203 – 2031N6-acetyllysineBy similarity
Modified residuei216 – 2161PhosphoserineBy similarity
Modified residuei222 – 2221N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PeptideAtlasiP04975.
PRIDEiP04975.

PTM databases

iPTMnetiP04975.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010740.
ExpressionAtlasiP04975. baseline.

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts (via N-terminus) with HIP1. Interacts with HIP1R.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP04975. 3 interactions.
MINTiMINT-1209554.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LVGX-ray7.94D/E/F89-169[»]
3LVHX-ray9.00D/E/F1-169[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni92 – 15463Involved in binding clathrin heavy chainAdd
BLAST

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP04975.
KOiK04645.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Brain (identifier: P04975-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDFGFFSS SESGAPEAAE EDPAAAFLAQ QESEIAGIEN DEGFGAPAGS
60 70 80 90 100
QGGLAQPGPA SGASEDMGAT VNGDVFQEAN GPADGYAAIA QADRLTQEPE
110 120 130 140 150
SIRKWREEQR KRLQELDAAS KVMEQEWREK AKKDLEEWNQ RQSEQVEKNK
160 170 180 190 200
INNRIADKAF YQQPDADIIG YVASEEAFVK ESKEETPGTE WEKVAQLCDF
210 220
NPKSSKQCKD VSRLRSVLMS LKQTPLSR
Length:228
Mass (Da):25,082
Last modified:August 13, 1987 - v1
Checksum:i3CE75F0884B47E1A
GO
Isoform Non-brain (identifier: P04975-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-172: Missing.

Show »
Length:210
Mass (Da):23,073
Checksum:i42218ABD8C597FD7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei155 – 17218Missing in isoform Non-brain. CuratedVSP_001097Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04852 mRNA. Translation: CAA28543.1.
X04853 mRNA. Translation: CAA28544.1.
PIRiC26599.
RefSeqiNP_776702.1. NM_174277.2. [P04975-2]
XP_005209178.1. XM_005209121.3. [P04975-1]
UniGeneiBt.10.

Genome annotation databases

EnsembliENSBTAT00000014218; ENSBTAP00000014218; ENSBTAG00000010740. [P04975-2]
ENSBTAT00000014220; ENSBTAP00000014220; ENSBTAG00000010740. [P04975-1]
GeneIDi281698.
KEGGibta:281698.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04852 mRNA. Translation: CAA28543.1.
X04853 mRNA. Translation: CAA28544.1.
PIRiC26599.
RefSeqiNP_776702.1. NM_174277.2. [P04975-2]
XP_005209178.1. XM_005209121.3. [P04975-1]
UniGeneiBt.10.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LVGX-ray7.94D/E/F89-169[»]
3LVHX-ray9.00D/E/F1-169[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04975. 3 interactions.
MINTiMINT-1209554.

PTM databases

iPTMnetiP04975.

Proteomic databases

PeptideAtlasiP04975.
PRIDEiP04975.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014218; ENSBTAP00000014218; ENSBTAG00000010740. [P04975-2]
ENSBTAT00000014220; ENSBTAP00000014220; ENSBTAG00000010740. [P04975-1]
GeneIDi281698.
KEGGibta:281698.

Organism-specific databases

CTDi1212.

Phylogenomic databases

GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP04975.
KOiK04645.

Enzyme and pathway databases

ReactomeiR-BTA-190873. Gap junction degradation.
R-BTA-196025. Formation of annular gap junctions.
R-BTA-432720. Lysosome Vesicle Biogenesis.
R-BTA-5099900. WNT5A-dependent internalization of FZD4.

Gene expression databases

BgeeiENSBTAG00000010740.
ExpressionAtlasiP04975. baseline.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLCB_BOVIN
AccessioniPrimary (citable) accession number: P04975
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.