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Protein

Clathrin light chain A

Gene

CLTA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_273045. Formation of annular gap junctions.
REACT_277648. Gap junction degradation.
REACT_304674. EGFR downregulation.
REACT_308252. Golgi Associated Vesicle Biogenesis.
REACT_319227. MHC class II antigen presentation.
REACT_338753. Lysosome Vesicle Biogenesis.
REACT_341021. Retrograde neurotrophin signalling.
REACT_343758. Recycling pathway of L1.
REACT_347102. WNT5A-dependent internalization of FZD4.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain A
Short name:
Lca
Gene namesi
Name:CLTA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Clathrin light chain APRO_0000205766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11Blocked amino end (Met)
Modified residuei100 – 1001PhosphoserineBy similarity
Modified residuei201 – 2011PhosphoserineBy similarity
Modified residuei231 – 2311PhosphoserineBy similarity
Modified residuei237 – 2371N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP04973.

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis (By similarity).By similarity

Protein-protein interaction databases

IntActiP04973. 2 interactions.
MINTiMINT-1209505.
STRINGi9913.ENSBTAP00000001518.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XI4electron microscopy7.90J/K/L/M/N/O/P/Q/R95-164[»]
3IYVelectron microscopy7.90J/K/L/M/N/O/P/Q/R95-164[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04973.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni95 – 15763Involved in binding clathrin heavy chainAdd
BLAST

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

eggNOGiNOG312397.
GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP04973.
KOiK04644.
OMAiDEWYARQ.
OrthoDBiEOG79KPH4.
TreeFamiTF313162.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Brain (identifier: P04973-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDPFGVP AGGPALGNGV AGEEDPAAAF LAQQESEIAG IENDEAFAIL
60 70 80 90 100
DGGAPGSQPH GEPPGIPDAV DGVTNGDYYQ ESNGPTDSYA AISQVDRLQS
110 120 130 140 150
EPESIRKWRE EQTERLEALD ANSRKQEAEW KEKAIKELDE WYARQDEQLQ
160 170 180 190 200
KTKANNRVAD EAFYKQPFAD VIGYVTNINH PCYSLEQAAE EAFVNDIEES
210 220 230 240
SPGTEWERVA RLCDFNPKSS KQAKDVSRMR SVLISLKQAP LVH
Length:243
Mass (Da):26,723
Last modified:August 13, 1987 - v1
Checksum:iB1967A24DC14A06F
GO
Isoform Non-brain (identifier: P04973-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-187: Missing.

Show »
Length:213
Mass (Da):23,308
Checksum:iFCF2754AC7B684DE
GO
Isoform 3 (identifier: P04973-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-187: Missing.

Show »
Length:231
Mass (Da):25,323
Checksum:i4B2F0359CECAC709
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141P → H in CAA28542 (PubMed:3821891).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei158 – 18730Missing in isoform Non-brain. 1 PublicationVSP_001094Add
BLAST
Alternative sequencei176 – 18712Missing in isoform 3. 1 PublicationVSP_024237Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04849 mRNA. Translation: CAA28540.1.
X04851 mRNA. Translation: CAA28542.1.
BC118427 mRNA. Translation: AAI18428.1.
PIRiA26599.
RefSeqiNP_776447.1. NM_174022.2. [P04973-1]
XP_005210116.1. XM_005210059.2. [P04973-3]
XP_005210119.1. XM_005210062.2. [P04973-2]
UniGeneiBt.1617.

Genome annotation databases

EnsembliENSBTAT00000001518; ENSBTAP00000001518; ENSBTAG00000001137. [P04973-1]
ENSBTAT00000046425; ENSBTAP00000043729; ENSBTAG00000001137. [P04973-3]
ENSBTAT00000055956; ENSBTAP00000047748; ENSBTAG00000001137. [P04973-2]
GeneIDi281078.
KEGGibta:281078.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04849 mRNA. Translation: CAA28540.1.
X04851 mRNA. Translation: CAA28542.1.
BC118427 mRNA. Translation: AAI18428.1.
PIRiA26599.
RefSeqiNP_776447.1. NM_174022.2. [P04973-1]
XP_005210116.1. XM_005210059.2. [P04973-3]
XP_005210119.1. XM_005210062.2. [P04973-2]
UniGeneiBt.1617.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XI4electron microscopy7.90J/K/L/M/N/O/P/Q/R95-164[»]
3IYVelectron microscopy7.90J/K/L/M/N/O/P/Q/R95-164[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04973. 2 interactions.
MINTiMINT-1209505.
STRINGi9913.ENSBTAP00000001518.

Proteomic databases

PRIDEiP04973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001518; ENSBTAP00000001518; ENSBTAG00000001137. [P04973-1]
ENSBTAT00000046425; ENSBTAP00000043729; ENSBTAG00000001137. [P04973-3]
ENSBTAT00000055956; ENSBTAP00000047748; ENSBTAG00000001137. [P04973-2]
GeneIDi281078.
KEGGibta:281078.

Organism-specific databases

CTDi1211.

Phylogenomic databases

eggNOGiNOG312397.
GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP04973.
KOiK04644.
OMAiDEWYARQ.
OrthoDBiEOG79KPH4.
TreeFamiTF313162.

Enzyme and pathway databases

ReactomeiREACT_273045. Formation of annular gap junctions.
REACT_277648. Gap junction degradation.
REACT_304674. EGFR downregulation.
REACT_308252. Golgi Associated Vesicle Biogenesis.
REACT_319227. MHC class II antigen presentation.
REACT_338753. Lysosome Vesicle Biogenesis.
REACT_341021. Retrograde neurotrophin signalling.
REACT_343758. Recycling pathway of L1.
REACT_347102. WNT5A-dependent internalization of FZD4.

Miscellaneous databases

EvolutionaryTraceiP04973.
NextBioi20805157.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Clathrin light chains contain brain-specific insertion sequences and a region of homology with intermediate filaments."
    Jackson A.P., Seow H.-F., Holmes N., Drickamer K., Parham P.
    Nature 326:154-159(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BRAIN AND NON-BRAIN).
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: Hereford.
    Tissue: Fetal cerebellum.
  3. "Localization of clathrin light-chain sequences mediating heavy-chain binding and coated vesicle diversity."
    Brodsky F.M., Galloway C.J., Blank G.S., Jackson A.P., Seow H.-F., Drickamer K., Parham P.
    Nature 326:203-205(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN CLATHRIN HEAVY CHAIN BINDING.

Entry informationi

Entry nameiCLCA_BOVIN
AccessioniPrimary (citable) accession number: P04973
Secondary accession number(s): Q17QD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 22, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.