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P04973

- CLCA_BOVIN

UniProt

P04973 - CLCA_BOVIN

Protein

Clathrin light chain A

Gene

CLTA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. vesicle-mediated transport Source: InterPro

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_202205. Retrograde neurotrophin signalling.
    REACT_202965. Formation of annular gap junctions.
    REACT_205891. Lysosome Vesicle Biogenesis.
    REACT_207353. Gap junction degradation.
    REACT_211133. MHC class II antigen presentation.
    REACT_217186. EGFR downregulation.
    REACT_217562. WNT5A-dependent internalization of FZD4.
    REACT_219531. Golgi Associated Vesicle Biogenesis.
    REACT_223433. Recycling pathway of L1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Clathrin light chain A
    Short name:
    Lca
    Gene namesi
    Name:CLTA
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 8

    Subcellular locationi

    GO - Cellular componenti

    1. clathrin coat of coated pit Source: InterPro
    2. clathrin coat of trans-Golgi network vesicle Source: InterPro
    3. clathrin complex Source: Ensembl

    Keywords - Cellular componenti

    Coated pit, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 243243Clathrin light chain APRO_0000205766Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11Blocked amino end (Met)
    Modified residuei100 – 1001PhosphoserineBy similarity
    Modified residuei201 – 2011PhosphoserineBy similarity
    Modified residuei231 – 2311PhosphoserineBy similarity
    Modified residuei237 – 2371N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiP04973.

    Interactioni

    Subunit structurei

    Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis By similarity.By similarity

    Protein-protein interaction databases

    IntActiP04973. 2 interactions.
    MINTiMINT-1209505.
    STRINGi9913.ENSBTAP00000001518.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XI4electron microscopy7.90J/K/L/M/N/O/P/Q/R95-164[»]
    3IYVelectron microscopy7.90J/K/L/M/N/O/P/Q/R95-164[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP04973.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni95 – 15763Involved in binding clathrin heavy chainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the clathrin light chain family.Curated

    Phylogenomic databases

    eggNOGiNOG312397.
    GeneTreeiENSGT00390000010441.
    HOGENOMiHOG000008147.
    HOVERGENiHBG003386.
    InParanoidiP04973.
    KOiK04644.
    OMAiMDDFDML.
    OrthoDBiEOG79KPH4.
    TreeFamiTF313162.

    Family and domain databases

    InterProiIPR000996. Clathrin_L-chain.
    [Graphical view]
    PANTHERiPTHR10639. PTHR10639. 1 hit.
    PfamiPF01086. Clathrin_lg_ch. 1 hit.
    [Graphical view]
    PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
    PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform Brain (identifier: P04973-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAELDPFGVP AGGPALGNGV AGEEDPAAAF LAQQESEIAG IENDEAFAIL    50
    DGGAPGSQPH GEPPGIPDAV DGVTNGDYYQ ESNGPTDSYA AISQVDRLQS 100
    EPESIRKWRE EQTERLEALD ANSRKQEAEW KEKAIKELDE WYARQDEQLQ 150
    KTKANNRVAD EAFYKQPFAD VIGYVTNINH PCYSLEQAAE EAFVNDIEES 200
    SPGTEWERVA RLCDFNPKSS KQAKDVSRMR SVLISLKQAP LVH 243
    Length:243
    Mass (Da):26,723
    Last modified:August 13, 1987 - v1
    Checksum:iB1967A24DC14A06F
    GO
    Isoform Non-brain (identifier: P04973-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         158-187: Missing.

    Show »
    Length:213
    Mass (Da):23,308
    Checksum:iFCF2754AC7B684DE
    GO
    Isoform 3 (identifier: P04973-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         176-187: Missing.

    Show »
    Length:231
    Mass (Da):25,323
    Checksum:i4B2F0359CECAC709
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141P → H in CAA28542. (PubMed:3821891)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei158 – 18730Missing in isoform Non-brain. 1 PublicationVSP_001094Add
    BLAST
    Alternative sequencei176 – 18712Missing in isoform 3. 1 PublicationVSP_024237Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04849 mRNA. Translation: CAA28540.1.
    X04851 mRNA. Translation: CAA28542.1.
    BC118427 mRNA. Translation: AAI18428.1.
    PIRiA26599.
    RefSeqiNP_776447.1. NM_174022.2. [P04973-1]
    XP_005210116.1. XM_005210059.1. [P04973-3]
    XP_005210119.1. XM_005210062.1. [P04973-2]
    UniGeneiBt.1617.

    Genome annotation databases

    EnsembliENSBTAT00000001518; ENSBTAP00000001518; ENSBTAG00000001137. [P04973-1]
    ENSBTAT00000046425; ENSBTAP00000043729; ENSBTAG00000001137. [P04973-3]
    ENSBTAT00000055956; ENSBTAP00000047748; ENSBTAG00000001137. [P04973-2]
    GeneIDi281078.
    KEGGibta:281078.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04849 mRNA. Translation: CAA28540.1 .
    X04851 mRNA. Translation: CAA28542.1 .
    BC118427 mRNA. Translation: AAI18428.1 .
    PIRi A26599.
    RefSeqi NP_776447.1. NM_174022.2. [P04973-1 ]
    XP_005210116.1. XM_005210059.1. [P04973-3 ]
    XP_005210119.1. XM_005210062.1. [P04973-2 ]
    UniGenei Bt.1617.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XI4 electron microscopy 7.90 J/K/L/M/N/O/P/Q/R 95-164 [» ]
    3IYV electron microscopy 7.90 J/K/L/M/N/O/P/Q/R 95-164 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P04973. 2 interactions.
    MINTi MINT-1209505.
    STRINGi 9913.ENSBTAP00000001518.

    Proteomic databases

    PRIDEi P04973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000001518 ; ENSBTAP00000001518 ; ENSBTAG00000001137 . [P04973-1 ]
    ENSBTAT00000046425 ; ENSBTAP00000043729 ; ENSBTAG00000001137 . [P04973-3 ]
    ENSBTAT00000055956 ; ENSBTAP00000047748 ; ENSBTAG00000001137 . [P04973-2 ]
    GeneIDi 281078.
    KEGGi bta:281078.

    Organism-specific databases

    CTDi 1211.

    Phylogenomic databases

    eggNOGi NOG312397.
    GeneTreei ENSGT00390000010441.
    HOGENOMi HOG000008147.
    HOVERGENi HBG003386.
    InParanoidi P04973.
    KOi K04644.
    OMAi MDDFDML.
    OrthoDBi EOG79KPH4.
    TreeFami TF313162.

    Enzyme and pathway databases

    Reactomei REACT_202205. Retrograde neurotrophin signalling.
    REACT_202965. Formation of annular gap junctions.
    REACT_205891. Lysosome Vesicle Biogenesis.
    REACT_207353. Gap junction degradation.
    REACT_211133. MHC class II antigen presentation.
    REACT_217186. EGFR downregulation.
    REACT_217562. WNT5A-dependent internalization of FZD4.
    REACT_219531. Golgi Associated Vesicle Biogenesis.
    REACT_223433. Recycling pathway of L1.

    Miscellaneous databases

    EvolutionaryTracei P04973.
    NextBioi 20805157.

    Family and domain databases

    InterProi IPR000996. Clathrin_L-chain.
    [Graphical view ]
    PANTHERi PTHR10639. PTHR10639. 1 hit.
    Pfami PF01086. Clathrin_lg_ch. 1 hit.
    [Graphical view ]
    PROSITEi PS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
    PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Clathrin light chains contain brain-specific insertion sequences and a region of homology with intermediate filaments."
      Jackson A.P., Seow H.-F., Holmes N., Drickamer K., Parham P.
      Nature 326:154-159(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BRAIN AND NON-BRAIN).
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: Hereford.
      Tissue: Fetal cerebellum.
    3. "Localization of clathrin light-chain sequences mediating heavy-chain binding and coated vesicle diversity."
      Brodsky F.M., Galloway C.J., Blank G.S., Jackson A.P., Seow H.-F., Drickamer K., Parham P.
      Nature 326:203-205(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOMAIN CLATHRIN HEAVY CHAIN BINDING.

    Entry informationi

    Entry nameiCLCA_BOVIN
    AccessioniPrimary (citable) accession number: P04973
    Secondary accession number(s): Q17QD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3