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P04973

- CLCA_BOVIN

UniProt

P04973 - CLCA_BOVIN

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Protein

Clathrin light chain A

Gene

CLTA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. intracellular protein transport Source: InterPro
  2. vesicle-mediated transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_202205. Retrograde neurotrophin signalling.
REACT_202965. Formation of annular gap junctions.
REACT_205891. Lysosome Vesicle Biogenesis.
REACT_207353. Gap junction degradation.
REACT_211133. MHC class II antigen presentation.
REACT_217186. EGFR downregulation.
REACT_217562. WNT5A-dependent internalization of FZD4.
REACT_219531. Golgi Associated Vesicle Biogenesis.
REACT_223433. Recycling pathway of L1.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain A
Short name:
Lca
Gene namesi
Name:CLTA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 8

Subcellular locationi

GO - Cellular componenti

  1. clathrin coat of coated pit Source: InterPro
  2. clathrin coat of trans-Golgi network vesicle Source: InterPro
  3. clathrin complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Clathrin light chain APRO_0000205766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11Blocked amino end (Met)
Modified residuei100 – 1001PhosphoserineBy similarity
Modified residuei201 – 2011PhosphoserineBy similarity
Modified residuei231 – 2311PhosphoserineBy similarity
Modified residuei237 – 2371N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP04973.

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis (By similarity).By similarity

Protein-protein interaction databases

IntActiP04973. 2 interactions.
MINTiMINT-1209505.
STRINGi9913.ENSBTAP00000001518.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XI4electron microscopy7.90J/K/L/M/N/O/P/Q/R95-164[»]
3IYVelectron microscopy7.90J/K/L/M/N/O/P/Q/R95-164[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04973.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni95 – 15763Involved in binding clathrin heavy chainAdd
BLAST

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

eggNOGiNOG312397.
GeneTreeiENSGT00390000010441.
HOGENOMiHOG000008147.
HOVERGENiHBG003386.
InParanoidiP04973.
KOiK04644.
OMAiMDDFDML.
OrthoDBiEOG79KPH4.
TreeFamiTF313162.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Brain (identifier: P04973-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDPFGVP AGGPALGNGV AGEEDPAAAF LAQQESEIAG IENDEAFAIL
60 70 80 90 100
DGGAPGSQPH GEPPGIPDAV DGVTNGDYYQ ESNGPTDSYA AISQVDRLQS
110 120 130 140 150
EPESIRKWRE EQTERLEALD ANSRKQEAEW KEKAIKELDE WYARQDEQLQ
160 170 180 190 200
KTKANNRVAD EAFYKQPFAD VIGYVTNINH PCYSLEQAAE EAFVNDIEES
210 220 230 240
SPGTEWERVA RLCDFNPKSS KQAKDVSRMR SVLISLKQAP LVH
Length:243
Mass (Da):26,723
Last modified:August 13, 1987 - v1
Checksum:iB1967A24DC14A06F
GO
Isoform Non-brain (identifier: P04973-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-187: Missing.

Show »
Length:213
Mass (Da):23,308
Checksum:iFCF2754AC7B684DE
GO
Isoform 3 (identifier: P04973-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-187: Missing.

Show »
Length:231
Mass (Da):25,323
Checksum:i4B2F0359CECAC709
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141P → H in CAA28542. (PubMed:3821891)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei158 – 18730Missing in isoform Non-brain. 1 PublicationVSP_001094Add
BLAST
Alternative sequencei176 – 18712Missing in isoform 3. 1 PublicationVSP_024237Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04849 mRNA. Translation: CAA28540.1.
X04851 mRNA. Translation: CAA28542.1.
BC118427 mRNA. Translation: AAI18428.1.
PIRiA26599.
RefSeqiNP_776447.1. NM_174022.2. [P04973-1]
XP_005210116.1. XM_005210059.1. [P04973-3]
XP_005210119.1. XM_005210062.1. [P04973-2]
UniGeneiBt.1617.

Genome annotation databases

EnsembliENSBTAT00000001518; ENSBTAP00000001518; ENSBTAG00000001137. [P04973-1]
ENSBTAT00000046425; ENSBTAP00000043729; ENSBTAG00000001137. [P04973-3]
ENSBTAT00000055956; ENSBTAP00000047748; ENSBTAG00000001137. [P04973-2]
GeneIDi281078.
KEGGibta:281078.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04849 mRNA. Translation: CAA28540.1 .
X04851 mRNA. Translation: CAA28542.1 .
BC118427 mRNA. Translation: AAI18428.1 .
PIRi A26599.
RefSeqi NP_776447.1. NM_174022.2. [P04973-1 ]
XP_005210116.1. XM_005210059.1. [P04973-3 ]
XP_005210119.1. XM_005210062.1. [P04973-2 ]
UniGenei Bt.1617.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XI4 electron microscopy 7.90 J/K/L/M/N/O/P/Q/R 95-164 [» ]
3IYV electron microscopy 7.90 J/K/L/M/N/O/P/Q/R 95-164 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P04973. 2 interactions.
MINTi MINT-1209505.
STRINGi 9913.ENSBTAP00000001518.

Proteomic databases

PRIDEi P04973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000001518 ; ENSBTAP00000001518 ; ENSBTAG00000001137 . [P04973-1 ]
ENSBTAT00000046425 ; ENSBTAP00000043729 ; ENSBTAG00000001137 . [P04973-3 ]
ENSBTAT00000055956 ; ENSBTAP00000047748 ; ENSBTAG00000001137 . [P04973-2 ]
GeneIDi 281078.
KEGGi bta:281078.

Organism-specific databases

CTDi 1211.

Phylogenomic databases

eggNOGi NOG312397.
GeneTreei ENSGT00390000010441.
HOGENOMi HOG000008147.
HOVERGENi HBG003386.
InParanoidi P04973.
KOi K04644.
OMAi MDDFDML.
OrthoDBi EOG79KPH4.
TreeFami TF313162.

Enzyme and pathway databases

Reactomei REACT_202205. Retrograde neurotrophin signalling.
REACT_202965. Formation of annular gap junctions.
REACT_205891. Lysosome Vesicle Biogenesis.
REACT_207353. Gap junction degradation.
REACT_211133. MHC class II antigen presentation.
REACT_217186. EGFR downregulation.
REACT_217562. WNT5A-dependent internalization of FZD4.
REACT_219531. Golgi Associated Vesicle Biogenesis.
REACT_223433. Recycling pathway of L1.

Miscellaneous databases

EvolutionaryTracei P04973.
NextBioi 20805157.

Family and domain databases

InterProi IPR000996. Clathrin_L-chain.
[Graphical view ]
PANTHERi PTHR10639. PTHR10639. 1 hit.
Pfami PF01086. Clathrin_lg_ch. 1 hit.
[Graphical view ]
PROSITEi PS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Clathrin light chains contain brain-specific insertion sequences and a region of homology with intermediate filaments."
    Jackson A.P., Seow H.-F., Holmes N., Drickamer K., Parham P.
    Nature 326:154-159(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BRAIN AND NON-BRAIN).
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: Hereford.
    Tissue: Fetal cerebellum.
  3. "Localization of clathrin light-chain sequences mediating heavy-chain binding and coated vesicle diversity."
    Brodsky F.M., Galloway C.J., Blank G.S., Jackson A.P., Seow H.-F., Drickamer K., Parham P.
    Nature 326:203-205(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN CLATHRIN HEAVY CHAIN BINDING.

Entry informationi

Entry nameiCLCA_BOVIN
AccessioniPrimary (citable) accession number: P04973
Secondary accession number(s): Q17QD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 1, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3