Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P04973 (CLCA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Clathrin light chain A

Short name=Lca
Gene names
Name:CLTA
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

Subunit structure

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis By similarity.

Subcellular location

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membranecoated pit; Peripheral membrane protein; Cytoplasmic side. Note: Cytoplasmic face of coated pits and vesicles.

Sequence similarities

Belongs to the clathrin light chain family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform Brain (identifier: P04973-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Non-brain (identifier: P04973-2)

The sequence of this isoform differs from the canonical sequence as follows:
     158-187: Missing.
Isoform 3 (identifier: P04973-3)

The sequence of this isoform differs from the canonical sequence as follows:
     176-187: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 243243Clathrin light chain A
PRO_0000205766

Regions

Region95 – 15763Involved in binding clathrin heavy chain

Amino acid modifications

Modified residue11Blocked amino end (Met)
Modified residue1001Phosphoserine By similarity
Modified residue2011Phosphoserine By similarity
Modified residue2311Phosphoserine By similarity
Modified residue2371N6-acetyllysine By similarity

Natural variations

Alternative sequence158 – 18730Missing in isoform Non-brain.
VSP_001094
Alternative sequence176 – 18712Missing in isoform 3.
VSP_024237

Experimental info

Sequence conflict141P → H in CAA28542. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform Brain [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: B1967A24DC14A06F

FASTA24326,723
        10         20         30         40         50         60 
MAELDPFGVP AGGPALGNGV AGEEDPAAAF LAQQESEIAG IENDEAFAIL DGGAPGSQPH 

        70         80         90        100        110        120 
GEPPGIPDAV DGVTNGDYYQ ESNGPTDSYA AISQVDRLQS EPESIRKWRE EQTERLEALD 

       130        140        150        160        170        180 
ANSRKQEAEW KEKAIKELDE WYARQDEQLQ KTKANNRVAD EAFYKQPFAD VIGYVTNINH 

       190        200        210        220        230        240 
PCYSLEQAAE EAFVNDIEES SPGTEWERVA RLCDFNPKSS KQAKDVSRMR SVLISLKQAP 


LVH 

« Hide

Isoform Non-brain [UniParc].

Checksum: FCF2754AC7B684DE
Show »

FASTA21323,308
Isoform 3 [UniParc].

Checksum: 4B2F0359CECAC709
Show »

FASTA23125,323

References

« Hide 'large scale' references
[1]"Clathrin light chains contain brain-specific insertion sequences and a region of homology with intermediate filaments."
Jackson A.P., Seow H.-F., Holmes N., Drickamer K., Parham P.
Nature 326:154-159(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BRAIN AND NON-BRAIN).
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: Hereford.
Tissue: Fetal cerebellum.
[3]"Localization of clathrin light-chain sequences mediating heavy-chain binding and coated vesicle diversity."
Brodsky F.M., Galloway C.J., Blank G.S., Jackson A.P., Seow H.-F., Drickamer K., Parham P.
Nature 326:203-205(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: DOMAIN CLATHRIN HEAVY CHAIN BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04849 mRNA. Translation: CAA28540.1.
X04851 mRNA. Translation: CAA28542.1.
BC118427 mRNA. Translation: AAI18428.1.
PIRA26599.
RefSeqNP_776447.1. NM_174022.2. [P04973-1]
XP_005210116.1. XM_005210059.1. [P04973-3]
XP_005210119.1. XM_005210062.1. [P04973-2]
UniGeneBt.1617.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1XI4electron microscopy7.90J/K/L/M/N/O/P/Q/R95-164[»]
3IYVelectron microscopy7.90J/K/L/M/N/O/P/Q/R95-164[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP04973. 2 interactions.
MINTMINT-1209505.
STRING9913.ENSBTAP00000001518.

Proteomic databases

PRIDEP04973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000001518; ENSBTAP00000001518; ENSBTAG00000001137. [P04973-1]
ENSBTAT00000046425; ENSBTAP00000043729; ENSBTAG00000001137. [P04973-3]
ENSBTAT00000055956; ENSBTAP00000047748; ENSBTAG00000001137. [P04973-2]
GeneID281078.
KEGGbta:281078.

Organism-specific databases

CTD1211.

Phylogenomic databases

eggNOGNOG312397.
GeneTreeENSGT00390000010441.
HOGENOMHOG000008147.
HOVERGENHBG003386.
InParanoidP04973.
KOK04644.
OMAMDDFDML.
OrthoDBEOG79KPH4.
TreeFamTF313162.

Family and domain databases

InterProIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERPTHR10639. PTHR10639. 1 hit.
PfamPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEPS00224. CLATHRIN_LIGHT_CHN_1. 1 hit.
PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP04973.
NextBio20805157.

Entry information

Entry nameCLCA_BOVIN
AccessionPrimary (citable) accession number: P04973
Secondary accession number(s): Q17QD2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 14, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references