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Protein

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

PDE6G

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

  • 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
  • cGMP binding Source: InterPro
  • zinc ion binding Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processSensory transduction, Vision
LigandcGMP

Enzyme and pathway databases

ReactomeiR-BTA-2485179 Activation of the phototransduction cascade
R-BTA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-BTA-4086398 Ca2+ pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:PDE6G
Synonyms:PDEG
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:32683 PDE6G

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2096979

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001661131 – 87Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaAdd BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP04972
PRIDEiP04972

PTM databases

iPTMnetiP04972

Expressioni

Gene expression databases

BgeeiENSBTAG00000000354

Interactioni

Subunit structurei

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.1 Publication

Protein-protein interaction databases

IntActiP04972, 2 interactors
MINTiP04972
STRINGi9913.ENSBTAP00000000459

Chemistry databases

BindingDBiP04972

Structurei

Secondary structure

187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 17Combined sources4
Beta strandi24 – 27Combined sources4
Beta strandi34 – 37Combined sources4
Beta strandi45 – 48Combined sources4
Beta strandi56 – 59Combined sources4
Helixi62 – 65Combined sources4
Helixi69 – 73Combined sources5
Helixi78 – 83Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FQJX-ray2.02C46-87[»]
2JU4NMR-A1-87[»]
3JABelectron microscopy11.00D/P70-87[»]
3JBQelectron microscopy11.00D/X70-87[»]
DisProtiDP00347
ProteinModelPortaliP04972
SMRiP04972
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04972

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 45Arg/Lys-rich (basic)Add BLAST22

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IZA8 Eukaryota
ENOG410YN07 LUCA
GeneTreeiENSGT00390000013260
HOVERGENiHBG000447
InParanoidiP04972
KOiK13759
OMAiTRVMGGP
OrthoDBiEOG091G14J5
TreeFamiTF333297

Family and domain databases

Gene3Di4.10.1120.10, 1 hit
InterProiView protein in InterPro
IPR006952 PDE6_gamma
IPR037030 PDE6_gamma_sf
PANTHERiPTHR12122 PTHR12122, 1 hit
PfamiView protein in Pfam
PF04868 PDE6_gamma, 1 hit
PIRSFiPIRSF000969 35-cGMP_Pdiase_g, 1 hit

Sequencei

Sequence statusi: Complete.

P04972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLEPPKAEI RSATRVMGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF
60 70 80
GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII
Length:87
Mass (Da):9,669
Last modified:August 13, 1987 - v1
Checksum:i3AA2D6B5D7D14D58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04823 mRNA Translation: CAA28507.1
X04270 mRNA Translation: CAA27821.1
PIRiA25268
RefSeqiNP_776846.1, NM_174421.2
XP_010814750.1, XM_010816448.2
XP_010814751.1, XM_010816449.1
UniGeneiBt.54

Genome annotation databases

EnsembliENSBTAT00000000459; ENSBTAP00000000459; ENSBTAG00000000354
GeneIDi281977
KEGGibta:281977

Entry informationi

Entry nameiCNRG_BOVIN
AccessioniPrimary (citable) accession number: P04972
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health