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P04972 (CNRG_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Short name=GMP-PDE gamma
EC=3.1.4.35
Gene names
Name:PDE6G
Synonyms:PDEG
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length87 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activity

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Subunit structure

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

Sequence similarities

Belongs to the rod/cone cGMP-PDE gamma subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8787Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
PRO_0000166113

Regions

Compositional bias24 – 4522Arg/Lys-rich (basic)

Amino acid modifications

Modified residue11N-acetylmethionine

Secondary structure

................. 87
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P04972 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 3AA2D6B5D7D14D58

FASTA879,669
        10         20         30         40         50         60 
MNLEPPKAEI RSATRVMGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL 

        70         80 
GTDITVICPW EAFNHLELHE LAQYGII 

« Hide

References

[1]"Cyclic GMP-phosphodiesterase from the cattle retina. Amino acid sequence of the gamma subunit."
Ovchinnikov Y.A., Muradov K.G., Feigina M.Y., Nazimov I.V., Khoroshilova N.I.
Dokl. Akad. Nauk SSSR 287:1496-1498(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Retina.
[2]"Cyclic GMP phosphodiesterase from bovine retina. Nucleotide sequence of cDNA of the gamma-subunit."
Ovchinnikov Y.A., Gubanov V.V., Khramtsov N.V., Akhmedov N.B., Zagranichny V.E., Ishchenko K.A., Muradov K.G., Barinov A.A., Bondarenko V.A., Kumarev V.P., Kobzev V.F., Lipkin V.M.
Dokl. Biochem. 288:216-218(1986)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[3]"Cyclic GMP phosphodiesterase from cattle retina. Amino acid sequence of the gamma-subunit and nucleotide sequence of the corresponding cDNA."
Ovchinnikov Y.A., Lipkin V.M., Kumarev V.P., Gubanov V.V., Khramtsov N.V., Akhmedov N.B., Zagranichny V.E., Muradov K.G.
FEBS Lett. 204:288-292(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[4]"Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A."
Slep K.C., Kercher M.A., He W., Cowan C.W., Wensel T.G., Sigler P.B.
Nature 409:1071-1077(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 46-87 IN COMPLEX WITH RGS9 AND GNAT1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04823 mRNA. Translation: CAA28507.1.
X04270 mRNA. Translation: CAA27821.1.
PIRA25268.
RefSeqNP_776846.1. NM_174421.2.
XP_005221057.1. XM_005221000.1.
XP_005221058.1. XM_005221001.1.
UniGeneBt.54.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FQJX-ray2.02C46-87[»]
2JU4NMR-A1-87[»]
DisProtDP00347.
DP00638.
ProteinModelPortalP04972.
SMRP04972. Positions 1-87.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP04972. 2 interactions.
STRING9913.ENSBTAP00000000459.

Chemistry

BindingDBP04972.
ChEMBLCHEMBL2096979.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000000459; ENSBTAP00000000459; ENSBTAG00000000354.
GeneID281977.
KEGGbta:281977.

Organism-specific databases

CTD5148.

Phylogenomic databases

eggNOGNOG44345.
GeneTreeENSGT00390000013260.
HOVERGENHBG000447.
InParanoidP04972.
KOK13759.
OMATRVMGGP.
OrthoDBEOG7SN8FW.
TreeFamTF333297.

Enzyme and pathway databases

ReactomeREACT_207087. Disease.
REACT_214353. Signal Transduction.

Family and domain databases

Gene3D4.10.1120.10. 1 hit.
InterProIPR006952. PDE6_gamma.
[Graphical view]
PANTHERPTHR12122. PTHR12122. 1 hit.
PfamPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP04972.
NextBio20805848.

Entry information

Entry nameCNRG_BOVIN
AccessionPrimary (citable) accession number: P04972
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 14, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references