Reviewed,
UniProtKB/Swiss-Prot P04972 (CNRG_BOVIN)
Last modified
June 16, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Short name=GMP-PDE gamma EC=3.1.4.17 | ||||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||||
| Taxonomic identifier | 9913 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 87 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. |
| Catalytic activity | Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. |
| Subunit structure | Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain. |
| Sequence similarities | Belongs to the rod/cone cGMP-PDE gamma subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Sensory transduction Vision |
| Ligand | cGMP |
| Molecular function | Hydrolase |
| PTM | Acetylation |
| Technical term | 3D-structure Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW visual perceptionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC cGMP bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||
Molecule processing | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 87 | 87 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | PRO_0000166113 | |||||||||||
Regions | |||||||||||||||
| Compositional bias | 24 – 45 | 22 | Arg/Lys-rich (basic) | ||||||||||||
Amino acid modifications | |||||||||||||||
| Modified residue | 1 | 1 | N-acetylmethionine | ||||||||||||
Secondary structure | |||||||||||||||
Helix Strand Turn | |||||||||||||||
| Helix | 62 – 65 | 4 | |||||||||||||
| Helix | 69 – 73 | 5 | |||||||||||||
| Helix | 78 – 83 | 6 | |||||||||||||
Sequences
References
| [1] | "Cyclic GMP-phosphodiesterase from the cattle retina. Amino acid sequence of the gamma subunit." Ovchinnikov Y.A., Muradov K.G., Feigina M.Y., Nazimov I.V., Khoroshilova N.I. Dokl. Akad. Nauk SSSR 287:1496-1498(1986) [PubMed: 3011376] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Retina. |
| [2] | "Cyclic GMP phosphodiesterase from bovine retina. Nucleotide sequence of cDNA of the gamma-subunit." Ovchinnikov Y.A., Gubanov V.V., Khramtsov N.V., Akhmedov N.B., Zagranichny V.E., Ishchenko K.A., Muradov K.G., Barinov A.A., Bondarenko V.A., Kumarev V.P., Kobzev V.F., Lipkin V.M. Dokl. Biochem. 288:216-218(1986) Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina. |
| [3] | "Cyclic GMP phosphodiesterase from cattle retina. Amino acid sequence of the gamma-subunit and nucleotide sequence of the corresponding cDNA." Ovchinnikov Y.A., Lipkin V.M., Kumarev V.P., Gubanov V.V., Khramtsov N.V., Akhmedov N.B., Zagranichny V.E., Muradov K.G. FEBS Lett. 204:288-292(1986) [PubMed: 3015681] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina. |
| [4] | "Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A." Slep K.C., Kercher M.A., He W., Cowan C.W., Wensel T.G., Sigler P.B. Nature 409:1071-1077(2001) [PubMed: 11234020] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 46-87 IN COMPLEX WITH RGS9 AND GNAT1. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| X04823 mRNA. Translation: CAA28507.1. X04270 mRNA. Translation: CAA27821.1. | |||||||||||||||||||
| IPI | IPI00704598. | ||||||||||||||||||
| PIR | A25268. | ||||||||||||||||||
| RefSeq | NP_776846.1. | ||||||||||||||||||
| UniGene | Bt.54 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
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| DisProt | DP00347. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENSBTAG00000000354. Bos taurus. [Contig view] | ||||||||||||||||||
| GeneID | 281977. | ||||||||||||||||||
| KEGG | bta:281977. | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOVERGEN | P04972. | ||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||
| BRENDA | 3.1.4.17. 251. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR006952. PDE6_gamma. [Graphical view] | ||||||||||||||||||
| PANTHER | PTHR12122. PDE6_gamma. 1 hit. | ||||||||||||||||||
| Pfam | PF04868. PDE6_gamma. 1 hit. [Graphical view] | ||||||||||||||||||
| PIRSF | PIRSF000969. 35-cGMP_Pdiase_g. 1 hit. | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Entry information
| Entry name | CNRG_BOVIN | ||||||||
| Accession | Primary (citable) accession number: P04972 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


