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Protein

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

PDE6G

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

cGMP

Enzyme and pathway databases

ReactomeiR-BTA-2485179. Activation of the phototransduction cascade.
R-BTA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-BTA-4086398. Ca2+ pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:PDE6G
Synonyms:PDEG
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2096979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8787Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP04972.

PTM databases

iPTMnetiP04972.

Expressioni

Gene expression databases

BgeeiENSBTAG00000000354.

Interactioni

Subunit structurei

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.1 Publication

Protein-protein interaction databases

IntActiP04972. 2 interactions.
STRINGi9913.ENSBTAP00000000459.

Chemistry

BindingDBiP04972.

Structurei

Secondary structure

1
87
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 174Combined sources
Beta strandi24 – 274Combined sources
Beta strandi34 – 374Combined sources
Beta strandi45 – 484Combined sources
Beta strandi56 – 594Combined sources
Helixi62 – 654Combined sources
Helixi69 – 735Combined sources
Helixi78 – 836Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FQJX-ray2.02C46-87[»]
2JU4NMR-A1-87[»]
3JABelectron microscopy11.00D/P70-87[»]
3JBQelectron microscopy11.00D/X70-87[»]
DisProtiDP00347.
DP00638.
ProteinModelPortaliP04972.
SMRiP04972. Positions 1-87.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04972.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 4522Arg/Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IZA8. Eukaryota.
ENOG410YN07. LUCA.
GeneTreeiENSGT00390000013260.
HOVERGENiHBG000447.
InParanoidiP04972.
KOiK13759.
OMAiDCSRRES.
OrthoDBiEOG091G14J5.
TreeFamiTF333297.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

Sequencei

Sequence statusi: Complete.

P04972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLEPPKAEI RSATRVMGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF
60 70 80
GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII
Length:87
Mass (Da):9,669
Last modified:August 13, 1987 - v1
Checksum:i3AA2D6B5D7D14D58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04823 mRNA. Translation: CAA28507.1.
X04270 mRNA. Translation: CAA27821.1.
PIRiA25268.
RefSeqiNP_776846.1. NM_174421.2.
XP_010814750.1. XM_010816448.2.
XP_010814751.1. XM_010816449.1.
UniGeneiBt.54.

Genome annotation databases

EnsembliENSBTAT00000000459; ENSBTAP00000000459; ENSBTAG00000000354.
GeneIDi281977.
KEGGibta:281977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04823 mRNA. Translation: CAA28507.1.
X04270 mRNA. Translation: CAA27821.1.
PIRiA25268.
RefSeqiNP_776846.1. NM_174421.2.
XP_010814750.1. XM_010816448.2.
XP_010814751.1. XM_010816449.1.
UniGeneiBt.54.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FQJX-ray2.02C46-87[»]
2JU4NMR-A1-87[»]
3JABelectron microscopy11.00D/P70-87[»]
3JBQelectron microscopy11.00D/X70-87[»]
DisProtiDP00347.
DP00638.
ProteinModelPortaliP04972.
SMRiP04972. Positions 1-87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04972. 2 interactions.
STRINGi9913.ENSBTAP00000000459.

Chemistry

BindingDBiP04972.
ChEMBLiCHEMBL2096979.

PTM databases

iPTMnetiP04972.

Proteomic databases

PaxDbiP04972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000459; ENSBTAP00000000459; ENSBTAG00000000354.
GeneIDi281977.
KEGGibta:281977.

Organism-specific databases

CTDi5148.

Phylogenomic databases

eggNOGiENOG410IZA8. Eukaryota.
ENOG410YN07. LUCA.
GeneTreeiENSGT00390000013260.
HOVERGENiHBG000447.
InParanoidiP04972.
KOiK13759.
OMAiDCSRRES.
OrthoDBiEOG091G14J5.
TreeFamiTF333297.

Enzyme and pathway databases

ReactomeiR-BTA-2485179. Activation of the phototransduction cascade.
R-BTA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-BTA-4086398. Ca2+ pathway.

Miscellaneous databases

EvolutionaryTraceiP04972.
PROiP04972.

Gene expression databases

BgeeiENSBTAG00000000354.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCNRG_BOVIN
AccessioniPrimary (citable) accession number: P04972
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.