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P04964 (DDH_CORGL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Meso-diaminopimelate D-dehydrogenase

Short name=Meso-DAP dehydrogenase
EC=1.4.1.16
Gene names
Name:ddh
Ordered Locus Names:Cgl2617, cg2900
OrganismCorynebacterium glutamicum (Brevibacterium flavum)
Taxonomic identifier1718 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Meso-diaminopimelate D-dehydrogenase
PRO_0000079848

Secondary structure

.............................................................. 320
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P04964 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: D29D3EB6DFDA35DE

FASTA32035,199
        10         20         30         40         50         60 
MTNIRVAIVG YGNLGRSVEK LIAKQPDMDL VGIFSRRATL DTKTPVFDVA DVDKHADDVD 

        70         80         90        100        110        120 
VLFLCMGSAT DIPEQAPKFA QFACTVDTYD NHRDIPRHRQ VMNEAATAAG NVALVSTGWD 

       130        140        150        160        170        180 
PGMFSINRVY AAAVLAEHQQ HTFWGPGLSQ GHSDALRRIP GVQKAVQYTL PSEDALEKAR 

       190        200        210        220        230        240 
RGEAGDLTGK QTHKRQCFVV ADAADHERIE NDIRTMPDYF VGYEVEVNFI DEATFDSEHT 

       250        260        270        280        290        300 
GMPHGGHVIT TGDTGGFNHT VEYILKLDRN PDFTASSQIA FGRAAHRMKQ QGQSGAFTVL 

       310        320 
EVAPYLLSPE NLDDLIARDV 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the meso-diaminopimelate D-dehydrogenase gene from Corynebacterium glutamicum."
Ishino S., Mizukami T., Yamaguchi K., Katsumata R., Araki K.
Nucleic Acids Res. 15:3917-3917(1987) [PubMed: 3588313] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: KY 10755.
[2]"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032."
Nakagawa S.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[3]"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins."
Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. expand/collapse author list , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.
J. Biotechnol. 104:5-25(2003) [PubMed: 12948626] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[4]"Three-dimensional structure of meso-diaminopimelic acid dehydrogenase from Corynebacterium glutamicum."
Scapin G., Reddy S.G., Blanchard J.S.
Biochemistry 35:13540-13551(1996) [PubMed: 8885833] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
Strain: KY 10755.
[5]"Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase."
Scapin G., Cirilli M., Reddy S.G., Gao Y., Vederas J.C., Blanchard J.S.
Biochemistry 37:3278-3285(1998) [PubMed: 9521647] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00151 Genomic DNA. Translation: CAA68346.1.
BA000036 Genomic DNA. Translation: BAC00011.1.
BX927155 Genomic DNA. Translation: CAF21279.1.
PIRS07384.
RefSeqNP_601818.2. NC_003450.3.
YP_226858.1. NC_006958.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1DAPX-ray2.20A/B1-320[»]
1F06X-ray2.10A/B1-320[»]
2DAPX-ray2.20A1-320[»]
3DAPX-ray2.20A/B1-320[»]
ProteinModelPortalP04964.
SMRP04964. Positions 1-320.
ModBaseSearch...

2D gel databases

World-2DPAGE0001:P04964.

Proteomic databases

PRIDEP04964.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1020564.
3344238.
GenomeReviewsGene locus Cgl2617 in contig BA000036_GR.
Gene locus cg2900 in contig BX927147_GR.
KEGGcgb:cg2900.
cgl:NCgl2528.
PATRIC21497280. VBICorGlu203724_2553.

Phylogenomic databases

HOGENOMHBG730618.
OMADSFDTHA.
ProtClustDBCLSK904830.

Enzyme and pathway databases

BioCycCGLU196627:CG2900-MONOMER.
MetaCyc:MONOMER-6621.

Family and domain databases

InterProIPR000846. DapB_N.
IPR010190. Diaminopimelate_DH_Ddh.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK03340.
PfamPF01113. DapB_N. 1 hit.
[Graphical view]
PIRSFPIRSF025648. DDH. 1 hit.
TIGRFAMsTIGR01921. DAP-DH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDDH_CORGL
AccessionPrimary (citable) accession number: P04964
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references