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Protein

Endoglucanase B

Gene

celB

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei204Proton donorBy similarity1
Active sitei363NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-561-MONOMER
MetaCyc:MONOMER-16415

Protein family/group databases

CAZyiGH5 Glycoside Hydrolase Family 5

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase B (EC:3.2.1.4)
Alternative name(s):
Cellulase B
Endo-1,4-beta-glucanase B
Short name:
EgB
Gene namesi
Name:celB
Ordered Locus Names:Cthe_0536
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Or 31Add BLAST27
ChainiPRO_000000785028 – 563Endoglucanase BAdd BLAST536

Interactioni

Protein-protein interaction databases

STRINGi203119.Cthe_0536

Structurei

3D structure databases

ProteinModelPortaliP04956
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini496 – 562DockerinPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107FVX Bacteria
COG2730 LUCA
HOGENOMiHOG000225207
OMAiETDNMGH
OrthoDBiPOG091H07QZ

Family and domain databases

InterProiView protein in InterPro
IPR002105 Dockerin_1_rpt
IPR016134 Dockerin_dom
IPR036439 Dockerin_dom_sf
IPR018247 EF_Hand_1_Ca_BS
IPR001547 Glyco_hydro_5
IPR018087 Glyco_hydro_5_CS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00150 Cellulase, 1 hit
PF00404 Dockerin_1, 2 hits
SUPFAMiSSF51445 SSF51445, 1 hit
SSF63446 SSF63446, 1 hit
PROSITEiView protein in PROSITE
PS00448 CLOS_CELLULOSOME_RPT, 2 hits
PS51766 DOCKERIN, 1 hit
PS00018 EF_HAND_1, 1 hit
PS00659 GLYCOSYL_HYDROL_F5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKFLVLLIA LIMIATLLVV PGVQTSAEGS YADLAEPDDD WLHVEGTNIV
60 70 80 90 100
DKYGNKVWIT GANWFGFNCR ERMLLDSYHS DIIADIELVA DKGINVVRMP
110 120 130 140 150
IATDLLYAWS QGIYPPSTDT SYNNPALAGL NSYELFNFML ENFKRVGIKV
160 170 180 190 200
ILDVHSPETD NQGHNYPLWY NTTITEEIFK KAWVWVAERY KNDDTIIGFD
210 220 230 240 250
LKNEPHTNTG TMKIKAQSAI WDDSNHPNNW KRVAEETALA ILEVHPNVLI
260 270 280 290 300
FVEGVEMYPK DGIWDDETFD TSPWTGNNDY YGNWWGGNLR GVKDYPINLG
310 320 330 340 350
KYQSQLVYSP HDYGPIVYEQ DWFKGDFITA NDEQAKRILY EQCWRDNWAY
360 370 380 390 400
IMEEGISPLL LGEWGGMTEG GHPLLDLNLK YLRCMRDFIL ENKYKLHHTF
410 420 430 440 450
WCINIDSADT GGLFTRDEGT PFPGGRDLKW NDNKYDNYLY PVLWKTEDGK
460 470 480 490 500
FIGLDHKIPL GRNGISISQL SNYTPSVTPS PSATPSPTTI TAPPTDTVTY
510 520 530 540 550
GDVNGDGRVN SSDVALLKRY LLGLVENINK EAADVNVSGT VNSTDLAIMK
560
RYVLRSISEL PYK
Length:563
Mass (Da):63,929
Last modified:August 13, 1987 - v1
Checksum:i866FE55704A1DE4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03592 Genomic DNA Translation: CAA27266.1
CP000568 Genomic DNA Translation: ABN51772.1
PIRiA23512 CZCLBM
RefSeqiWP_003517581.1, NC_009012.1

Genome annotation databases

EnsemblBacteriaiABN51772; ABN51772; Cthe_0536
GeneIDi35803054
KEGGicth:Cthe_0536

Similar proteinsi

Entry informationi

Entry nameiGUNB_CLOTH
AccessioniPrimary (citable) accession number: P04956
Secondary accession number(s): A3DCU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: April 25, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health