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Reviewed, UniProtKB/Swiss-Prot P04949 (FLIC_ECOLI)

Last modified January 19, 2010. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Flagellin
Gene names
Name: fliC
Synonyms: flaF, hag
Ordered Locus Names: b1923, JW1908
OrganismEscherichia coli (strain K12) [Complete proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

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Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.

Subcellular location

Secreted. Bacterial flagellum.

Sequence similarities

Belongs to the bacterial flagellin family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7 Ref.8
Chain2 – 498497Flagellin
PRO_0000182560

Experimental info

Sequence conflict2851P → L in CAA35488. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P04949-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 14A0ED3E68E326A1

FASTA49851,295
        10         20         30         40         50         60 
MAQVINTNSL SLITQNNINK NQSALSSSIE RLSSGLRINS AKDDAAGQAI ANRFTSNIKG 

        70         80         90        100        110        120 
LTQAARNAND GISVAQTTEG ALSEINNNLQ RVRELTVQAT TGTNSESDLS SIQDEIKSRL 

       130        140        150        160        170        180 
DEIDRVSGQT QFNGVNVLAK NGSMKIQVGA NDNQTITIDL KQIDAKTLGL DGFSVKNNDT 

       190        200        210        220        230        240 
VTTSAPVTAF GATTTNNIKL TGITLSTEAA TDTGGTNPAS IEGVYTDNGN DYYAKITGGD 

       250        260        270        280        290        300 
NDGKYYAVTV ANDGTVTMAT GATANATVTD ANTTKATTIT SGGTPVQIDN TAGSATANLG 

       310        320        330        340        350        360 
AVSLVKLQDS KGNDTDTYAL KDTNGNLYAA DVNETTGAVS VKTITYTDSS GAASSPTAVK 

       370        380        390        400        410        420 
LGGDDGKTEV VDIDGKTYDS ADLNGGNLQT GLTAGGEALT AVANGKTTDP LKALDDAIAS 

       430        440        450        460        470        480 
VDKFRSSLGA VQNRLDSAVT NLNNTTTNLS EAQSRIQDAD YATEVSNMSK AQIIQQAGNS 

       490 
VLAKANQVPQ QVLSLLQG

« Hide

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References

« Hide 'large scale' references
[1]"Nucleotide sequence of the hag gene encoding flagellin of Escherichia coli."
Kuwajima G., Asaka J., Fujiwara T., Fujiwara T., Node K., Kondo E.
J. Bacteriol. 168:1479-1483(1986) [PubMed: 3536885] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"Isolation and characterization of Escherichia coli hag operator mutants whose hag48 expression has become repressible by a Salmonella H1 repressor."
Hanafusa T., Sakai A., Tominaga A., Enomoto M.
Mol. Gen. Genet. 216:44-50(1989) [PubMed: 2659972] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[3]"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map."
Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. expand/collapse author list , Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., Horiuchi T.
DNA Res. 3:379-392(1996) [PubMed: 9097040] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[5]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]"DNA sequence adjacent to flagellar genes and evolution of flagellar-phase variation."
Szekely E., Simon M.
J. Bacteriol. 155:74-81(1983) [PubMed: 6305924] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
[7]"Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12."
Link A.J., Robison K., Church G.M.
Electrophoresis 18:1259-1313(1997) [PubMed: 9298646] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-13.
Strain: K12 / EMG2.
[8]"Protein identification with N and C-terminal sequence tags in proteome projects."
Wilkins M.R., Gasteiger E., Tonella L., Ou K., Tyler M., Sanchez J.-C., Gooley A.A., Walsh B.J., Bairoch A., Appel R.D., Williams K.L., Hochstrasser D.F.
J. Mol. Biol. 278:599-608(1998) [PubMed: 9600841] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-5.
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M14358 Genomic DNA. Translation: AAA23950.1.
X17440 Genomic DNA. Translation: CAA35488.1.
U00096 Genomic DNA. Translation: AAC74990.1.
AP009048 Genomic DNA. Translation: BAA15751.1.
J01607 Genomic DNA. Translation: AAA92491.1.
PIRFLEC. A37249.
RefSeqAP_002538.1.
NP_416433.1.

3D structure databases

SMRP04949. Positions 57-453, 458-496.
ModBaseSearch...

Protein-protein interaction databases

STRINGP04949.

2-D gel databases

SWISS-2DPAGEP04949.

Proteomic databases

PRIDEP04949.

Genome annotation databases

GeneID949101.
GenomeReviewsGene locus JW1908 in contig AP009048_GR.
Gene locus b1923 in contig U00096_GR.
KEGGecj:JW1908.
eco:b1923.

Organism-specific databases

EchoBASEEB0317.
EcoGeneEG10321. fliC.
CMRSearch...

Phylogenomic databases

eggNOGCOG1344.
HOGENOMHBG758847.
OMAEINARDI.

Enzyme and pathway databases

BioCycEcoCyc:EG10321-MONOMER.
ECOL168927:B1923-MONOMER.
ReactomeREACT_6900. Signaling in Immune system.

Gene expression databases

GenevestigatorP04949.

Family and domain databases

InterProIPR001029. Flagellin_C.
IPR014981. Flagellin_D3.
IPR001492. Flagellin_N.
[Graphical view]
PfamPF00700. Flagellin_C. 1 hit.
PF08884. Flagellin_D3. 1 hit.
PF00669. Flagellin_N. 1 hit.
[Graphical view]
PRINTSPR00207. FLAGELLIN.
ProtoNetSearch...

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Entry information

Entry nameFLIC_ECOLI
AccessionPrimary (citable) accession number: P04949
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: January 19, 2010
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents