Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Flagellin

Gene

fliC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG10321-MONOMER.
ECOL316407:JW1908-MONOMER.
ReactomeiR-HSA-168176. Toll Like Receptor 5 (TLR5) Cascade.
R-HSA-5602680. MyD88 deficiency (TLR5).
R-HSA-5603037. IRAK4 deficiency (TLR5).
R-HSA-975871. MyD88 cascade initiated on plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellin
Gene namesi
Name:fliC
Synonyms:flaF, hag
Ordered Locus Names:b1923, JW1908
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10321. fliC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Bacterial flagellum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 498497FlagellinPRO_0000182560Add
BLAST

Proteomic databases

PaxDbiP04949.
PRIDEiP04949.

2D gel databases

SWISS-2DPAGEP04949.

Interactioni

Protein-protein interaction databases

BioGridi4259658. 6 interactions.
DIPiDIP-9649N.
IntActiP04949. 11 interactions.
STRINGi511145.b1923.

Structurei

3D structure databases

ProteinModelPortaliP04949.
SMRiP04949. Positions 44-221, 401-452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial flagellin family.Curated

Phylogenomic databases

eggNOGiENOG4105I03. Bacteria.
COG1344. LUCA.
HOGENOMiHOG000255144.
InParanoidiP04949.
KOiK02406.
OMAiRINHNIN.
OrthoDBiEOG6M9DVB.
PhylomeDBiP04949.

Family and domain databases

Gene3Di1.20.1330.10. 2 hits.
InterProiIPR001492. Flagellin.
IPR001029. Flagellin_D0/D1.
IPR014981. Flagellin_D3.
[Graphical view]
PfamiPF00700. Flagellin_C. 1 hit.
PF08884. Flagellin_D3. 1 hit.
PF00669. Flagellin_N. 1 hit.
[Graphical view]
PRINTSiPR00207. FLAGELLIN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVINTNSL SLITQNNINK NQSALSSSIE RLSSGLRINS AKDDAAGQAI
60 70 80 90 100
ANRFTSNIKG LTQAARNAND GISVAQTTEG ALSEINNNLQ RVRELTVQAT
110 120 130 140 150
TGTNSESDLS SIQDEIKSRL DEIDRVSGQT QFNGVNVLAK NGSMKIQVGA
160 170 180 190 200
NDNQTITIDL KQIDAKTLGL DGFSVKNNDT VTTSAPVTAF GATTTNNIKL
210 220 230 240 250
TGITLSTEAA TDTGGTNPAS IEGVYTDNGN DYYAKITGGD NDGKYYAVTV
260 270 280 290 300
ANDGTVTMAT GATANATVTD ANTTKATTIT SGGTPVQIDN TAGSATANLG
310 320 330 340 350
AVSLVKLQDS KGNDTDTYAL KDTNGNLYAA DVNETTGAVS VKTITYTDSS
360 370 380 390 400
GAASSPTAVK LGGDDGKTEV VDIDGKTYDS ADLNGGNLQT GLTAGGEALT
410 420 430 440 450
AVANGKTTDP LKALDDAIAS VDKFRSSLGA VQNRLDSAVT NLNNTTTNLS
460 470 480 490
EAQSRIQDAD YATEVSNMSK AQIIQQAGNS VLAKANQVPQ QVLSLLQG
Length:498
Mass (Da):51,295
Last modified:January 23, 2007 - v2
Checksum:i14A0ED3E68E326A1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti285 – 2851P → L in CAA35488 (PubMed:2659972).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14358 Genomic DNA. Translation: AAA23950.1.
X17440 Genomic DNA. Translation: CAA35488.1.
U00096 Genomic DNA. Translation: AAC74990.1.
AP009048 Genomic DNA. Translation: BAA15751.1.
J01607 Genomic DNA. Translation: AAA92491.1.
PIRiA37249. FLEC.
RefSeqiNP_416433.1. NC_000913.3.
WP_000079739.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74990; AAC74990; b1923.
BAA15751; BAA15751; BAA15751.
GeneIDi949101.
KEGGiecj:JW1908.
eco:b1923.
PATRICi32119181. VBIEscCol129921_2005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14358 Genomic DNA. Translation: AAA23950.1.
X17440 Genomic DNA. Translation: CAA35488.1.
U00096 Genomic DNA. Translation: AAC74990.1.
AP009048 Genomic DNA. Translation: BAA15751.1.
J01607 Genomic DNA. Translation: AAA92491.1.
PIRiA37249. FLEC.
RefSeqiNP_416433.1. NC_000913.3.
WP_000079739.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP04949.
SMRiP04949. Positions 44-221, 401-452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259658. 6 interactions.
DIPiDIP-9649N.
IntActiP04949. 11 interactions.
STRINGi511145.b1923.

2D gel databases

SWISS-2DPAGEP04949.

Proteomic databases

PaxDbiP04949.
PRIDEiP04949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74990; AAC74990; b1923.
BAA15751; BAA15751; BAA15751.
GeneIDi949101.
KEGGiecj:JW1908.
eco:b1923.
PATRICi32119181. VBIEscCol129921_2005.

Organism-specific databases

EchoBASEiEB0317.
EcoGeneiEG10321. fliC.

Phylogenomic databases

eggNOGiENOG4105I03. Bacteria.
COG1344. LUCA.
HOGENOMiHOG000255144.
InParanoidiP04949.
KOiK02406.
OMAiRINHNIN.
OrthoDBiEOG6M9DVB.
PhylomeDBiP04949.

Enzyme and pathway databases

BioCyciEcoCyc:EG10321-MONOMER.
ECOL316407:JW1908-MONOMER.
ReactomeiR-HSA-168176. Toll Like Receptor 5 (TLR5) Cascade.
R-HSA-5602680. MyD88 deficiency (TLR5).
R-HSA-5603037. IRAK4 deficiency (TLR5).
R-HSA-975871. MyD88 cascade initiated on plasma membrane.

Miscellaneous databases

PROiP04949.

Family and domain databases

Gene3Di1.20.1330.10. 2 hits.
InterProiIPR001492. Flagellin.
IPR001029. Flagellin_D0/D1.
IPR014981. Flagellin_D3.
[Graphical view]
PfamiPF00700. Flagellin_C. 1 hit.
PF08884. Flagellin_D3. 1 hit.
PF00669. Flagellin_N. 1 hit.
[Graphical view]
PRINTSiPR00207. FLAGELLIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the hag gene encoding flagellin of Escherichia coli."
    Kuwajima G., Asaka J., Fujiwara T., Fujiwara T., Node K., Kondo E.
    J. Bacteriol. 168:1479-1483(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Isolation and characterization of Escherichia coli hag operator mutants whose hag48 expression has become repressible by a Salmonella H1 repressor."
    Hanafusa T., Sakai A., Tominaga A., Enomoto M.
    Mol. Gen. Genet. 216:44-50(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "DNA sequence adjacent to flagellar genes and evolution of flagellar-phase variation."
    Szekely E., Simon M.
    J. Bacteriol. 155:74-81(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
  7. "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12."
    Link A.J., Robison K., Church G.M.
    Electrophoresis 18:1259-1313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-13.
    Strain: K12 / EMG2.
  8. Cited for: PROTEIN SEQUENCE OF 2-5.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiFLIC_ECOLI
AccessioniPrimary (citable) accession number: P04949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: January 20, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.