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Protein

Flagellin

Gene

fliC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyciEcoCyc:EG10321-MONOMER
ReactomeiR-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-5602680 MyD88 deficiency (TLR5)
R-HSA-5603037 IRAK4 deficiency (TLR5)
R-HSA-975871 MyD88 cascade initiated on plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellin
Gene namesi
Name:fliC
Synonyms:flaF, hag
Ordered Locus Names:b1923, JW1908
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10321 fliC

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Bacterial flagellum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001825602 – 498FlagellinAdd BLAST497

Proteomic databases

PaxDbiP04949
PRIDEiP04949

2D gel databases

SWISS-2DPAGEP04949

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
etpAQ29XT75EBI-1112859,EBI-15745451From Escherichia coli.

Protein-protein interaction databases

BioGridi4259658, 13 interactors
DIPiDIP-9649N
IntActiP04949, 12 interactors
STRINGi316407.1736591

Structurei

3D structure databases

ProteinModelPortaliP04949
SMRiP04949
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial flagellin family.Curated

Phylogenomic databases

eggNOGiENOG4105I03 Bacteria
COG1344 LUCA
HOGENOMiHOG000255144
InParanoidiP04949
KOiK02406
OMAiFEHTINN
PhylomeDBiP04949

Family and domain databases

InterProiView protein in InterPro
IPR001492 Flagellin
IPR001029 Flagellin_D0/D1
IPR014981 Flagellin_D3
PfamiView protein in Pfam
PF00700 Flagellin_C, 1 hit
PF08884 Flagellin_D3, 1 hit
PF00669 Flagellin_N, 1 hit
PRINTSiPR00207 FLAGELLIN

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVINTNSL SLITQNNINK NQSALSSSIE RLSSGLRINS AKDDAAGQAI
60 70 80 90 100
ANRFTSNIKG LTQAARNAND GISVAQTTEG ALSEINNNLQ RVRELTVQAT
110 120 130 140 150
TGTNSESDLS SIQDEIKSRL DEIDRVSGQT QFNGVNVLAK NGSMKIQVGA
160 170 180 190 200
NDNQTITIDL KQIDAKTLGL DGFSVKNNDT VTTSAPVTAF GATTTNNIKL
210 220 230 240 250
TGITLSTEAA TDTGGTNPAS IEGVYTDNGN DYYAKITGGD NDGKYYAVTV
260 270 280 290 300
ANDGTVTMAT GATANATVTD ANTTKATTIT SGGTPVQIDN TAGSATANLG
310 320 330 340 350
AVSLVKLQDS KGNDTDTYAL KDTNGNLYAA DVNETTGAVS VKTITYTDSS
360 370 380 390 400
GAASSPTAVK LGGDDGKTEV VDIDGKTYDS ADLNGGNLQT GLTAGGEALT
410 420 430 440 450
AVANGKTTDP LKALDDAIAS VDKFRSSLGA VQNRLDSAVT NLNNTTTNLS
460 470 480 490
EAQSRIQDAD YATEVSNMSK AQIIQQAGNS VLAKANQVPQ QVLSLLQG
Length:498
Mass (Da):51,295
Last modified:January 23, 2007 - v2
Checksum:i14A0ED3E68E326A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285P → L in CAA35488 (PubMed:2659972).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14358 Genomic DNA Translation: AAA23950.1
X17440 Genomic DNA Translation: CAA35488.1
U00096 Genomic DNA Translation: AAC74990.1
AP009048 Genomic DNA Translation: BAA15751.1
J01607 Genomic DNA Translation: AAA92491.1
PIRiA37249 FLEC
RefSeqiNP_416433.1, NC_000913.3
WP_000079739.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74990; AAC74990; b1923
BAA15751; BAA15751; BAA15751
GeneIDi949101
KEGGiecj:JW1908
eco:b1923
PATRICifig|1411691.4.peg.326

Similar proteinsi

Entry informationi

Entry nameiFLIC_ECOLI
AccessioniPrimary (citable) accession number: P04949
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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