P04940 (KV6A6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig kappa chain V-VI region NQ2-17.4.1
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function

Anti-2-phenyl oxazolone (PHOX) Antibody.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain
PTM	Disulfide bond
Technical term	Complete proteome Hybridoma Reference proteome
Gene Ontology (GO)
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›107	›107	Ig kappa chain V-VI region NQ2-17.4.1		PRO_0000059815
Regions
	Region	1 – 23	23	Framework-1
	Region	24 – 33	10	Complementarity-determining-1
	Region	34 – 48	15	Framework-2
	Region	49 – 55	7	Complementarity-determining-2
	Region	56 – 87	32	Framework-3
	Region	88 – 96	9	Complementarity-determining-3
	Region	97 – 106	10	Framework-4
Amino acid modifications
	Disulfide bond	23 ↔ 87		By similarity
Experimental info
	Non-terminal residue	107	1

Sequences

	Sequence		Length	Mass (Da)
	P04940 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 6F694284ECFA68E6	FASTA	107	11,561
	10 20 30 40 50 60 QIVLTQSPAI MSASPGQKVT MTCSASSSVS YMHWYQQKSG TSPKRWIYDT SKLASGVPAR 70 80 90 100 FSGSGSATSY SLTITSMQAE DAATYYCQQW SSNPLTFGAG TKLELKR

References

[1]	"mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification." Kaartinen M., Griffiths G.M., Markham A.F., Milstein C. Nature 304:320-324(1983) [PubMed: 6877353] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	K00735 mRNA. Translation: AAA38680.1.
IPI	IPI00462890.
PIR	B49049. PH1084.
3D structure databases
ProteinModelPortal	P04940.
SMR	P04940. Positions 1-107.
ModBase	Search...
Protein family/group databases
IMGT	Search...
Proteomic databases
PRIDE	P04940.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG018013.
Gene expression databases
Genevestigator	P04940.
GermOnline	ENSMUSG00000071393. Mus musculus.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KV6A6_MOUSE

Accession

Primary (citable) accession number: P04940

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	September 21, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program