##gff-version 3
P04925	UniProtKB	Signal peptide	1	22	.	.	.	Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2894984;Dbxref=PMID:2894984	
P04925	UniProtKB	Chain	23	230	.	.	.	ID=PRO_0000025697;Note=Major prion protein	
P04925	UniProtKB	Propeptide	231	254	.	.	.	ID=PRO_0000025698;Note=Removed in mature form;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04273	
P04925	UniProtKB	Repeat	51	58	.	.	.	Note=1	
P04925	UniProtKB	Repeat	59	66	.	.	.	Note=2	
P04925	UniProtKB	Repeat	67	74	.	.	.	Note=3	
P04925	UniProtKB	Repeat	75	82	.	.	.	Note=4	
P04925	UniProtKB	Repeat	83	90	.	.	.	Note=5	
P04925	UniProtKB	Region	23	231	.	.	.	Note=Interaction with GRB2%2C ERI3 and SYN1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11571277;Dbxref=PMID:11571277	
P04925	UniProtKB	Region	23	38	.	.	.	Note=Interaction with ADGRG6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27501152;Dbxref=PMID:27501152	
P04925	UniProtKB	Region	25	104	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P04925	UniProtKB	Region	51	90	.	.	.	Note=5 X 8 AA tandem repeats of P-H-G-G-G-W-G-Q	
P04925	UniProtKB	Binding site	60	60	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P04925	UniProtKB	Binding site	61	61	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P04925	UniProtKB	Binding site	62	62	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P04925	UniProtKB	Binding site	68	68	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P04925	UniProtKB	Binding site	69	69	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P04925	UniProtKB	Binding site	70	70	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P04925	UniProtKB	Binding site	76	76	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P04925	UniProtKB	Binding site	77	77	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P04925	UniProtKB	Binding site	78	78	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P04925	UniProtKB	Binding site	84	84	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P04925	UniProtKB	Binding site	85	85	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P04925	UniProtKB	Binding site	86	86	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04156	
P04925	UniProtKB	Modified residue	44	44	.	.	.	Note=Hydroxyproline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11032800;Dbxref=PMID:11032800	
P04925	UniProtKB	Lipidation	230	230	.	.	.	Note=GPI-anchor amidated serine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04273	
P04925	UniProtKB	Glycosylation	180	180	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P04925	UniProtKB	Glycosylation	196	196	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19349973;Dbxref=PMID:19349973	
P04925	UniProtKB	Disulfide bond	178	213	.	.	.	.	
P04925	UniProtKB	Natural variant	108	108	.	.	.	Note=Linked to long incubation time. L->F	
P04925	UniProtKB	Natural variant	189	189	.	.	.	Note=Linked to long incubation time%3B requires 2 nucleotide substitutions. T->V	
P04925	UniProtKB	Mutagenesis	101	101	.	.	.	Note=No effect on interaction with GRB2. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11571277;Dbxref=PMID:11571277	
P04925	UniProtKB	Mutagenesis	104	104	.	.	.	Note=No effect on interaction with GRB2. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11571277;Dbxref=PMID:11571277	
P04925	UniProtKB	Sequence conflict	133	133	.	.	.	Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P04925	UniProtKB	Beta strand	95	99	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8A00	
P04925	UniProtKB	Beta strand	106	112	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8A00	
P04925	UniProtKB	Beta strand	114	116	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8A00	
P04925	UniProtKB	Beta strand	119	121	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HER	
P04925	UniProtKB	Beta strand	124	128	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HER	
P04925	UniProtKB	Beta strand	132	134	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8A00	
P04925	UniProtKB	Beta strand	137	139	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7QIG	
P04925	UniProtKB	Helix	143	152	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HER	
P04925	UniProtKB	Helix	153	155	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HER	
P04925	UniProtKB	Beta strand	158	162	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8A00	
P04925	UniProtKB	Helix	165	167	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HER	
P04925	UniProtKB	Beta strand	168	170	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HER	
P04925	UniProtKB	Helix	171	188	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HER	
P04925	UniProtKB	Turn	192	194	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6AQ7	
P04925	UniProtKB	Helix	199	225	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6HER	
P04925	UniProtKB	Helix	226	228	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KU5