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Protein

Glycophorin-C

Gene

GYPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei8 – 81Not glycosylated; in variant Webb antigen

Keywords - Molecular functioni

Blood group antigen

Keywords - Ligandi

Sialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Glycophorin-C
Alternative name(s):
Glycoconnectin
Glycophorin-D
Short name:
GPD
Glycoprotein beta
PAS-2'
Sialoglycoprotein D
CD_antigen: CD236
Gene namesi
Name:GYPC
Synonyms:GLPC, GPC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4704. GYPC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757ExtracellularAdd
BLAST
Transmembranei58 – 8124Helical; Signal-anchor for type III membrane proteinAdd
BLAST
Topological domaini82 – 12847CytoplasmicAdd
BLAST

GO - Cellular componenti

  • cortical cytoskeleton Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi611162. phenotype.
616089. phenotype.
Orphaneti288. Hereditary elliptocytosis.
PharmGKBiPA29082.

Polymorphism and mutation databases

BioMutaiGYPC.
DMDMi121407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Glycophorin-CPRO_0000149050Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31O-linked (GalNAc...)2 Publications
Glycosylationi4 – 41O-linked (GalNAc...)2 Publications
Glycosylationi6 – 61O-linked (GalNAc...)2 Publications
Glycosylationi8 – 81N-linked (GlcNAc...)1 Publication
Glycosylationi9 – 91O-linked (GalNAc...)1 Publication
Glycosylationi10 – 101O-linked (GalNAc...)1 Publication
Glycosylationi15 – 151O-linked (GalNAc...)2 Publications
Glycosylationi24 – 241O-linked (GalNAc...)2 Publications
Glycosylationi26 – 261O-linked (GalNAc...)2 Publications
Glycosylationi27 – 271O-linked (GalNAc...)2 Publications
Glycosylationi28 – 281O-linked (GalNAc...)2 Publications
Glycosylationi31 – 311O-linked (GalNAc...)2 Publications
Glycosylationi32 – 321O-linked (GalNAc...)2 Publications
Glycosylationi33 – 331O-linked (GalNAc...)2 Publications
Glycosylationi42 – 421O-linked (GalNAc...)3 Publications
Modified residuei104 – 1041Phosphoserine1 Publication
Modified residuei122 – 1221Phosphoserine1 Publication

Post-translational modificationi

O-glycosylated with core 1 or possibly core 8 glycans.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP04921.
PRIDEiP04921.

PTM databases

PhosphoSiteiP04921.

Expressioni

Tissue specificityi

Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.1 Publication

Gene expression databases

BgeeiP04921.
CleanExiHS_GYPC.
GenevisibleiP04921. HS.

Organism-specific databases

HPAiCAB009445.
HPA008965.

Interactioni

Protein-protein interaction databases

BioGridi109250. 1 interaction.
IntActiP04921. 1 interaction.
MINTiMINT-1527497.
STRINGi9606.ENSP00000259254.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EJYNMR-B117-126[»]
ProteinModelPortaliP04921.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04921.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycophorin-C family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146330.
GeneTreeiENSGT00510000049102.
HOGENOMiHOG000112742.
HOVERGENiHBG094619.
InParanoidiP04921.
KOiK06576.
OMAiMHTTTIA.
OrthoDBiEOG7VDXSF.
PhylomeDBiP04921.
TreeFamiTF337016.

Family and domain databases

InterProiIPR001195. Glycophorin.
IPR003585. Neurexin-like.
[Graphical view]
PIRSFiPIRSF002466. Glycophorin. 1 hit.
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Glycophorin-C (identifier: P04921-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSTRSPNST AWPLSLEPDP GMASASTTMH TTTIAEPDPG MSGWPDGRME
60 70 80 90 100
TSTPTIMDIV VIAGVIAAVA IVLVSLLFVM LRYMYRHKGT YHTNEAKGTE
110 120
FAESADAALQ GDPALQDAGD SSRKEYFI
Length:128
Mass (Da):13,811
Last modified:August 13, 1987 - v1
Checksum:iC9C654009A5642D5
GO
Isoform Glycophorin-D (identifier: P04921-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:107
Mass (Da):11,499
Checksum:iB7D025DEF0555290
GO
Isoform 3 (identifier: P04921-3) [UniParc]FASTAAdd to basket

Also known as: IsoGPC

The sequence of this isoform differs from the canonical sequence as follows:
     18-36: Missing.

Show »
Length:109
Mass (Da):11,910
Checksum:i226D848E8D619180
GO

Sequence cautioni

The sequence CAA32093.1 differs from that shown. Reason: Frameshift at position 35. Curated

Polymorphismi

GYPC is responsible for the Gerbich blood group system (Ge) [MIMi:616089]. Ge negative individuals carry a deletion of GYPC exon 3.1 Publication
Deletion of exon 3 in GYPC results in resistance to Plasmodium falciparum invasion and protection against severe malaria [MIMi:611162].1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81N → S Polymorphism in Webb (WB) antigen. 1 Publication
VAR_003193
Natural varianti14 – 141L → F Polymorphism in Duch (DH(a)) antigen. 1 Publication
VAR_003194
Natural varianti23 – 231A → S Polymorphism in Ahonen (AN(a)) antigen. 1 Publication
VAR_003195
Natural varianti124 – 1241K → E.1 Publication
Corresponds to variant rs28370000 [ dbSNP | Ensembl ].
VAR_021342

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121Missing in isoform Glycophorin-D. CuratedVSP_001777Add
BLAST
Alternative sequencei18 – 3619Missing in isoform 3. 1 PublicationVSP_054790Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11802 mRNA. Translation: AAA60023.1.
M36284 mRNA. Translation: AAA52625.1.
X12496 mRNA. Translation: CAA31016.1.
M28335 mRNA. Translation: AAA52574.1.
X51973 mRNA. Translation: CAA36235.1.
AK312032 mRNA. Translation: BAG34969.1.
AY838876 Genomic DNA. Translation: AAV80423.1.
AC013474 Genomic DNA. Translation: AAY14660.1.
BC106051 mRNA. Translation: AAI06052.1.
BC104246 mRNA. Translation: AAI04247.1.
BC104247 mRNA. Translation: AAI04248.1.
X14242 Genomic DNA. Translation: CAA32458.1.
M29662 Genomic DNA. Translation: AAA52626.1.
X13890, X13892, X13893 Genomic DNA. Translation: CAA32093.1. Frameshift.
CCDSiCCDS2136.1. [P04921-1]
CCDS46402.1. [P04921-3]
CCDS58724.1. [P04921-2]
PIRiA92573. GFHUC.
RefSeqiNP_001243513.1. NM_001256584.1. [P04921-2]
NP_002092.1. NM_002101.4. [P04921-1]
NP_058131.1. NM_016815.3. [P04921-3]
UniGeneiHs.59138.

Genome annotation databases

EnsembliENST00000259254; ENSP00000259254; ENSG00000136732. [P04921-1]
ENST00000356887; ENSP00000349354; ENSG00000136732. [P04921-2]
ENST00000409836; ENSP00000386904; ENSG00000136732. [P04921-3]
GeneIDi2995.
KEGGihsa:2995.
UCSCiuc002tnq.4. human. [P04921-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Wikipedia

Glycophorin C entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11802 mRNA. Translation: AAA60023.1.
M36284 mRNA. Translation: AAA52625.1.
X12496 mRNA. Translation: CAA31016.1.
M28335 mRNA. Translation: AAA52574.1.
X51973 mRNA. Translation: CAA36235.1.
AK312032 mRNA. Translation: BAG34969.1.
AY838876 Genomic DNA. Translation: AAV80423.1.
AC013474 Genomic DNA. Translation: AAY14660.1.
BC106051 mRNA. Translation: AAI06052.1.
BC104246 mRNA. Translation: AAI04247.1.
BC104247 mRNA. Translation: AAI04248.1.
X14242 Genomic DNA. Translation: CAA32458.1.
M29662 Genomic DNA. Translation: AAA52626.1.
X13890, X13892, X13893 Genomic DNA. Translation: CAA32093.1. Frameshift.
CCDSiCCDS2136.1. [P04921-1]
CCDS46402.1. [P04921-3]
CCDS58724.1. [P04921-2]
PIRiA92573. GFHUC.
RefSeqiNP_001243513.1. NM_001256584.1. [P04921-2]
NP_002092.1. NM_002101.4. [P04921-1]
NP_058131.1. NM_016815.3. [P04921-3]
UniGeneiHs.59138.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EJYNMR-B117-126[»]
ProteinModelPortaliP04921.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109250. 1 interaction.
IntActiP04921. 1 interaction.
MINTiMINT-1527497.
STRINGi9606.ENSP00000259254.

PTM databases

PhosphoSiteiP04921.

Polymorphism and mutation databases

BioMutaiGYPC.
DMDMi121407.

Proteomic databases

PaxDbiP04921.
PRIDEiP04921.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259254; ENSP00000259254; ENSG00000136732. [P04921-1]
ENST00000356887; ENSP00000349354; ENSG00000136732. [P04921-2]
ENST00000409836; ENSP00000386904; ENSG00000136732. [P04921-3]
GeneIDi2995.
KEGGihsa:2995.
UCSCiuc002tnq.4. human. [P04921-1]

Organism-specific databases

CTDi2995.
GeneCardsiGC02P127413.
HGNCiHGNC:4704. GYPC.
HPAiCAB009445.
HPA008965.
MIMi110750. gene.
611162. phenotype.
616089. phenotype.
neXtProtiNX_P04921.
Orphaneti288. Hereditary elliptocytosis.
PharmGKBiPA29082.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146330.
GeneTreeiENSGT00510000049102.
HOGENOMiHOG000112742.
HOVERGENiHBG094619.
InParanoidiP04921.
KOiK06576.
OMAiMHTTTIA.
OrthoDBiEOG7VDXSF.
PhylomeDBiP04921.
TreeFamiTF337016.

Miscellaneous databases

ChiTaRSiGYPC. human.
EvolutionaryTraceiP04921.
GenomeRNAii2995.
NextBioi11870.
PROiP04921.
SOURCEiSearch...

Gene expression databases

BgeeiP04921.
CleanExiHS_GYPC.
GenevisibleiP04921. HS.

Family and domain databases

InterProiIPR001195. Glycophorin.
IPR003585. Neurexin-like.
[Graphical view]
PIRSFiPIRSF002466. Glycophorin. 1 hit.
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNA clones and complete amino acid sequence of human erythrocyte glycophorin C."
    Colin Y., Rahuel C., London J., Romeo P.-H., D'Auriol L., Galibert F., Cartron J.-P.
    J. Biol. Chem. 261:229-233(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GLYCOPHORIN-C).
  2. "Human erythrocyte membrane sialoglycoprotein beta. The cDNA sequence suggests the absence of a cleaved N-terminal signal sequence."
    High S., Tanner M.J.A.
    Biochem. J. 243:277-280(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GLYCOPHORIN-C).
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GLYCOPHORIN-C).
  4. "Gerbich blood group deficiency of the Ge:-1,-2,-3 and Ge:-1,-2,3 types. Immunochemical study and genomic analysis with cDNA probes."
    le van Kim C., Colin Y., Blanchard D., Dahr W., London J., Cartron J.-P.
    Eur. J. Biochem. 165:571-579(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GLYCOPHORIN-C).
    Tissue: Liver.
  5. "An ubiquitous isoform of glycophorin C is produced by alternative splicing."
    le van Kim C., Mitjavila M.T., Clerget M., Cartron J.-P., Colin Y.
    Nucleic Acids Res. 18:3076-3076(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    Tissue: Spleen.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GLYCOPHORIN-C).
  7. SeattleSNPs variation discovery resource
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-124.
  8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GLYCOPHORIN-C).
  10. "Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis."
    Blanchard D., Dahr W., Hummel M., Latron F., Beyreuther K., Cartron J.-P.
    J. Biol. Chem. 262:5808-5811(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 49-88.
  11. "Isolation and structural analysis of glycophorin C."
    Dahr W., Humel M., Blanchard D., Beyreuther K., Cartron J.-P.
    Biol. Chem. Hoppe-Seyler 366:777-778(1985)
    Cited for: PROTEIN SEQUENCE OF 1-87.
    Tissue: Blood.
  12. "A revision of the N-terminal structure of sialoglycoprotein D (glycophorin C) from human erythrocyte membranes."
    Dahr W., Beyreuther K.
    Biol. Chem. Hoppe-Seyler 366:1067-1070(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-48.
    Tissue: Blood.
  13. "N-terminal amino acid sequence of sialoglycoprotein D (glycophorin C) from human erythrocyte membranes."
    Dahr W., Beyreuther K., Kordowicz M., Krueger J.
    Eur. J. Biochem. 125:57-62(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE OF 1-48, GLYCOSYLATION AT SER-3; THR-4; SER-6; ASN-8; SER-9; THR-10; SER-15; SER-24; SER-26; THR-27; THR-28; THR-31; THR-32; THR-33 AND SER-42.
    Tissue: Blood.
  14. "Structural homology between glycophorins C and D of human erythrocytes."
    El-Maliki B., Blanchard D., Dahr W., Beyreuther K., Cartron J.-P.
    Eur. J. Biochem. 183:639-643(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-91.
  15. "Structure of the promoter region and tissue specificity of the human glycophorin C gene."
    le van Kim C., Colin Y., Mitjavila M.T., Clerget M., Dubart A., Nakazawa M., Vainchenker W., Cartron J.-P.
    J. Biol. Chem. 264:20407-20414(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.
  16. "Rearrangements of the red-cell membrane glycophorin C (sialoglycoprotein beta) gene. A further study of alterations in the glycophorin C gene."
    High S., Tanner M.J.A., Macdonald E.N., Anstee D.J.
    Biochem. J. 262:47-54(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-128.
  17. "Human erythrocyte glycophorin C. Gene structure and rearrangement in genetic variants."
    Colin Y., le van Kim C., Tsapis A., Clerget M., D'Auriol L., London J., Galibert F., Cartron J.-P.
    J. Biol. Chem. 264:3773-3780(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE STRUCTURE.
  18. "Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations."
    Maier A.G., Duraisingh M.T., Reeder J.C., Patel S.S., Kazura J.W., Zimmerman P.A., Cowman A.F.
    Nat. Med. 9:87-92(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM, INVOLVEMENT IN PROTECTION AGAINST MALARIA.
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  20. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
    Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT SER-42, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  22. "Molecular characterization of erythrocyte glycophorin C variants."
    Chang S., Reid M.E., Conboy J., Kan Y.W., Mohandas N.
    Blood 77:644-648(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM, VARIANT SER-8.
  23. "Point mutation in the glycophorin C gene results in the expression of the blood group antigen Dha."
    King M.J., Avent N.D., Mallinson G., Reid M.E.
    Vox Sang. 63:56-58(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM, VARIANT PHE-14.
  24. "A point mutation in the GYPC gene results in the expression of the blood group Ana antigen on glycophorin D but not on glycophorin C: further evidence that glycophorin D is a product of the GYPC gene."
    Daniels G., King M.J., Avent N.D., Khalid G., Reid M.E., Mallinson G., Symthe J., Cedergren B.
    Blood 82:3198-3203(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM, VARIANT SER-23.

Entry informationi

Entry nameiGLPC_HUMAN
AccessioniPrimary (citable) accession number: P04921
Secondary accession number(s): B2R522, Q53SV9, Q92642
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 24, 2015
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.