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Protein

Glycophorin-C

Gene

GYPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei8 – 81Not glycosylated; in variant Webb antigen

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen

Keywords - Ligandi

Sialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Glycophorin-C
Alternative name(s):
Glycoconnectin
Glycophorin-D
Short name:
GPD
Glycoprotein beta
PAS-2'
Sialoglycoprotein D
CD_antigen: CD236
Gene namesi
Name:GYPC
Synonyms:GLPC, GPC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4704. GYPC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757ExtracellularAdd
BLAST
Transmembranei58 – 8124Helical; Signal-anchor for type III membrane proteinAdd
BLAST
Topological domaini82 – 12847CytoplasmicAdd
BLAST

GO - Cellular componenti

  • cortical cytoskeleton Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MalaCardsiGYPC.
MIMi611162. phenotype.
616089. phenotype.
Orphaneti288. Hereditary elliptocytosis.
PharmGKBiPA29082.

Polymorphism and mutation databases

BioMutaiGYPC.
DMDMi121407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Glycophorin-CPRO_0000149050Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31O-linked (GalNAc...)2 Publications
Glycosylationi4 – 41O-linked (GalNAc...)2 Publications
Glycosylationi6 – 61O-linked (GalNAc...)2 Publications
Glycosylationi8 – 81N-linked (GlcNAc...)1 Publication
Glycosylationi9 – 91O-linked (GalNAc...)1 Publication
Glycosylationi10 – 101O-linked (GalNAc...)1 Publication
Glycosylationi15 – 151O-linked (GalNAc...)2 Publications
Glycosylationi24 – 241O-linked (GalNAc...)2 Publications
Glycosylationi26 – 261O-linked (GalNAc...)2 Publications
Glycosylationi27 – 271O-linked (GalNAc...)2 Publications
Glycosylationi28 – 281O-linked (GalNAc...)2 Publications
Glycosylationi31 – 311O-linked (GalNAc...)2 Publications
Glycosylationi32 – 321O-linked (GalNAc...)2 Publications
Glycosylationi33 – 331O-linked (GalNAc...)2 Publications
Glycosylationi42 – 421O-linked (GalNAc...)3 Publications
Modified residuei104 – 1041PhosphoserineCombined sources
Modified residuei122 – 1221PhosphoserineCombined sources

Post-translational modificationi

O-glycosylated with core 1 or possibly core 8 glycans.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP04921.
PaxDbiP04921.
PeptideAtlasiP04921.
PRIDEiP04921.

PTM databases

iPTMnetiP04921.
PhosphoSiteiP04921.
UniCarbKBiP04921.

Expressioni

Tissue specificityi

Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000136732.
CleanExiHS_GYPC.
GenevisibleiP04921. HS.

Organism-specific databases

HPAiCAB009445.
HPA008965.

Interactioni

Protein-protein interaction databases

BioGridi109250. 1 interaction.
IntActiP04921. 1 interaction.
MINTiMINT-1527497.
STRINGi9606.ENSP00000259254.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EJYNMR-B117-126[»]
ProteinModelPortaliP04921.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04921.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycophorin-C family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2G2. Eukaryota.
ENOG410YT9G. LUCA.
GeneTreeiENSGT00510000049102.
HOGENOMiHOG000112742.
HOVERGENiHBG094619.
InParanoidiP04921.
KOiK06576.
OMAiMHTTTIA.
OrthoDBiEOG091G1481.
PhylomeDBiP04921.
TreeFamiTF337016.

Family and domain databases

InterProiIPR001195. Glycophorin.
IPR003585. Neurexin-like.
[Graphical view]
PIRSFiPIRSF002466. Glycophorin. 1 hit.
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Glycophorin-C (identifier: P04921-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSTRSPNST AWPLSLEPDP GMASASTTMH TTTIAEPDPG MSGWPDGRME
60 70 80 90 100
TSTPTIMDIV VIAGVIAAVA IVLVSLLFVM LRYMYRHKGT YHTNEAKGTE
110 120
FAESADAALQ GDPALQDAGD SSRKEYFI
Length:128
Mass (Da):13,811
Last modified:August 13, 1987 - v1
Checksum:iC9C654009A5642D5
GO
Isoform Glycophorin-D (identifier: P04921-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:107
Mass (Da):11,499
Checksum:iB7D025DEF0555290
GO
Isoform 3 (identifier: P04921-3) [UniParc]FASTAAdd to basket
Also known as: IsoGPC

The sequence of this isoform differs from the canonical sequence as follows:
     18-36: Missing.

Show »
Length:109
Mass (Da):11,910
Checksum:i226D848E8D619180
GO

Sequence cautioni

The sequence CAA32093 differs from that shown. Reason: Frameshift at position 35. Curated

Polymorphismi

GYPC is responsible for the Gerbich blood group system (Ge) [MIMi:616089]. Ge negative individuals carry a deletion of GYPC exon 3.1 Publication
Deletion of exon 3 in GYPC results in resistance to Plasmodium falciparum invasion and protection against severe malaria [MIMi:611162].1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81N → S Polymorphism; Webb (WB) antigen. 1 Publication
Corresponds to variant rs121912760 [ dbSNP | Ensembl ].
VAR_003193
Natural varianti14 – 141L → F Polymorphism; Duch (DH(a)) antigen. 1 Publication
Corresponds to variant rs121912761 [ dbSNP | Ensembl ].
VAR_003194
Natural varianti23 – 231A → S Polymorphism; Ahonen (AN(a)) antigen. 1 Publication
Corresponds to variant rs774359594 [ dbSNP | Ensembl ].
VAR_003195
Natural varianti124 – 1241K → E.1 Publication
Corresponds to variant rs28370000 [ dbSNP | Ensembl ].
VAR_021342

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121Missing in isoform Glycophorin-D. CuratedVSP_001777Add
BLAST
Alternative sequencei18 – 3619Missing in isoform 3. 1 PublicationVSP_054790Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11802 mRNA. Translation: AAA60023.1.
M36284 mRNA. Translation: AAA52625.1.
X12496 mRNA. Translation: CAA31016.1.
M28335 mRNA. Translation: AAA52574.1.
X51973 mRNA. Translation: CAA36235.1.
AK312032 mRNA. Translation: BAG34969.1.
AY838876 Genomic DNA. Translation: AAV80423.1.
AC013474 Genomic DNA. Translation: AAY14660.1.
BC106051 mRNA. Translation: AAI06052.1.
BC104246 mRNA. Translation: AAI04247.1.
BC104247 mRNA. Translation: AAI04248.1.
X14242 Genomic DNA. Translation: CAA32458.1.
M29662 Genomic DNA. Translation: AAA52626.1.
X13890, X13892, X13893 Genomic DNA. Translation: CAA32093.1. Frameshift.
CCDSiCCDS2136.1. [P04921-1]
CCDS46402.1. [P04921-3]
CCDS58724.1. [P04921-2]
PIRiA92573. GFHUC.
RefSeqiNP_001243513.1. NM_001256584.1. [P04921-2]
NP_002092.1. NM_002101.4. [P04921-1]
NP_058131.1. NM_016815.3. [P04921-3]
UniGeneiHs.59138.

Genome annotation databases

EnsembliENST00000259254; ENSP00000259254; ENSG00000136732. [P04921-1]
ENST00000356887; ENSP00000349354; ENSG00000136732. [P04921-2]
ENST00000409836; ENSP00000386904; ENSG00000136732. [P04921-3]
GeneIDi2995.
KEGGihsa:2995.
UCSCiuc002tnq.5. human. [P04921-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Wikipedia

Glycophorin C entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11802 mRNA. Translation: AAA60023.1.
M36284 mRNA. Translation: AAA52625.1.
X12496 mRNA. Translation: CAA31016.1.
M28335 mRNA. Translation: AAA52574.1.
X51973 mRNA. Translation: CAA36235.1.
AK312032 mRNA. Translation: BAG34969.1.
AY838876 Genomic DNA. Translation: AAV80423.1.
AC013474 Genomic DNA. Translation: AAY14660.1.
BC106051 mRNA. Translation: AAI06052.1.
BC104246 mRNA. Translation: AAI04247.1.
BC104247 mRNA. Translation: AAI04248.1.
X14242 Genomic DNA. Translation: CAA32458.1.
M29662 Genomic DNA. Translation: AAA52626.1.
X13890, X13892, X13893 Genomic DNA. Translation: CAA32093.1. Frameshift.
CCDSiCCDS2136.1. [P04921-1]
CCDS46402.1. [P04921-3]
CCDS58724.1. [P04921-2]
PIRiA92573. GFHUC.
RefSeqiNP_001243513.1. NM_001256584.1. [P04921-2]
NP_002092.1. NM_002101.4. [P04921-1]
NP_058131.1. NM_016815.3. [P04921-3]
UniGeneiHs.59138.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EJYNMR-B117-126[»]
ProteinModelPortaliP04921.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109250. 1 interaction.
IntActiP04921. 1 interaction.
MINTiMINT-1527497.
STRINGi9606.ENSP00000259254.

PTM databases

iPTMnetiP04921.
PhosphoSiteiP04921.
UniCarbKBiP04921.

Polymorphism and mutation databases

BioMutaiGYPC.
DMDMi121407.

Proteomic databases

EPDiP04921.
PaxDbiP04921.
PeptideAtlasiP04921.
PRIDEiP04921.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259254; ENSP00000259254; ENSG00000136732. [P04921-1]
ENST00000356887; ENSP00000349354; ENSG00000136732. [P04921-2]
ENST00000409836; ENSP00000386904; ENSG00000136732. [P04921-3]
GeneIDi2995.
KEGGihsa:2995.
UCSCiuc002tnq.5. human. [P04921-1]

Organism-specific databases

CTDi2995.
GeneCardsiGYPC.
HGNCiHGNC:4704. GYPC.
HPAiCAB009445.
HPA008965.
MalaCardsiGYPC.
MIMi110750. gene.
611162. phenotype.
616089. phenotype.
neXtProtiNX_P04921.
Orphaneti288. Hereditary elliptocytosis.
PharmGKBiPA29082.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2G2. Eukaryota.
ENOG410YT9G. LUCA.
GeneTreeiENSGT00510000049102.
HOGENOMiHOG000112742.
HOVERGENiHBG094619.
InParanoidiP04921.
KOiK06576.
OMAiMHTTTIA.
OrthoDBiEOG091G1481.
PhylomeDBiP04921.
TreeFamiTF337016.

Miscellaneous databases

ChiTaRSiGYPC. human.
EvolutionaryTraceiP04921.
GenomeRNAii2995.
PROiP04921.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136732.
CleanExiHS_GYPC.
GenevisibleiP04921. HS.

Family and domain databases

InterProiIPR001195. Glycophorin.
IPR003585. Neurexin-like.
[Graphical view]
PIRSFiPIRSF002466. Glycophorin. 1 hit.
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLPC_HUMAN
AccessioniPrimary (citable) accession number: P04921
Secondary accession number(s): B2R522, Q53SV9, Q92642
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 7, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.