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P04920

- B3A2_HUMAN

UniProt

P04920 - B3A2_HUMAN

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Protein

Anion exchange protein 2

Gene

SLC4A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plasma membrane anion exchange protein of wide distribution.

GO - Molecular functioni

  1. anion transmembrane transporter activity Source: ProtInc
  2. chloride transmembrane transporter activity Source: Ensembl
  3. inorganic anion exchanger activity Source: InterPro

GO - Biological processi

  1. anion transport Source: ProtInc
  2. bicarbonate transport Source: Reactome
  3. ion transport Source: Reactome
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_19298. Bicarbonate transporters.

Protein family/group databases

TCDBi2.A.31.1.2. the anion exchanger (ae) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 2
Short name:
AE 2
Short name:
Anion exchanger 2
Alternative name(s):
Non-erythroid band 3-like protein
Short name:
BND3L
Solute carrier family 4 member 2
Gene namesi
Name:SLC4A2
Synonyms:AE2, EPB3L1, HKB3, MPB3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:11028. SLC4A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 707707CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei708 – 73124HelicalSequence AnalysisAdd
BLAST
Transmembranei737 – 77438HelicalSequence AnalysisAdd
BLAST
Transmembranei784 – 81633HelicalSequence AnalysisAdd
BLAST
Transmembranei826 – 84722HelicalSequence AnalysisAdd
BLAST
Topological domaini848 – 90053ExtracellularSequence AnalysisAdd
BLAST
Transmembranei901 – 91818HelicalSequence AnalysisAdd
BLAST
Topological domaini919 – 93315CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei934 – 95421HelicalSequence AnalysisAdd
BLAST
Transmembranei988 – 101023HelicalSequence AnalysisAdd
BLAST
Transmembranei1036 – 105924HelicalSequence AnalysisAdd
BLAST
Transmembranei1091 – 113646HelicalSequence AnalysisAdd
BLAST
Transmembranei1163 – 119937HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. focal adhesion Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: UniProtKB
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35896.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12411241Anion exchange protein 2PRO_0000079215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131Phosphoserine1 Publication
Modified residuei132 – 1321Phosphoserine1 Publication
Modified residuei144 – 1441Phosphoserine1 Publication
Modified residuei170 – 1701PhosphoserineBy similarity
Modified residuei172 – 1721PhosphoserineBy similarity
Modified residuei173 – 1731Phosphoserine1 Publication
Modified residuei183 – 1831Phosphothreonine1 Publication
Modified residuei257 – 2571PhosphothreonineBy similarity
Modified residuei443 – 4431Phosphoserine1 Publication
Glycosylationi859 – 8591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi868 – 8681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi882 – 8821N-linked (GlcNAc...)Sequence Analysis
Lipidationi1173 – 11731S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP04920.
PaxDbiP04920.
PeptideAtlasiP04920.
PRIDEiP04920.

PTM databases

PhosphoSiteiP04920.

Expressioni

Gene expression databases

BgeeiP04920.
CleanExiHS_SLC4A2.
ExpressionAtlasiP04920. baseline and differential.
GenevestigatoriP04920.

Organism-specific databases

HPAiHPA019339.

Interactioni

Protein-protein interaction databases

BioGridi112413. 12 interactions.
IntActiP04920. 4 interactions.
STRINGi9606.ENSP00000311402.

Structurei

3D structure databases

ProteinModelPortaliP04920.
SMRiP04920. Positions 322-637, 692-733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni708 – 1241534Membrane (anion exchange)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 320316Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
GeneTreeiENSGT00760000119021.
HOVERGENiHBG004326.
InParanoidiP04920.
KOiK13855.
OMAiDREMKCL.
OrthoDBiEOG7TMZR0.
PhylomeDBiP04920.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform A (identifier: P04920-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSAPRRPAK GADSFCTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI
60 70 80 90 100
LQEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ
110 120 130 140 150
GPGRKPRRRP GASPTGETPT IEEGEEDEDE ASEAEGARAL TQPSPVSTPS
160 170 180 190 200
SVQFFLQEDD SADRKAERTS PSSPAPLPHQ EATPRASKGA QAGTQVEEAE
210 220 230 240 250
AEAVAVASGT AGGDDGGASG RPLPKAQPGH RSYNLQERRR IGSMTGAEQA
260 270 280 290 300
LLPRVPTDEI EAQTLATADL DLMKSHRFED VPGVRRHLVR KNAKGSTQSG
310 320 330 340 350
REGREPGPTP RARPRAPHKP HEVFVELNEL LLDKNQEPQW RETARWIKFE
360 370 380 390 400
EDVEEETERW GKPHVASLSF RSLLELRRTL AHGAVLLDLD QQTLPGVAHQ
410 420 430 440 450
VVEQMVISDQ IKAEDRANVL RALLLKHSHP SDEKDFSFPR NISAGSLGSL
460 470 480 490 500
LGHHHGQGAE SDPHVTEPLM GGVPETRLEV ERERELPPPA PPAGITRSKS
510 520 530 540 550
KHELKLLEKI PENAEATVVL VGCVEFLSRP TMAFVRLREA VELDAVLEVP
560 570 580 590 600
VPVRFLFLLL GPSSANMDYH EIGRSISTLM SDKQFHEAAY LADEREDLLT
610 620 630 640 650
AINAFLDCSV VLPPSEVQGE ELLRSVAHFQ RQMLKKREEQ GRLLPTGAGL
660 670 680 690 700
EPKSAQDKAL LQMVEAAGAA EDDPLRRTGR PFGGLIRDVR RRYPHYLSDF
710 720 730 740 750
RDALDPQCLA AVIFIYFAAL SPAITFGGLL GEKTQDLIGV SELIMSTALQ
760 770 780 790 800
GVVFCLLGAQ PLLVIGFSGP LLVFEEAFFS FCSSNHLEYL VGRVWIGFWL
810 820 830 840 850
VFLALLMVAL EGSFLVRFVS RFTQEIFAFL ISLIFIYETF YKLVKIFQEH
860 870 880 890 900
PLHGCSASNS SEVDGGENMT WAGARPTLGP GNRSLAGQSG QGKPRGQPNT
910 920 930 940 950
ALLSLVLMAG TFFIAFFLRK FKNSRFFPGR IRRVIGDFGV PIAILIMVLV
960 970 980 990 1000
DYSIEDTYTQ KLSVPSGFSV TAPEKRGWVI NPLGEKSPFP VWMMVASLLP
1010 1020 1030 1040 1050
AILVFILIFM ETQITTLIIS KKERMLQKGS GFHLDLLLIV AMGGICALFG
1060 1070 1080 1090 1100
LPWLAAATVR SVTHANALTV MSKAVAPGDK PKIQEVKEQR VTGLLVALLV
1110 1120 1130 1140 1150
GLSIVIGDLL RQIPLAVLFG IFLYMGVTSL NGIQFYERLH LLLMPPKHHP
1160 1170 1180 1190 1200
DVTYVKKVRT LRMHLFTALQ LLCLALLWAV MSTAASLAFP FILILTVPLR
1210 1220 1230 1240
MVVLTRIFTD REMKCLDANE AEPVFDEREG VDEYNEMPMP V
Length:1,241
Mass (Da):137,009
Last modified:January 24, 2006 - v4
Checksum:i35E32D9FC34DFB61
GO
Isoform B1 (identifier: P04920-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPAKGADSFCT → MTQ

Show »
Length:1,227
Mass (Da):135,606
Checksum:iBA59FBFDF46178F2
GO
Isoform 3 (identifier: P04920-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPAKGADSFCT → MDFLLRPQ

Note: No experimental confirmation available.

Show »
Length:1,232
Mass (Da):136,247
Checksum:iC57606D7CA9D34D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71R → L in CAA44067. (PubMed:1562608)Curated
Sequence conflicti68 – 681E → M in CAA44067. (PubMed:1562608)Curated
Sequence conflicti74 – 741H → R in CAA44067. (PubMed:1562608)Curated
Sequence conflicti92 – 921D → G in CAA44067. (PubMed:1562608)Curated
Sequence conflicti122 – 1221E → V in CAA44067. (PubMed:1562608)Curated
Sequence conflicti157 – 1571Q → R in CAA44067. (PubMed:1562608)Curated
Sequence conflicti248 – 2481E → R in CAA44067. (PubMed:1562608)Curated
Sequence conflicti399 – 3991Missing in CAA27556. (PubMed:3015590)Curated
Sequence conflicti447 – 4471L → V in CAA44067. (PubMed:1562608)Curated
Sequence conflicti450 – 47526LLGHH…GGVPE → CWGITMVRGLRVTPTSPSLS WEVFLR in CAA27556. (PubMed:3015590)CuratedAdd
BLAST
Sequence conflicti485 – 4862EL → DV in CAA44067. (PubMed:1562608)Curated
Sequence conflicti485 – 4862EL → DV in CAA27556. (PubMed:3015590)Curated
Sequence conflicti571 – 5711E → K in BAG58592. (PubMed:14702039)Curated
Sequence conflicti666 – 68116AAGAA…RTGRP → RQGQLKMIPSADGAA in CAA44067. (PubMed:1562608)CuratedAdd
BLAST
Sequence conflicti666 – 68116AAGAA…RTGRP → RQGQLKMIPSADGAA in CAA27556. (PubMed:3015590)CuratedAdd
BLAST
Sequence conflicti824 – 8241Q → R in CAA44067. (PubMed:1562608)Curated
Sequence conflicti824 – 8241Q → R in CAA27556. (PubMed:3015590)Curated
Sequence conflicti902 – 9021L → P in CAA44067. (PubMed:1562608)Curated
Sequence conflicti902 – 9021L → P in CAA27556. (PubMed:3015590)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261G → E.1 Publication
Corresponds to variant rs2303929 [ dbSNP | Ensembl ].
VAR_025168
Natural varianti202 – 2021E → V.1 Publication
Corresponds to variant rs2229551 [ dbSNP | Ensembl ].
VAR_025169
Natural varianti208 – 2081S → T.
Corresponds to variant rs2229552 [ dbSNP | Ensembl ].
VAR_048349
Natural varianti311 – 3111R → W.1 Publication
Corresponds to variant rs35016052 [ dbSNP | Ensembl ].
VAR_025170
Natural varianti1204 – 12041L → F.1 Publication
Corresponds to variant rs34918764 [ dbSNP | Ensembl ].
VAR_025171

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717MSSAP…DSFCT → MDFLLRPQ in isoform 3. 1 PublicationVSP_045953Add
BLAST
Alternative sequencei1 – 1717MSSAP…DSFCT → MTQ in isoform B1. 1 PublicationVSP_000456Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62137 mRNA. Translation: CAA44067.1.
DQ149844 Genomic DNA. Translation: AAZ38724.1.
AK295767 mRNA. Translation: BAG58592.1.
AK312699 mRNA. Translation: BAG35577.1.
AC010973 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54046.1.
CH471173 Genomic DNA. Translation: EAW54047.1.
BC009386 mRNA. Translation: AAH09386.1.
BC009434 mRNA. Translation: AAH09434.1.
X03918 mRNA. Translation: CAA27556.1.
CCDSiCCDS56520.1. [P04920-3]
CCDS56521.1. [P04920-2]
CCDS5917.1. [P04920-1]
PIRiS21086.
RefSeqiNP_001186621.1. NM_001199692.1. [P04920-1]
NP_001186622.1. NM_001199693.1. [P04920-3]
NP_001186623.1. NM_001199694.1. [P04920-2]
NP_003031.3. NM_003040.3. [P04920-1]
UniGeneiHs.647069.

Genome annotation databases

EnsembliENST00000392826; ENSP00000376571; ENSG00000164889. [P04920-3]
ENST00000413384; ENSP00000405600; ENSG00000164889. [P04920-1]
ENST00000461735; ENSP00000419164; ENSG00000164889. [P04920-2]
ENST00000485713; ENSP00000419412; ENSG00000164889. [P04920-1]
GeneIDi6522.
KEGGihsa:6522.
UCSCiuc003wit.4. human. [P04920-1]
uc003wiu.4. human. [P04920-2]

Polymorphism databases

DMDMi85687559.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62137 mRNA. Translation: CAA44067.1 .
DQ149844 Genomic DNA. Translation: AAZ38724.1 .
AK295767 mRNA. Translation: BAG58592.1 .
AK312699 mRNA. Translation: BAG35577.1 .
AC010973 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54046.1 .
CH471173 Genomic DNA. Translation: EAW54047.1 .
BC009386 mRNA. Translation: AAH09386.1 .
BC009434 mRNA. Translation: AAH09434.1 .
X03918 mRNA. Translation: CAA27556.1 .
CCDSi CCDS56520.1. [P04920-3 ]
CCDS56521.1. [P04920-2 ]
CCDS5917.1. [P04920-1 ]
PIRi S21086.
RefSeqi NP_001186621.1. NM_001199692.1. [P04920-1 ]
NP_001186622.1. NM_001199693.1. [P04920-3 ]
NP_001186623.1. NM_001199694.1. [P04920-2 ]
NP_003031.3. NM_003040.3. [P04920-1 ]
UniGenei Hs.647069.

3D structure databases

ProteinModelPortali P04920.
SMRi P04920. Positions 322-637, 692-733.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112413. 12 interactions.
IntActi P04920. 4 interactions.
STRINGi 9606.ENSP00000311402.

Protein family/group databases

TCDBi 2.A.31.1.2. the anion exchanger (ae) family.

PTM databases

PhosphoSitei P04920.

Polymorphism databases

DMDMi 85687559.

Proteomic databases

MaxQBi P04920.
PaxDbi P04920.
PeptideAtlasi P04920.
PRIDEi P04920.

Protocols and materials databases

DNASUi 6522.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000392826 ; ENSP00000376571 ; ENSG00000164889 . [P04920-3 ]
ENST00000413384 ; ENSP00000405600 ; ENSG00000164889 . [P04920-1 ]
ENST00000461735 ; ENSP00000419164 ; ENSG00000164889 . [P04920-2 ]
ENST00000485713 ; ENSP00000419412 ; ENSG00000164889 . [P04920-1 ]
GeneIDi 6522.
KEGGi hsa:6522.
UCSCi uc003wit.4. human. [P04920-1 ]
uc003wiu.4. human. [P04920-2 ]

Organism-specific databases

CTDi 6522.
GeneCardsi GC07P150754.
HGNCi HGNC:11028. SLC4A2.
HPAi HPA019339.
MIMi 109280. gene.
neXtProti NX_P04920.
PharmGKBi PA35896.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG268067.
GeneTreei ENSGT00760000119021.
HOVERGENi HBG004326.
InParanoidi P04920.
KOi K13855.
OMAi DREMKCL.
OrthoDBi EOG7TMZR0.
PhylomeDBi P04920.
TreeFami TF313630.

Enzyme and pathway databases

Reactomei REACT_19298. Bicarbonate transporters.

Miscellaneous databases

ChiTaRSi SLC4A2. human.
GeneWikii SLC4A2.
GenomeRNAii 6522.
NextBioi 25371.
PROi P04920.
SOURCEi Search...

Gene expression databases

Bgeei P04920.
CleanExi HS_SLC4A2.
ExpressionAtlasi P04920. baseline and differential.
Genevestigatori P04920.

Family and domain databases

Gene3Di 3.40.1100.10. 1 hit.
InterProi IPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
PTHR11453:SF14. PTHR11453:SF14. 1 hit.
Pfami PF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view ]
PRINTSi PR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMi SSF55804. SSF55804. 2 hits.
TIGRFAMsi TIGR00834. ae. 1 hit.
PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney."
    Gehrig H., Mueller W., Appelhans H.
    Biochim. Biophys. Acta 1130:326-328(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
  2. NIEHS SNPs program
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-26; VAL-202; TRP-311 AND PHE-1204.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND 3).
    Tissue: Hippocampus.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B1).
    Tissue: Brain.
  7. "Cloning and structural characterization of a human non-erythroid band 3-like protein."
    Demuth D.R., Showe L.C., Ballantine M., Palumbo A., Fraser P.J., Cioe L., Rovera G., Curtis P.J.
    EMBO J. 5:1205-1214(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 375-1241.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; SER-132; SER-173 AND THR-183, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiB3A2_HUMAN
AccessioniPrimary (citable) accession number: P04920
Secondary accession number(s): B2R6T0
, B4DIT0, D3DX05, F8W682, Q45EY5, Q969L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 160 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3