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Protein

Anion exchange protein 2

Gene

SLC4A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plasma membrane anion exchange protein of wide distribution.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164889-MONOMER.
ReactomeiR-HSA-425381. Bicarbonate transporters.

Protein family/group databases

TCDBi2.A.31.1.2. the anion exchanger (ae) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 2
Short name:
AE 2
Short name:
Anion exchanger 2
Alternative name(s):
Non-erythroid band 3-like protein
Short name:
BND3L
Solute carrier family 4 member 2
Gene namesi
Name:SLC4A2
Synonyms:AE2, EPB3L1, HKB3, MPB3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11028. SLC4A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 707CytoplasmicSequence analysisAdd BLAST707
Transmembranei708 – 731HelicalSequence analysisAdd BLAST24
Transmembranei737 – 774HelicalSequence analysisAdd BLAST38
Transmembranei784 – 816HelicalSequence analysisAdd BLAST33
Transmembranei826 – 847HelicalSequence analysisAdd BLAST22
Topological domaini848 – 900ExtracellularSequence analysisAdd BLAST53
Transmembranei901 – 918HelicalSequence analysisAdd BLAST18
Topological domaini919 – 933CytoplasmicSequence analysisAdd BLAST15
Transmembranei934 – 954HelicalSequence analysisAdd BLAST21
Transmembranei988 – 1010HelicalSequence analysisAdd BLAST23
Transmembranei1036 – 1059HelicalSequence analysisAdd BLAST24
Transmembranei1091 – 1136HelicalSequence analysisAdd BLAST46
Transmembranei1163 – 1199HelicalSequence analysisAdd BLAST37

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • basolateral plasma membrane Source: Ensembl
  • focal adhesion Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6522.
OpenTargetsiENSG00000164889.
PharmGKBiPA35896.

Polymorphism and mutation databases

BioMutaiSLC4A2.
DMDMi85687559.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792151 – 1241Anion exchange protein 2Add BLAST1241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei170PhosphoserineBy similarity1
Modified residuei172PhosphoserineBy similarity1
Modified residuei173PhosphoserineCombined sources1
Modified residuei183PhosphothreonineCombined sources1
Modified residuei243PhosphoserineCombined sources1
Modified residuei257PhosphothreonineBy similarity1
Modified residuei274N6-methyllysineCombined sources1
Modified residuei301Omega-N-methylarginineBy similarity1
Modified residuei443PhosphoserineCombined sources1
Glycosylationi859N-linked (GlcNAc...)Sequence analysis1
Glycosylationi868N-linked (GlcNAc...)Sequence analysis1
Glycosylationi882N-linked (GlcNAc...)Sequence analysis1
Lipidationi1173S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

EPDiP04920.
MaxQBiP04920.
PaxDbiP04920.
PeptideAtlasiP04920.
PRIDEiP04920.

PTM databases

iPTMnetiP04920.
PhosphoSitePlusiP04920.
SwissPalmiP04920.

Expressioni

Gene expression databases

BgeeiENSG00000164889.
CleanExiHS_SLC4A2.
ExpressionAtlasiP04920. baseline and differential.
GenevisibleiP04920. HS.

Organism-specific databases

HPAiHPA019339.

Interactioni

Protein-protein interaction databases

BioGridi112413. 31 interactors.
IntActiP04920. 17 interactors.
STRINGi9606.ENSP00000405600.

Structurei

3D structure databases

ProteinModelPortaliP04920.
SMRiP04920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni708 – 1241Membrane (anion exchange)Add BLAST534

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 320Pro-richAdd BLAST316

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP04920.
KOiK13855.
OMAiANEHFHS.
OrthoDBiEOG091G01FT.
PhylomeDBiP04920.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF14. PTHR11453:SF14. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform A (identifier: P04920-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSAPRRPAK GADSFCTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI
60 70 80 90 100
LQEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ
110 120 130 140 150
GPGRKPRRRP GASPTGETPT IEEGEEDEDE ASEAEGARAL TQPSPVSTPS
160 170 180 190 200
SVQFFLQEDD SADRKAERTS PSSPAPLPHQ EATPRASKGA QAGTQVEEAE
210 220 230 240 250
AEAVAVASGT AGGDDGGASG RPLPKAQPGH RSYNLQERRR IGSMTGAEQA
260 270 280 290 300
LLPRVPTDEI EAQTLATADL DLMKSHRFED VPGVRRHLVR KNAKGSTQSG
310 320 330 340 350
REGREPGPTP RARPRAPHKP HEVFVELNEL LLDKNQEPQW RETARWIKFE
360 370 380 390 400
EDVEEETERW GKPHVASLSF RSLLELRRTL AHGAVLLDLD QQTLPGVAHQ
410 420 430 440 450
VVEQMVISDQ IKAEDRANVL RALLLKHSHP SDEKDFSFPR NISAGSLGSL
460 470 480 490 500
LGHHHGQGAE SDPHVTEPLM GGVPETRLEV ERERELPPPA PPAGITRSKS
510 520 530 540 550
KHELKLLEKI PENAEATVVL VGCVEFLSRP TMAFVRLREA VELDAVLEVP
560 570 580 590 600
VPVRFLFLLL GPSSANMDYH EIGRSISTLM SDKQFHEAAY LADEREDLLT
610 620 630 640 650
AINAFLDCSV VLPPSEVQGE ELLRSVAHFQ RQMLKKREEQ GRLLPTGAGL
660 670 680 690 700
EPKSAQDKAL LQMVEAAGAA EDDPLRRTGR PFGGLIRDVR RRYPHYLSDF
710 720 730 740 750
RDALDPQCLA AVIFIYFAAL SPAITFGGLL GEKTQDLIGV SELIMSTALQ
760 770 780 790 800
GVVFCLLGAQ PLLVIGFSGP LLVFEEAFFS FCSSNHLEYL VGRVWIGFWL
810 820 830 840 850
VFLALLMVAL EGSFLVRFVS RFTQEIFAFL ISLIFIYETF YKLVKIFQEH
860 870 880 890 900
PLHGCSASNS SEVDGGENMT WAGARPTLGP GNRSLAGQSG QGKPRGQPNT
910 920 930 940 950
ALLSLVLMAG TFFIAFFLRK FKNSRFFPGR IRRVIGDFGV PIAILIMVLV
960 970 980 990 1000
DYSIEDTYTQ KLSVPSGFSV TAPEKRGWVI NPLGEKSPFP VWMMVASLLP
1010 1020 1030 1040 1050
AILVFILIFM ETQITTLIIS KKERMLQKGS GFHLDLLLIV AMGGICALFG
1060 1070 1080 1090 1100
LPWLAAATVR SVTHANALTV MSKAVAPGDK PKIQEVKEQR VTGLLVALLV
1110 1120 1130 1140 1150
GLSIVIGDLL RQIPLAVLFG IFLYMGVTSL NGIQFYERLH LLLMPPKHHP
1160 1170 1180 1190 1200
DVTYVKKVRT LRMHLFTALQ LLCLALLWAV MSTAASLAFP FILILTVPLR
1210 1220 1230 1240
MVVLTRIFTD REMKCLDANE AEPVFDEREG VDEYNEMPMP V
Length:1,241
Mass (Da):137,009
Last modified:January 24, 2006 - v4
Checksum:i35E32D9FC34DFB61
GO
Isoform B1 (identifier: P04920-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPAKGADSFCT → MTQ

Show »
Length:1,227
Mass (Da):135,606
Checksum:iBA59FBFDF46178F2
GO
Isoform 3 (identifier: P04920-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPAKGADSFCT → MDFLLRPQ

Note: No experimental confirmation available.
Show »
Length:1,232
Mass (Da):136,247
Checksum:iC57606D7CA9D34D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7R → L in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti68E → M in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti74H → R in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti92D → G in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti122E → V in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti157Q → R in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti248E → R in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti399Missing in CAA27556 (PubMed:3015590).Curated1
Sequence conflicti447L → V in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti450 – 475LLGHH…GGVPE → CWGITMVRGLRVTPTSPSLS WEVFLR in CAA27556 (PubMed:3015590).CuratedAdd BLAST26
Sequence conflicti485 – 486EL → DV in CAA44067 (PubMed:1562608).Curated2
Sequence conflicti485 – 486EL → DV in CAA27556 (PubMed:3015590).Curated2
Sequence conflicti571E → K in BAG58592 (PubMed:14702039).Curated1
Sequence conflicti666 – 681AAGAA…RTGRP → RQGQLKMIPSADGAA in CAA44067 (PubMed:1562608).CuratedAdd BLAST16
Sequence conflicti666 – 681AAGAA…RTGRP → RQGQLKMIPSADGAA in CAA27556 (PubMed:3015590).CuratedAdd BLAST16
Sequence conflicti824Q → R in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti824Q → R in CAA27556 (PubMed:3015590).Curated1
Sequence conflicti902L → P in CAA44067 (PubMed:1562608).Curated1
Sequence conflicti902L → P in CAA27556 (PubMed:3015590).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02516826G → E.1 PublicationCorresponds to variant rs2303929dbSNPEnsembl.1
Natural variantiVAR_025169202E → V.1 PublicationCorresponds to variant rs2229551dbSNPEnsembl.1
Natural variantiVAR_048349208S → T.Corresponds to variant rs2229552dbSNPEnsembl.1
Natural variantiVAR_025170311R → W.1 PublicationCorresponds to variant rs35016052dbSNPEnsembl.1
Natural variantiVAR_0251711204L → F.1 PublicationCorresponds to variant rs34918764dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0459531 – 17MSSAP…DSFCT → MDFLLRPQ in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0004561 – 17MSSAP…DSFCT → MTQ in isoform B1. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62137 mRNA. Translation: CAA44067.1.
DQ149844 Genomic DNA. Translation: AAZ38724.1.
AK295767 mRNA. Translation: BAG58592.1.
AK312699 mRNA. Translation: BAG35577.1.
AC010973 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54046.1.
CH471173 Genomic DNA. Translation: EAW54047.1.
BC009386 mRNA. Translation: AAH09386.1.
BC009434 mRNA. Translation: AAH09434.1.
X03918 mRNA. Translation: CAA27556.1.
CCDSiCCDS56520.1. [P04920-3]
CCDS56521.1. [P04920-2]
CCDS5917.1. [P04920-1]
PIRiS21086.
RefSeqiNP_001186621.1. NM_001199692.1. [P04920-1]
NP_001186622.1. NM_001199693.1. [P04920-3]
NP_001186623.1. NM_001199694.1. [P04920-2]
NP_003031.3. NM_003040.3. [P04920-1]
UniGeneiHs.647069.

Genome annotation databases

EnsembliENST00000392826; ENSP00000376571; ENSG00000164889. [P04920-3]
ENST00000413384; ENSP00000405600; ENSG00000164889. [P04920-1]
ENST00000461735; ENSP00000419164; ENSG00000164889. [P04920-2]
ENST00000485713; ENSP00000419412; ENSG00000164889. [P04920-1]
GeneIDi6522.
KEGGihsa:6522.
UCSCiuc003wit.4. human. [P04920-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62137 mRNA. Translation: CAA44067.1.
DQ149844 Genomic DNA. Translation: AAZ38724.1.
AK295767 mRNA. Translation: BAG58592.1.
AK312699 mRNA. Translation: BAG35577.1.
AC010973 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54046.1.
CH471173 Genomic DNA. Translation: EAW54047.1.
BC009386 mRNA. Translation: AAH09386.1.
BC009434 mRNA. Translation: AAH09434.1.
X03918 mRNA. Translation: CAA27556.1.
CCDSiCCDS56520.1. [P04920-3]
CCDS56521.1. [P04920-2]
CCDS5917.1. [P04920-1]
PIRiS21086.
RefSeqiNP_001186621.1. NM_001199692.1. [P04920-1]
NP_001186622.1. NM_001199693.1. [P04920-3]
NP_001186623.1. NM_001199694.1. [P04920-2]
NP_003031.3. NM_003040.3. [P04920-1]
UniGeneiHs.647069.

3D structure databases

ProteinModelPortaliP04920.
SMRiP04920.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112413. 31 interactors.
IntActiP04920. 17 interactors.
STRINGi9606.ENSP00000405600.

Protein family/group databases

TCDBi2.A.31.1.2. the anion exchanger (ae) family.

PTM databases

iPTMnetiP04920.
PhosphoSitePlusiP04920.
SwissPalmiP04920.

Polymorphism and mutation databases

BioMutaiSLC4A2.
DMDMi85687559.

Proteomic databases

EPDiP04920.
MaxQBiP04920.
PaxDbiP04920.
PeptideAtlasiP04920.
PRIDEiP04920.

Protocols and materials databases

DNASUi6522.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392826; ENSP00000376571; ENSG00000164889. [P04920-3]
ENST00000413384; ENSP00000405600; ENSG00000164889. [P04920-1]
ENST00000461735; ENSP00000419164; ENSG00000164889. [P04920-2]
ENST00000485713; ENSP00000419412; ENSG00000164889. [P04920-1]
GeneIDi6522.
KEGGihsa:6522.
UCSCiuc003wit.4. human. [P04920-1]

Organism-specific databases

CTDi6522.
DisGeNETi6522.
GeneCardsiSLC4A2.
HGNCiHGNC:11028. SLC4A2.
HPAiHPA019339.
MIMi109280. gene.
neXtProtiNX_P04920.
OpenTargetsiENSG00000164889.
PharmGKBiPA35896.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000280683.
HOVERGENiHBG004326.
InParanoidiP04920.
KOiK13855.
OMAiANEHFHS.
OrthoDBiEOG091G01FT.
PhylomeDBiP04920.
TreeFamiTF313630.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164889-MONOMER.
ReactomeiR-HSA-425381. Bicarbonate transporters.

Miscellaneous databases

ChiTaRSiSLC4A2. human.
GeneWikiiSLC4A2.
GenomeRNAii6522.
PROiP04920.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164889.
CleanExiHS_SLC4A2.
ExpressionAtlasiP04920. baseline and differential.
GenevisibleiP04920. HS.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF14. PTHR11453:SF14. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3A2_HUMAN
AccessioniPrimary (citable) accession number: P04920
Secondary accession number(s): B2R6T0
, B4DIT0, D3DX05, F8W682, Q45EY5, Q969L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 24, 2006
Last modified: November 2, 2016
This is version 180 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.