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P04920

- B3A2_HUMAN

UniProt

P04920 - B3A2_HUMAN

Protein

Anion exchange protein 2

Gene

SLC4A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 4 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Plasma membrane anion exchange protein of wide distribution.

    GO - Molecular functioni

    1. anion transmembrane transporter activity Source: ProtInc
    2. chloride transmembrane transporter activity Source: Ensembl
    3. inorganic anion exchanger activity Source: InterPro

    GO - Biological processi

    1. anion transport Source: ProtInc
    2. bicarbonate transport Source: Reactome
    3. ion transport Source: Reactome
    4. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19298. Bicarbonate transporters.

    Protein family/group databases

    TCDBi2.A.31.1.2. the anion exchanger (ae) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anion exchange protein 2
    Short name:
    AE 2
    Short name:
    Anion exchanger 2
    Alternative name(s):
    Non-erythroid band 3-like protein
    Short name:
    BND3L
    Solute carrier family 4 member 2
    Gene namesi
    Name:SLC4A2
    Synonyms:AE2, EPB3L1, HKB3, MPB3L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:11028. SLC4A2.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35896.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12411241Anion exchange protein 2PRO_0000079215Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei113 – 1131Phosphoserine1 Publication
    Modified residuei132 – 1321Phosphoserine1 Publication
    Modified residuei144 – 1441Phosphoserine1 Publication
    Modified residuei170 – 1701PhosphoserineBy similarity
    Modified residuei172 – 1721PhosphoserineBy similarity
    Modified residuei173 – 1731Phosphoserine1 Publication
    Modified residuei183 – 1831Phosphothreonine1 Publication
    Modified residuei257 – 2571PhosphothreonineBy similarity
    Modified residuei443 – 4431Phosphoserine1 Publication
    Glycosylationi859 – 8591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi868 – 8681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi882 – 8821N-linked (GlcNAc...)Sequence Analysis
    Lipidationi1173 – 11731S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    MaxQBiP04920.
    PaxDbiP04920.
    PeptideAtlasiP04920.
    PRIDEiP04920.

    PTM databases

    PhosphoSiteiP04920.

    Expressioni

    Gene expression databases

    ArrayExpressiP04920.
    BgeeiP04920.
    CleanExiHS_SLC4A2.
    GenevestigatoriP04920.

    Organism-specific databases

    HPAiHPA019339.

    Interactioni

    Protein-protein interaction databases

    BioGridi112413. 2 interactions.
    IntActiP04920. 4 interactions.
    STRINGi9606.ENSP00000311402.

    Structurei

    3D structure databases

    ProteinModelPortaliP04920.
    SMRiP04920. Positions 322-637, 692-733.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 707707CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini848 – 90053ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini919 – 93315CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei708 – 73124HelicalSequence AnalysisAdd
    BLAST
    Transmembranei737 – 77438HelicalSequence AnalysisAdd
    BLAST
    Transmembranei784 – 81633HelicalSequence AnalysisAdd
    BLAST
    Transmembranei826 – 84722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei901 – 91818HelicalSequence AnalysisAdd
    BLAST
    Transmembranei934 – 95421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei988 – 101023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1036 – 105924HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1091 – 113646HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1163 – 119937HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni708 – 1241534Membrane (anion exchange)Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 320316Pro-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268067.
    HOVERGENiHBG004326.
    InParanoidiP04920.
    KOiK13855.
    OMAiDREMKCL.
    OrthoDBiEOG7TMZR0.
    PhylomeDBiP04920.
    TreeFamiTF313630.

    Family and domain databases

    Gene3Di3.40.1100.10. 1 hit.
    InterProiIPR001717. Anion_exchange.
    IPR002978. Anion_exchange_2.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF14. PTHR11453:SF14. 1 hit.
    PfamiPF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view]
    PRINTSiPR00165. ANIONEXCHNGR.
    PR01188. ANIONEXHNGR2.
    PR01231. HCO3TRNSPORT.
    SUPFAMiSSF55804. SSF55804. 2 hits.
    TIGRFAMsiTIGR00834. ae. 1 hit.
    PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform A (identifier: P04920-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSAPRRPAK GADSFCTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI     50
    LQEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ 100
    GPGRKPRRRP GASPTGETPT IEEGEEDEDE ASEAEGARAL TQPSPVSTPS 150
    SVQFFLQEDD SADRKAERTS PSSPAPLPHQ EATPRASKGA QAGTQVEEAE 200
    AEAVAVASGT AGGDDGGASG RPLPKAQPGH RSYNLQERRR IGSMTGAEQA 250
    LLPRVPTDEI EAQTLATADL DLMKSHRFED VPGVRRHLVR KNAKGSTQSG 300
    REGREPGPTP RARPRAPHKP HEVFVELNEL LLDKNQEPQW RETARWIKFE 350
    EDVEEETERW GKPHVASLSF RSLLELRRTL AHGAVLLDLD QQTLPGVAHQ 400
    VVEQMVISDQ IKAEDRANVL RALLLKHSHP SDEKDFSFPR NISAGSLGSL 450
    LGHHHGQGAE SDPHVTEPLM GGVPETRLEV ERERELPPPA PPAGITRSKS 500
    KHELKLLEKI PENAEATVVL VGCVEFLSRP TMAFVRLREA VELDAVLEVP 550
    VPVRFLFLLL GPSSANMDYH EIGRSISTLM SDKQFHEAAY LADEREDLLT 600
    AINAFLDCSV VLPPSEVQGE ELLRSVAHFQ RQMLKKREEQ GRLLPTGAGL 650
    EPKSAQDKAL LQMVEAAGAA EDDPLRRTGR PFGGLIRDVR RRYPHYLSDF 700
    RDALDPQCLA AVIFIYFAAL SPAITFGGLL GEKTQDLIGV SELIMSTALQ 750
    GVVFCLLGAQ PLLVIGFSGP LLVFEEAFFS FCSSNHLEYL VGRVWIGFWL 800
    VFLALLMVAL EGSFLVRFVS RFTQEIFAFL ISLIFIYETF YKLVKIFQEH 850
    PLHGCSASNS SEVDGGENMT WAGARPTLGP GNRSLAGQSG QGKPRGQPNT 900
    ALLSLVLMAG TFFIAFFLRK FKNSRFFPGR IRRVIGDFGV PIAILIMVLV 950
    DYSIEDTYTQ KLSVPSGFSV TAPEKRGWVI NPLGEKSPFP VWMMVASLLP 1000
    AILVFILIFM ETQITTLIIS KKERMLQKGS GFHLDLLLIV AMGGICALFG 1050
    LPWLAAATVR SVTHANALTV MSKAVAPGDK PKIQEVKEQR VTGLLVALLV 1100
    GLSIVIGDLL RQIPLAVLFG IFLYMGVTSL NGIQFYERLH LLLMPPKHHP 1150
    DVTYVKKVRT LRMHLFTALQ LLCLALLWAV MSTAASLAFP FILILTVPLR 1200
    MVVLTRIFTD REMKCLDANE AEPVFDEREG VDEYNEMPMP V 1241
    Length:1,241
    Mass (Da):137,009
    Last modified:January 24, 2006 - v4
    Checksum:i35E32D9FC34DFB61
    GO
    Isoform B1 (identifier: P04920-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-17: MSSAPRRPAKGADSFCT → MTQ

    Show »
    Length:1,227
    Mass (Da):135,606
    Checksum:iBA59FBFDF46178F2
    GO
    Isoform 3 (identifier: P04920-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-17: MSSAPRRPAKGADSFCT → MDFLLRPQ

    Note: No experimental confirmation available.

    Show »
    Length:1,232
    Mass (Da):136,247
    Checksum:iC57606D7CA9D34D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71R → L in CAA44067. (PubMed:1562608)Curated
    Sequence conflicti68 – 681E → M in CAA44067. (PubMed:1562608)Curated
    Sequence conflicti74 – 741H → R in CAA44067. (PubMed:1562608)Curated
    Sequence conflicti92 – 921D → G in CAA44067. (PubMed:1562608)Curated
    Sequence conflicti122 – 1221E → V in CAA44067. (PubMed:1562608)Curated
    Sequence conflicti157 – 1571Q → R in CAA44067. (PubMed:1562608)Curated
    Sequence conflicti248 – 2481E → R in CAA44067. (PubMed:1562608)Curated
    Sequence conflicti399 – 3991Missing in CAA27556. (PubMed:3015590)Curated
    Sequence conflicti447 – 4471L → V in CAA44067. (PubMed:1562608)Curated
    Sequence conflicti450 – 47526LLGHH…GGVPE → CWGITMVRGLRVTPTSPSLS WEVFLR in CAA27556. (PubMed:3015590)CuratedAdd
    BLAST
    Sequence conflicti485 – 4862EL → DV in CAA44067. (PubMed:1562608)Curated
    Sequence conflicti485 – 4862EL → DV in CAA27556. (PubMed:3015590)Curated
    Sequence conflicti571 – 5711E → K in BAG58592. (PubMed:14702039)Curated
    Sequence conflicti666 – 68116AAGAA…RTGRP → RQGQLKMIPSADGAA in CAA44067. (PubMed:1562608)CuratedAdd
    BLAST
    Sequence conflicti666 – 68116AAGAA…RTGRP → RQGQLKMIPSADGAA in CAA27556. (PubMed:3015590)CuratedAdd
    BLAST
    Sequence conflicti824 – 8241Q → R in CAA44067. (PubMed:1562608)Curated
    Sequence conflicti824 – 8241Q → R in CAA27556. (PubMed:3015590)Curated
    Sequence conflicti902 – 9021L → P in CAA44067. (PubMed:1562608)Curated
    Sequence conflicti902 – 9021L → P in CAA27556. (PubMed:3015590)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti26 – 261G → E.1 Publication
    Corresponds to variant rs2303929 [ dbSNP | Ensembl ].
    VAR_025168
    Natural varianti202 – 2021E → V.1 Publication
    Corresponds to variant rs2229551 [ dbSNP | Ensembl ].
    VAR_025169
    Natural varianti208 – 2081S → T.
    Corresponds to variant rs2229552 [ dbSNP | Ensembl ].
    VAR_048349
    Natural varianti311 – 3111R → W.1 Publication
    Corresponds to variant rs35016052 [ dbSNP | Ensembl ].
    VAR_025170
    Natural varianti1204 – 12041L → F.1 Publication
    Corresponds to variant rs34918764 [ dbSNP | Ensembl ].
    VAR_025171

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1717MSSAP…DSFCT → MDFLLRPQ in isoform 3. 1 PublicationVSP_045953Add
    BLAST
    Alternative sequencei1 – 1717MSSAP…DSFCT → MTQ in isoform B1. 1 PublicationVSP_000456Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62137 mRNA. Translation: CAA44067.1.
    DQ149844 Genomic DNA. Translation: AAZ38724.1.
    AK295767 mRNA. Translation: BAG58592.1.
    AK312699 mRNA. Translation: BAG35577.1.
    AC010973 Genomic DNA. No translation available.
    CH471173 Genomic DNA. Translation: EAW54046.1.
    CH471173 Genomic DNA. Translation: EAW54047.1.
    BC009386 mRNA. Translation: AAH09386.1.
    BC009434 mRNA. Translation: AAH09434.1.
    X03918 mRNA. Translation: CAA27556.1.
    CCDSiCCDS56520.1. [P04920-3]
    CCDS56521.1. [P04920-2]
    CCDS5917.1. [P04920-1]
    PIRiS21086.
    RefSeqiNP_001186621.1. NM_001199692.1. [P04920-1]
    NP_001186622.1. NM_001199693.1. [P04920-3]
    NP_001186623.1. NM_001199694.1. [P04920-2]
    NP_003031.3. NM_003040.3. [P04920-1]
    UniGeneiHs.647069.

    Genome annotation databases

    EnsembliENST00000392826; ENSP00000376571; ENSG00000164889. [P04920-3]
    ENST00000413384; ENSP00000405600; ENSG00000164889. [P04920-1]
    ENST00000461735; ENSP00000419164; ENSG00000164889. [P04920-2]
    ENST00000485713; ENSP00000419412; ENSG00000164889. [P04920-1]
    GeneIDi6522.
    KEGGihsa:6522.
    UCSCiuc003wit.4. human. [P04920-1]
    uc003wiu.4. human. [P04920-2]

    Polymorphism databases

    DMDMi85687559.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62137 mRNA. Translation: CAA44067.1 .
    DQ149844 Genomic DNA. Translation: AAZ38724.1 .
    AK295767 mRNA. Translation: BAG58592.1 .
    AK312699 mRNA. Translation: BAG35577.1 .
    AC010973 Genomic DNA. No translation available.
    CH471173 Genomic DNA. Translation: EAW54046.1 .
    CH471173 Genomic DNA. Translation: EAW54047.1 .
    BC009386 mRNA. Translation: AAH09386.1 .
    BC009434 mRNA. Translation: AAH09434.1 .
    X03918 mRNA. Translation: CAA27556.1 .
    CCDSi CCDS56520.1. [P04920-3 ]
    CCDS56521.1. [P04920-2 ]
    CCDS5917.1. [P04920-1 ]
    PIRi S21086.
    RefSeqi NP_001186621.1. NM_001199692.1. [P04920-1 ]
    NP_001186622.1. NM_001199693.1. [P04920-3 ]
    NP_001186623.1. NM_001199694.1. [P04920-2 ]
    NP_003031.3. NM_003040.3. [P04920-1 ]
    UniGenei Hs.647069.

    3D structure databases

    ProteinModelPortali P04920.
    SMRi P04920. Positions 322-637, 692-733.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112413. 2 interactions.
    IntActi P04920. 4 interactions.
    STRINGi 9606.ENSP00000311402.

    Protein family/group databases

    TCDBi 2.A.31.1.2. the anion exchanger (ae) family.

    PTM databases

    PhosphoSitei P04920.

    Polymorphism databases

    DMDMi 85687559.

    Proteomic databases

    MaxQBi P04920.
    PaxDbi P04920.
    PeptideAtlasi P04920.
    PRIDEi P04920.

    Protocols and materials databases

    DNASUi 6522.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000392826 ; ENSP00000376571 ; ENSG00000164889 . [P04920-3 ]
    ENST00000413384 ; ENSP00000405600 ; ENSG00000164889 . [P04920-1 ]
    ENST00000461735 ; ENSP00000419164 ; ENSG00000164889 . [P04920-2 ]
    ENST00000485713 ; ENSP00000419412 ; ENSG00000164889 . [P04920-1 ]
    GeneIDi 6522.
    KEGGi hsa:6522.
    UCSCi uc003wit.4. human. [P04920-1 ]
    uc003wiu.4. human. [P04920-2 ]

    Organism-specific databases

    CTDi 6522.
    GeneCardsi GC07P150754.
    HGNCi HGNC:11028. SLC4A2.
    HPAi HPA019339.
    MIMi 109280. gene.
    neXtProti NX_P04920.
    PharmGKBi PA35896.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG268067.
    HOVERGENi HBG004326.
    InParanoidi P04920.
    KOi K13855.
    OMAi DREMKCL.
    OrthoDBi EOG7TMZR0.
    PhylomeDBi P04920.
    TreeFami TF313630.

    Enzyme and pathway databases

    Reactomei REACT_19298. Bicarbonate transporters.

    Miscellaneous databases

    ChiTaRSi SLC4A2. human.
    GeneWikii SLC4A2.
    GenomeRNAii 6522.
    NextBioi 25371.
    PROi P04920.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P04920.
    Bgeei P04920.
    CleanExi HS_SLC4A2.
    Genevestigatori P04920.

    Family and domain databases

    Gene3Di 3.40.1100.10. 1 hit.
    InterProi IPR001717. Anion_exchange.
    IPR002978. Anion_exchange_2.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    PTHR11453:SF14. PTHR11453:SF14. 1 hit.
    Pfami PF07565. Band_3_cyto. 1 hit.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view ]
    PRINTSi PR00165. ANIONEXCHNGR.
    PR01188. ANIONEXHNGR2.
    PR01231. HCO3TRNSPORT.
    SUPFAMi SSF55804. SSF55804. 2 hits.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney."
      Gehrig H., Mueller W., Appelhans H.
      Biochim. Biophys. Acta 1130:326-328(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    2. NIEHS SNPs program
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-26; VAL-202; TRP-311 AND PHE-1204.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND 3).
      Tissue: Hippocampus.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B1).
      Tissue: Brain.
    7. "Cloning and structural characterization of a human non-erythroid band 3-like protein."
      Demuth D.R., Showe L.C., Ballantine M., Palumbo A., Fraser P.J., Cioe L., Rovera G., Curtis P.J.
      EMBO J. 5:1205-1214(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 375-1241.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; SER-132; SER-173 AND THR-183, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiB3A2_HUMAN
    AccessioniPrimary (citable) accession number: P04920
    Secondary accession number(s): B2R6T0
    , B4DIT0, D3DX05, F8W682, Q45EY5, Q969L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 159 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3