P04920 (B3A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anion exchange protein 2
Short name=AE 2
Short name=Anion exchanger 2

Alternative name(s):
Non-erythroid band 3-like protein
Short name=BND3L
Solute carrier family 4 member 2

Gene names

Name:	SLC4A2
Synonyms:	AE2, EPB3L1, HKB3, MPB3L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1241 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plasma membrane anion exchange protein of wide distribution.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Ontologies

Keywords
Biological process	Anion exchange Antiport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bicarbonate transport Traceable author statement. Source: Reactome
Cellular_component	basolateral plasma membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	anion transmembrane transporter activity Traceable author statement Ref.7. Source: ProtInc chloride transmembrane transporter activity Inferred from electronic annotation. Source: Compara inorganic anion exchanger activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform A (identifier: P04920-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B1 (identifier: P04920-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPAKGADSFCT → MTQ

Isoform 3 (identifier: P04920-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSSAPRRPAKGADSFCT → MDFLLRPQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1241	1241	Anion exchange protein 2		PRO_0000079215
Regions
	Topological domain	1 – 707	707	Cytoplasmic Potential
	Transmembrane	708 – 731	24	Helical; Potential
	Transmembrane	737 – 774	38	Helical; Potential
	Transmembrane	784 – 816	33	Helical; Potential
	Transmembrane	826 – 847	22	Helical; Potential
	Topological domain	848 – 900	53	Extracellular Potential
	Transmembrane	901 – 918	18	Helical; Potential
	Topological domain	919 – 933	15	Cytoplasmic Potential
	Transmembrane	934 – 954	21	Helical; Potential
	Transmembrane	988 – 1010	23	Helical; Potential
	Transmembrane	1036 – 1059	24	Helical; Potential
	Transmembrane	1091 – 1136	46	Helical; Potential
	Transmembrane	1163 – 1199	37	Helical; Potential
	Region	708 – 1241	534	Membrane (anion exchange)
	Compositional bias	5 – 320	316	Pro-rich
Amino acid modifications
	Modified residue	113	1	Phosphoserine Ref.9
	Modified residue	132	1	Phosphoserine Ref.9
	Modified residue	144	1	Phosphoserine Ref.10
	Modified residue	173	1	Phosphoserine Ref.9
	Modified residue	183	1	Phosphothreonine Ref.9
	Modified residue	443	1	Phosphoserine Ref.12
	Lipidation	1173	1	S-palmitoyl cysteine By similarity
	Glycosylation	859	1	N-linked (GlcNAc...) Potential
	Glycosylation	868	1	N-linked (GlcNAc...) Potential
	Glycosylation	882	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 17	17	MSSAP…DSFCT → MDFLLRPQ in isoform 3.		VSP_045953
	Alternative sequence	1 – 17	17	MSSAP…DSFCT → MTQ in isoform B1.		VSP_000456
	Natural variant	26	1	G → E. Ref.2 Corresponds to variant rs2303929 [ dbSNP | Ensembl ].		VAR_025168
	Natural variant	202	1	E → V. Ref.2 Corresponds to variant rs2229551 [ dbSNP | Ensembl ].		VAR_025169
	Natural variant	208	1	S → T. Corresponds to variant rs2229552 [ dbSNP | Ensembl ].		VAR_048349
	Natural variant	311	1	R → W. Ref.2 Corresponds to variant rs35016052 [ dbSNP | Ensembl ].		VAR_025170
	Natural variant	1204	1	L → F. Ref.2 Corresponds to variant rs34918764 [ dbSNP | Ensembl ].		VAR_025171
Experimental info
	Sequence conflict	7	1	R → L in CAA44067. Ref.1
	Sequence conflict	68	1	E → M in CAA44067. Ref.1
	Sequence conflict	74	1	H → R in CAA44067. Ref.1
	Sequence conflict	92	1	D → G in CAA44067. Ref.1
	Sequence conflict	122	1	E → V in CAA44067. Ref.1
	Sequence conflict	157	1	Q → R in CAA44067. Ref.1
	Sequence conflict	248	1	E → R in CAA44067. Ref.1
	Sequence conflict	399	1	Missing in CAA27556. Ref.7
	Sequence conflict	447	1	L → V in CAA44067. Ref.1
	Sequence conflict	450 – 475	26	LLGHH…GGVPE → CWGITMVRGLRVTPTSPSLS WEVFLR in CAA27556. Ref.7
	Sequence conflict	485 – 486	2	EL → DV in CAA44067. Ref.1
	Sequence conflict	485 – 486	2	EL → DV in CAA27556. Ref.7
	Sequence conflict	571	1	E → K in BAG58592. Ref.3
	Sequence conflict	666 – 681	16	AAGAA…RTGRP → RQGQLKMIPSADGAA in CAA44067. Ref.1
	Sequence conflict	666 – 681	16	AAGAA…RTGRP → RQGQLKMIPSADGAA in CAA27556. Ref.7
	Sequence conflict	824	1	Q → R in CAA44067. Ref.1
	Sequence conflict	824	1	Q → R in CAA27556. Ref.7
	Sequence conflict	902	1	L → P in CAA44067. Ref.1
	Sequence conflict	902	1	L → P in CAA27556. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified January 24, 2006. Version 4. Checksum: 35E32D9FC34DFB61	FASTA	1,241	137,009
	10 20 30 40 50 60 MSSAPRRPAK GADSFCTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI LQEAGSRGGE 70 80 90 100 110 120 EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ GPGRKPRRRP GASPTGETPT 130 140 150 160 170 180 IEEGEEDEDE ASEAEGARAL TQPSPVSTPS SVQFFLQEDD SADRKAERTS PSSPAPLPHQ 190 200 210 220 230 240 EATPRASKGA QAGTQVEEAE AEAVAVASGT AGGDDGGASG RPLPKAQPGH RSYNLQERRR 250 260 270 280 290 300 IGSMTGAEQA LLPRVPTDEI EAQTLATADL DLMKSHRFED VPGVRRHLVR KNAKGSTQSG 310 320 330 340 350 360 REGREPGPTP RARPRAPHKP HEVFVELNEL LLDKNQEPQW RETARWIKFE EDVEEETERW 370 380 390 400 410 420 GKPHVASLSF RSLLELRRTL AHGAVLLDLD QQTLPGVAHQ VVEQMVISDQ IKAEDRANVL 430 440 450 460 470 480 RALLLKHSHP SDEKDFSFPR NISAGSLGSL LGHHHGQGAE SDPHVTEPLM GGVPETRLEV 490 500 510 520 530 540 ERERELPPPA PPAGITRSKS KHELKLLEKI PENAEATVVL VGCVEFLSRP TMAFVRLREA 550 560 570 580 590 600 VELDAVLEVP VPVRFLFLLL GPSSANMDYH EIGRSISTLM SDKQFHEAAY LADEREDLLT 610 620 630 640 650 660 AINAFLDCSV VLPPSEVQGE ELLRSVAHFQ RQMLKKREEQ GRLLPTGAGL EPKSAQDKAL 670 680 690 700 710 720 LQMVEAAGAA EDDPLRRTGR PFGGLIRDVR RRYPHYLSDF RDALDPQCLA AVIFIYFAAL 730 740 750 760 770 780 SPAITFGGLL GEKTQDLIGV SELIMSTALQ GVVFCLLGAQ PLLVIGFSGP LLVFEEAFFS 790 800 810 820 830 840 FCSSNHLEYL VGRVWIGFWL VFLALLMVAL EGSFLVRFVS RFTQEIFAFL ISLIFIYETF 850 860 870 880 890 900 YKLVKIFQEH PLHGCSASNS SEVDGGENMT WAGARPTLGP GNRSLAGQSG QGKPRGQPNT 910 920 930 940 950 960 ALLSLVLMAG TFFIAFFLRK FKNSRFFPGR IRRVIGDFGV PIAILIMVLV DYSIEDTYTQ 970 980 990 1000 1010 1020 KLSVPSGFSV TAPEKRGWVI NPLGEKSPFP VWMMVASLLP AILVFILIFM ETQITTLIIS 1030 1040 1050 1060 1070 1080 KKERMLQKGS GFHLDLLLIV AMGGICALFG LPWLAAATVR SVTHANALTV MSKAVAPGDK 1090 1100 1110 1120 1130 1140 PKIQEVKEQR VTGLLVALLV GLSIVIGDLL RQIPLAVLFG IFLYMGVTSL NGIQFYERLH 1150 1160 1170 1180 1190 1200 LLLMPPKHHP DVTYVKKVRT LRMHLFTALQ LLCLALLWAV MSTAASLAFP FILILTVPLR 1210 1220 1230 1240 MVVLTRIFTD REMKCLDANE AEPVFDEREG VDEYNEMPMP V
	Isoform B1 [UniParc]. Checksum: BA59FBFDF46178F2	FASTA	1,227	135,606
	10 20 30 40 50 60 MTQPEPESLG PGTPGFPEQE EDELHRTLGV ERFEEILQEA GSRGGEEPGR SYGEEDFEYH 70 80 90 100 110 120 RQSSHHIHHP LSTHLPPDAR RRKTPQGPGR KPRRRPGASP TGETPTIEEG EEDEDEASEA 130 140 150 160 170 180 EGARALTQPS PVSTPSSVQF FLQEDDSADR KAERTSPSSP APLPHQEATP RASKGAQAGT 190 200 210 220 230 240 QVEEAEAEAV AVASGTAGGD DGGASGRPLP KAQPGHRSYN LQERRRIGSM TGAEQALLPR 250 260 270 280 290 300 VPTDEIEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSTQSGREGR EPGPTPRARP 310 320 330 340 350 360 RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE EETERWGKPH VASLSFRSLL 370 380 390 400 410 420 ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ MVISDQIKAE DRANVLRALL LKHSHPSDEK 430 440 450 460 470 480 DFSFPRNISA GSLGSLLGHH HGQGAESDPH VTEPLMGGVP ETRLEVERER ELPPPAPPAG 490 500 510 520 530 540 ITRSKSKHEL KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR 550 560 570 580 590 600 FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE REDLLTAINA FLDCSVVLPP 610 620 630 640 650 660 SEVQGEELLR SVAHFQRQML KKREEQGRLL PTGAGLEPKS AQDKALLQMV EAAGAAEDDP 670 680 690 700 710 720 LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL DPQCLAAVIF IYFAALSPAI TFGGLLGEKT 730 740 750 760 770 780 QDLIGVSELI MSTALQGVVF CLLGAQPLLV IGFSGPLLVF EEAFFSFCSS NHLEYLVGRV 790 800 810 820 830 840 WIGFWLVFLA LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLV KIFQEHPLHG 850 860 870 880 890 900 CSASNSSEVD GGENMTWAGA RPTLGPGNRS LAGQSGQGKP RGQPNTALLS LVLMAGTFFI 910 920 930 940 950 960 AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI EDTYTQKLSV PSGFSVTAPE 970 980 990 1000 1010 1020 KRGWVINPLG EKSPFPVWMM VASLLPAILV FILIFMETQI TTLIISKKER MLQKGSGFHL 1030 1040 1050 1060 1070 1080 DLLLIVAMGG ICALFGLPWL AAATVRSVTH ANALTVMSKA VAPGDKPKIQ EVKEQRVTGL 1090 1100 1110 1120 1130 1140 LVALLVGLSI VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM PPKHHPDVTY 1150 1160 1170 1180 1190 1200 VKKVRTLRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL TRIFTDREMK 1210 1220 CLDANEAEPV FDEREGVDEY NEMPMPV
	Isoform 3 [UniParc]. Checksum: C57606D7CA9D34D2	FASTA	1,232	136,247
	10 20 30 40 50 60 MDFLLRPQPE PESLGPGTPG FPEQEEDELH RTLGVERFEE ILQEAGSRGG EEPGRSYGEE 70 80 90 100 110 120 DFEYHRQSSH HIHHPLSTHL PPDARRRKTP QGPGRKPRRR PGASPTGETP TIEEGEEDED 130 140 150 160 170 180 EASEAEGARA LTQPSPVSTP SSVQFFLQED DSADRKAERT SPSSPAPLPH QEATPRASKG 190 200 210 220 230 240 AQAGTQVEEA EAEAVAVASG TAGGDDGGAS GRPLPKAQPG HRSYNLQERR RIGSMTGAEQ 250 260 270 280 290 300 ALLPRVPTDE IEAQTLATAD LDLMKSHRFE DVPGVRRHLV RKNAKGSTQS GREGREPGPT 310 320 330 340 350 360 PRARPRAPHK PHEVFVELNE LLLDKNQEPQ WRETARWIKF EEDVEEETER WGKPHVASLS 370 380 390 400 410 420 FRSLLELRRT LAHGAVLLDL DQQTLPGVAH QVVEQMVISD QIKAEDRANV LRALLLKHSH 430 440 450 460 470 480 PSDEKDFSFP RNISAGSLGS LLGHHHGQGA ESDPHVTEPL MGGVPETRLE VERERELPPP 490 500 510 520 530 540 APPAGITRSK SKHELKLLEK IPENAEATVV LVGCVEFLSR PTMAFVRLRE AVELDAVLEV 550 560 570 580 590 600 PVPVRFLFLL LGPSSANMDY HEIGRSISTL MSDKQFHEAA YLADEREDLL TAINAFLDCS 610 620 630 640 650 660 VVLPPSEVQG EELLRSVAHF QRQMLKKREE QGRLLPTGAG LEPKSAQDKA LLQMVEAAGA 670 680 690 700 710 720 AEDDPLRRTG RPFGGLIRDV RRRYPHYLSD FRDALDPQCL AAVIFIYFAA LSPAITFGGL 730 740 750 760 770 780 LGEKTQDLIG VSELIMSTAL QGVVFCLLGA QPLLVIGFSG PLLVFEEAFF SFCSSNHLEY 790 800 810 820 830 840 LVGRVWIGFW LVFLALLMVA LEGSFLVRFV SRFTQEIFAF LISLIFIYET FYKLVKIFQE 850 860 870 880 890 900 HPLHGCSASN SSEVDGGENM TWAGARPTLG PGNRSLAGQS GQGKPRGQPN TALLSLVLMA 910 920 930 940 950 960 GTFFIAFFLR KFKNSRFFPG RIRRVIGDFG VPIAILIMVL VDYSIEDTYT QKLSVPSGFS 970 980 990 1000 1010 1020 VTAPEKRGWV INPLGEKSPF PVWMMVASLL PAILVFILIF METQITTLII SKKERMLQKG 1030 1040 1050 1060 1070 1080 SGFHLDLLLI VAMGGICALF GLPWLAAATV RSVTHANALT VMSKAVAPGD KPKIQEVKEQ 1090 1100 1110 1120 1130 1140 RVTGLLVALL VGLSIVIGDL LRQIPLAVLF GIFLYMGVTS LNGIQFYERL HLLLMPPKHH 1150 1160 1170 1180 1190 1200 PDVTYVKKVR TLRMHLFTAL QLLCLALLWA VMSTAASLAF PFILILTVPL RMVVLTRIFT 1210 1220 1230 DREMKCLDAN EAEPVFDERE GVDEYNEMPM PV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney." Gehrig H., Mueller W., Appelhans H. Biochim. Biophys. Acta 1130:326-328(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
[2]	NIEHS SNPs program Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-26; VAL-202; TRP-311 AND PHE-1204.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND 3). Tissue: Hippocampus.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B1). Tissue: Brain.
[7]	"Cloning and structural characterization of a human non-erythroid band 3-like protein." Demuth D.R., Showe L.C., Ballantine M., Palumbo A., Fraser P.J., Cioe L., Rovera G., Curtis P.J. EMBO J. 5:1205-1214(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 375-1241.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; SER-132; SER-173 AND THR-183, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	X62137 mRNA. Translation: CAA44067.1. DQ149844 Genomic DNA. Translation: AAZ38724.1. AK295767 mRNA. Translation: BAG58592.1. AK312699 mRNA. Translation: BAG35577.1. AC010973 Genomic DNA. No translation available. CH471173 Genomic DNA. Translation: EAW54046.1. CH471173 Genomic DNA. Translation: EAW54047.1. BC009386 mRNA. Translation: AAH09386.1. BC009434 mRNA. Translation: AAH09434.1. X03918 mRNA. Translation: CAA27556.1.
IPI	IPI00383597. IPI00477139. IPI00946699.
PIR	S21086.
RefSeq	NP_001186621.1. NM_001199692.1. NP_001186622.1. NM_001199693.1. NP_001186623.1. NM_001199694.1. NP_003031.3. NM_003040.3.
UniGene	Hs.647069.
3D structure databases
ProteinModelPortal	P04920.
ModBase	Search...
Protein-protein interaction databases
IntAct	P04920. 3 interactions.
STRING	9606.ENSP00000311402.
Protein family/group databases
TCDB	2.A.31.1.2. anion exchanger (AE) family.
PTM databases
PhosphoSite	P04920.
Polymorphism databases
DMDM	85687559.
Proteomic databases
PaxDb	P04920.
PeptideAtlas	P04920.
PRIDE	P04920.
Protocols and materials databases
DNASU	6522.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000392826; ENSP00000376571; ENSG00000164889. ENST00000413384; ENSP00000405600; ENSG00000164889. ENST00000461735; ENSP00000419164; ENSG00000164889. ENST00000485713; ENSP00000419412; ENSG00000164889.
GeneID	6522.
KEGG	hsa:6522.
UCSC	uc003wit.4. human. uc003wiu.4. human. uc011kve.2. human.
Organism-specific databases
CTD	6522.
GeneCards	GC07P150754.
HGNC	HGNC:11028. SLC4A2.
HPA	HPA019339.
MIM	109280. gene.
neXtProt	NX_P04920.
PharmGKB	PA35896.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG268067.
HOVERGEN	HBG004326.
InParanoid	P04920.
KO	K13855.
OMA	ALQGVIF.
OrthoDB	EOG4WDDB2.
PhylomeDB	P04920.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	P04920.
Bgee	P04920.
CleanEx	HS_SLC4A2.
Genevestigator	P04920.
GermOnline	ENSG00000164889. Homo sapiens.
Family and domain databases
Gene3D	3.40.1100.10. 1 hit.
InterPro	IPR001717. Anion_exchange. IPR002978. Anion_exchange_2. IPR018241. Anion_exchange_CS. IPR013769. Band3_cytoplasmic_dom. IPR011531. HCO3_transpt_C. IPR003020. HCO3_transpt_euk. IPR016152. PTrfase/Anion_transptr. [Graphical view]
PANTHER	PTHR11453. PTHR11453. 1 hit. PTHR11453:SF14. PTHR11453:SF14. 1 hit.
Pfam	PF07565. Band_3_cyto. 1 hit. PF00955. HCO3_cotransp. 1 hit. [Graphical view]
PRINTS	PR00165. ANIONEXCHNGR. PR01188. ANIONEXHNGR2. PR01231. HCO3TRNSPORT.
SUPFAM	SSF55804. PTrfase/Anion_transptr. 1 hit.
TIGRFAMs	TIGR00834. ae. 1 hit.
PROSITE	PS00219. ANION_EXCHANGER_1. 1 hit. PS00220. ANION_EXCHANGER_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC4A2. human.
GenomeRNAi	6522.
NextBio	25371.
SOURCE	Search...

Entry information

Entry name

B3A2_HUMAN

Accession

Primary (citable) accession number: P04920
Secondary accession number(s): B2R6T0 , B4DIT0, D3DX05, F8W682, Q45EY5, Q969L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	January 24, 2006
Last modified:	May 29, 2013
This is version 146 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.