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Protein

Serum amyloid A-3 protein

Gene

Saa3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Molecular functioni

  • chemoattractant activity Source: MGI
  • Toll-like receptor 4 binding Source: MGI

GO - Biological processi

  • acute-phase response Source: UniProtKB-KW
  • cell chemotaxis Source: MGI
  • cellular response to interleukin-1 Source: MGI
  • I-kappaB phosphorylation Source: MGI
  • response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Acute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-3 protein
Gene namesi
Name:Saa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98223. Saa3.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
  • high-density lipoprotein particle Source: UniProtKB-KW
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000003159120 – 122Serum amyloid A-3 proteinAdd BLAST103

Proteomic databases

MaxQBiP04918.
PaxDbiP04918.
PRIDEiP04918.

Expressioni

Tissue specificityi

Found in various tissues.

Inductioni

Upon cytokine stimulation.

Gene expression databases

BgeeiENSMUSG00000040026.
CleanExiMM_SAA3.
GenevisibleiP04918. MM.

Interactioni

GO - Molecular functioni

  • Toll-like receptor 4 binding Source: MGI

Protein-protein interaction databases

IntActiP04918. 1 interactor.
STRINGi10090.ENSMUSP00000006956.

Structurei

Secondary structure

1122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 45Combined sources25
Helixi51 – 64Combined sources14
Helixi67 – 85Combined sources19
Helixi94 – 105Combined sources12
Helixi110 – 113Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q5GX-ray2.06A/B19-122[»]
ProteinModelPortaliP04918.
SMRiP04918.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXU4. Eukaryota.
ENOG410YSBK. LUCA.
GeneTreeiENSGT00390000004737.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP04918.
KOiK17310.
OMAiANDSDKY.
OrthoDBiEOG091G17YH.
PhylomeDBiP04918.
TreeFamiTF332544.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSIAIILC ILILGVDSQR WVQFMKEAGQ GSRDMWRAYS DMKKANWKNS
60 70 80 90 100
DKYFHARGNY DAARRGPGGA WAAKVISDAR EAVQKFTGHG AEDSRADQFA
110 120
NEWGRSGKDP NHFRPAGLPK RY
Length:122
Mass (Da):13,774
Last modified:August 13, 1987 - v1
Checksum:iB9435F82D1B0B705
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57R → G in AAA40088 (PubMed:3624868).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03479 mRNA. Translation: CAA27199.1.
X03505, X03506, X03507 Genomic DNA. Translation: CAA27219.1.
BC055885 mRNA. Translation: AAH55885.1.
M25467 mRNA. Translation: AAA37231.1.
M17792 Genomic DNA. Translation: AAA40088.1.
CCDSiCCDS21282.1.
PIRiA23521.
I71950.
RefSeqiNP_035445.1. NM_011315.3.
UniGeneiMm.14277.

Genome annotation databases

EnsembliENSMUST00000006956; ENSMUSP00000006956; ENSMUSG00000040026.
GeneIDi20210.
KEGGimmu:20210.
UCSCiuc009gyw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03479 mRNA. Translation: CAA27199.1.
X03505, X03506, X03507 Genomic DNA. Translation: CAA27219.1.
BC055885 mRNA. Translation: AAH55885.1.
M25467 mRNA. Translation: AAA37231.1.
M17792 Genomic DNA. Translation: AAA40088.1.
CCDSiCCDS21282.1.
PIRiA23521.
I71950.
RefSeqiNP_035445.1. NM_011315.3.
UniGeneiMm.14277.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q5GX-ray2.06A/B19-122[»]
ProteinModelPortaliP04918.
SMRiP04918.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04918. 1 interactor.
STRINGi10090.ENSMUSP00000006956.

Proteomic databases

MaxQBiP04918.
PaxDbiP04918.
PRIDEiP04918.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006956; ENSMUSP00000006956; ENSMUSG00000040026.
GeneIDi20210.
KEGGimmu:20210.
UCSCiuc009gyw.1. mouse.

Organism-specific databases

CTDi20210.
MGIiMGI:98223. Saa3.

Phylogenomic databases

eggNOGiENOG410IXU4. Eukaryota.
ENOG410YSBK. LUCA.
GeneTreeiENSGT00390000004737.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP04918.
KOiK17310.
OMAiANDSDKY.
OrthoDBiEOG091G17YH.
PhylomeDBiP04918.
TreeFamiTF332544.

Miscellaneous databases

PROiP04918.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040026.
CleanExiMM_SAA3.
GenevisibleiP04918. MM.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAA3_MOUSE
AccessioniPrimary (citable) accession number: P04918
Secondary accession number(s): Q62201
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.