P04916 (RET4_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinol-binding protein 4

Alternative name(s):
Plasma retinol-binding protein
Short name=PRBP
Short name=RBP

Gene names

Name:

Rbp4

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
Subcellular location	Secreted.
Sequence similarities	Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Secreted
Domain	Signal
Ligand	Retinol-binding Vitamin A
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	response to ethanol Inferred from expression pattern. Source: RGD
Cellular component	extracellular space Inferred from direct assay. Source: RGD
Molecular function	retinal binding Inferred from electronic annotation. Source: UniProtKB-KW retinol binding Traceable author statement Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Ref.2
	Chain	19 – 201	183	Retinol-binding protein 4		PRO_0000017970
Amino acid modifications
	Disulfide bond	22 ↔ 178		By similarity
	Disulfide bond	88 ↔ 192		By similarity
	Disulfide bond	138 ↔ 147		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P04916 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: E6737E293B37A30A	FASTA	201	23,220
	10 20 30 40 50 60 MEWVWALVLL AALGGGSAER DCRVSSFRVK ENFDKARFSG LWYAIAKKDP EGLFLQDNII 70 80 90 100 110 120 AEFSVDEKGH MSATAKGRVR LLSNWEVCAD MVGTFTDTED PAKFKMKYWG VASFLQRGND 130 140 150 160 170 180 DHWIIDTDYD TFALQYSCRL QNLDGTCADS YSFVFSRDPN GLTPETRRLV RQRQEELCLE 190 200 RQYRWIEHNG YCQSRPSRNS L

References

[1]	"Characterization of the rat retinol-binding protein gene and its comparison to the three-dimensional structure of the protein." Laurent B.C., Nilsson M.H.L., Bavik C.O., Jones T.A., Sundelin J., Peterson P.A. J. Biol. Chem. 260:11476-11480(1985) [PubMed: 4044565] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Amino acid sequence homologies between rabbit, rat, and human serum retinol-binding proteins." Sundelin J., Laurent B.C., Anundi H., Traegaardh L., Larhammar D., Bjoerck L., Eriksson U., Aakerstroem B., Jones A., Newcomer M., Peterson P.A., Rask L. J. Biol. Chem. 260:6472-6480(1985) [PubMed: 3838985] [Abstract] Cited for: PROTEIN SEQUENCE OF 19-59, NUCLEOTIDE SEQUENCE OF 30-201.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	K03046, M10610 Genomic DNA. Translation: AAA42018.1. M10934 mRNA. Translation: AAA42020.1.
IPI	IPI00876581.
PIR	VART. A92493.
RefSeq	NP_037294.1. NM_013162.1.
UniGene	Rn.108214.
3D structure databases
ProteinModelPortal	P04916.
SMR	P04916. Positions 19-192.
ModBase	Search...
Protein-protein interaction databases
STRING	P04916.
Proteomic databases
PRIDE	P04916.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000021055; ENSRNOP00000021055; ENSRNOG00000015518.
GeneID	25703.
KEGG	rno:25703.
Organism-specific databases
CTD	5950.
RGD	3546. Rbp4.
Phylogenomic databases
GeneTree	ENSGT00510000047107.
HOVERGEN	HBG004493.
InParanoid	P04916.
OMA	MEWVWAL.
OrthoDB	EOG4T4CWM.
PhylomeDB	P04916.
Gene expression databases
ArrayExpress	P04916.
Genevestigator	P04916.
GermOnline	ENSRNOG00000015518. Rattus norvegicus.
Family and domain databases
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR002345. Lipocalin. IPR022271. Lipocalin_ApoD. IPR022272. Lipocalin_CS. IPR000566. Lipocln_cytosolic_FA-bd_dom. IPR002449. Retinol-bd. [Graphical view]
Gene3D	G3DSA:2.40.128.20. Calycin. 1 hit.
PANTHER	PTHR11873. Retinol_bd. 1 hit.
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PIRSF	PIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTS	PR00179. LIPOCALIN. PR01174. RETINOLBNDNG.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00213. LIPOCALIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	607739.

Entry information

Entry name

RET4_RAT

Accession

Primary (citable) accession number: P04916

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	September 21, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program