Reviewed,
UniProtKB/Swiss-Prot P04916 (RET4_RAT)
Last modified
June 16, 2009.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Retinol-binding protein 4 Alternative name(s): Plasma retinol-binding protein Short name=PRBP Short name=RBP | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 201 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. |
| Subcellular location | |
| Sequence similarities | Belongs to the calycin superfamily. Lipocalin family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transport |
| Cellular component | Secreted |
| Domain | Signal |
| Ligand | Retinol-binding Vitamin A |
| PTM | Disulfide bond |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | response to ethanol Inferred from expression pattern. Source: RGD |
| Cellular component | extracellular space Inferred from direct assay. Source: RGD |
| Molecular function | retinal binding Inferred from electronic annotation. Source: UniProtKB-KW retinol binding Ref.1Traceable author statement. Source: RGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | Ref.2 | ||||||||
| Chain | 19 – 201 | 183 | Retinol-binding protein 4 | PRO_0000017970 | |||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 22 ↔ 178 | By similarity | |||||||||
| Disulfide bond | 88 ↔ 192 | By similarity | |||||||||
| Disulfide bond | 138 ↔ 147 | By similarity | |||||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Characterization of the rat retinol-binding protein gene and its comparison to the three-dimensional structure of the protein." Laurent B.C., Nilsson M.H.L., Bavik C.O., Jones T.A., Sundelin J., Peterson P.A. J. Biol. Chem. 260:11476-11480(1985) [PubMed: 4044565] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. |
| [2] | "Amino acid sequence homologies between rabbit, rat, and human serum retinol-binding proteins." Sundelin J., Laurent B.C., Anundi H., Traegaardh L., Larhammar D., Bjoerck L., Eriksson U., Aakerstroem B., Jones A., Newcomer M., Peterson P.A., Rask L. J. Biol. Chem. 260:6472-6480(1985) [PubMed: 3838985] [Abstract] Cited for: PROTEIN SEQUENCE OF 19-59, NUCLEOTIDE SEQUENCE OF 30-201. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| K03046, M10610 Genomic DNA. Translation: AAA42018.1. M10934 mRNA. Translation: AAA42020.1. | |
| IPI | IPI00876581. |
| PIR | VART. A92493. |
| RefSeq | NP_037294.1. |
| UniGene | Rn.108214 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1RBP based on UniProtKB P02753. |
| SMR | P04916. Positions 19-192. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P04916. |
Genome annotation databases | |
| Ensembl | ENSRNOG00000015518. Rattus norvegicus. [Contig view] |
| GeneID | 25703. |
| KEGG | rno:25703. |
Organism-specific databases | |
| RGD | 3546. Rbp4. |
Phylogenomic databases | |
| HOVERGEN | P04916. |
| OMA | P04916. MEWVWAL. |
Gene expression databases | |
| ArrayExpress | P04916. |
| GermOnline | ENSRNOG00000015518. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR012674. Calycin. IPR002345. Lipocalin. IPR000566. Lipocln_cytFABP. IPR002449. Retinol_bd. [Graphical view] |
| Gene3D | G3DSA:2.40.128.20. Calycin. 1 hit. |
| PANTHER | PTHR11873. Retinol_bd. 1 hit. |
| Pfam | PF00061. Lipocalin. 1 hit. [Graphical view] |
| PRINTS | PR00179. LIPOCALIN. PR01174. RETINOLBNDNG. |
| PROSITE | PS00213. LIPOCALIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 607739. |
Entry information
| Entry name | RET4_RAT | ||||||||
| Accession | Primary (citable) accession number: P04916 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


