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P04916 (RET4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Retinol-binding protein 4
Alternative name(s):
Plasma retinol-binding protein
Short name=PRBP
Short name=RBP
Gene names
Name:Rbp4
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

Subcellular location

Secreted.

Sequence similarities

Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentSecreted
   DomainSignal
   LigandRetinol-binding
Vitamin A
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processresponse to ethanol

Inferred from expression pattern. Source: RGD

   Cellular componentextracellular space

Inferred from direct assay. Source: RGD

   Molecular functionretinal binding

Inferred from electronic annotation. Source: UniProtKB-KW

retinol binding

Traceable author statement Ref.1. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.2
Chain19 – 201183Retinol-binding protein 4
PRO_0000017970

Amino acid modifications

Disulfide bond22 ↔ 178 By similarity
Disulfide bond88 ↔ 192 By similarity
Disulfide bond138 ↔ 147 By similarity

Sequences

Sequence LengthMass (Da)Tools
P04916 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: E6737E293B37A30A

FASTA20123,220
        10         20         30         40         50         60 
MEWVWALVLL AALGGGSAER DCRVSSFRVK ENFDKARFSG LWYAIAKKDP EGLFLQDNII 

        70         80         90        100        110        120 
AEFSVDEKGH MSATAKGRVR LLSNWEVCAD MVGTFTDTED PAKFKMKYWG VASFLQRGND 

       130        140        150        160        170        180 
DHWIIDTDYD TFALQYSCRL QNLDGTCADS YSFVFSRDPN GLTPETRRLV RQRQEELCLE 

       190        200 
RQYRWIEHNG YCQSRPSRNS L 

« Hide

References

[1]"Characterization of the rat retinol-binding protein gene and its comparison to the three-dimensional structure of the protein."
Laurent B.C., Nilsson M.H.L., Bavik C.O., Jones T.A., Sundelin J., Peterson P.A.
J. Biol. Chem. 260:11476-11480(1985) [PubMed: 4044565] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Amino acid sequence homologies between rabbit, rat, and human serum retinol-binding proteins."
Sundelin J., Laurent B.C., Anundi H., Traegaardh L., Larhammar D., Bjoerck L., Eriksson U., Aakerstroem B., Jones A., Newcomer M., Peterson P.A., Rask L.
J. Biol. Chem. 260:6472-6480(1985) [PubMed: 3838985] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-59, NUCLEOTIDE SEQUENCE OF 30-201.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K03046, M10610 Genomic DNA. Translation: AAA42018.1.
M10934 mRNA. Translation: AAA42020.1.
IPIIPI00876581.
PIRVART. A92493.
RefSeqNP_037294.1. NM_013162.1.
UniGeneRn.108214.

3D structure databases

ProteinModelPortalP04916.
SMRP04916. Positions 19-192.
ModBaseSearch...

Protein-protein interaction databases

STRINGP04916.

Proteomic databases

PRIDEP04916.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000021055; ENSRNOP00000021055; ENSRNOG00000015518.
GeneID25703.
KEGGrno:25703.

Organism-specific databases

CTD5950.
RGD3546. Rbp4.

Phylogenomic databases

GeneTreeENSGT00510000047107.
HOVERGENHBG004493.
InParanoidP04916.
OMAMEWVWAL.
OrthoDBEOG4T4CWM.
PhylomeDBP04916.

Gene expression databases

ArrayExpressP04916.
GenevestigatorP04916.
GermOnlineENSRNOG00000015518. Rattus norvegicus.

Family and domain databases

InterProIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002449. Retinol-bd.
[Graphical view]
Gene3DG3DSA:2.40.128.20. Calycin. 1 hit.
PANTHERPTHR11873. Retinol_bd. 1 hit.
PfamPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFPIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSPR00179. LIPOCALIN.
PR01174. RETINOLBNDNG.
SUPFAMSSF50814. Calycin. 1 hit.
PROSITEPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio607739.

Entry information

Entry nameRET4_RAT
AccessionPrimary (citable) accession number: P04916
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 21, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families