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Protein

Retinol-binding protein 4

Gene

Rbp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues (PubMed:4708098). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • retinal binding Source: UniProtKB-KW
  • retinol binding Source: UniProtKB
  • retinol transmembrane transporter activity Source: InterPro

GO - Biological processi

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-RNO-2453902 The canonical retinoid cycle in rods (twilight vision)
R-RNO-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 4
Alternative name(s):
Plasma retinol-binding protein
Short name:
PRBP
Short name:
RBP1 Publication
Gene namesi
Name:Rbp4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3546 Rbp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001797019 – 201Retinol-binding protein 4By similarity1 PublicationAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 178By similarity
Disulfide bondi88 ↔ 192By similarity
Disulfide bondi138 ↔ 147By similarity
Modified residuei139Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Methylation

Proteomic databases

PaxDbiP04916
PRIDEiP04916

Expressioni

Tissue specificityi

Detected in blood plasma (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000015518
ExpressionAtlasiP04916 baseline and differential
GenevisibleiP04916 RN

Interactioni

Subunit structurei

Interacts with TTR (PubMed:4708098). Interaction with TTR prevents its loss by filtration through the kidney glomeruli (Probable). Interacts with STRA6 (By similarity).By similarityCurated1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021055

Structurei

3D structure databases

ProteinModelPortaliP04916
SMRiP04916
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJHC Eukaryota
ENOG4111K1Y LUCA
GeneTreeiENSGT00510000047107
HOGENOMiHOG000293156
HOVERGENiHBG004493
InParanoidiP04916
KOiK18271
OMAiGHMSATA
OrthoDBiEOG091G0KIM
PhylomeDBiP04916
TreeFamiTF331445

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR022271 Lipocalin_ApoD
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002449 Retinol-bd/Purpurin
PANTHERiPTHR11873 PTHR11873, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PIRSFiPIRSF036893 Lipocalin_ApoD, 1 hit
PIRSF500204 RBP_purpurin, 1 hit
PRINTSiPR01174 RETINOLBNDNG
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWVWALVLL AALGGGSAER DCRVSSFRVK ENFDKARFSG LWYAIAKKDP
60 70 80 90 100
EGLFLQDNII AEFSVDEKGH MSATAKGRVR LLSNWEVCAD MVGTFTDTED
110 120 130 140 150
PAKFKMKYWG VASFLQRGND DHWIIDTDYD TFALQYSCRL QNLDGTCADS
160 170 180 190 200
YSFVFSRDPN GLTPETRRLV RQRQEELCLE RQYRWIEHNG YCQSRPSRNS

L
Length:201
Mass (Da):23,220
Last modified:August 13, 1987 - v1
Checksum:iE6737E293B37A30A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03046, M10610 Genomic DNA Translation: AAA42018.1
M10934 mRNA Translation: AAA42020.1
PIRiA92493 VART
RefSeqiNP_037294.1, NM_013162.1
UniGeneiRn.108214

Genome annotation databases

EnsembliENSRNOT00000021055; ENSRNOP00000021055; ENSRNOG00000015518
GeneIDi25703
KEGGirno:25703
UCSCiRGD:3546 rat

Similar proteinsi

Entry informationi

Entry nameiRET4_RAT
AccessioniPrimary (citable) accession number: P04916
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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