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Protein

Glutathione S-transferase 3

Gene

GST3

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the detoxification of certain herbicides.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12GlutathioneBy similarity1

GO - Molecular functioni

  • glutathione transferase activity Source: AgBase
  • protein homodimerization activity Source: AgBase

GO - Biological processi

  • response to herbicide Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 3 (EC:2.5.1.18)
Alternative name(s):
GST class-phi member 3
GST-III
Gene namesi
Name:GST3
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi65344.

Subcellular locationi

GO - Cellular componenti

  • protein complex Source: AgBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001858422 – 222Glutathione S-transferase 3Add BLAST221

Proteomic databases

PRIDEiP04907.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • protein homodimerization activity Source: AgBase

Structurei

3D structure databases

ProteinModelPortaliP04907.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 83GST N-terminalAdd BLAST82
Domaini89 – 219GST C-terminalAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 42Glutathione bindingBy similarity2
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Phi family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

HOGENOMiHOG000125746.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLKLYGMP LSPNVVRVAT VLNEKGLDFE IVPVDLTTGA HKQPDFLALN
60 70 80 90 100
PFGQIPALVD GDEVLFESRA INRYIASKYA SEGTDLLPAT ASAAKLEVWL
110 120 130 140 150
EVESHHFHPN ASPLVFQLLV RPLLGGAPDA AVVEKHAEQL AKVLDVYEAH
160 170 180 190 200
LARNKYLAGD EFTLADANHA LLPALTSARP PRPGCVAARP HVKAWWEAIA
210 220
ARPAFQKTVA AIPLPPPPSS SA
Length:222
Mass (Da):23,849
Last modified:January 23, 2007 - v4
Checksum:i4CB77A3B1B6E3C46
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108H → Y (PubMed:3532034).Curated1
Sequence conflicti111 – 127ASPLV…LLGGA → RVAAGVPAAREAAPGRR in CAA27957 (PubMed:3532034).CuratedAdd BLAST17
Sequence conflicti111 – 127ASPLV…LLGGA → RVAAGVPAAREAAPGRR in CAA28053 (PubMed:3532034).CuratedAdd BLAST17
Sequence conflicti134E → D in CAA27957 (PubMed:3532034).Curated1
Sequence conflicti134E → D in CAA28053 (PubMed:3532034).Curated1
Sequence conflicti149 – 180AHLAR…TSARP → RTSPATSTSPGTSSRSPTPT TRSYLLYLSKT in CAA27957 (PubMed:3532034).CuratedAdd BLAST32
Sequence conflicti184 – 189GCVAAR → ARRRP in CAA27957 (PubMed:3532034).Curated6
Sequence conflicti200A → V in CAA27957 (PubMed:3532034).Curated1
Sequence conflicti200A → V in CAA28053 (PubMed:3532034).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06755 mRNA. Translation: CAA29929.1.
X04375 mRNA. Translation: CAA27957.1.
X04455 mRNA. Translation: CAA28053.1.
PIRiA24703. XUZM31.
S00717. XUZM32.
UniGeneiZm.103382.
Zm.93693.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06755 mRNA. Translation: CAA29929.1.
X04375 mRNA. Translation: CAA27957.1.
X04455 mRNA. Translation: CAA28053.1.
PIRiA24703. XUZM31.
S00717. XUZM32.
UniGeneiZm.103382.
Zm.93693.

3D structure databases

ProteinModelPortaliP04907.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP04907.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MaizeGDBi65344.

Phylogenomic databases

HOGENOMiHOG000125746.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTF3_MAIZE
AccessioniPrimary (citable) accession number: P04907
Secondary accession number(s): P15542
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.