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Protein

Glutathione S-transferase P

Gene

Gstp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei14GlutathioneBy similarity1
Binding sitei39GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

  • dinitrosyl-iron complex binding Source: RGD
  • drug binding Source: RGD
  • glutathione binding Source: RGD
  • glutathione peroxidase activity Source: RGD
  • glutathione transferase activity Source: RGD
  • JUN kinase binding Source: BHF-UCL
  • kinase regulator activity Source: BHF-UCL
  • protein kinase binding Source: RGD
  • S-nitrosoglutathione binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-RNO-156590 Glutathione conjugation
R-RNO-3299685 Detoxification of Reactive Oxygen Species
R-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P (EC:2.5.1.18)
Alternative name(s):
Chain 7
GST 7-7
GST class-pi
Gene namesi
Name:Gstp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2758 Gstp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00001859072 – 210Glutathione S-transferase PAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4Phosphotyrosine; by EGFRBy similarity1
Modified residuei62PhosphothreonineBy similarity1
Modified residuei103N6-succinyllysineBy similarity1
Modified residuei116N6-succinyllysineBy similarity1
Modified residuei128N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP04906
PRIDEiP04906

2D gel databases

World-2DPAGEi0004:P04906

PTM databases

iPTMnetiP04906
PhosphoSitePlusiP04906

Miscellaneous databases

PMAP-CutDBiP04906

Expressioni

Tissue specificityi

Present in kidney, lung, testis and placenta, very low levels in liver.

Gene expression databases

BgeeiENSRNOG00000018237
ExpressionAtlasiP04906 baseline and differential
GenevisibleiP04906 RN

Interactioni

Subunit structurei

Homodimer. Interacts with CDK5 (By similarity).By similarity

GO - Molecular functioni

  • JUN kinase binding Source: BHF-UCL
  • protein kinase binding Source: RGD

Protein-protein interaction databases

BioGridi246591, 1 interactor
IntActiP04906, 1 interactor
STRINGi10116.ENSRNOP00000024601

Structurei

3D structure databases

ProteinModelPortaliP04906
SMRiP04906
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 81GST N-terminalAdd BLAST80
Domaini83 – 204GST C-terminalAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 53Glutathione bindingBy similarity2
Regioni65 – 66Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115733
HOVERGENiHBG108324
InParanoidiP04906
KOiK00799
OMAiLRCKYAT
OrthoDBiEOG091G0K2E
PhylomeDBiP04906
TreeFamiTF105321

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003082 GST_pi
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01268 GSTRNSFRASEP
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPYTIVYFP VRGRCEATRM LLADQGQSWK EEVVTIDVWL QGSLKSTCLY
60 70 80 90 100
GQLPKFEDGD LTLYQSNAIL RHLGRSLGLY GKDQKEAALV DMVNDGVEDL
110 120 130 140 150
RCKYGTLIYT NYENGKDDYV KALPGHLKPF ETLLSQNQGG KAFIVGNQIS
160 170 180 190 200
FADYNLLDLL LVHQVLAPGC LDNFPLLSAY VARLSARPKI KAFLSSPDHL
210
NRPINGNGKQ
Length:210
Mass (Da):23,439
Last modified:January 23, 2007 - v2
Checksum:i9B71785D1FC28FDB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15C → Y AA sequence (PubMed:3359441).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02904 mRNA Translation: CAA26664.1
L29427 Genomic DNA Translation: AAB59718.1
BC058439 mRNA Translation: AAH58439.1
BC058440 mRNA Translation: AAH58440.1
PIRiA26546 XURTGP
S59902
RefSeqiNP_036709.1, NM_012577.2
UniGeneiRn.87063

Genome annotation databases

EnsembliENSRNOT00000024601; ENSRNOP00000024601; ENSRNOG00000018237
GeneIDi24426
KEGGirno:24426
UCSCiRGD:2758 rat

Similar proteinsi

Entry informationi

Entry nameiGSTP1_RAT
AccessioniPrimary (citable) accession number: P04906
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health