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Protein

Glutathione S-transferase P

Gene

Gstp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei14GlutathioneBy similarity1
Binding sitei39GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

  • dinitrosyl-iron complex binding Source: Ensembl
  • drug binding Source: RGD
  • glutathione binding Source: RGD
  • glutathione peroxidase activity Source: Ensembl
  • glutathione transferase activity Source: RGD
  • JUN kinase binding Source: BHF-UCL
  • kinase regulator activity Source: BHF-UCL
  • protein kinase binding Source: RGD
  • S-nitrosoglutathione binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-RNO-156590. Glutathione conjugation.
R-RNO-3299685. Detoxification of Reactive Oxygen Species.
R-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P (EC:2.5.1.18)
Alternative name(s):
Chain 7
GST 7-7
GST class-pi
Gene namesi
Name:Gstp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2758. Gstp1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00001859072 – 210Glutathione S-transferase PAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4Phosphotyrosine; by EGFRBy similarity1
Modified residuei62PhosphothreonineBy similarity1
Modified residuei103N6-succinyllysineBy similarity1
Modified residuei116N6-succinyllysineBy similarity1
Modified residuei128N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP04906.
PRIDEiP04906.

2D gel databases

World-2DPAGEi0004:P04906.

PTM databases

iPTMnetiP04906.
PhosphoSitePlusiP04906.

Miscellaneous databases

PMAP-CutDBiP04906.

Expressioni

Tissue specificityi

Present in kidney, lung, testis and placenta, very low levels in liver.

Gene expression databases

BgeeiENSRNOG00000018237.
ExpressionAtlasiP04906. baseline and differential.
GenevisibleiP04906. RN.

Interactioni

Subunit structurei

Homodimer. Interacts with CDK5 (By similarity).By similarity

GO - Molecular functioni

  • JUN kinase binding Source: BHF-UCL
  • protein kinase binding Source: RGD

Protein-protein interaction databases

BioGridi246591. 1 interactor.
IntActiP04906. 1 interactor.
STRINGi10116.ENSRNOP00000024601.

Structurei

3D structure databases

ProteinModelPortaliP04906.
SMRiP04906.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 81GST N-terminalAdd BLAST80
Domaini83 – 204GST C-terminalAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 53Glutathione bindingBy similarity2
Regioni65 – 66Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.Curated

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115733.
HOVERGENiHBG108324.
InParanoidiP04906.
KOiK00799.
OMAiLRCKYAT.
OrthoDBiEOG091G0K2E.
PhylomeDBiP04906.
TreeFamiTF105321.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPYTIVYFP VRGRCEATRM LLADQGQSWK EEVVTIDVWL QGSLKSTCLY
60 70 80 90 100
GQLPKFEDGD LTLYQSNAIL RHLGRSLGLY GKDQKEAALV DMVNDGVEDL
110 120 130 140 150
RCKYGTLIYT NYENGKDDYV KALPGHLKPF ETLLSQNQGG KAFIVGNQIS
160 170 180 190 200
FADYNLLDLL LVHQVLAPGC LDNFPLLSAY VARLSARPKI KAFLSSPDHL
210
NRPINGNGKQ
Length:210
Mass (Da):23,439
Last modified:January 23, 2007 - v2
Checksum:i9B71785D1FC28FDB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15C → Y AA sequence (PubMed:3359441).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02904 mRNA. Translation: CAA26664.1.
L29427 Genomic DNA. Translation: AAB59718.1.
BC058439 mRNA. Translation: AAH58439.1.
BC058440 mRNA. Translation: AAH58440.1.
PIRiA26546. XURTGP.
S59902.
RefSeqiNP_036709.1. NM_012577.2.
UniGeneiRn.87063.

Genome annotation databases

EnsembliENSRNOT00000024601; ENSRNOP00000024601; ENSRNOG00000018237.
GeneIDi24426.
KEGGirno:24426.
UCSCiRGD:2758. rat.

Similar proteinsi

Entry informationi

Entry nameiGSTP1_RAT
AccessioniPrimary (citable) accession number: P04906
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families