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P04903 (GSTA2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase alpha-2

EC=2.5.1.18
Alternative name(s):
GST 1b-1b
GST A2-2
Glutathione S-transferase Ya-2
Short name=GST Ya2
Gene names
Name:Gsta2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Miscellaneous

In addition to its enzymatic activity, the homodimer of Ya chains, called ligandin, binds various organic anions, xenobiotics, and azocarcinogen dyes.

Sequence similarities

Belongs to the GST superfamily. Alpha family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 222221Glutathione S-transferase alpha-2
PRO_0000185793

Regions

Domain3 – 8381GST N-terminal
Domain85 – 208124GST C-terminal
Region54 – 552Glutathione binding By similarity
Region67 – 682Glutathione binding By similarity

Sites

Binding site91Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P04903 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: AA342417E9857A9F

FASTA22225,559
        10         20         30         40         50         60 
MSGKPVLHYF NARGRMECIR WLLAAAGVEF EEKLIQSPED LEKLKKDGNL MFDQVPMVEI 

        70         80         90        100        110        120 
DGMKLAQTRA ILNYIATKYD LYGKDMKERA LIDMYSEGIL DLTEMIIQLV ICPPDQREAK 

       130        140        150        160        170        180 
TALAKDRTKN RYLPAFEKVL KSHGQDYLVG NRLTRVDIHL LELLLYVEEF DASLLTSFPL 

       190        200        210        220 
LKAFKSRISS LPNVKKFLQP GSQRKPAMDA KQIEEARKVF KF 

« Hide

References

[1]"Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital."
Pickett C.B., Telakowski-Hopkins C.A., Ding G.J.-F., Argenbright L., Lu A.Y.H.
J. Biol. Chem. 259:5182-5188(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.
[2]"Expression and sequence analysis of rat liver glutathione S-transferase genes."
Pickett C.B., Telakowsi-Hopkins C.A., Ding G.J.-F., Ding V.D.-H.
Adv. Exp. Med. Biol. 197:185-193(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Structural analysis of a rat liver glutathione S-transferase Ya gene."
Telakowski-Hopkins C.A., Rothkopf G.S., Pickett C.B.
Proc. Natl. Acad. Sci. U.S.A. 83:9393-9397(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Construction and characterization of a plasmid containing complementary DNA to mRNA encoding the N-terminal amino acid sequence of the rat glutathione transferase Ya subunit."
Taylor J.B., Craig R.K., Beale D., Ketterer B.
Biochem. J. 219:223-231(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-129.
[5]"Expression of a cDNA encoding a rat liver glutathione S-transferase Ya subunit in Escherichia coli."
Wang R.W., Pickett C.B., Lu A.Y.H.
Arch. Biochem. Biophys. 269:536-543(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31.
Tissue: Liver.
[6]"Cloning and sequence analysis of a cDNA plasmid for one of the rat liver glutathione S-transferase subunits."
Tu C.-P.D., Weiss M.J., Karakawa W.W., Reddy C.C.
Nucleic Acids Res. 10:5407-5419(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 81-222.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K00136 mRNA. Translation: AAA41282.1.
M25891 mRNA. Translation: AAA41290.1.
M14991 expand/collapse EMBL AC list , M14986, M14987, M14988, M14989, M14990 Genomic DNA. Translation: AAA41295.1.
X00520 mRNA. Translation: CAA25203.1.
M27446 mRNA. Translation: AAA41291.1.
PIRA24735.
A26653.
XURTG. A92479.
RefSeqNP_001010921.1. NM_001010921.1.
UniGeneRn.40574.

3D structure databases

ProteinModelPortalP04903.
SMRP04903. Positions 2-221.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP04903.
PRIDEP04903.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID494499.
KEGGrno:494499.
UCSCRGD:2754. rat.

Organism-specific databases

CTD221357.
RGD2754. Gsta2.

Phylogenomic databases

eggNOGNOG266414.
HOGENOMHOG000115734.
HOVERGENHBG053749.
InParanoidP04903.
KOK00799.
PhylomeDBP04903.

Gene expression databases

GenevestigatorP04903.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01266. GSTRNSFRASEA.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio697636.

Entry information

Entry nameGSTA2_RAT
AccessionPrimary (citable) accession number: P04903
Secondary accession number(s): Q63715
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families