Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P04903

- GSTA2_RAT

UniProt

P04903 - GSTA2_RAT

Protein

Glutathione S-transferase alpha-2

Gene

Gsta2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei9 – 91GlutathioneBy similarity

    GO - Molecular functioni

    1. drug binding Source: RGD
    2. glutathione binding Source: RGD
    3. glutathione transferase activity Source: RGD

    GO - Biological processi

    1. aging Source: RGD
    2. xenobiotic catabolic process Source: RGD

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase alpha-2 (EC:2.5.1.18)
    Alternative name(s):
    GST 1b-1b
    GST A2-2
    Glutathione S-transferase Ya-2
    Short name:
    GST Ya2
    Gene namesi
    Name:Gsta2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2754. Gsta2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. nuclear outer membrane Source: RGD
    3. nucleus Source: RGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 222221Glutathione S-transferase alpha-2PRO_0000185793Add
    BLAST

    Proteomic databases

    PaxDbiP04903.
    PRIDEiP04903.

    Expressioni

    Gene expression databases

    GenevestigatoriP04903.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP04903.
    SMRiP04903. Positions 2-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 8381GST N-terminalAdd
    BLAST
    Domaini85 – 208124GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni54 – 552Glutathione bindingBy similarity
    Regioni67 – 682Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Alpha family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG266414.
    HOGENOMiHOG000115734.
    HOVERGENiHBG053749.
    InParanoidiP04903.
    KOiK00799.
    PhylomeDBiP04903.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR003080. GST_alpha.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01266. GSTRNSFRASEA.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04903-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGKPVLHYF NARGRMECIR WLLAAAGVEF EEKLIQSPED LEKLKKDGNL    50
    MFDQVPMVEI DGMKLAQTRA ILNYIATKYD LYGKDMKERA LIDMYSEGIL 100
    DLTEMIIQLV ICPPDQREAK TALAKDRTKN RYLPAFEKVL KSHGQDYLVG 150
    NRLTRVDIHL LELLLYVEEF DASLLTSFPL LKAFKSRISS LPNVKKFLQP 200
    GSQRKPAMDA KQIEEARKVF KF 222
    Length:222
    Mass (Da):25,559
    Last modified:January 23, 2007 - v2
    Checksum:iAA342417E9857A9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K00136 mRNA. Translation: AAA41282.1.
    M25891 mRNA. Translation: AAA41290.1.
    M14991
    , M14986, M14987, M14988, M14989, M14990 Genomic DNA. Translation: AAA41295.1.
    X00520 mRNA. Translation: CAA25203.1.
    M27446 mRNA. Translation: AAA41291.1.
    PIRiA24735.
    A26653.
    A92479. XURTG.
    RefSeqiNP_001010921.1. NM_001010921.1.
    UniGeneiRn.40574.

    Genome annotation databases

    GeneIDi494499.
    KEGGirno:494499.
    UCSCiRGD:2754. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K00136 mRNA. Translation: AAA41282.1 .
    M25891 mRNA. Translation: AAA41290.1 .
    M14991
    , M14986 , M14987 , M14988 , M14989 , M14990 Genomic DNA. Translation: AAA41295.1 .
    X00520 mRNA. Translation: CAA25203.1 .
    M27446 mRNA. Translation: AAA41291.1 .
    PIRi A24735.
    A26653.
    A92479. XURTG.
    RefSeqi NP_001010921.1. NM_001010921.1.
    UniGenei Rn.40574.

    3D structure databases

    ProteinModelPortali P04903.
    SMRi P04903. Positions 2-221.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P04903.
    PRIDEi P04903.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 494499.
    KEGGi rno:494499.
    UCSCi RGD:2754. rat.

    Organism-specific databases

    CTDi 221357.
    RGDi 2754. Gsta2.

    Phylogenomic databases

    eggNOGi NOG266414.
    HOGENOMi HOG000115734.
    HOVERGENi HBG053749.
    InParanoidi P04903.
    KOi K00799.
    PhylomeDBi P04903.

    Miscellaneous databases

    NextBioi 697636.

    Gene expression databases

    Genevestigatori P04903.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR003080. GST_alpha.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01266. GSTRNSFRASEA.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital."
      Pickett C.B., Telakowski-Hopkins C.A., Ding G.J.-F., Argenbright L., Lu A.Y.H.
      J. Biol. Chem. 259:5182-5188(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. "Expression and sequence analysis of rat liver glutathione S-transferase genes."
      Pickett C.B., Telakowsi-Hopkins C.A., Ding G.J.-F., Ding V.D.-H.
      Adv. Exp. Med. Biol. 197:185-193(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Structural analysis of a rat liver glutathione S-transferase Ya gene."
      Telakowski-Hopkins C.A., Rothkopf G.S., Pickett C.B.
      Proc. Natl. Acad. Sci. U.S.A. 83:9393-9397(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Construction and characterization of a plasmid containing complementary DNA to mRNA encoding the N-terminal amino acid sequence of the rat glutathione transferase Ya subunit."
      Taylor J.B., Craig R.K., Beale D., Ketterer B.
      Biochem. J. 219:223-231(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-129.
    5. "Expression of a cDNA encoding a rat liver glutathione S-transferase Ya subunit in Escherichia coli."
      Wang R.W., Pickett C.B., Lu A.Y.H.
      Arch. Biochem. Biophys. 269:536-543(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31.
      Tissue: Liver.
    6. "Cloning and sequence analysis of a cDNA plasmid for one of the rat liver glutathione S-transferase subunits."
      Tu C.-P.D., Weiss M.J., Karakawa W.W., Reddy C.C.
      Nucleic Acids Res. 10:5407-5419(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 81-222.

    Entry informationi

    Entry nameiGSTA2_RAT
    AccessioniPrimary (citable) accession number: P04903
    Secondary accession number(s): Q63715
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In addition to its enzymatic activity, the homodimer of Ya chains, called ligandin, binds various organic anions, xenobiotics, and azocarcinogen dyes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3