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Protein

Envelopment polyprotein

Gene

GP

Organism
Bunyavirus snowshoe hare
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Glycoprotein C and Glycoprotein N interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelopment polyprotein
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Glycoprotein NBy similarity
Short name:
Gn
Alternative name(s):
Glycoprotein G2
Non-structural protein MBy similarity
Short name:
NSm
Glycoprotein CBy similarity
Short name:
Gc
Alternative name(s):
Glycoprotein G1
Gene namesi
Name:GP
OrganismiBunyavirus snowshoe hare
Taxonomic identifieri11580 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Canis lupus familiaris (Dog) (Canis familiaris) [TaxID: 9615]
Culex [TaxID: 7174]
Culiseta [TaxID: 174825]
Equus caballus (Horse) [TaxID: 9796]
Gallus gallus (Chicken) [TaxID: 9031]
Homo sapiens (Human) [TaxID: 9606]
Lepus americanus (Snowshoe hare) [TaxID: 48086]

Subcellular locationi

Glycoprotein C :
Glycoprotein N :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini14 – 200LumenalSequence analysisAdd BLAST187
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 305CytoplasmicSequence analysisAdd BLAST84
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 365LumenalSequence analysisAdd BLAST39
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Topological domaini387 – 452CytoplasmicSequence analysisAdd BLAST66
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 1395LumenalSequence analysisAdd BLAST922
Transmembranei1396 – 1416HelicalSequence analysisAdd BLAST21
Topological domaini1417 – 1441CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 13Add BLAST13
ChainiPRO_000003679414 – 1441Envelopment polyproteinAdd BLAST1428
ChainiPRO_000003679514 – 299Glycoprotein NAdd BLAST286
ChainiPRO_0000036796300 – 473Non-structural protein MAdd BLAST174
ChainiPRO_0000036797474 – 1441Glycoprotein CAdd BLAST968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi490N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi1177N-linked (GlcNAc...); by hostSequence analysis1

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein C, and glycoprotein N.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei473 – 474Cleavage; by host signal peptidaseBy similarity2

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP04875.

Interactioni

Subunit structurei

Glycoprotein C and Glycoprotein N interact with each other.By similarity

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICILILFAV TAASPVYQRC FQDGAIVKQN PSKEAVTEVC LKDDVSMIKT
60 70 80 90 100
EARYIKNATG VFSNNVAIRK WLVSDWHDCR PKKITGGHIN VIEVGDDLSL
110 120 130 140 150
HTESYVCSAD CTIGVDKETA QVRLQTDTTN HFEIAGTIVK SGWFKSTTYI
160 170 180 190 200
TLDQTCEHLK VSCGPKSIQF HACFNQHMSC VRFLHRTILP GSIANSICQN
210 220 230 240 250
IEIIILVTLT LLIFILLSVL SKTYICYLLM PVFIPIAYAY GIIYNKSCKK
260 270 280 290 300
CKLCGLVYHP FTECGTHCVC GARYDTSDRM KLHRASGLCP GYKSLRAARV
310 320 330 340 350
MCKSKGPASI LSVITAILIL TFVTPINSMV VGESKEVFEL EQLPDDMLDM
360 370 380 390 400
ALRINFYYFV CIMNYAVTWG LIIIGLLIGL LFKKYQHRFS NLYAMYCEEC
410 420 430 440 450
DMYHDRSGLK RNGDFTNKCR QCTCGQYEDA TGLMTHRKTY NCLVRYKAKW
460 470 480 490 500
VMNFLIAYML LTLIKDSAIV VQAAGTDFTT CLETENINWN CTGPFLNLGN
510 520 530 540 550
CQKQQKKEPY ANIATQLKGL QAISVLDMPM IASIPEDIAG ALRYIEEKET
560 570 580 590 600
FHVQLTAEYA MLSRYCDYYA QFSDNSGYSQ TTWRVYLRSH DFDACILYPN
610 620 630 640 650
QHFCRCVKRG DKCSSSNGDF ANEMKNYYSG KQNKFDKDLN LALMALHHAF
660 670 680 690 700
RGTSSAYIAT MLSKKSNDDL IAYTNKIKEK FPGNALLKAI VDYIAYMKSL
710 720 730 740 750
SEMSSFKYDE FWDDLLYKSA PTKAPSLSRG SEPSYNFKLV VSSRSIKSCK
760 770 780 790 800
NVKSVVCLSP RSGVSYDSII ACGDPNGPSV YRKPSDGVFQ SNADQSTYCL
810 820 830 840 850
ADSHCLEDFE VVSQEELDAI KKSKCWEAEY PDVKLSKLTD GVKSCRMKDS
860 870 880 890 900
GNCNVAANRW PIIQCENDKF YYSELQKDYD KTQDIGHFCL SPGCSTVRFP
910 920 930 940 950
INPKHISNCN WQVSRSSIAK IDVHNIEDID QYRKAITQKL QTSLSLFKYA
960 970 980 990 1000
KTKNLPHIKP IYKYITIEGT ETAEGIESAY IESEIPALAG TSIGFKITSK
1010 1020 1030 1040 1050
EGKHLLDVIG YVKSASCSSI YTKLYTTGPT SGINTKHDEL CTGPCPAKIN
1060 1070 1080 1090 1100
HQTGWLTFAK ERTSSWGCEE FGCLAISDGC VFGSCQDIIR DELTVYRKET
1110 1120 1130 1140 1150
DEVTDVELCL TFSDKTYCTN LNPITPIITD LFEVQFKTVE TYSLPRIVAI
1160 1170 1180 1190 1200
QNHEIKIGQV NDLGVYSKGC GNVQKVNGTV YGNGVPKFDY LCHLASRKEV
1210 1220 1230 1240 1250
IVRKCFDNDY QACKFLQSPA SYRLEEDSGT VTVIDYKKIL GTIKMKAILG
1260 1270 1280 1290 1300
DVKYKTFADN VDMTAEGSCT GCINCFENIH CELTLHTTIE ASCPIVSTCT
1310 1320 1330 1340 1350
VFHDRILVTP NEHKYALKVV CTEKPGNTLT IRICNTKVEA SLALVDAKPI
1360 1370 1380 1390 1400
LELAPVDQTA YIREKDERCK TWMCRVRDEG LQVILEPFKN LFGSYIGIFY
1410 1420 1430 1440
TFIISIIALL IIIYIVLPIC FKLRDTLRKH EDAYKREMKI R
Length:1,441
Mass (Da):162,390
Last modified:August 13, 1987 - v1
Checksum:i51F01DB268D1A08B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02539 Genomic RNA. Translation: AAA47827.1.
J02392 Genomic RNA. No translation available.
PIRiA04102. GNVUSV.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02539 Genomic RNA. Translation: AAA47827.1.
J02392 Genomic RNA. No translation available.
PIRiA04102. GNVUSV.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP04875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGP_BUNSH
AccessioniPrimary (citable) accession number: P04875
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 5, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.