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P04875

- GP_BUNSH

UniProt

P04875 - GP_BUNSH

Protein

Envelope glycoprotein

Gene

GP

Organism
Bunyavirus snowshoe hare
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei473 – 4742Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. modulation by virus of host morphology or physiology Source: InterPro
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:GP
    OrganismiBunyavirus snowshoe hare
    Taxonomic identifieri11580 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
    Virus hostiAedes [TaxID: 7158]
    Bos taurus (Bovine) [TaxID: 9913]
    Canis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
    Culex [TaxID: 7174]
    Culiseta [TaxID: 174825]
    Equus caballus (Horse) [TaxID: 9796]
    Gallus gallus (Chicken) [TaxID: 9031]
    Homo sapiens (Human) [TaxID: 9606]
    Lepus americanus (Snowshoe hare) [TaxID: 48086]

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.By similarity
    Chain Glycoprotein G2 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated
    Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1313Add
    BLAST
    Chaini14 – 14411428Envelope glycoproteinPRO_0000036794Add
    BLAST
    Chaini14 – 299286Glycoprotein G2PRO_0000036795Add
    BLAST
    Chaini300 – 473174Non-structural protein NSmPRO_0000036796Add
    BLAST
    Chaini474 – 1441968Glycoprotein G1PRO_0000036797Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi57 – 571N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi490 – 4901N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1177 – 11771N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.1 Publication

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini14 – 200187LumenalSequence AnalysisAdd
    BLAST
    Topological domaini222 – 30584CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini327 – 36539LumenalSequence AnalysisAdd
    BLAST
    Topological domaini387 – 45266CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini474 – 1395922LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1417 – 144125CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei366 – 38621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei453 – 47321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1396 – 141621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR005167. Bunya_G1.
    IPR005168. Bunya_G2.
    IPR026400. Bunya_nonstruc_pro_NSm.
    IPR014413. M_poly_OrthobunV.
    [Graphical view]
    PfamiPF03557. Bunya_G1. 1 hit.
    PF03563. Bunya_G2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
    TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04875-1 [UniParc]FASTAAdd to Basket

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    MICILILFAV TAASPVYQRC FQDGAIVKQN PSKEAVTEVC LKDDVSMIKT     50
    EARYIKNATG VFSNNVAIRK WLVSDWHDCR PKKITGGHIN VIEVGDDLSL 100
    HTESYVCSAD CTIGVDKETA QVRLQTDTTN HFEIAGTIVK SGWFKSTTYI 150
    TLDQTCEHLK VSCGPKSIQF HACFNQHMSC VRFLHRTILP GSIANSICQN 200
    IEIIILVTLT LLIFILLSVL SKTYICYLLM PVFIPIAYAY GIIYNKSCKK 250
    CKLCGLVYHP FTECGTHCVC GARYDTSDRM KLHRASGLCP GYKSLRAARV 300
    MCKSKGPASI LSVITAILIL TFVTPINSMV VGESKEVFEL EQLPDDMLDM 350
    ALRINFYYFV CIMNYAVTWG LIIIGLLIGL LFKKYQHRFS NLYAMYCEEC 400
    DMYHDRSGLK RNGDFTNKCR QCTCGQYEDA TGLMTHRKTY NCLVRYKAKW 450
    VMNFLIAYML LTLIKDSAIV VQAAGTDFTT CLETENINWN CTGPFLNLGN 500
    CQKQQKKEPY ANIATQLKGL QAISVLDMPM IASIPEDIAG ALRYIEEKET 550
    FHVQLTAEYA MLSRYCDYYA QFSDNSGYSQ TTWRVYLRSH DFDACILYPN 600
    QHFCRCVKRG DKCSSSNGDF ANEMKNYYSG KQNKFDKDLN LALMALHHAF 650
    RGTSSAYIAT MLSKKSNDDL IAYTNKIKEK FPGNALLKAI VDYIAYMKSL 700
    SEMSSFKYDE FWDDLLYKSA PTKAPSLSRG SEPSYNFKLV VSSRSIKSCK 750
    NVKSVVCLSP RSGVSYDSII ACGDPNGPSV YRKPSDGVFQ SNADQSTYCL 800
    ADSHCLEDFE VVSQEELDAI KKSKCWEAEY PDVKLSKLTD GVKSCRMKDS 850
    GNCNVAANRW PIIQCENDKF YYSELQKDYD KTQDIGHFCL SPGCSTVRFP 900
    INPKHISNCN WQVSRSSIAK IDVHNIEDID QYRKAITQKL QTSLSLFKYA 950
    KTKNLPHIKP IYKYITIEGT ETAEGIESAY IESEIPALAG TSIGFKITSK 1000
    EGKHLLDVIG YVKSASCSSI YTKLYTTGPT SGINTKHDEL CTGPCPAKIN 1050
    HQTGWLTFAK ERTSSWGCEE FGCLAISDGC VFGSCQDIIR DELTVYRKET 1100
    DEVTDVELCL TFSDKTYCTN LNPITPIITD LFEVQFKTVE TYSLPRIVAI 1150
    QNHEIKIGQV NDLGVYSKGC GNVQKVNGTV YGNGVPKFDY LCHLASRKEV 1200
    IVRKCFDNDY QACKFLQSPA SYRLEEDSGT VTVIDYKKIL GTIKMKAILG 1250
    DVKYKTFADN VDMTAEGSCT GCINCFENIH CELTLHTTIE ASCPIVSTCT 1300
    VFHDRILVTP NEHKYALKVV CTEKPGNTLT IRICNTKVEA SLALVDAKPI 1350
    LELAPVDQTA YIREKDERCK TWMCRVRDEG LQVILEPFKN LFGSYIGIFY 1400
    TFIISIIALL IIIYIVLPIC FKLRDTLRKH EDAYKREMKI R 1441
    Length:1,441
    Mass (Da):162,390
    Last modified:August 13, 1987 - v1
    Checksum:i51F01DB268D1A08B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02539 Genomic RNA. Translation: AAA47827.1.
    J02392 Genomic RNA. No translation available.
    PIRiA04102. GNVUSV.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02539 Genomic RNA. Translation: AAA47827.1 .
    J02392 Genomic RNA. No translation available.
    PIRi A04102. GNVUSV.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR005167. Bunya_G1.
    IPR005168. Bunya_G2.
    IPR026400. Bunya_nonstruc_pro_NSm.
    IPR014413. M_poly_OrthobunV.
    [Graphical view ]
    Pfami PF03557. Bunya_G1. 1 hit.
    PF03563. Bunya_G2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003944. M_poly_OrthobunV. 1 hit.
    TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of the M RNA of snowshoe hare bunyavirus reveals the presence of internal hydrophobic domains in the viral glycoprotein."
      Eshita Y., Bishop D.H.L.
      Virology 137:227-240(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Nucleotide sequence analyses and predicted coding of bunyavirus genome RNA species."
      Clerx-Van Haaster C.M., Akashi H., Auperin D.D., Bishop D.H.L.
      J. Virol. 41:119-128(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-46.
    3. "Organization of the middle RNA segment of snowshoe hare Bunyavirus."
      Fazakerley J.K., Gonzalez-Scarano F., Strickler J., Dietz-Schold B., Karush F., Nathanson N.
      Virology 167:422-432(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING OF POLYPROTEIN.

    Entry informationi

    Entry nameiGP_BUNSH
    AccessioniPrimary (citable) accession number: P04875
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3