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P04875 (GP_BUNSH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein

Short name=GP
Alternative name(s):
M polyprotein

Cleaved into the following 3 chains:

  1. Glycoprotein G2
    Short name=Gn
  2. Non-structural protein NSm
  3. Glycoprotein G1
    Short name=Gc
Gene names
Name:GP
OrganismBunyavirus snowshoe hare
Taxonomic identifier11580 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Canis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
Culex [TaxID: 7174]
Culiseta [TaxID: 174825]
Equus caballus (Horse) [TaxID: 9796]
Gallus gallus (Chicken) [TaxID: 9031]
Homo sapiens (Human) [TaxID: 9606]
Lepus americanus (Snowshoe hare) [TaxID: 48086]

Protein attributes

Sequence length1441 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region By similarity.

Non-structural protein NSm: Host Golgi apparatus membrane; Multi-pass membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Sequence similarities

Belongs to the orthobunyavirus envelope glycoprotein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1313
Chain14 – 14411428Envelope glycoprotein
PRO_0000036794
Chain14 – 299286Glycoprotein G2
PRO_0000036795
Chain300 – 473174Non-structural protein NSm
PRO_0000036796
Chain474 – 1441968Glycoprotein G1
PRO_0000036797

Regions

Topological domain14 – 200187Lumenal Potential
Transmembrane201 – 22121Helical; Potential
Topological domain222 – 30584Cytoplasmic Potential
Transmembrane306 – 32621Helical; Potential
Topological domain327 – 36539Lumenal Potential
Transmembrane366 – 38621Helical; Potential
Topological domain387 – 45266Cytoplasmic Potential
Transmembrane453 – 47321Helical; Potential
Topological domain474 – 1395922Lumenal Potential
Transmembrane1396 – 141621Helical; Potential
Topological domain1417 – 144125Cytoplasmic Potential

Sites

Site473 – 4742Cleavage; by host signal peptidase By similarity

Amino acid modifications

Glycosylation571N-linked (GlcNAc...); by host Potential
Glycosylation4901N-linked (GlcNAc...); by host Potential
Glycosylation11771N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P04875 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 51F01DB268D1A08B

FASTA1,441162,390
        10         20         30         40         50         60 
MICILILFAV TAASPVYQRC FQDGAIVKQN PSKEAVTEVC LKDDVSMIKT EARYIKNATG 

        70         80         90        100        110        120 
VFSNNVAIRK WLVSDWHDCR PKKITGGHIN VIEVGDDLSL HTESYVCSAD CTIGVDKETA 

       130        140        150        160        170        180 
QVRLQTDTTN HFEIAGTIVK SGWFKSTTYI TLDQTCEHLK VSCGPKSIQF HACFNQHMSC 

       190        200        210        220        230        240 
VRFLHRTILP GSIANSICQN IEIIILVTLT LLIFILLSVL SKTYICYLLM PVFIPIAYAY 

       250        260        270        280        290        300 
GIIYNKSCKK CKLCGLVYHP FTECGTHCVC GARYDTSDRM KLHRASGLCP GYKSLRAARV 

       310        320        330        340        350        360 
MCKSKGPASI LSVITAILIL TFVTPINSMV VGESKEVFEL EQLPDDMLDM ALRINFYYFV 

       370        380        390        400        410        420 
CIMNYAVTWG LIIIGLLIGL LFKKYQHRFS NLYAMYCEEC DMYHDRSGLK RNGDFTNKCR 

       430        440        450        460        470        480 
QCTCGQYEDA TGLMTHRKTY NCLVRYKAKW VMNFLIAYML LTLIKDSAIV VQAAGTDFTT 

       490        500        510        520        530        540 
CLETENINWN CTGPFLNLGN CQKQQKKEPY ANIATQLKGL QAISVLDMPM IASIPEDIAG 

       550        560        570        580        590        600 
ALRYIEEKET FHVQLTAEYA MLSRYCDYYA QFSDNSGYSQ TTWRVYLRSH DFDACILYPN 

       610        620        630        640        650        660 
QHFCRCVKRG DKCSSSNGDF ANEMKNYYSG KQNKFDKDLN LALMALHHAF RGTSSAYIAT 

       670        680        690        700        710        720 
MLSKKSNDDL IAYTNKIKEK FPGNALLKAI VDYIAYMKSL SEMSSFKYDE FWDDLLYKSA 

       730        740        750        760        770        780 
PTKAPSLSRG SEPSYNFKLV VSSRSIKSCK NVKSVVCLSP RSGVSYDSII ACGDPNGPSV 

       790        800        810        820        830        840 
YRKPSDGVFQ SNADQSTYCL ADSHCLEDFE VVSQEELDAI KKSKCWEAEY PDVKLSKLTD 

       850        860        870        880        890        900 
GVKSCRMKDS GNCNVAANRW PIIQCENDKF YYSELQKDYD KTQDIGHFCL SPGCSTVRFP 

       910        920        930        940        950        960 
INPKHISNCN WQVSRSSIAK IDVHNIEDID QYRKAITQKL QTSLSLFKYA KTKNLPHIKP 

       970        980        990       1000       1010       1020 
IYKYITIEGT ETAEGIESAY IESEIPALAG TSIGFKITSK EGKHLLDVIG YVKSASCSSI 

      1030       1040       1050       1060       1070       1080 
YTKLYTTGPT SGINTKHDEL CTGPCPAKIN HQTGWLTFAK ERTSSWGCEE FGCLAISDGC 

      1090       1100       1110       1120       1130       1140 
VFGSCQDIIR DELTVYRKET DEVTDVELCL TFSDKTYCTN LNPITPIITD LFEVQFKTVE 

      1150       1160       1170       1180       1190       1200 
TYSLPRIVAI QNHEIKIGQV NDLGVYSKGC GNVQKVNGTV YGNGVPKFDY LCHLASRKEV 

      1210       1220       1230       1240       1250       1260 
IVRKCFDNDY QACKFLQSPA SYRLEEDSGT VTVIDYKKIL GTIKMKAILG DVKYKTFADN 

      1270       1280       1290       1300       1310       1320 
VDMTAEGSCT GCINCFENIH CELTLHTTIE ASCPIVSTCT VFHDRILVTP NEHKYALKVV 

      1330       1340       1350       1360       1370       1380 
CTEKPGNTLT IRICNTKVEA SLALVDAKPI LELAPVDQTA YIREKDERCK TWMCRVRDEG 

      1390       1400       1410       1420       1430       1440 
LQVILEPFKN LFGSYIGIFY TFIISIIALL IIIYIVLPIC FKLRDTLRKH EDAYKREMKI 


R 

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References

[1]"The complete sequence of the M RNA of snowshoe hare bunyavirus reveals the presence of internal hydrophobic domains in the viral glycoprotein."
Eshita Y., Bishop D.H.L.
Virology 137:227-240(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Nucleotide sequence analyses and predicted coding of bunyavirus genome RNA species."
Clerx-Van Haaster C.M., Akashi H., Auperin D.D., Bishop D.H.L.
J. Virol. 41:119-128(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-46.
[3]"Organization of the middle RNA segment of snowshoe hare Bunyavirus."
Fazakerley J.K., Gonzalez-Scarano F., Strickler J., Dietz-Schold B., Karush F., Nathanson N.
Virology 167:422-432(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC PROCESSING OF POLYPROTEIN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K02539 Genomic RNA. Translation: AAA47827.1.
J02392 Genomic RNA. No translation available.
PIRGNVUSV. A04102.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsTIGR04210. bunya_NSm. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGP_BUNSH
AccessionPrimary (citable) accession number: P04875
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families