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P04875

- GP_BUNSH

UniProt

P04875 - GP_BUNSH

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Protein

Envelope glycoprotein

Gene

GP

Organism
Bunyavirus snowshoe hare
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei473 – 4742Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. modulation by virus of host morphology or physiology Source: InterPro
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiBunyavirus snowshoe hare
Taxonomic identifieri11580 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Canis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
Culex [TaxID: 7174]
Culiseta [TaxID: 174825]
Equus caballus (Horse) [TaxID: 9796]
Gallus gallus (Chicken) [TaxID: 9031]
Homo sapiens (Human) [TaxID: 9606]
Lepus americanus (Snowshoe hare) [TaxID: 48086]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs (By similarity).By similarity
Chain Glycoprotein G2 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated
Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region.By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1313Add
BLAST
Chaini14 – 14411428Envelope glycoproteinPRO_0000036794Add
BLAST
Chaini14 – 299286Glycoprotein G2PRO_0000036795Add
BLAST
Chaini300 – 473174Non-structural protein NSmPRO_0000036796Add
BLAST
Chaini474 – 1441968Glycoprotein G1PRO_0000036797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi490 – 4901N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi1177 – 11771N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.1 Publication

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini14 – 200187LumenalSequence AnalysisAdd
BLAST
Topological domaini222 – 30584CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini327 – 36539LumenalSequence AnalysisAdd
BLAST
Topological domaini387 – 45266CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini474 – 1395922LumenalSequence AnalysisAdd
BLAST
Topological domaini1417 – 144125CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei201 – 22121HelicalSequence AnalysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence AnalysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence AnalysisAdd
BLAST
Transmembranei453 – 47321HelicalSequence AnalysisAdd
BLAST
Transmembranei1396 – 141621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04875-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MICILILFAV TAASPVYQRC FQDGAIVKQN PSKEAVTEVC LKDDVSMIKT
60 70 80 90 100
EARYIKNATG VFSNNVAIRK WLVSDWHDCR PKKITGGHIN VIEVGDDLSL
110 120 130 140 150
HTESYVCSAD CTIGVDKETA QVRLQTDTTN HFEIAGTIVK SGWFKSTTYI
160 170 180 190 200
TLDQTCEHLK VSCGPKSIQF HACFNQHMSC VRFLHRTILP GSIANSICQN
210 220 230 240 250
IEIIILVTLT LLIFILLSVL SKTYICYLLM PVFIPIAYAY GIIYNKSCKK
260 270 280 290 300
CKLCGLVYHP FTECGTHCVC GARYDTSDRM KLHRASGLCP GYKSLRAARV
310 320 330 340 350
MCKSKGPASI LSVITAILIL TFVTPINSMV VGESKEVFEL EQLPDDMLDM
360 370 380 390 400
ALRINFYYFV CIMNYAVTWG LIIIGLLIGL LFKKYQHRFS NLYAMYCEEC
410 420 430 440 450
DMYHDRSGLK RNGDFTNKCR QCTCGQYEDA TGLMTHRKTY NCLVRYKAKW
460 470 480 490 500
VMNFLIAYML LTLIKDSAIV VQAAGTDFTT CLETENINWN CTGPFLNLGN
510 520 530 540 550
CQKQQKKEPY ANIATQLKGL QAISVLDMPM IASIPEDIAG ALRYIEEKET
560 570 580 590 600
FHVQLTAEYA MLSRYCDYYA QFSDNSGYSQ TTWRVYLRSH DFDACILYPN
610 620 630 640 650
QHFCRCVKRG DKCSSSNGDF ANEMKNYYSG KQNKFDKDLN LALMALHHAF
660 670 680 690 700
RGTSSAYIAT MLSKKSNDDL IAYTNKIKEK FPGNALLKAI VDYIAYMKSL
710 720 730 740 750
SEMSSFKYDE FWDDLLYKSA PTKAPSLSRG SEPSYNFKLV VSSRSIKSCK
760 770 780 790 800
NVKSVVCLSP RSGVSYDSII ACGDPNGPSV YRKPSDGVFQ SNADQSTYCL
810 820 830 840 850
ADSHCLEDFE VVSQEELDAI KKSKCWEAEY PDVKLSKLTD GVKSCRMKDS
860 870 880 890 900
GNCNVAANRW PIIQCENDKF YYSELQKDYD KTQDIGHFCL SPGCSTVRFP
910 920 930 940 950
INPKHISNCN WQVSRSSIAK IDVHNIEDID QYRKAITQKL QTSLSLFKYA
960 970 980 990 1000
KTKNLPHIKP IYKYITIEGT ETAEGIESAY IESEIPALAG TSIGFKITSK
1010 1020 1030 1040 1050
EGKHLLDVIG YVKSASCSSI YTKLYTTGPT SGINTKHDEL CTGPCPAKIN
1060 1070 1080 1090 1100
HQTGWLTFAK ERTSSWGCEE FGCLAISDGC VFGSCQDIIR DELTVYRKET
1110 1120 1130 1140 1150
DEVTDVELCL TFSDKTYCTN LNPITPIITD LFEVQFKTVE TYSLPRIVAI
1160 1170 1180 1190 1200
QNHEIKIGQV NDLGVYSKGC GNVQKVNGTV YGNGVPKFDY LCHLASRKEV
1210 1220 1230 1240 1250
IVRKCFDNDY QACKFLQSPA SYRLEEDSGT VTVIDYKKIL GTIKMKAILG
1260 1270 1280 1290 1300
DVKYKTFADN VDMTAEGSCT GCINCFENIH CELTLHTTIE ASCPIVSTCT
1310 1320 1330 1340 1350
VFHDRILVTP NEHKYALKVV CTEKPGNTLT IRICNTKVEA SLALVDAKPI
1360 1370 1380 1390 1400
LELAPVDQTA YIREKDERCK TWMCRVRDEG LQVILEPFKN LFGSYIGIFY
1410 1420 1430 1440
TFIISIIALL IIIYIVLPIC FKLRDTLRKH EDAYKREMKI R
Length:1,441
Mass (Da):162,390
Last modified:August 13, 1987 - v1
Checksum:i51F01DB268D1A08B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02539 Genomic RNA. Translation: AAA47827.1.
J02392 Genomic RNA. No translation available.
PIRiA04102. GNVUSV.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02539 Genomic RNA. Translation: AAA47827.1 .
J02392 Genomic RNA. No translation available.
PIRi A04102. GNVUSV.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view ]
Pfami PF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view ]
PIRSFi PIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete sequence of the M RNA of snowshoe hare bunyavirus reveals the presence of internal hydrophobic domains in the viral glycoprotein."
    Eshita Y., Bishop D.H.L.
    Virology 137:227-240(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Nucleotide sequence analyses and predicted coding of bunyavirus genome RNA species."
    Clerx-Van Haaster C.M., Akashi H., Auperin D.D., Bishop D.H.L.
    J. Virol. 41:119-128(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-46.
  3. "Organization of the middle RNA segment of snowshoe hare Bunyavirus."
    Fazakerley J.K., Gonzalez-Scarano F., Strickler J., Dietz-Schold B., Karush F., Nathanson N.
    Virology 167:422-432(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING OF POLYPROTEIN.

Entry informationi

Entry nameiGP_BUNSH
AccessioniPrimary (citable) accession number: P04875
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3