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P04875

- GP_BUNSH

UniProt

P04875 - GP_BUNSH

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Protein
Envelope glycoprotein
Gene
GP
Organism
Bunyavirus snowshoe hare
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei473 – 4742Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. modulation by virus of host morphology or physiology Source: InterPro
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiBunyavirus snowshoe hare
Taxonomic identifieri11580 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Canis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
Culex [TaxID: 7174]
Culiseta [TaxID: 174825]
Equus caballus (Horse) [TaxID: 9796]
Gallus gallus (Chicken) [TaxID: 9031]
Homo sapiens (Human) [TaxID: 9606]
Lepus americanus (Snowshoe hare) [TaxID: 48086]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.
Chain Glycoprotein G2 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction
Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini14 – 200187Lumenal Reviewed prediction
Add
BLAST
Transmembranei201 – 22121Helical; Reviewed prediction
Add
BLAST
Topological domaini222 – 30584Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei306 – 32621Helical; Reviewed prediction
Add
BLAST
Topological domaini327 – 36539Lumenal Reviewed prediction
Add
BLAST
Transmembranei366 – 38621Helical; Reviewed prediction
Add
BLAST
Topological domaini387 – 45266Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei453 – 47321Helical; Reviewed prediction
Add
BLAST
Topological domaini474 – 1395922Lumenal Reviewed prediction
Add
BLAST
Transmembranei1396 – 141621Helical; Reviewed prediction
Add
BLAST
Topological domaini1417 – 144125Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1313
Add
BLAST
Chaini14 – 14411428Envelope glycoprotein
PRO_0000036794Add
BLAST
Chaini14 – 299286Glycoprotein G2
PRO_0000036795Add
BLAST
Chaini300 – 473174Non-structural protein NSm
PRO_0000036796Add
BLAST
Chaini474 – 1441968Glycoprotein G1
PRO_0000036797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi490 – 4901N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1177 – 11771N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04875-1 [UniParc]FASTAAdd to Basket

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MICILILFAV TAASPVYQRC FQDGAIVKQN PSKEAVTEVC LKDDVSMIKT     50
EARYIKNATG VFSNNVAIRK WLVSDWHDCR PKKITGGHIN VIEVGDDLSL 100
HTESYVCSAD CTIGVDKETA QVRLQTDTTN HFEIAGTIVK SGWFKSTTYI 150
TLDQTCEHLK VSCGPKSIQF HACFNQHMSC VRFLHRTILP GSIANSICQN 200
IEIIILVTLT LLIFILLSVL SKTYICYLLM PVFIPIAYAY GIIYNKSCKK 250
CKLCGLVYHP FTECGTHCVC GARYDTSDRM KLHRASGLCP GYKSLRAARV 300
MCKSKGPASI LSVITAILIL TFVTPINSMV VGESKEVFEL EQLPDDMLDM 350
ALRINFYYFV CIMNYAVTWG LIIIGLLIGL LFKKYQHRFS NLYAMYCEEC 400
DMYHDRSGLK RNGDFTNKCR QCTCGQYEDA TGLMTHRKTY NCLVRYKAKW 450
VMNFLIAYML LTLIKDSAIV VQAAGTDFTT CLETENINWN CTGPFLNLGN 500
CQKQQKKEPY ANIATQLKGL QAISVLDMPM IASIPEDIAG ALRYIEEKET 550
FHVQLTAEYA MLSRYCDYYA QFSDNSGYSQ TTWRVYLRSH DFDACILYPN 600
QHFCRCVKRG DKCSSSNGDF ANEMKNYYSG KQNKFDKDLN LALMALHHAF 650
RGTSSAYIAT MLSKKSNDDL IAYTNKIKEK FPGNALLKAI VDYIAYMKSL 700
SEMSSFKYDE FWDDLLYKSA PTKAPSLSRG SEPSYNFKLV VSSRSIKSCK 750
NVKSVVCLSP RSGVSYDSII ACGDPNGPSV YRKPSDGVFQ SNADQSTYCL 800
ADSHCLEDFE VVSQEELDAI KKSKCWEAEY PDVKLSKLTD GVKSCRMKDS 850
GNCNVAANRW PIIQCENDKF YYSELQKDYD KTQDIGHFCL SPGCSTVRFP 900
INPKHISNCN WQVSRSSIAK IDVHNIEDID QYRKAITQKL QTSLSLFKYA 950
KTKNLPHIKP IYKYITIEGT ETAEGIESAY IESEIPALAG TSIGFKITSK 1000
EGKHLLDVIG YVKSASCSSI YTKLYTTGPT SGINTKHDEL CTGPCPAKIN 1050
HQTGWLTFAK ERTSSWGCEE FGCLAISDGC VFGSCQDIIR DELTVYRKET 1100
DEVTDVELCL TFSDKTYCTN LNPITPIITD LFEVQFKTVE TYSLPRIVAI 1150
QNHEIKIGQV NDLGVYSKGC GNVQKVNGTV YGNGVPKFDY LCHLASRKEV 1200
IVRKCFDNDY QACKFLQSPA SYRLEEDSGT VTVIDYKKIL GTIKMKAILG 1250
DVKYKTFADN VDMTAEGSCT GCINCFENIH CELTLHTTIE ASCPIVSTCT 1300
VFHDRILVTP NEHKYALKVV CTEKPGNTLT IRICNTKVEA SLALVDAKPI 1350
LELAPVDQTA YIREKDERCK TWMCRVRDEG LQVILEPFKN LFGSYIGIFY 1400
TFIISIIALL IIIYIVLPIC FKLRDTLRKH EDAYKREMKI R 1441
Length:1,441
Mass (Da):162,390
Last modified:August 13, 1987 - v1
Checksum:i51F01DB268D1A08B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02539 Genomic RNA. Translation: AAA47827.1.
J02392 Genomic RNA. No translation available.
PIRiA04102. GNVUSV.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02539 Genomic RNA. Translation: AAA47827.1 .
J02392 Genomic RNA. No translation available.
PIRi A04102. GNVUSV.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view ]
Pfami PF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view ]
PIRSFi PIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete sequence of the M RNA of snowshoe hare bunyavirus reveals the presence of internal hydrophobic domains in the viral glycoprotein."
    Eshita Y., Bishop D.H.L.
    Virology 137:227-240(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Nucleotide sequence analyses and predicted coding of bunyavirus genome RNA species."
    Clerx-Van Haaster C.M., Akashi H., Auperin D.D., Bishop D.H.L.
    J. Virol. 41:119-128(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-46.
  3. "Organization of the middle RNA segment of snowshoe hare Bunyavirus."
    Fazakerley J.K., Gonzalez-Scarano F., Strickler J., Dietz-Schold B., Karush F., Nathanson N.
    Virology 167:422-432(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING OF POLYPROTEIN.

Entry informationi

Entry nameiGP_BUNSH
AccessioniPrimary (citable) accession number: P04875
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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