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P04874

- NSS_BUNLC

UniProt

P04874 - NSS_BUNLC

Protein

Non-structural protein NS-S

Gene

N

Organism
Bunyavirus La Crosse
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1 By similarity.By similarity

    GO - Biological processi

    1. suppression by virus of host gene expression Source: UniProtKB-KW

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of eukaryotic host transcription initiation by virus

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein NS-S
    Gene namesi
    Name:N
    OrganismiBunyavirus La Crosse
    Taxonomic identifieri11577 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
    Virus hostiCervidae (deer) [TaxID: 9850]
    Homo sapiens (Human) [TaxID: 9606]
    Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
    Tamias [TaxID: 13712]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9292Non-structural protein NS-SPRO_0000221973Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR000797. Bunya_NSs.
    [Graphical view]
    PfamiPF01104. Bunya_NS-S. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003954. NS-S_OrthobunV. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform NSS (identifier: P04874-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMSHQQVQMD LILMQGIWTS VLKMQNHSTL LQLGSSSSMP QRPRLLSRVS   50
    QRGRLTLNLE SGRWRLSIII FLETGTTQLV TTILPSTDYL GI 92

    Note: Produced by alternative initiation in the N gene, but encoded on another frame.

    Length:92
    Mass (Da):10,441
    Last modified:August 13, 1987 - v1
    Checksum:i03572181F26C6348
    GO
    Isoform N (identifier: P04873-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P04873.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:235
    Mass (Da):26,530
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401P → L in AAA42780. (PubMed:6684362)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K00610 Genomic RNA. Translation: AAA42783.1.
    K00108 Genomic RNA. Translation: AAA42780.1.
    PIRiA04106. MNVULV.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K00610 Genomic RNA. Translation: AAA42783.1 .
    K00108 Genomic RNA. Translation: AAA42780.1 .
    PIRi A04106. MNVULV.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000797. Bunya_NSs.
    [Graphical view ]
    Pfami PF01104. Bunya_NS-S. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003954. NS-S_OrthobunV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the sequences and coding of La Crosse and snowshoe hare bunyavirus S RNA species."
      Akashi H., Bishop D.H.L.
      J. Virol. 45:1155-1158(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Molecular cloning and sequencing of the La Crosse virus S RNA."
      Cabradilla C.D. Jr., Holloway B.P., Obijeski J.F.
      Virology 128:463-468(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNSS_BUNLC
    AccessioniPrimary (citable) accession number: P04874
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3