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P04874 (NSS_BUNLC) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein NS-S
Gene names
Name:N
OrganismBunyavirus La Crosse
Taxonomic identifier11577 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostCervidae (deer) [TaxID: 9850]
Homo sapiens (Human) [TaxID: 9606]
Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
Tamias [TaxID: 13712]

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1 By similarity.

Sequence similarities

Belongs to the orthobunyavirus NS-S protein family.

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform NSS (identifier: P04874-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by alternative initiation in the N gene, but encoded on another frame.
Isoform N (identifier: P04873-1)

The sequence of this isoform can be found in the external entry P04873.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9292Non-structural protein NS-S
PRO_0000221973

Experimental info

Sequence conflict401P → L in AAA42780. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform NSS [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 03572181F26C6348

FASTA9210,441
        10         20         30         40         50         60 
MMSHQQVQMD LILMQGIWTS VLKMQNHSTL LQLGSSSSMP QRPRLLSRVS QRGRLTLNLE 

        70         80         90 
SGRWRLSIII FLETGTTQLV TTILPSTDYL GI 

« Hide

Isoform N [UniParc].

See P04873.

References

[1]"Comparison of the sequences and coding of La Crosse and snowshoe hare bunyavirus S RNA species."
Akashi H., Bishop D.H.L.
J. Virol. 45:1155-1158(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Molecular cloning and sequencing of the La Crosse virus S RNA."
Cabradilla C.D. Jr., Holloway B.P., Obijeski J.F.
Virology 128:463-468(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K00610 Genomic RNA. Translation: AAA42783.1.
K00108 Genomic RNA. Translation: AAA42780.1.
PIRMNVULV. A04106.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000797. Bunya_NSs.
[Graphical view]
PfamPF01104. Bunya_NS-S. 1 hit.
[Graphical view]
PIRSFPIRSF003954. NS-S_OrthobunV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNSS_BUNLC
AccessionPrimary (citable) accession number: P04874
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families