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P04873

- NCAP_BUNLC

UniProt

P04873 - NCAP_BUNLC

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Protein

Nucleoprotein

Gene

N

Organism
Bunyavirus La Crosse
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication. Seems to participate in the nuclear relocalization of host PABP1, thereby inhibiting host cellular translation (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. suppression by virus of host gene expression Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:N
OrganismiBunyavirus La Crosse
Taxonomic identifieri11577 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiCervidae (deer) [TaxID: 9850]
Homo sapiens (Human) [TaxID: 9606]
Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
Tamias [TaxID: 13712]

Subcellular locationi

Virion
Note: Internal protein of virus particle.

GO - Cellular componenti

  1. helical viral capsid Source: UniProtKB-KW
  2. ribonucleoprotein complex Source: UniProtKB-KW
  3. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235NucleoproteinPRO_0000221990Add
BLAST

Interactioni

Subunit structurei

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with host PABP1.By similarity

Structurei

Secondary structure

235
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni1 – 44Combined sources
Helixi19 – 3012Combined sources
Turni31 – 333Combined sources
Helixi36 – 5318Combined sources
Beta strandi59 – 613Combined sources
Helixi78 – 803Combined sources
Helixi92 – 10918Combined sources
Helixi113 – 12210Combined sources
Helixi126 – 1305Combined sources
Helixi135 – 1373Combined sources
Helixi139 – 1435Combined sources
Helixi149 – 1524Combined sources
Turni153 – 1586Combined sources
Helixi159 – 16911Combined sources
Helixi175 – 1784Combined sources
Helixi179 – 1824Combined sources
Beta strandi186 – 1883Combined sources
Helixi191 – 1977Combined sources
Helixi199 – 21012Combined sources
Helixi221 – 2288Combined sources
Turni229 – 2313Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BGPX-ray1.80A1-235[»]
4BHHX-ray3.40B/D/F/Z1-235[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001784. Bunya_nucleocap.
[Graphical view]
PfamiPF00952. Bunya_nucleocap. 1 hit.
[Graphical view]
PIRSFiPIRSF003947. N_OrthobunV. 1 hit.
ProDomiPD001909. Bunya_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform N (identifier: P04873-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDLVFYDVA STGANGFDPD AGYMDFCVKN AESLNLAAVR IFFLNAAKAK
60 70 80 90 100
AALSRKPERK ANPKFGEWQV EVINNHFPGN RNNPIGNNDL TIHRLSGYLA
110 120 130 140 150
RWVLDQYNEN DDESQHELIR TTIINPIAES NGVGWDSGPE IYLSFFPGTE
160 170 180 190 200
MFLETFKFYP LTIGIHRVKQ GMMDPQYLKK ALRQRYGTLT ADKWMSQKVA
210 220 230
AIAKSLKDVE QLKWGKGGLS DTAKTFLQKF GIRLP
Length:235
Mass (Da):26,530
Last modified:August 13, 1987 - v1
Checksum:i56EBB4D64AD04A96
GO
Isoform NSS (identifier: P04874-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P04874.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative initiation in the N gene, but encoded on another frame.

Length:92
Mass (Da):10,441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00610 Genomic RNA. Translation: AAA42782.1.
K00108 Genomic RNA. Translation: AAA42779.1.
PIRiA04104. VHVULV.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00610 Genomic RNA. Translation: AAA42782.1 .
K00108 Genomic RNA. Translation: AAA42779.1 .
PIRi A04104. VHVULV.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BGP X-ray 1.80 A 1-235 [» ]
4BHH X-ray 3.40 B/D/F/Z 1-235 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001784. Bunya_nucleocap.
[Graphical view ]
Pfami PF00952. Bunya_nucleocap. 1 hit.
[Graphical view ]
PIRSFi PIRSF003947. N_OrthobunV. 1 hit.
ProDomi PD001909. Bunya_nucleocap. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the sequences and coding of La Crosse and snowshoe hare bunyavirus S RNA species."
    Akashi H., Bishop D.H.L.
    J. Virol. 45:1155-1158(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Molecular cloning and sequencing of the La Crosse virus S RNA."
    Cabradilla C.D. Jr., Holloway B.P., Obijeski J.F.
    Virology 128:463-468(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNCAP_BUNLC
AccessioniPrimary (citable) accession number: P04873
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3