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Protein

Nucleoprotein

Gene

N

Organism
Bunyavirus La Crosse
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication. Seems to participate in the nuclear relocalization of host PABP1, thereby inhibiting host cellular translation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:N
OrganismiBunyavirus La Crosse
Taxonomic identifieri11577 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiCervidae (deer) [TaxID: 9850]
Homo sapiens (Human) [TaxID: 9606]
Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
Tamias [TaxID: 13712]

Subcellular locationi

  • Virion

  • Note: Internal protein of virus particle.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002219901 – 235NucleoproteinAdd BLAST235

Interactioni

Subunit structurei

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with host PABP1.By similarity

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni1 – 4Combined sources4
Helixi19 – 30Combined sources12
Turni31 – 33Combined sources3
Helixi36 – 53Combined sources18
Beta strandi59 – 61Combined sources3
Helixi78 – 80Combined sources3
Helixi92 – 109Combined sources18
Helixi113 – 122Combined sources10
Helixi126 – 130Combined sources5
Helixi135 – 137Combined sources3
Helixi139 – 143Combined sources5
Helixi149 – 152Combined sources4
Turni153 – 158Combined sources6
Helixi159 – 169Combined sources11
Helixi175 – 178Combined sources4
Helixi179 – 182Combined sources4
Beta strandi186 – 188Combined sources3
Helixi191 – 197Combined sources7
Helixi199 – 210Combined sources12
Helixi221 – 228Combined sources8
Turni229 – 231Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BGPX-ray1.80A1-235[»]
4BHHX-ray3.40B/D/F/Z1-235[»]
SMRiP04873.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001784. Bunya_nucleocap.
[Graphical view]
PfamiPF00952. Bunya_nucleocap. 1 hit.
[Graphical view]
PIRSFiPIRSF003947. N_OrthobunV. 1 hit.
ProDomiPD001909. Bunya_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform N (identifier: P04873-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDLVFYDVA STGANGFDPD AGYMDFCVKN AESLNLAAVR IFFLNAAKAK
60 70 80 90 100
AALSRKPERK ANPKFGEWQV EVINNHFPGN RNNPIGNNDL TIHRLSGYLA
110 120 130 140 150
RWVLDQYNEN DDESQHELIR TTIINPIAES NGVGWDSGPE IYLSFFPGTE
160 170 180 190 200
MFLETFKFYP LTIGIHRVKQ GMMDPQYLKK ALRQRYGTLT ADKWMSQKVA
210 220 230
AIAKSLKDVE QLKWGKGGLS DTAKTFLQKF GIRLP
Length:235
Mass (Da):26,530
Last modified:August 13, 1987 - v1
Checksum:i56EBB4D64AD04A96
GO
Isoform NSS (identifier: P04874-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P04874.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by alternative initiation in the N gene, but encoded on another frame.
Length:92
Mass (Da):10,441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00610 Genomic RNA. Translation: AAA42782.1.
K00108 Genomic RNA. Translation: AAA42779.1.
PIRiA04104. VHVULV.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00610 Genomic RNA. Translation: AAA42782.1.
K00108 Genomic RNA. Translation: AAA42779.1.
PIRiA04104. VHVULV.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BGPX-ray1.80A1-235[»]
4BHHX-ray3.40B/D/F/Z1-235[»]
SMRiP04873.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR001784. Bunya_nucleocap.
[Graphical view]
PfamiPF00952. Bunya_nucleocap. 1 hit.
[Graphical view]
PIRSFiPIRSF003947. N_OrthobunV. 1 hit.
ProDomiPD001909. Bunya_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiNCAP_BUNLC
AccessioniPrimary (citable) accession number: P04873
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.