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P04873 (NCAP_BUNLC) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name=Protein N
Gene names
Name:N
OrganismBunyavirus La Crosse
Taxonomic identifier11577 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostCervidae (deer) [TaxID: 9850]
Homo sapiens (Human) [TaxID: 9606]
Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
Tamias [TaxID: 13712]

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication. Seems to participate in the nuclear relocalization of host PABP1, thereby inhibiting host cellular translation By similarity.

Subunit structure

Homomultimerizes to form the nucleocapsid By similarity. Binds to viral genomic RNA By similarity. Interacts with host PABP1 By similarity.

Subcellular location

Virion. Note: Internal protein of virus particle.

Sequence similarities

Belongs to the orthobunyavirus nucleocapsid protein family.

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform N (identifier: P04873-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform NSS (identifier: P04874-1)

The sequence of this isoform can be found in the external entry P04874.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by alternative initiation in the N gene, but encoded on another frame.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Nucleoprotein
PRO_0000221990

Secondary structure

..................................... 235
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform N [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 56EBB4D64AD04A96

FASTA23526,530
        10         20         30         40         50         60 
MSDLVFYDVA STGANGFDPD AGYMDFCVKN AESLNLAAVR IFFLNAAKAK AALSRKPERK 

        70         80         90        100        110        120 
ANPKFGEWQV EVINNHFPGN RNNPIGNNDL TIHRLSGYLA RWVLDQYNEN DDESQHELIR 

       130        140        150        160        170        180 
TTIINPIAES NGVGWDSGPE IYLSFFPGTE MFLETFKFYP LTIGIHRVKQ GMMDPQYLKK 

       190        200        210        220        230 
ALRQRYGTLT ADKWMSQKVA AIAKSLKDVE QLKWGKGGLS DTAKTFLQKF GIRLP 

« Hide

Isoform NSS [UniParc].

See P04874.

References

[1]"Comparison of the sequences and coding of La Crosse and snowshoe hare bunyavirus S RNA species."
Akashi H., Bishop D.H.L.
J. Virol. 45:1155-1158(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Molecular cloning and sequencing of the La Crosse virus S RNA."
Cabradilla C.D. Jr., Holloway B.P., Obijeski J.F.
Virology 128:463-468(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K00610 Genomic RNA. Translation: AAA42782.1.
K00108 Genomic RNA. Translation: AAA42779.1.
PIRVHVULV. A04104.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4BGPX-ray1.80A1-235[»]
4BHHX-ray3.40B/D/F/Z1-235[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001784. Bunya_nucleocap.
[Graphical view]
PfamPF00952. Bunya_nucleocap. 1 hit.
[Graphical view]
PIRSFPIRSF003947. N_OrthobunV. 1 hit.
ProDomPD001909. Bunya_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameNCAP_BUNLC
AccessionPrimary (citable) accession number: P04873
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references