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P04850

- HN_SV5

UniProt

P04850 - HN_SV5

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Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Simian virus 5 (strain W3) (SV5)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiSimian virus 5 (strain W3) (SV5)
Taxonomic identifieri11208 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
Virus hostiCanis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
Homo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007232: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Hemagglutinin-neuraminidasePRO_0000142641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...); by host
Disulfide bondi161 ↔ 185
Disulfide bondi175 ↔ 236
Disulfide bondi227 ↔ 240
Glycosylationi267 – 2671N-linked (GlcNAc...); by host
Disulfide bondi365 ↔ 375
Disulfide bondi448 ↔ 458
Glycosylationi504 – 5041N-linked (GlcNAc...); by host
Disulfide bondi528 ↔ 539

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

DIPiDIP-48442N.

Structurei

Secondary structure

1
565
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi66 – 694
Helixi72 – 809
Helixi82 – 9918
Turni121 – 1255
Beta strandi126 – 1294
Helixi134 – 1374
Beta strandi140 – 1456
Beta strandi156 – 1594
Beta strandi161 – 1699
Beta strandi174 – 18411
Beta strandi192 – 20211
Beta strandi206 – 21813
Beta strandi224 – 2329
Beta strandi235 – 2428
Helixi247 – 2526
Beta strandi253 – 2553
Beta strandi258 – 2658
Beta strandi270 – 2756
Turni281 – 2833
Beta strandi284 – 2896
Beta strandi295 – 2973
Beta strandi300 – 30910
Helixi314 – 3196
Turni330 – 3323
Helixi337 – 34610
Turni351 – 3555
Beta strandi356 – 36712
Beta strandi376 – 3794
Turni382 – 3843
Beta strandi391 – 3966
Beta strandi399 – 4046
Beta strandi414 – 43421
Helixi446 – 4483
Beta strandi466 – 4705
Helixi472 – 4743
Beta strandi475 – 4773
Turni478 – 4814
Beta strandi483 – 4897
Beta strandi491 – 4966
Beta strandi498 – 5069
Beta strandi508 – 5136
Beta strandi520 – 53112
Turni532 – 5354
Beta strandi536 – 54611
Beta strandi548 – 56417

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z4VX-ray2.30A37-565[»]
1Z4WX-ray2.70A37-565[»]
1Z4XX-ray2.50A37-565[»]
1Z4YX-ray2.60A37-565[»]
1Z4ZX-ray2.50A37-565[»]
1Z50X-ray2.80A37-565[»]
3TSIX-ray2.65A/B/C/D56-117[»]
4JF7X-ray2.50A/B/C/D56-565[»]
ProteinModelPortaliP04850.
SMRiP04850. Positions 118-565.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04850.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919IntravirionSequence AnalysisAdd
BLAST
Topological domaini41 – 565525Virion surfaceSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P04850-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAEDAPVRA TCRVLFRTTT LIFLCTLLAL SISILYESLI TQKQIMSQAG
60 70 80 90 100
STGSNSGLGS ITDLLNNILS VANQIIYNSA VALPLQLDTL ESTLLTAIKS
110 120 130 140 150
LQTSDKLEQN CSWSAALIND NRYINGINQF YFSIAEGRNL TLGPLLNMPS
160 170 180 190 200
FIPTATTPEG CTRIPSFSLT KTHWCYTHNV ILNGCQDHVS SNQFVSMGII
210 220 230 240 250
EPTSAGFPFF RTLKTLYLSD GVNRKSCSIS TVPGGCMMYC FVSTQPERDD
260 270 280 290 300
YFSAAPPEQR IIIMYYNDTI VERIINPPGV LDVWATLNPG TGSGVYYLGW
310 320 330 340 350
VLFPIYGGVI KGTSLWNNQA NKYFIPQMVA ALCSQNQATQ VQNAKSSYYS
360 370 380 390 400
SWFGNRMIQS GILACPLRQD LTNECLVLPF SNDQVLMGAE GRLYMYGDSV
410 420 430 440 450
YYYQRSNSWW PMTMLYKVTI TFTNGQPSAI SAQNVPTQQV PRPGTGDCSA
460 470 480 490 500
TNRCPGFCLT GVYADAWLLT NPSSTSTFGS EATFTGSYLN TATQRINPTM
510 520 530 540 550
YIANNTQIIS SQQFGSSGQE AAYGHTTCFR DTGSVMVYCI YIIELSSSLL
560
GQFQIVPFIR QVTLS
Length:565
Mass (Da):62,205
Last modified:August 13, 1987 - v1
Checksum:i30A4A7068A25B563
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S76876 mRNA. Translation: AAB21114.1.
K02870 Genomic RNA. Translation: AAA47878.1.
AF052755 Genomic RNA. Translation: AAC95517.1.
PIRiA00879. HNNZSV.
RefSeqiYP_138517.1. NC_006430.1.

Genome annotation databases

GeneIDi3160803.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S76876 mRNA. Translation: AAB21114.1 .
K02870 Genomic RNA. Translation: AAA47878.1 .
AF052755 Genomic RNA. Translation: AAC95517.1 .
PIRi A00879. HNNZSV.
RefSeqi YP_138517.1. NC_006430.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Z4V X-ray 2.30 A 37-565 [» ]
1Z4W X-ray 2.70 A 37-565 [» ]
1Z4X X-ray 2.50 A 37-565 [» ]
1Z4Y X-ray 2.60 A 37-565 [» ]
1Z4Z X-ray 2.50 A 37-565 [» ]
1Z50 X-ray 2.80 A 37-565 [» ]
3TSI X-ray 2.65 A/B/C/D 56-117 [» ]
4JF7 X-ray 2.50 A/B/C/D 56-565 [» ]
ProteinModelPortali P04850.
SMRi P04850. Positions 118-565.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-48442N.

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3160803.

Miscellaneous databases

EvolutionaryTracei P04850.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: nucleotide sequence of the mRNA predicts an N-terminal membrane anchor."
    Hiebert S.W., Paterson R.G., Lamb R.A.
    J. Virol. 54:1-6(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5."
    Baty D.U., Southern J.A., Randall R.E.
    J. Gen. Virol. 72:3103-3107(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose."
    Yuan P., Thompson T.B., Wurzburg B.A., Paterson R.G., Lamb R.A., Jardetzky T.S.
    Structure 13:803-815(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 37-565.

Entry informationi

Entry nameiHN_SV5
AccessioniPrimary (citable) accession number: P04850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3