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Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiParainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5)
Taxonomic identifieri11208 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeRubulavirus
Virus hostiCanis lupus familiaris (Dog) (Canis familiaris) [TaxID: 9615]
Homo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007232 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19IntravirionSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 565Virion surfaceSequence analysisAdd BLAST525

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001426411 – 565Hemagglutinin-neuraminidaseAdd BLAST565

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...); by host1
Disulfide bondi161 ↔ 185
Disulfide bondi175 ↔ 236
Disulfide bondi227 ↔ 240
Glycosylationi267N-linked (GlcNAc...); by host1
Disulfide bondi365 ↔ 375
Disulfide bondi448 ↔ 458
Glycosylationi504N-linked (GlcNAc...); by host1
Disulfide bondi528 ↔ 539

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

DIPiDIP-48442N.

Structurei

Secondary structure

1565
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi66 – 69Combined sources4
Helixi72 – 80Combined sources9
Helixi82 – 99Combined sources18
Helixi103 – 106Combined sources4
Beta strandi109 – 113Combined sources5
Turni121 – 125Combined sources5
Beta strandi126 – 129Combined sources4
Helixi134 – 137Combined sources4
Beta strandi140 – 145Combined sources6
Beta strandi156 – 159Combined sources4
Beta strandi161 – 169Combined sources9
Beta strandi174 – 184Combined sources11
Beta strandi192 – 202Combined sources11
Beta strandi206 – 218Combined sources13
Beta strandi224 – 232Combined sources9
Beta strandi235 – 242Combined sources8
Helixi247 – 252Combined sources6
Beta strandi253 – 255Combined sources3
Beta strandi258 – 265Combined sources8
Beta strandi270 – 275Combined sources6
Turni281 – 283Combined sources3
Beta strandi284 – 289Combined sources6
Beta strandi295 – 297Combined sources3
Beta strandi300 – 309Combined sources10
Helixi314 – 319Combined sources6
Turni330 – 332Combined sources3
Helixi337 – 346Combined sources10
Turni351 – 355Combined sources5
Beta strandi356 – 367Combined sources12
Beta strandi376 – 379Combined sources4
Turni382 – 384Combined sources3
Beta strandi391 – 396Combined sources6
Beta strandi399 – 404Combined sources6
Beta strandi414 – 434Combined sources21
Helixi446 – 448Combined sources3
Beta strandi466 – 470Combined sources5
Helixi472 – 474Combined sources3
Beta strandi475 – 477Combined sources3
Turni478 – 481Combined sources4
Beta strandi483 – 489Combined sources7
Beta strandi491 – 496Combined sources6
Beta strandi498 – 506Combined sources9
Beta strandi508 – 513Combined sources6
Beta strandi520 – 531Combined sources12
Turni532 – 535Combined sources4
Beta strandi536 – 546Combined sources11
Beta strandi548 – 564Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z4VX-ray2.30A37-565[»]
1Z4WX-ray2.70A37-565[»]
1Z4XX-ray2.50A37-565[»]
1Z4YX-ray2.60A37-565[»]
1Z4ZX-ray2.50A37-565[»]
1Z50X-ray2.80A37-565[»]
3TSIX-ray2.65A/B/C/D56-117[»]
4JF7X-ray2.50A/B/C/D56-565[»]
ProteinModelPortaliP04850.
SMRiP04850.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04850.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK19247.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR016285. Hemagglutn-neuramid.
IPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P04850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAEDAPVRA TCRVLFRTTT LIFLCTLLAL SISILYESLI TQKQIMSQAG
60 70 80 90 100
STGSNSGLGS ITDLLNNILS VANQIIYNSA VALPLQLDTL ESTLLTAIKS
110 120 130 140 150
LQTSDKLEQN CSWSAALIND NRYINGINQF YFSIAEGRNL TLGPLLNMPS
160 170 180 190 200
FIPTATTPEG CTRIPSFSLT KTHWCYTHNV ILNGCQDHVS SNQFVSMGII
210 220 230 240 250
EPTSAGFPFF RTLKTLYLSD GVNRKSCSIS TVPGGCMMYC FVSTQPERDD
260 270 280 290 300
YFSAAPPEQR IIIMYYNDTI VERIINPPGV LDVWATLNPG TGSGVYYLGW
310 320 330 340 350
VLFPIYGGVI KGTSLWNNQA NKYFIPQMVA ALCSQNQATQ VQNAKSSYYS
360 370 380 390 400
SWFGNRMIQS GILACPLRQD LTNECLVLPF SNDQVLMGAE GRLYMYGDSV
410 420 430 440 450
YYYQRSNSWW PMTMLYKVTI TFTNGQPSAI SAQNVPTQQV PRPGTGDCSA
460 470 480 490 500
TNRCPGFCLT GVYADAWLLT NPSSTSTFGS EATFTGSYLN TATQRINPTM
510 520 530 540 550
YIANNTQIIS SQQFGSSGQE AAYGHTTCFR DTGSVMVYCI YIIELSSSLL
560
GQFQIVPFIR QVTLS
Length:565
Mass (Da):62,205
Last modified:August 13, 1987 - v1
Checksum:i30A4A7068A25B563
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76876 mRNA. Translation: AAB21114.1.
K02870 Genomic RNA. Translation: AAA47878.1.
AF052755 Genomic RNA. Translation: AAC95517.1.
PIRiA00879. HNNZSV.
RefSeqiYP_138517.1. NC_006430.1.

Genome annotation databases

GeneIDi3160803.
KEGGivg:3160803.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76876 mRNA. Translation: AAB21114.1.
K02870 Genomic RNA. Translation: AAA47878.1.
AF052755 Genomic RNA. Translation: AAC95517.1.
PIRiA00879. HNNZSV.
RefSeqiYP_138517.1. NC_006430.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z4VX-ray2.30A37-565[»]
1Z4WX-ray2.70A37-565[»]
1Z4XX-ray2.50A37-565[»]
1Z4YX-ray2.60A37-565[»]
1Z4ZX-ray2.50A37-565[»]
1Z50X-ray2.80A37-565[»]
3TSIX-ray2.65A/B/C/D56-117[»]
4JF7X-ray2.50A/B/C/D56-565[»]
ProteinModelPortaliP04850.
SMRiP04850.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48442N.

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3160803.
KEGGivg:3160803.

Phylogenomic databases

KOiK19247.

Miscellaneous databases

EvolutionaryTraceiP04850.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR016285. Hemagglutn-neuramid.
IPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHN_PIV5
AccessioniPrimary (citable) accession number: P04850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.