nlpA

Functionⁱ

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG10657-MONOMER.

BioCycⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lipoprotein 28
Gene namesⁱ	Name:nlpA Ordered Locus Names:b3661, JW3635
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10657. nlpA.

EcoGeneⁱ

EG10657. nlpA.

Subcellular locationⁱ

Cell inner membrane ; Lipid-anchor

GO - Cellular componentⁱ

plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15911532
- 17309111

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Add BLAST		23
ChainⁱPRO_0000019737	24 – 272	Lipoprotein 28Add BLAST		249

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	24	N-palmitoyl cysteineCurated		1
Lipidationⁱ	24	S-diacylglycerol cysteinePROSITE-ProRule annotation1 Publication		1

Keywords - PTMⁱ

Lipoprotein, Palmitate

Proteomic databases

EPDⁱ	P04846.
PaxDbⁱ	P04846.
PRIDEⁱ	P04846.

2D gel databases

SWISS-2DPAGEⁱ	P04846.

SWISS-2DPAGEⁱ

P04846.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4259626. 12 interactors.
IntActⁱ	P04846. 8 interactors.
STRINGⁱ	316385.ECDH10B_3843.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P04846.
SMRⁱ	P04846.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NlpA lipoprotein family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG4105D01. Bacteria. COG1464. LUCA.
HOGENOMⁱ	HOG000222926.
InParanoidⁱ	P04846.
KEGG Orthology (KO) More...KOⁱ	K02073.
OMAⁱ	EQDNKAH.
PhylomeDBⁱ	P04846.

Family and domain databases

InterProⁱ	View protein in InterPro IPR004872. Lipoprotein_NlpA.
PANTHERⁱ	PTHR30429. PTHR30429. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03180. Lipoprotein_9. 1 hit.
PIRSFⁱ	PIRSF002854. MetQ. 1 hit.
TIGRFAMsⁱ	TIGR00363. TIGR00363. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51257. PROKAR_LIPOPROTEIN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P04846-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKLTTHHLRT GAALLLAGIL LAGCDQSSSD AKHIKVGVIN GAEQDVAEVA 
        60         70         80         90        100
KKVAKEKYGL DVELVGFSGS LLPNDATNHG ELDANVFQHR PFLEQDNQAH 
       110        120        130        140        150
GYKLVAVGNT FVFPMAGYSK KIKTVAQIKE GATVAIPNDP TNLGRALLLL 
       160        170        180        190        200
QKEKLITLKE GKGLLPTALD ITDNPRHLQI MELEGAQLPR VLDDPKVDVA 
       210        220        230        240        250
IISTTYIQQT GLSPVHDSVF IEDKNSPYVN ILVAREDNKN AENVKEFLQS 
       260        270 
YQSPEVAKAA ETIFNGGAVP GW

Length:272

Mass (Da):29,424

Last modified:August 13, 1987 - v1

Checksum:ⁱE3C249E753AB1B33

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12163 Genomic DNA. Translation: AAA24080.1. L10328 Genomic DNA. Translation: AAA62013.1. U00096 Genomic DNA. Translation: AAC76684.1. AP009048 Genomic DNA. Translation: BAE77633.1.
PIRⁱ	A26286. LPEC28.
NCBI Reference Sequences More...RefSeqⁱ	NP_418117.1. NC_000913.3. WP_000779426.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAC76684; AAC76684; b3661. BAE77633; BAE77633; BAE77633.
GeneIDⁱ	948175.
KEGGⁱ	ecj:JW3635. eco:b3661.
PATRICⁱ	fig\|1411691.4.peg.3045.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P04846	A0A222QS01 A0A1S6THH2 A0A024LBL3 F4SR61 C8TZ36 K4Y382 D7Y1C0 M9G7N8 S1HPQ4 A0A074HPA3 +40	Escherichia coli NCCP15648 Escherichia coli M8 Escherichia coli Escherichia coli H736 Escherichia coli O103:H2 (strain 12009 / EHEC) Escherichia coli O111:H11 str. CVM9455 Escherichia coli MS 115-1 Escherichia coli MP021561.2 Escherichia coli KTE107 Escherichia coli 1-392-07_S4_C1 And more	272	UniRef100_P04846	Cluster: Lipoprotein 28	51

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P04846	A0A222QS01 A0A1S6THH2 A0A024LBL3 F4SR61 C8TZ36 K4Y382 D7Y1C0 M9G7N8 S1HPQ4 A0A074HPA3 +533	Escherichia coli NCCP15648 Escherichia coli M8 Escherichia coli Escherichia coli H736 Escherichia coli O103:H2 (strain 12009 / EHEC) Escherichia coli O111:H11 str. CVM9455 Escherichia coli MS 115-1 Escherichia coli MP021561.2 Escherichia coli KTE107 Escherichia coli 1-392-07_S4_C1 And more	272	UniRef90_P04846	Cluster: Lipoprotein 28	544

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P04846	A0A222QS01 A0A1S6THH2 A0A024LBL3 F4SR61 C8TZ36 K4Y382 D7Y1C0 M9G7N8 S1HPQ4 A0A074HPA3 +919	Escherichia coli NCCP15648 Escherichia coli M8 Escherichia coli Escherichia coli H736 Escherichia coli O103:H2 (strain 12009 / EHEC) Escherichia coli O111:H11 str. CVM9455 Escherichia coli MS 115-1 Escherichia coli MP021561.2 Escherichia coli KTE107 Escherichia coli 1-392-07_S4_C1 And more	272	UniRef50_P04846	Cluster: Lipoprotein 28	930

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12163 Genomic DNA. Translation: AAA24080.1. L10328 Genomic DNA. Translation: AAA62013.1. U00096 Genomic DNA. Translation: AAC76684.1. AP009048 Genomic DNA. Translation: BAE77633.1.
PIRⁱ	A26286. LPEC28.
NCBI Reference Sequences More...RefSeqⁱ	NP_418117.1. NC_000913.3. WP_000779426.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortalⁱ	P04846.
SMRⁱ	P04846.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4259626. 12 interactors.
IntActⁱ	P04846. 8 interactors.
STRINGⁱ	316385.ECDH10B_3843.

2D gel databases

SWISS-2DPAGEⁱ	P04846.

SWISS-2DPAGEⁱ

P04846.

Proteomic databases

EPDⁱ	P04846.
PaxDbⁱ	P04846.
PRIDEⁱ	P04846.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC76684; AAC76684; b3661. BAE77633; BAE77633; BAE77633.
GeneIDⁱ	948175.
KEGGⁱ	ecj:JW3635. eco:b3661.
PATRICⁱ	fig\|1411691.4.peg.3045.

Organism-specific databases

EchoBASEⁱ	EB0651.
EcoGeneⁱ	EG10657. nlpA.

Phylogenomic databases

eggNOGⁱ	ENOG4105D01. Bacteria. COG1464. LUCA.
HOGENOMⁱ	HOG000222926.
InParanoidⁱ	P04846.
KEGG Orthology (KO) More...KOⁱ	K02073.
OMAⁱ	EQDNKAH.
PhylomeDBⁱ	P04846.

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG10657-MONOMER.

BioCycⁱ

EcoCyc:EG10657-MONOMER.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P04846.

PROⁱ

PR:P04846.

Family and domain databases

InterProⁱ	View protein in InterPro IPR004872. Lipoprotein_NlpA.
PANTHERⁱ	PTHR30429. PTHR30429. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03180. Lipoprotein_9. 1 hit.
PIRSFⁱ	PIRSF002854. MetQ. 1 hit.
TIGRFAMsⁱ	TIGR00363. TIGR00363. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51257. PROKAR_LIPOPROTEIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NLPA_ECOLI
Accessionⁱ	P04846Primary (citable) accession number: P04846 Secondary accession number(s): Q2M7X3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	August 13, 1987
	Last modified:	March 28, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P04846 (NLPA_ECOLI)

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Lipoprotein 28

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ