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Protein

Lipoprotein 28

Gene

nlpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:EG10657-MONOMER.
ECOL316407:JW3635-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein 28
Gene namesi
Name:nlpA
Ordered Locus Names:b3661, JW3635
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10657. nlpA.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 272249Lipoprotein 28PRO_0000019737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi24 – 241N-palmitoyl cysteineCurated
Lipidationi24 – 241S-diacylglycerol cysteinePROSITE-ProRule annotation1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiP04846.
PaxDbiP04846.
PRIDEiP04846.

2D gel databases

SWISS-2DPAGEP04846.

Interactioni

Protein-protein interaction databases

BioGridi4259626. 9 interactions.
IntActiP04846. 8 interactions.
STRINGi511145.b3661.

Structurei

3D structure databases

ProteinModelPortaliP04846.
SMRiP04846. Positions 30-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NlpA lipoprotein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105D01. Bacteria.
COG1464. LUCA.
HOGENOMiHOG000222926.
InParanoidiP04846.
KOiK02073.
OMAiMQSYQSP.
PhylomeDBiP04846.

Family and domain databases

InterProiIPR004872. Lipoprotein_NlpA.
[Graphical view]
PANTHERiPTHR30429. PTHR30429. 1 hit.
PfamiPF03180. Lipoprotein_9. 1 hit.
[Graphical view]
PIRSFiPIRSF002854. MetQ. 1 hit.
TIGRFAMsiTIGR00363. TIGR00363. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTTHHLRT GAALLLAGIL LAGCDQSSSD AKHIKVGVIN GAEQDVAEVA
60 70 80 90 100
KKVAKEKYGL DVELVGFSGS LLPNDATNHG ELDANVFQHR PFLEQDNQAH
110 120 130 140 150
GYKLVAVGNT FVFPMAGYSK KIKTVAQIKE GATVAIPNDP TNLGRALLLL
160 170 180 190 200
QKEKLITLKE GKGLLPTALD ITDNPRHLQI MELEGAQLPR VLDDPKVDVA
210 220 230 240 250
IISTTYIQQT GLSPVHDSVF IEDKNSPYVN ILVAREDNKN AENVKEFLQS
260 270
YQSPEVAKAA ETIFNGGAVP GW
Length:272
Mass (Da):29,424
Last modified:August 13, 1987 - v1
Checksum:iE3C249E753AB1B33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12163 Genomic DNA. Translation: AAA24080.1.
L10328 Genomic DNA. Translation: AAA62013.1.
U00096 Genomic DNA. Translation: AAC76684.1.
AP009048 Genomic DNA. Translation: BAE77633.1.
PIRiA26286. LPEC28.
RefSeqiNP_418117.1. NC_000913.3.
WP_000779426.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76684; AAC76684; b3661.
BAE77633; BAE77633; BAE77633.
GeneIDi948175.
KEGGiecj:JW3635.
eco:b3661.
PATRICi32122811. VBIEscCol129921_3781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12163 Genomic DNA. Translation: AAA24080.1.
L10328 Genomic DNA. Translation: AAA62013.1.
U00096 Genomic DNA. Translation: AAC76684.1.
AP009048 Genomic DNA. Translation: BAE77633.1.
PIRiA26286. LPEC28.
RefSeqiNP_418117.1. NC_000913.3.
WP_000779426.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP04846.
SMRiP04846. Positions 30-272.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259626. 9 interactions.
IntActiP04846. 8 interactions.
STRINGi511145.b3661.

2D gel databases

SWISS-2DPAGEP04846.

Proteomic databases

EPDiP04846.
PaxDbiP04846.
PRIDEiP04846.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76684; AAC76684; b3661.
BAE77633; BAE77633; BAE77633.
GeneIDi948175.
KEGGiecj:JW3635.
eco:b3661.
PATRICi32122811. VBIEscCol129921_3781.

Organism-specific databases

EchoBASEiEB0651.
EcoGeneiEG10657. nlpA.

Phylogenomic databases

eggNOGiENOG4105D01. Bacteria.
COG1464. LUCA.
HOGENOMiHOG000222926.
InParanoidiP04846.
KOiK02073.
OMAiMQSYQSP.
PhylomeDBiP04846.

Enzyme and pathway databases

BioCyciEcoCyc:EG10657-MONOMER.
ECOL316407:JW3635-MONOMER.

Miscellaneous databases

PROiP04846.

Family and domain databases

InterProiIPR004872. Lipoprotein_NlpA.
[Graphical view]
PANTHERiPTHR30429. PTHR30429. 1 hit.
PfamiPF03180. Lipoprotein_9. 1 hit.
[Graphical view]
PIRSFiPIRSF002854. MetQ. 1 hit.
TIGRFAMsiTIGR00363. TIGR00363. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNLPA_ECOLI
AccessioniPrimary (citable) accession number: P04846
Secondary accession number(s): Q2M7X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 7, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.