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P04844

- RPN2_HUMAN

UniProt

P04844 - RPN2_HUMAN

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Protein

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

Gene

RPN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.

Catalytic activityi

Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.

Pathwayi

GO - Molecular functioni

  1. ribosome binding Source: Ensembl
  2. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular protein metabolic process Source: Reactome
  3. cellular protein modification process Source: ProtInc
  4. gene expression Source: Reactome
  5. post-translational protein modification Source: Reactome
  6. protein N-linked glycosylation via asparagine Source: HGNC
  7. response to drug Source: Ensembl
  8. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  9. translation Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_22426. Asparagine N-linked glycosylation.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (EC:2.4.99.18)
Alternative name(s):
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit
RIBIIR
Ribophorin II
Short name:
RPN-II
Ribophorin-2
Gene namesi
Name:RPN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:10382. RPN2.

Subcellular locationi

GO - Cellular componenti

  1. autophagic vacuole membrane Source: Ensembl
  2. endoplasmic reticulum Source: HPA
  3. endoplasmic reticulum membrane Source: Reactome
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane Source: UniProtKB
  6. nucleus Source: HPA
  7. oligosaccharyltransferase complex Source: HGNC
  8. rough endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 631609Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2PRO_0000022244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...)1 Publication
Cross-linki154 – 154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP04844.
PaxDbiP04844.
PRIDEiP04844.

PTM databases

PhosphoSiteiP04844.

Expressioni

Tissue specificityi

Expressed in all tissues tested.

Gene expression databases

BgeeiP04844.
CleanExiHS_RPN2.
ExpressionAtlasiP04844. baseline and differential.
GenevestigatoriP04844.

Organism-specific databases

HPAiCAB019277.
HPA008297.
HPA025922.

Interactioni

Subunit structurei

Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Also identified as part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP. This contains known members of the OST complex and may be a form of this complex.3 Publications

Protein-protein interaction databases

BioGridi112100. 39 interactions.
IntActiP04844. 15 interactions.
MINTiMINT-8247596.
STRINGi9606.ENSP00000237530.

Structurei

3D structure databases

ProteinModelPortaliP04844.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 540518LumenalSequence AnalysisAdd
BLAST
Topological domaini562 – 57110CytoplasmicSequence Analysis
Topological domaini593 – 5964LumenalSequence Analysis
Topological domaini618 – 63114CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei541 – 56121HelicalSequence AnalysisAdd
BLAST
Transmembranei572 – 59221HelicalSequence AnalysisAdd
BLAST
Transmembranei597 – 61721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the SWP1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG258688.
GeneTreeiENSGT00390000002635.
HOGENOMiHOG000231261.
HOVERGENiHBG002365.
InParanoidiP04844.
KOiK12667.
OMAiPTHYLTK.
OrthoDBiEOG78SQHS.
PhylomeDBiP04844.
TreeFamiTF106146.

Family and domain databases

InterProiIPR008814. Swp1.
[Graphical view]
PANTHERiPTHR12640:SF0. PTHR12640:SF0. 1 hit.
PfamiPF05817. Ribophorin_II. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P04844-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPGSSTVF LLALTIIAST WALTPTHYLT KHDVERLKAS LDRPFTNLES
60 70 80 90 100
AFYSIVGLSS LGAQVPDAKK ACTYIRSNLD PSNVDSLFYA AQASQALSGC
110 120 130 140 150
EISISNETKD LLLAAVSEDS SVTQIYHAVA ALSGFGLPLA SQEALSALTA
160 170 180 190 200
RLSKEETVLA TVQALQTASH LSQQADLRSI VEEIEDLVAR LDELGGVYLQ
210 220 230 240 250
FEEGLETTAL FVAATYKLMD HVGTEPSIKE DQVIQLMNAI FSKKNFESLS
260 270 280 290 300
EAFSVASAAA VLSHNRYHVP VVVVPEGSAS DTHEQAILRL QVTNVLSQPL
310 320 330 340 350
TQATVKLEHA KSVASRATVL QKTSFTPVGD VFELNFMNVK FSSGYYDFLV
360 370 380 390 400
EVEGDNRYIA NTVELRVKIS TEVGITNVDL STVDKDQSIA PKTTRVTYPA
410 420 430 440 450
KAKGTFIADS HQNFALFFQL VDVNTGAELT PHQTFVRLHN QKTGQEVVFV
460 470 480 490 500
AEPDNKNVYK FELDTSERKI EFDSASGTYT LYLIIGDATL KNPILWNVAD
510 520 530 540 550
VVIKFPEEEA PSTVLSQNLF TPKQEIQHLF REPEKRPPTV VSNTFTALIL
560 570 580 590 600
SPLLLLFALW IRIGANVSNF TFAPSTIIFH LGHAAMLGLM YVYWTQLNMF
610 620 630
QTLKYLAILG SVTFLAGNRM LAQQAVKRTA H
Length:631
Mass (Da):69,284
Last modified:December 1, 2000 - v3
Checksum:iE24D7B3565141676
GO
Isoform 2 (identifier: P04844-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-101: Missing.
     627-627: K → KRIAAEQSSRLAKYRTL

Note: No experimental confirmation available.

Show »
Length:615
Mass (Da):67,723
Checksum:iFC967C1FA17A011E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971V → L in CAA68393. (PubMed:3034581)Curated
Sequence conflicti201 – 2011F → C in CAA68393. (PubMed:3034581)Curated
Sequence conflicti260 – 2601A → S in CAA68393. (PubMed:3034581)Curated
Sequence conflicti286 – 2861A → S in CAG33180. 1 PublicationCurated
Sequence conflicti423 – 4231V → M in CAA68393. (PubMed:3034581)Curated
Sequence conflicti427 – 4271A → V in CAG33180. 1 PublicationCurated
Sequence conflicti571 – 5711T → I in AAH13028. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti597 – 5971L → F.
Corresponds to variant rs34951322 [ dbSNP | Ensembl ].
VAR_054040

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei70 – 10132Missing in isoform 2. 1 PublicationVSP_043051Add
BLAST
Alternative sequencei627 – 6271K → KRIAAEQSSRLAKYRTL in isoform 2. 1 PublicationVSP_043052

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00282 mRNA. Translation: CAA68393.1.
AJ237734
, AJ237735, AJ237733, AJ237736, AJ237737, AJ237738, AJ237739, AJ237740, AJ237741, AJ237742, AJ237743, AJ237744, AJ237745, AJ237746, AJ237747, AJ237748, AJ237749 Genomic DNA. Translation: CAB54801.1.
AK096243 mRNA. Translation: BAG53237.1.
CR456899 mRNA. Translation: CAG33180.1.
AL031659 Genomic DNA. Translation: CAB41763.1.
AL031659 Genomic DNA. Translation: CAI42668.1.
CH471077 Genomic DNA. Translation: EAW76073.1.
BC002380 mRNA. Translation: AAH02380.2.
BC003560 mRNA. Translation: AAH03560.1.
BC013028 mRNA. Translation: AAH13028.2.
BC020222 mRNA. Translation: AAH20222.1.
CCDSiCCDS13291.1. [P04844-1]
CCDS46599.1. [P04844-2]
PIRiB26168.
RefSeqiNP_001129243.1. NM_001135771.1. [P04844-2]
NP_002942.2. NM_002951.3. [P04844-1]
UniGeneiHs.370895.

Genome annotation databases

EnsembliENST00000237530; ENSP00000237530; ENSG00000118705. [P04844-1]
ENST00000373622; ENSP00000362724; ENSG00000118705. [P04844-2]
GeneIDi6185.
KEGGihsa:6185.
UCSCiuc002xgp.3. human. [P04844-1]
uc002xgq.3. human. [P04844-2]

Polymorphism databases

DMDMi9297108.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00282 mRNA. Translation: CAA68393.1 .
AJ237734
, AJ237735 , AJ237733 , AJ237736 , AJ237737 , AJ237738 , AJ237739 , AJ237740 , AJ237741 , AJ237742 , AJ237743 , AJ237744 , AJ237745 , AJ237746 , AJ237747 , AJ237748 , AJ237749 Genomic DNA. Translation: CAB54801.1 .
AK096243 mRNA. Translation: BAG53237.1 .
CR456899 mRNA. Translation: CAG33180.1 .
AL031659 Genomic DNA. Translation: CAB41763.1 .
AL031659 Genomic DNA. Translation: CAI42668.1 .
CH471077 Genomic DNA. Translation: EAW76073.1 .
BC002380 mRNA. Translation: AAH02380.2 .
BC003560 mRNA. Translation: AAH03560.1 .
BC013028 mRNA. Translation: AAH13028.2 .
BC020222 mRNA. Translation: AAH20222.1 .
CCDSi CCDS13291.1. [P04844-1 ]
CCDS46599.1. [P04844-2 ]
PIRi B26168.
RefSeqi NP_001129243.1. NM_001135771.1. [P04844-2 ]
NP_002942.2. NM_002951.3. [P04844-1 ]
UniGenei Hs.370895.

3D structure databases

ProteinModelPortali P04844.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112100. 39 interactions.
IntActi P04844. 15 interactions.
MINTi MINT-8247596.
STRINGi 9606.ENSP00000237530.

PTM databases

PhosphoSitei P04844.

Polymorphism databases

DMDMi 9297108.

Proteomic databases

MaxQBi P04844.
PaxDbi P04844.
PRIDEi P04844.

Protocols and materials databases

DNASUi 6185.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000237530 ; ENSP00000237530 ; ENSG00000118705 . [P04844-1 ]
ENST00000373622 ; ENSP00000362724 ; ENSG00000118705 . [P04844-2 ]
GeneIDi 6185.
KEGGi hsa:6185.
UCSCi uc002xgp.3. human. [P04844-1 ]
uc002xgq.3. human. [P04844-2 ]

Organism-specific databases

CTDi 6185.
GeneCardsi GC20P035806.
HGNCi HGNC:10382. RPN2.
HPAi CAB019277.
HPA008297.
HPA025922.
MIMi 180490. gene.
neXtProti NX_P04844.
PharmGKBi PA34778.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258688.
GeneTreei ENSGT00390000002635.
HOGENOMi HOG000231261.
HOVERGENi HBG002365.
InParanoidi P04844.
KOi K12667.
OMAi PTHYLTK.
OrthoDBi EOG78SQHS.
PhylomeDBi P04844.
TreeFami TF106146.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_22426. Asparagine N-linked glycosylation.

Miscellaneous databases

ChiTaRSi RPN2. human.
GeneWikii RPN2.
GenomeRNAii 6185.
NextBioi 24021.
PROi P04844.
SOURCEi Search...

Gene expression databases

Bgeei P04844.
CleanExi HS_RPN2.
ExpressionAtlasi P04844. baseline and differential.
Genevestigatori P04844.

Family and domain databases

InterProi IPR008814. Swp1.
[Graphical view ]
PANTHERi PTHR12640:SF0. PTHR12640:SF0. 1 hit.
Pfami PF05817. Ribophorin_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins."
    Crimaudo C., Hortsch M., Gausepohl H., Meyer D.I.
    EMBO J. 6:75-82(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Genomic structure of human ribophorin II gene."
    Iolascon A., Totaro A., Gasparini P.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Muscle, Pancreas and Placenta.
  8. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-36.
    Tissue: Platelet.
  9. "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties."
    Kelleher D.J., Karaoglu D., Mandon E.C., Gilmore R.
    Mol. Cell 12:101-111(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE OLIGOSACCHARYLTRANSFERASE (OST) COMPLEX.
  10. "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits."
    Shibatani T., David L.L., McCormack A.L., Frueh K., Skach W.R.
    Biochemistry 44:5982-5992(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE OLIGOSACCHARYLTRANSFERASE (OST) COMPLEX.
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-106.
    Tissue: Liver.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis."
    Shchedrina V.A., Everley R.A., Zhang Y., Gygi S.P., Hatfield D.L., Gladyshev V.N.
    J. Biol. Chem. 286:42937-42948(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH CANX; DERL1; DERL2; DDOST; RPN1; SELK; STT3A; VCP AND VIMP.

Entry informationi

Entry nameiRPN2_HUMAN
AccessioniPrimary (citable) accession number: P04844
Secondary accession number(s): Q5JYR6
, Q6IBA5, Q96E21, Q9BUQ3, Q9UBE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3