Reviewed, UniProtKB/Swiss-Prot P04842 (ALOX_PICPA)

Names and origin

Protein names	Recommended name:     Alcohol oxidase       Short name=AOX     EC=1.1.3.13 Alternative name(s):     Methanol oxidase       Short name=MOX
Organism	Pichia pastoris (Yeast)
Taxonomic identifier	4922 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Pichia

Protein attributes

Sequence length	33 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	A primary alcohol + O2 = an aldehyde + H2O2.
Cofactor	FAD.
Pathway	Energy metabolism; methane degradation.
Subunit structure	Homooctamer.
Subcellular location	Peroxisome.
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Biological process	Methanol utilization
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	methanol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	alcohol oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›33	›33	Alcohol oxidase		PRO_0000205582
Regions
	Nucleotide binding	8 – ›33	›26	FAD Probable
Experimental info
	Non-terminal residue	33	1

Sequences

	Sequence		Length	Mass (Da)
	P04842-1 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 9C747B94793FE5CB	FASTA	33	3,372
	10 20 30 MAIPEEFDIL VLGGGSSGSC IAGRLANLDH SLK

References

[1]	"Isolation of alcohol oxidase and two other methanol regulatable genes from the yeast Pichia pastoris." Ellis S.B., Brust P.F., Koutz P.J., Waters A.F., Harpold M.M., Gingeras T.R. Mol. Cell. Biol. 5:1111-1121(1985) [PubMed: 3889590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Biosynthesis and assembly of alcohol oxidase, a peroxisomal matrix protein in methylotrophic yeasts: a review." van der Klei I.J., Harder W., Veenhuis M. Yeast 7:195-209(1991) [PubMed: 1882546] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X02646 Genomic DNA. Translation: CAA26484.1.
PIR	A23483.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.3.13. 390.
Family and domain databases
PROSITE	PS00623. GMC_OXRED_1. Partial match. PS00624. GMC_OXRED_2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALOX_PICPA

Accession

Primary (citable) accession number: P04842

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	January 19, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)