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Protein

Mitochondrial outer membrane protein porin 1

Gene

POR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Is the major permeability factor of the mitochondrial outer membrane.1 Publication

GO - Molecular functioni

  • porin activity Source: UniProtKB-KW
  • voltage-gated anion channel activity Source: SGD

GO - Biological processi

  • apoptotic process Source: SGD
  • cell redox homeostasis Source: SGD
  • DNA transport Source: SGD
  • ion transport Source: SGD
  • mitochondrion organization Source: SGD
  • protein targeting to mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33087-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Protein family/group databases

TCDBi1.B.8.1.1. the mitochondrial and plastid porin (mpp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial outer membrane protein porin 1
Alternative name(s):
Voltage-dependent anion-selective channel protein 1
Short name:
VDAC-1
Gene namesi
Name:POR1
Synonyms:OMP2, VDAC1
Ordered Locus Names:YNL055C
ORF Names:N2441, YNL2441C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL055C.
SGDiS000005000. POR1.

Subcellular locationi

GO - Cellular componenti

  • integral component of mitochondrial outer membrane Source: SGD
  • mitochondrial intermembrane space Source: Reactome
  • mitochondrial outer membrane Source: SGD
  • mitochondrion Source: SGD
  • pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi19K → E: 2.5-fold reduction in steepness of voltage dependence. 1 Publication1
Mutagenesisi51D → K: 2-fold increase in steepness of voltage dependence. 1 Publication1
Mutagenesisi61K → E: Alters the selectivity of VDAC. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000505242 – 283Mitochondrial outer membrane protein porin 1Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109PhosphoserineCombined sources1
Modified residuei117PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP04840.
PRIDEiP04840.

2D gel databases

UCD-2DPAGEP04840.

PTM databases

iPTMnetiP04840.

Interactioni

Subunit structurei

Interacts with AIM5, FCJ1 and MOS1.1 Publication

Protein-protein interaction databases

BioGridi35766. 197 interactors.
DIPiDIP-6453N.
IntActiP04840. 71 interactors.
MINTiMINT-677066.

Structurei

3D structure databases

ProteinModelPortaliP04840.
SMRiP04840.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of membrane-spanning sided beta-sheets. 19 strands distributed along the entire VDAC protein, have the potential to adopt transmembrane beta pleated sheet structures, which rolled together may form a "beta-barrel" type structure, possessing pore dimensions.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

GeneTreeiENSGT00390000011336.
HOGENOMiHOG000188277.
InParanoidiP04840.
KOiK15040.
OMAiAENKDVC.
OrthoDBiEOG092C3RNC.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPPVYSDIS RNINDLLNKD FYHATPAAFD VQTTTANGIK FSLKAKQPVK
60 70 80 90 100
DGPLSTNVEA KLNDKQTGLG LTQGWSNTNN LQTKLEFANL TPGLKNELIT
110 120 130 140 150
SLTPGVAKSA VLNTTFTQPF FTARGAFDLC LKSPTFVGDL TMAHEGIVGG
160 170 180 190 200
AEFGYDISAG SISRYAMALS YFAKDYSLGA TLNNEQITTV DFFQNVNAFL
210 220 230 240 250
QVGAKATMNC KLPNSNVNIE FATRYLPDAS SQVKAKVSDS GIVTLAYKQL
260 270 280
LRPGVTLGVG SSFDALKLSE PVHKLGWSLS FDA
Length:283
Mass (Da):30,428
Last modified:January 23, 2007 - v4
Checksum:iC99D03711AF9B54D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118Q → E in CAA26184 (PubMed:2408884).Curated1
Sequence conflicti118Q → E in AAA35208 (PubMed:2442148).Curated1
Sequence conflicti203 – 207GAKAT → AKATM in AAA35208 (PubMed:2442148).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02324 mRNA. Translation: CAA26184.1.
M34907 mRNA. Translation: AAA35208.1.
U12141 Genomic DNA. Translation: AAA99656.1.
Z71331 Genomic DNA. Translation: CAA95926.1.
BK006947 Genomic DNA. Translation: DAA10489.1.
PIRiS58721. MMBYP.
RefSeqiNP_014343.1. NM_001182894.1.

Genome annotation databases

EnsemblFungiiYNL055C; YNL055C; YNL055C.
GeneIDi855669.
KEGGisce:YNL055C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02324 mRNA. Translation: CAA26184.1.
M34907 mRNA. Translation: AAA35208.1.
U12141 Genomic DNA. Translation: AAA99656.1.
Z71331 Genomic DNA. Translation: CAA95926.1.
BK006947 Genomic DNA. Translation: DAA10489.1.
PIRiS58721. MMBYP.
RefSeqiNP_014343.1. NM_001182894.1.

3D structure databases

ProteinModelPortaliP04840.
SMRiP04840.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35766. 197 interactors.
DIPiDIP-6453N.
IntActiP04840. 71 interactors.
MINTiMINT-677066.

Protein family/group databases

TCDBi1.B.8.1.1. the mitochondrial and plastid porin (mpp) family.

PTM databases

iPTMnetiP04840.

2D gel databases

UCD-2DPAGEP04840.

Proteomic databases

MaxQBiP04840.
PRIDEiP04840.

Protocols and materials databases

DNASUi855669.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL055C; YNL055C; YNL055C.
GeneIDi855669.
KEGGisce:YNL055C.

Organism-specific databases

EuPathDBiFungiDB:YNL055C.
SGDiS000005000. POR1.

Phylogenomic databases

GeneTreeiENSGT00390000011336.
HOGENOMiHOG000188277.
InParanoidiP04840.
KOiK15040.
OMAiAENKDVC.
OrthoDBiEOG092C3RNC.

Enzyme and pathway databases

BioCyciYEAST:G3O-33087-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Miscellaneous databases

PROiP04840.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVDAC1_YEAST
AccessioniPrimary (citable) accession number: P04840
Secondary accession number(s): D6W1C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 156 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.