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Protein

Mitochondrial outer membrane protein porin 1

Gene

POR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Is the major permeability factor of the mitochondrial outer membrane.1 Publication

GO - Molecular functioni

  • porin activity Source: UniProtKB-KW
  • ubiquinone binding Source: SGD
  • voltage-gated anion channel activity Source: SGD

GO - Biological processi

  • apoptotic process Source: SGD
  • cell redox homeostasis Source: SGD
  • DNA transport Source: SGD
  • ion transport Source: SGD
  • mitochondrion organization Source: SGD

Keywordsi

Molecular functionPorin
Biological processIon transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33087-MONOMER

Protein family/group databases

TCDBi1.B.8.1.1 the mitochondrial and plastid porin (mpp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial outer membrane protein porin 1
Alternative name(s):
Voltage-dependent anion-selective channel protein 1
Short name:
VDAC-1
Gene namesi
Name:POR1
Synonyms:OMP2, VDAC1
Ordered Locus Names:YNL055C
ORF Names:N2441, YNL2441C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL055C
SGDiS000005000 POR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi19K → E: 2.5-fold reduction in steepness of voltage dependence. 1 Publication1
Mutagenesisi51D → K: 2-fold increase in steepness of voltage dependence. 1 Publication1
Mutagenesisi61K → E: Alters the selectivity of VDAC. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000505242 – 283Mitochondrial outer membrane protein porin 1Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109PhosphoserineCombined sources1
Modified residuei117PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP04840
PaxDbiP04840
PRIDEiP04840

2D gel databases

UCD-2DPAGEiP04840

PTM databases

iPTMnetiP04840

Interactioni

Subunit structurei

Interacts with AIM5, FCJ1 and MOS1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35766426 interactors.
DIPiDIP-6453N
IntActiP04840 101 interactors.
MINTiP04840
STRINGi4932.YNL055C

Structurei

3D structure databases

ProteinModelPortaliP04840
SMRiP04840
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of membrane-spanning sided beta-sheets. 19 strands distributed along the entire VDAC protein, have the potential to adopt transmembrane beta pleated sheet structures, which rolled together may form a "beta-barrel" type structure, possessing pore dimensions.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

GeneTreeiENSGT00390000011336
HOGENOMiHOG000188277
InParanoidiP04840
KOiK15040
OMAiAKINNAG
OrthoDBiEOG092C3RNC

Family and domain databases

Gene3Di2.40.160.101 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001925 Porin_Euk
IPR027246 Porin_Euk/Tom40
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit
PRINTSiPR00185 EUKARYTPORIN
PROSITEiView protein in PROSITE
PS00558 EUKARYOTIC_PORIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPPVYSDIS RNINDLLNKD FYHATPAAFD VQTTTANGIK FSLKAKQPVK
60 70 80 90 100
DGPLSTNVEA KLNDKQTGLG LTQGWSNTNN LQTKLEFANL TPGLKNELIT
110 120 130 140 150
SLTPGVAKSA VLNTTFTQPF FTARGAFDLC LKSPTFVGDL TMAHEGIVGG
160 170 180 190 200
AEFGYDISAG SISRYAMALS YFAKDYSLGA TLNNEQITTV DFFQNVNAFL
210 220 230 240 250
QVGAKATMNC KLPNSNVNIE FATRYLPDAS SQVKAKVSDS GIVTLAYKQL
260 270 280
LRPGVTLGVG SSFDALKLSE PVHKLGWSLS FDA
Length:283
Mass (Da):30,428
Last modified:January 23, 2007 - v4
Checksum:iC99D03711AF9B54D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118Q → E in CAA26184 (PubMed:2408884).Curated1
Sequence conflicti118Q → E in AAA35208 (PubMed:2442148).Curated1
Sequence conflicti203 – 207GAKAT → AKATM in AAA35208 (PubMed:2442148).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02324 mRNA Translation: CAA26184.1
M34907 mRNA Translation: AAA35208.1
U12141 Genomic DNA Translation: AAA99656.1
Z71331 Genomic DNA Translation: CAA95926.1
BK006947 Genomic DNA Translation: DAA10489.1
PIRiS58721 MMBYP
RefSeqiNP_014343.1, NM_001182894.1

Genome annotation databases

EnsemblFungiiYNL055C; YNL055C; YNL055C
GeneIDi855669
KEGGisce:YNL055C

Similar proteinsi

Entry informationi

Entry nameiVDAC1_YEAST
AccessioniPrimary (citable) accession number: P04840
Secondary accession number(s): D6W1C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 170 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome