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Protein

Interleukin-1 alpha

Gene

IL1A

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Mitogen, Pyrogen

Keywords - Biological processi

Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Gene namesi
Name:IL1A
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 2

Subcellular locationi

  • Secreted

  • Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 112112PRO_0000015277Add
BLAST
Chaini113 – 267155Interleukin-1 alphaPRO_0000015278Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Modified residuei87 – 871PhosphoserineBy similarity
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence analysis
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007573.

Structurei

3D structure databases

ProteinModelPortaliP04822.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
GeneTreeiENSGT00390000013353.
HOGENOMiHOG000113034.
HOVERGENiHBG002432.
InParanoidiP04822.
KOiK04383.
OMAiNQKSFYD.
OrthoDBiEOG091G0MAP.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDLFED LKNCFSENEE YSSAIDHLSL NQKSFYDASY EPLHEDCMNK
60 70 80 90 100
VVSLSTSETS VSPNLTFQEN VVAVTASGKI LKKRRLSLNQ PITDVDLETN
110 120 130 140 150
VSDPEEGIIK PRSVPYTFQR NMRYKYLRII KQEFTLNDAL NQSLVRDTSD
160 170 180 190 200
QYLRAAPLQN LGDAVKFDMG VYMTSEDSIL PVTLRISQTP LFVSAQNEDE
210 220 230 240 250
PVLLKEMPET PRIITDSESD ILFFWETQGN KNYFKSAANP QLFIATKPEH
260
LVHMARGLPS MTDFQIS
Length:267
Mass (Da):30,375
Last modified:August 13, 1987 - v1
Checksum:i6D20533FD1FA4822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02852 mRNA. Translation: CAA26605.1.
PIRiB24073.
RefSeqiNP_001095154.1. NM_001101684.1.
UniGeneiOcu.2080.

Genome annotation databases

EnsembliENSOCUT00000008771; ENSOCUP00000007573; ENSOCUG00000008771.
GeneIDi100009250.
KEGGiocu:100009250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02852 mRNA. Translation: CAA26605.1.
PIRiB24073.
RefSeqiNP_001095154.1. NM_001101684.1.
UniGeneiOcu.2080.

3D structure databases

ProteinModelPortaliP04822.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000008771; ENSOCUP00000007573; ENSOCUG00000008771.
GeneIDi100009250.
KEGGiocu:100009250.

Organism-specific databases

CTDi3552.

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
GeneTreeiENSGT00390000013353.
HOGENOMiHOG000113034.
HOVERGENiHBG002432.
InParanoidiP04822.
KOiK04383.
OMAiNQKSFYD.
OrthoDBiEOG091G0MAP.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL1A_RABIT
AccessioniPrimary (citable) accession number: P04822
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.