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Protein

Interleukin-1 alpha

Gene

IL1A

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Gene namesi
Name:IL1A
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152771 – 112Add BLAST112
ChainiPRO_0000015278113 – 267Interleukin-1 alphaAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei87PhosphoserineBy similarity1
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP04822

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007573

Structurei

3D structure databases

ProteinModelPortaliP04822
SMRiP04822
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI Eukaryota
ENOG411151X LUCA
GeneTreeiENSGT00390000013353
HOGENOMiHOG000113034
HOVERGENiHBG002432
InParanoidiP04822
KOiK04383
OMAiNQKSFYD
OrthoDBiEOG091G0MAP
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR003295 IL-1_alpha
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR45409 PTHR45409, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01358 INTRLEUKIN1A
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDLFED LKNCFSENEE YSSAIDHLSL NQKSFYDASY EPLHEDCMNK
60 70 80 90 100
VVSLSTSETS VSPNLTFQEN VVAVTASGKI LKKRRLSLNQ PITDVDLETN
110 120 130 140 150
VSDPEEGIIK PRSVPYTFQR NMRYKYLRII KQEFTLNDAL NQSLVRDTSD
160 170 180 190 200
QYLRAAPLQN LGDAVKFDMG VYMTSEDSIL PVTLRISQTP LFVSAQNEDE
210 220 230 240 250
PVLLKEMPET PRIITDSESD ILFFWETQGN KNYFKSAANP QLFIATKPEH
260
LVHMARGLPS MTDFQIS
Length:267
Mass (Da):30,375
Last modified:August 13, 1987 - v1
Checksum:i6D20533FD1FA4822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02852 mRNA Translation: CAA26605.1
PIRiB24073
RefSeqiNP_001095154.1, NM_001101684.1
XP_017205589.1, XM_017350100.1
UniGeneiOcu.2080

Genome annotation databases

EnsembliENSOCUT00000008771; ENSOCUP00000007573; ENSOCUG00000008771
GeneIDi100009250
KEGGiocu:100009250

Similar proteinsi

Entry informationi

Entry nameiIL1A_RABIT
AccessioniPrimary (citable) accession number: P04822
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health