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Protein

Arginine permease

Gene

CAN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity permease for arginine.1 Publication

GO - Molecular functioni

  • arginine transmembrane transporter activity Source: SGD
  • basic amino acid transmembrane transporter activity Source: SGD

GO - Biological processi

  • arginine transmembrane transport Source: GOC
  • arginine transport Source: SGD
  • basic amino acid transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30178-MONOMER.

Protein family/group databases

TCDBi2.A.3.10.4. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine permease
Gene namesi
Name:CAN1
Ordered Locus Names:YEL063C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome V

Organism-specific databases

CYGDiYEL063c.
EuPathDBiFungiDB:YEL063C.
SGDiS000000789. CAN1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei93 – 11018HelicalSequence AnalysisAdd
BLAST
Transmembranei230 – 25425HelicalSequence AnalysisAdd
BLAST
Transmembranei324 – 34320HelicalSequence AnalysisAdd
BLAST
Transmembranei377 – 39620HelicalSequence AnalysisAdd
BLAST
Transmembranei420 – 43718HelicalSequence AnalysisAdd
BLAST
Transmembranei451 – 46919HelicalSequence AnalysisAdd
BLAST
Transmembranei494 – 51825HelicalSequence AnalysisAdd
BLAST
Transmembranei525 – 54824HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endosome membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 590590Arginine permeasePRO_0000054148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei66 – 661PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP04817.

Interactioni

Subunit structurei

Interacts with RRT2.1 Publication

Protein-protein interaction databases

BioGridi36666. 67 interactions.
DIPiDIP-4062N.
IntActiP04817. 45 interactions.
MINTiMINT-476477.

Structurei

3D structure databases

ProteinModelPortaliP04817.
SMRiP04817. Positions 87-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9292HydrophilicAdd
BLAST
Regioni549 – 59042HydrophilicAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0833.
GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261850.
InParanoidiP04817.
KOiK16261.
OMAiICASHYM.
OrthoDBiEOG74J9HZ.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSKEDADI EEKHMYNEPV TTLFHDVEAS QTHHRRGSIP LKDEKSKELY
60 70 80 90 100
PLRSFPTRVN GEDTFSMEDG IGDEDEGEVQ NAEVKRELKQ RHIGMIALGG
110 120 130 140 150
TIGTGLFIGL STPLTNAGPV GALISYLFMG SLAYSVTQSL GEMATFIPVT
160 170 180 190 200
SSFTVFSQRF LSPAFGAANG YMYWFSWAIT FALELSVVGQ VIQFWTYKVP
210 220 230 240 250
LAAWISIFWV IITIMNLFPV KYYGEFEFWV ASIKVLAIIG FLIYCFCMVC
260 270 280 290 300
GAGVTGPVGF RYWRNPGAWG PGIISKDKNE GRFLGWVSSL INAAFTFQGT
310 320 330 340 350
ELVGITAGEA ANPRKSVPRA IKKVVFRILT FYIGSLLFIG LLVPYNDPKL
360 370 380 390 400
TQSTSYVSTS PFIIAIENSG TKVLPHIFNA VILTTIISAA NSNIYVGSRI
410 420 430 440 450
LFGLSKNKLA PKFLSRTTKG GVPYIAVFVT AAFGALAYME TSTGGDKVFE
460 470 480 490 500
WLLNITGVAG FFAWLFISIS HIRFMQALKY RGISRDELPF KAKLMPGLAY
510 520 530 540 550
YAATFMTIII IIQGFTAFAP KFNGVSFAAA YISIFLFLAV WILFQCIFRC
560 570 580 590
RFIWKIGDVD IDSDRRDIEA IVWEDHEPKT FWDKFWNVVA
Length:590
Mass (Da):65,785
Last modified:February 1, 1995 - v2
Checksum:i4E5A21C77145330D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti534 – 5341I → V in CAA27416 (PubMed:3327612).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03784 Genomic DNA. Translation: CAA27416.1.
M11724 Genomic DNA. Translation: AAA34467.1.
U18795 Genomic DNA. Translation: AAB65024.1.
BK006939 Genomic DNA. Translation: DAA07591.1.
PIRiA23922. QRBYPR.
RefSeqiNP_010851.1. NM_001178878.1.

Genome annotation databases

EnsemblFungiiYEL063C; YEL063C; YEL063C.
GeneIDi856646.
KEGGisce:YEL063C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03784 Genomic DNA. Translation: CAA27416.1.
M11724 Genomic DNA. Translation: AAA34467.1.
U18795 Genomic DNA. Translation: AAB65024.1.
BK006939 Genomic DNA. Translation: DAA07591.1.
PIRiA23922. QRBYPR.
RefSeqiNP_010851.1. NM_001178878.1.

3D structure databases

ProteinModelPortaliP04817.
SMRiP04817. Positions 87-471.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36666. 67 interactions.
DIPiDIP-4062N.
IntActiP04817. 45 interactions.
MINTiMINT-476477.

Protein family/group databases

TCDBi2.A.3.10.4. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbiP04817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYEL063C; YEL063C; YEL063C.
GeneIDi856646.
KEGGisce:YEL063C.

Organism-specific databases

CYGDiYEL063c.
EuPathDBiFungiDB:YEL063C.
SGDiS000000789. CAN1.

Phylogenomic databases

eggNOGiCOG0833.
GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261850.
InParanoidiP04817.
KOiK16261.
OMAiICASHYM.
OrthoDBiEOG74J9HZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-30178-MONOMER.

Miscellaneous databases

NextBioi982616.
PROiP04817.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast arginine permease: nucleotide sequence of the CAN1 gene."
    Ahmad M., Bussey H.
    Curr. Genet. 10:587-592(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular characterization of the CAN1 locus in Saccharomyces cerevisiae. A transmembrane protein without N-terminal hydrophobic signal sequence."
    Hoffmann W.
    J. Biol. Chem. 260:11831-11837(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae."
    Regenberg B., During-Olsen L., Kielland-Brandt M.C., Holmberg S.
    Curr. Genet. 36:317-328(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway."
    Shi Y., Stefan C.J., Rue S.M., Teis D., Emr S.D.
    Mol. Biol. Cell 22:4093-4107(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, RECYCLING, INTERACTION WITH RRT2.

Entry informationi

Entry nameiCAN1_YEAST
AccessioniPrimary (citable) accession number: P04817
Secondary accession number(s): D3DLI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 1, 1995
Last modified: July 22, 2015
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.