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P04817 (CAN1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine permease
Gene names
Name:CAN1
Ordered Locus Names:YEL063C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length590 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High-affinity permease for arginine. Ref.5

Subunit structure

Interacts with RRT2. Ref.6

Subcellular location

Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note: Recycled via the retromer-mediated pathway. Ref.6

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 590590Arginine permease
PRO_0000054148

Regions

Transmembrane93 – 11018Helical; Potential
Transmembrane230 – 25425Helical; Potential
Transmembrane324 – 34320Helical; Potential
Transmembrane377 – 39620Helical; Potential
Transmembrane420 – 43718Helical; Potential
Transmembrane451 – 46919Helical; Potential
Transmembrane494 – 51825Helical; Potential
Transmembrane525 – 54824Helical; Potential
Region1 – 9292Hydrophilic
Region549 – 59042Hydrophilic

Experimental info

Sequence conflict5341I → V in CAA27416. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P04817 [UniParc].

Last modified February 1, 1995. Version 2.
Checksum: 4E5A21C77145330D

FASTA59065,785
        10         20         30         40         50         60 
MTNSKEDADI EEKHMYNEPV TTLFHDVEAS QTHHRRGSIP LKDEKSKELY PLRSFPTRVN 

        70         80         90        100        110        120 
GEDTFSMEDG IGDEDEGEVQ NAEVKRELKQ RHIGMIALGG TIGTGLFIGL STPLTNAGPV 

       130        140        150        160        170        180 
GALISYLFMG SLAYSVTQSL GEMATFIPVT SSFTVFSQRF LSPAFGAANG YMYWFSWAIT 

       190        200        210        220        230        240 
FALELSVVGQ VIQFWTYKVP LAAWISIFWV IITIMNLFPV KYYGEFEFWV ASIKVLAIIG 

       250        260        270        280        290        300 
FLIYCFCMVC GAGVTGPVGF RYWRNPGAWG PGIISKDKNE GRFLGWVSSL INAAFTFQGT 

       310        320        330        340        350        360 
ELVGITAGEA ANPRKSVPRA IKKVVFRILT FYIGSLLFIG LLVPYNDPKL TQSTSYVSTS 

       370        380        390        400        410        420 
PFIIAIENSG TKVLPHIFNA VILTTIISAA NSNIYVGSRI LFGLSKNKLA PKFLSRTTKG 

       430        440        450        460        470        480 
GVPYIAVFVT AAFGALAYME TSTGGDKVFE WLLNITGVAG FFAWLFISIS HIRFMQALKY 

       490        500        510        520        530        540 
RGISRDELPF KAKLMPGLAY YAATFMTIII IIQGFTAFAP KFNGVSFAAA YISIFLFLAV 

       550        560        570        580        590 
WILFQCIFRC RFIWKIGDVD IDSDRRDIEA IVWEDHEPKT FWDKFWNVVA 

« Hide

References

« Hide 'large scale' references
[1]"Yeast arginine permease: nucleotide sequence of the CAN1 gene."
Ahmad M., Bussey H.
Curr. Genet. 10:587-592(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular characterization of the CAN1 locus in Saccharomyces cerevisiae. A transmembrane protein without N-terminal hydrophobic signal sequence."
Hoffmann W.
J. Biol. Chem. 260:11831-11837(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae."
Regenberg B., During-Olsen L., Kielland-Brandt M.C., Holmberg S.
Curr. Genet. 36:317-328(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway."
Shi Y., Stefan C.J., Rue S.M., Teis D., Emr S.D.
Mol. Biol. Cell 22:4093-4107(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, RECYCLING, INTERACTION WITH RRT2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X03784 Genomic DNA. Translation: CAA27416.1.
M11724 Genomic DNA. Translation: AAA34467.1.
U18795 Genomic DNA. Translation: AAB65024.1.
BK006939 Genomic DNA. Translation: DAA07591.1.
PIRQRBYPR. A23922.
RefSeqNP_010851.1. NM_001178878.1.

3D structure databases

ProteinModelPortalP04817.
SMRP04817. Positions 87-471.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36666. 68 interactions.
DIPDIP-4062N.
IntActP04817. 45 interactions.
MINTMINT-476477.
STRING4932.YEL063C.

Protein family/group databases

TCDB2.A.3.10.4. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbP04817.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYEL063C; YEL063C; YEL063C.
GeneID856646.
KEGGsce:YEL063C.

Organism-specific databases

CYGDYEL063c.
SGDS000000789. CAN1.

Phylogenomic databases

eggNOGCOG0833.
GeneTreeENSGT00510000049744.
HOGENOMHOG000261850.
KOK16261.
OMANIYVGSR.
OrthoDBEOG74J9HZ.

Enzyme and pathway databases

BioCycYEAST:G3O-30178-MONOMER.

Gene expression databases

GenevestigatorP04817.

Family and domain databases

InterProIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsTIGR00913. 2A0310. 1 hit.
PROSITEPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982616.

Entry information

Entry nameCAN1_YEAST
AccessionPrimary (citable) accession number: P04817
Secondary accession number(s): D3DLI7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families