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P04817

- CAN1_YEAST

UniProt

P04817 - CAN1_YEAST

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Protein
Arginine permease
Gene
CAN1, YEL063C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

High-affinity permease for arginine.1 Publication

GO - Molecular functioni

  1. arginine transmembrane transporter activity Source: SGD
  2. basic amino acid transmembrane transporter activity Source: SGD

GO - Biological processi

  1. arginine transport Source: SGD
  2. basic amino acid transport Source: SGD
  3. transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30178-MONOMER.

Protein family/group databases

TCDBi2.A.3.10.4. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine permease
Gene namesi
Name:CAN1
Ordered Locus Names:YEL063C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYEL063c.
SGDiS000000789. CAN1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein
Note: Recycled via the retromer-mediated pathway.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei93 – 11018Helical; Reviewed prediction
Add
BLAST
Transmembranei230 – 25425Helical; Reviewed prediction
Add
BLAST
Transmembranei324 – 34320Helical; Reviewed prediction
Add
BLAST
Transmembranei377 – 39620Helical; Reviewed prediction
Add
BLAST
Transmembranei420 – 43718Helical; Reviewed prediction
Add
BLAST
Transmembranei451 – 46919Helical; Reviewed prediction
Add
BLAST
Transmembranei494 – 51825Helical; Reviewed prediction
Add
BLAST
Transmembranei525 – 54824Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endosome membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: SGD
  4. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 590590Arginine permease
PRO_0000054148Add
BLAST

Proteomic databases

PaxDbiP04817.

Expressioni

Gene expression databases

GenevestigatoriP04817.

Interactioni

Subunit structurei

Interacts with RRT2.1 Publication

Protein-protein interaction databases

BioGridi36666. 68 interactions.
DIPiDIP-4062N.
IntActiP04817. 45 interactions.
MINTiMINT-476477.
STRINGi4932.YEL063C.

Structurei

3D structure databases

ProteinModelPortaliP04817.
SMRiP04817. Positions 87-471.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9292Hydrophilic
Add
BLAST
Regioni549 – 59042Hydrophilic
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0833.
GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261850.
KOiK16261.
OMAiNIYVGSR.
OrthoDBiEOG74J9HZ.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04817-1 [UniParc]FASTAAdd to Basket

« Hide

MTNSKEDADI EEKHMYNEPV TTLFHDVEAS QTHHRRGSIP LKDEKSKELY    50
PLRSFPTRVN GEDTFSMEDG IGDEDEGEVQ NAEVKRELKQ RHIGMIALGG 100
TIGTGLFIGL STPLTNAGPV GALISYLFMG SLAYSVTQSL GEMATFIPVT 150
SSFTVFSQRF LSPAFGAANG YMYWFSWAIT FALELSVVGQ VIQFWTYKVP 200
LAAWISIFWV IITIMNLFPV KYYGEFEFWV ASIKVLAIIG FLIYCFCMVC 250
GAGVTGPVGF RYWRNPGAWG PGIISKDKNE GRFLGWVSSL INAAFTFQGT 300
ELVGITAGEA ANPRKSVPRA IKKVVFRILT FYIGSLLFIG LLVPYNDPKL 350
TQSTSYVSTS PFIIAIENSG TKVLPHIFNA VILTTIISAA NSNIYVGSRI 400
LFGLSKNKLA PKFLSRTTKG GVPYIAVFVT AAFGALAYME TSTGGDKVFE 450
WLLNITGVAG FFAWLFISIS HIRFMQALKY RGISRDELPF KAKLMPGLAY 500
YAATFMTIII IIQGFTAFAP KFNGVSFAAA YISIFLFLAV WILFQCIFRC 550
RFIWKIGDVD IDSDRRDIEA IVWEDHEPKT FWDKFWNVVA 590
Length:590
Mass (Da):65,785
Last modified:February 1, 1995 - v2
Checksum:i4E5A21C77145330D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti534 – 5341I → V in CAA27416. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03784 Genomic DNA. Translation: CAA27416.1.
M11724 Genomic DNA. Translation: AAA34467.1.
U18795 Genomic DNA. Translation: AAB65024.1.
BK006939 Genomic DNA. Translation: DAA07591.1.
PIRiA23922. QRBYPR.
RefSeqiNP_010851.1. NM_001178878.1.

Genome annotation databases

EnsemblFungiiYEL063C; YEL063C; YEL063C.
GeneIDi856646.
KEGGisce:YEL063C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03784 Genomic DNA. Translation: CAA27416.1 .
M11724 Genomic DNA. Translation: AAA34467.1 .
U18795 Genomic DNA. Translation: AAB65024.1 .
BK006939 Genomic DNA. Translation: DAA07591.1 .
PIRi A23922. QRBYPR.
RefSeqi NP_010851.1. NM_001178878.1.

3D structure databases

ProteinModelPortali P04817.
SMRi P04817. Positions 87-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36666. 68 interactions.
DIPi DIP-4062N.
IntActi P04817. 45 interactions.
MINTi MINT-476477.
STRINGi 4932.YEL063C.

Protein family/group databases

TCDBi 2.A.3.10.4. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbi P04817.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YEL063C ; YEL063C ; YEL063C .
GeneIDi 856646.
KEGGi sce:YEL063C.

Organism-specific databases

CYGDi YEL063c.
SGDi S000000789. CAN1.

Phylogenomic databases

eggNOGi COG0833.
GeneTreei ENSGT00510000049744.
HOGENOMi HOG000261850.
KOi K16261.
OMAi NIYVGSR.
OrthoDBi EOG74J9HZ.

Enzyme and pathway databases

BioCyci YEAST:G3O-30178-MONOMER.

Miscellaneous databases

NextBioi 982616.

Gene expression databases

Genevestigatori P04817.

Family and domain databases

InterProi IPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF00324. AA_permease. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
TIGRFAMsi TIGR00913. 2A0310. 1 hit.
PROSITEi PS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast arginine permease: nucleotide sequence of the CAN1 gene."
    Ahmad M., Bussey H.
    Curr. Genet. 10:587-592(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular characterization of the CAN1 locus in Saccharomyces cerevisiae. A transmembrane protein without N-terminal hydrophobic signal sequence."
    Hoffmann W.
    J. Biol. Chem. 260:11831-11837(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae."
    Regenberg B., During-Olsen L., Kielland-Brandt M.C., Holmberg S.
    Curr. Genet. 36:317-328(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway."
    Shi Y., Stefan C.J., Rue S.M., Teis D., Emr S.D.
    Mol. Biol. Cell 22:4093-4107(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, RECYCLING, INTERACTION WITH RRT2.

Entry informationi

Entry nameiCAN1_YEAST
AccessioniPrimary (citable) accession number: P04817
Secondary accession number(s): D3DLI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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