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Reviewed, UniProtKB/Swiss-Prot P04817 (CAN1_YEAST)

Last modified November 24, 2009. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Arginine permease
Gene names
Name: CAN1
Ordered Locus Names: YEL063C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length590 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

High-affinity permease for arginine. Ref.4

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-3993,EBI-3993
P386941EBI-3993,EBI-24511
P388451EBI-3993,EBI-24770
P404741EBI-3993,EBI-25203
P538721EBI-3993,EBI-29075
AGP1P253761EBI-3993,EBI-2357
ARF1P110761EBI-3993,EBI-2816
ARL1P381161EBI-3993,EBI-2869
BAP2P380841EBI-3993,EBI-3414
CBR1P386261EBI-3993,EBI-2048224
CCW12Q121271EBI-3993,EBI-5303
CHO1P084561EBI-3993,EBI-14055
CHS1P080041EBI-3993,EBI-4618
DAL5P153651EBI-3993,EBI-5527
DFG5Q050311EBI-3993,EBI-27512
DIP5P533881EBI-3993,EBI-5904
DOP1Q039211EBI-3993,EBI-34442
EMP70P328021EBI-3993,EBI-6445
ERG11P106141EBI-3993,EBI-5127
ERG25P530451EBI-3993,EBI-6506
ERG5P547811EBI-3993,EBI-6563
ERP1Q053591EBI-3993,EBI-6581
ERP4Q124501EBI-3993,EBI-6598
ERV25P548371EBI-3993,EBI-6642
ERV41Q046511EBI-3993,EBI-27850
FCY2P170641EBI-3993,EBI-2047850
FMP45Q076511EBI-3993,EBI-2051056
GAP1P191451EBI-3993,EBI-7314
GNP1P488131EBI-3993,EBI-7758
GPI8P490181EBI-3993,EBI-7822
GTT1P405821EBI-3993,EBI-7941
HNM1P198071EBI-3993,EBI-8409
HXT1P324651EBI-3993,EBI-8759
HXT3P324661EBI-3993,EBI-8770
HXT5P386951EBI-3993,EBI-8778
HXT7P390041EBI-3993,EBI-8790
IST2P382501EBI-3993,EBI-21520
ITR1P306051EBI-3993,EBI-2050956
KEX1P096201EBI-3993,EBI-9653
MAG1P221341EBI-3993,EBI-10381
MUP1P502761EBI-3993,EBI-11624
NKP2Q061621EBI-3993,EBI-34256
NSG1P388371EBI-3993,EBI-24733
OST1P415431EBI-3993,EBI-12651
PDR5P333021EBI-3993,EBI-13038
PHO84P252971EBI-3993,EBI-13320
PHO88P382641EBI-3993,EBI-13350
PIS1P061971EBI-3993,EBI-13458
PLM2Q043831EBI-3993,EBI-2079237
PMP2P409751EBI-3993,EBI-2043041
PMP3P872841EBI-3993,EBI-13555
PUT4P153801EBI-3993,EBI-14315
RBD2Q122701EBI-3993,EBI-31471
RET3P536001EBI-3993,EBI-4905
SAC1P323681EBI-3993,EBI-16210
SCS7Q035291EBI-3993,EBI-16747
SDS23P531721EBI-3993,EBI-23782
SHR3Q027741EBI-3993,EBI-17099
SLY1P222131EBI-3993,EBI-17387
SNQ2P325681EBI-3993,EBI-17590
SOP4P395431EBI-3993,EBI-26193
SPC1P469651EBI-3993,EBI-17823
SPC2Q049691EBI-3993,EBI-27827
SPF1P399861EBI-3993,EBI-3128
SUR2P389921EBI-3993,EBI-18574
SWP1Q027951EBI-3993,EBI-12666
VHS3Q084381EBI-3993,EBI-30482
WBP1P337671EBI-3993,EBI-12658
YPT1P011231EBI-3993,EBI-29496

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 590590Arginine permease
PRO_0000054148

Regions

Transmembrane93 – 11018 Potential
Transmembrane230 – 25425 Potential
Transmembrane324 – 34320 Potential
Transmembrane377 – 39620 Potential
Transmembrane420 – 43718 Potential
Transmembrane451 – 46919 Potential
Transmembrane494 – 51825 Potential
Transmembrane525 – 54824 Potential
Region1 – 9292Hydrophilic
Region549 – 59042Hydrophilic

Amino acid modifications

Modified residue381Phosphoserine Ref.5 Ref.6

Experimental info

Sequence conflict5341I → V in CAA27416. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P04817-1 [UniParc].

Last modified February 1, 1995. Version 2.
Checksum: 4E5A21C77145330D

FASTA59065,785
        10         20         30         40         50         60 
MTNSKEDADI EEKHMYNEPV TTLFHDVEAS QTHHRRGSIP LKDEKSKELY PLRSFPTRVN 

        70         80         90        100        110        120 
GEDTFSMEDG IGDEDEGEVQ NAEVKRELKQ RHIGMIALGG TIGTGLFIGL STPLTNAGPV 

       130        140        150        160        170        180 
GALISYLFMG SLAYSVTQSL GEMATFIPVT SSFTVFSQRF LSPAFGAANG YMYWFSWAIT 

       190        200        210        220        230        240 
FALELSVVGQ VIQFWTYKVP LAAWISIFWV IITIMNLFPV KYYGEFEFWV ASIKVLAIIG 

       250        260        270        280        290        300 
FLIYCFCMVC GAGVTGPVGF RYWRNPGAWG PGIISKDKNE GRFLGWVSSL INAAFTFQGT 

       310        320        330        340        350        360 
ELVGITAGEA ANPRKSVPRA IKKVVFRILT FYIGSLLFIG LLVPYNDPKL TQSTSYVSTS 

       370        380        390        400        410        420 
PFIIAIENSG TKVLPHIFNA VILTTIISAA NSNIYVGSRI LFGLSKNKLA PKFLSRTTKG 

       430        440        450        460        470        480 
GVPYIAVFVT AAFGALAYME TSTGGDKVFE WLLNITGVAG FFAWLFISIS HIRFMQALKY 

       490        500        510        520        530        540 
RGISRDELPF KAKLMPGLAY YAATFMTIII IIQGFTAFAP KFNGVSFAAA YISIFLFLAV 

       550        560        570        580        590 
WILFQCIFRC RFIWKIGDVD IDSDRRDIEA IVWEDHEPKT FWDKFWNVVA

« Hide

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References

« Hide 'large scale' references
[1]"Yeast arginine permease: nucleotide sequence of the CAN1 gene."
Ahmad M., Bussey H.
Curr. Genet. 10:587-592(1986) [PubMed: 3327612] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular characterization of the CAN1 locus in Saccharomyces cerevisiae. A transmembrane protein without N-terminal hydrophobic signal sequence."
Hoffmann W.
J. Biol. Chem. 260:11831-11837(1985) [PubMed: 3900064] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed: 9169868] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[4]"Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae."
Regenberg B., During-Olsen L., Kielland-Brandt M.C., Holmberg S.
Curr. Genet. 36:317-328(1999) [PubMed: 10654085] [Abstract]
Cited for: FUNCTION.
[5]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, MASS SPECTROMETRY.
[6]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X03784 Genomic DNA. Translation: CAA27416.1.
M11724 Genomic DNA. Translation: AAA34467.1.
U18795 Genomic DNA. Translation: AAB65024.1.
PIRQRBYPR. A23922.
RefSeqNP_010851.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:4062N.
IntActP04817. 85 interactions.
STRINGP04817.

Protein family/group databases

TCDB2.A.3.10.4. amino acid-polyamine-organocation (APC) family.

Proteomic databases

PRIDEP04817.

Genome annotation databases

EnsemblYEL063C; YEL063C; YEL063C; Saccharomyces cerevisiae. [Genome view]
GeneID856646.
KEGGsce:YEL063C.
NMPDRfig|4932.3.peg.1899.

Organism-specific databases

CYGDYEL063c.
SGDS000000789. CAN1.

Phylogenomic databases

HOGENOMP04817.
OMAWLLNITA
OrthoDBEOG99W3XF

Gene expression databases

ArrayExpressP04817.
GenevestigatorP04817.
GermOnlineYEL063C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
IPR004841. Permease_region.
[Graphical view]
PANTHERPTHR11785. AA/rel_permease1. 1 hit.
PfamPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsTIGR00913. 2A0310. 1 hit.
PROSITEPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio982616.

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Entry information

Entry nameCAN1_YEAST
AccessionPrimary (citable) accession number: P04817
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 1, 1995
Last modified: November 24, 2009
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents