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P04817

- CAN1_YEAST

UniProt

P04817 - CAN1_YEAST

Protein

Arginine permease

Gene

CAN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    High-affinity permease for arginine.1 Publication

    GO - Molecular functioni

    1. arginine transmembrane transporter activity Source: SGD
    2. basic amino acid transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. arginine transport Source: SGD
    2. basic amino acid transport Source: SGD
    3. transmembrane transport Source: SGD

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30178-MONOMER.

    Protein family/group databases

    TCDBi2.A.3.10.4. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine permease
    Gene namesi
    Name:CAN1
    Ordered Locus Names:YEL063C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYEL063c.
    SGDiS000000789. CAN1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Endosome membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Recycled via the retromer-mediated pathway.

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: SGD
    4. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 590590Arginine permeasePRO_0000054148Add
    BLAST

    Proteomic databases

    PaxDbiP04817.

    Expressioni

    Gene expression databases

    GenevestigatoriP04817.

    Interactioni

    Subunit structurei

    Interacts with RRT2.1 Publication

    Protein-protein interaction databases

    BioGridi36666. 68 interactions.
    DIPiDIP-4062N.
    IntActiP04817. 45 interactions.
    MINTiMINT-476477.
    STRINGi4932.YEL063C.

    Structurei

    3D structure databases

    ProteinModelPortaliP04817.
    SMRiP04817. Positions 87-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei93 – 11018HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25425HelicalSequence AnalysisAdd
    BLAST
    Transmembranei324 – 34320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei377 – 39620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei420 – 43718HelicalSequence AnalysisAdd
    BLAST
    Transmembranei451 – 46919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei494 – 51825HelicalSequence AnalysisAdd
    BLAST
    Transmembranei525 – 54824HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9292HydrophilicAdd
    BLAST
    Regioni549 – 59042HydrophilicAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0833.
    GeneTreeiENSGT00510000049744.
    HOGENOMiHOG000261850.
    KOiK16261.
    OMAiNIYVGSR.
    OrthoDBiEOG74J9HZ.

    Family and domain databases

    InterProiIPR004841. AA-permease/SLC12A_dom.
    IPR002293. AA/rel_permease1.
    IPR004762. Amino_acid_permease_fungi.
    IPR004840. Amoino_acid_permease_CS.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF00324. AA_permease. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsiTIGR00913. 2A0310. 1 hit.
    PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P04817-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNSKEDADI EEKHMYNEPV TTLFHDVEAS QTHHRRGSIP LKDEKSKELY    50
    PLRSFPTRVN GEDTFSMEDG IGDEDEGEVQ NAEVKRELKQ RHIGMIALGG 100
    TIGTGLFIGL STPLTNAGPV GALISYLFMG SLAYSVTQSL GEMATFIPVT 150
    SSFTVFSQRF LSPAFGAANG YMYWFSWAIT FALELSVVGQ VIQFWTYKVP 200
    LAAWISIFWV IITIMNLFPV KYYGEFEFWV ASIKVLAIIG FLIYCFCMVC 250
    GAGVTGPVGF RYWRNPGAWG PGIISKDKNE GRFLGWVSSL INAAFTFQGT 300
    ELVGITAGEA ANPRKSVPRA IKKVVFRILT FYIGSLLFIG LLVPYNDPKL 350
    TQSTSYVSTS PFIIAIENSG TKVLPHIFNA VILTTIISAA NSNIYVGSRI 400
    LFGLSKNKLA PKFLSRTTKG GVPYIAVFVT AAFGALAYME TSTGGDKVFE 450
    WLLNITGVAG FFAWLFISIS HIRFMQALKY RGISRDELPF KAKLMPGLAY 500
    YAATFMTIII IIQGFTAFAP KFNGVSFAAA YISIFLFLAV WILFQCIFRC 550
    RFIWKIGDVD IDSDRRDIEA IVWEDHEPKT FWDKFWNVVA 590
    Length:590
    Mass (Da):65,785
    Last modified:February 1, 1995 - v2
    Checksum:i4E5A21C77145330D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti534 – 5341I → V in CAA27416. (PubMed:3327612)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03784 Genomic DNA. Translation: CAA27416.1.
    M11724 Genomic DNA. Translation: AAA34467.1.
    U18795 Genomic DNA. Translation: AAB65024.1.
    BK006939 Genomic DNA. Translation: DAA07591.1.
    PIRiA23922. QRBYPR.
    RefSeqiNP_010851.1. NM_001178878.1.

    Genome annotation databases

    EnsemblFungiiYEL063C; YEL063C; YEL063C.
    GeneIDi856646.
    KEGGisce:YEL063C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03784 Genomic DNA. Translation: CAA27416.1 .
    M11724 Genomic DNA. Translation: AAA34467.1 .
    U18795 Genomic DNA. Translation: AAB65024.1 .
    BK006939 Genomic DNA. Translation: DAA07591.1 .
    PIRi A23922. QRBYPR.
    RefSeqi NP_010851.1. NM_001178878.1.

    3D structure databases

    ProteinModelPortali P04817.
    SMRi P04817. Positions 87-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36666. 68 interactions.
    DIPi DIP-4062N.
    IntActi P04817. 45 interactions.
    MINTi MINT-476477.
    STRINGi 4932.YEL063C.

    Protein family/group databases

    TCDBi 2.A.3.10.4. the amino acid-polyamine-organocation (apc) family.

    Proteomic databases

    PaxDbi P04817.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YEL063C ; YEL063C ; YEL063C .
    GeneIDi 856646.
    KEGGi sce:YEL063C.

    Organism-specific databases

    CYGDi YEL063c.
    SGDi S000000789. CAN1.

    Phylogenomic databases

    eggNOGi COG0833.
    GeneTreei ENSGT00510000049744.
    HOGENOMi HOG000261850.
    KOi K16261.
    OMAi NIYVGSR.
    OrthoDBi EOG74J9HZ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30178-MONOMER.

    Miscellaneous databases

    NextBioi 982616.

    Gene expression databases

    Genevestigatori P04817.

    Family and domain databases

    InterProi IPR004841. AA-permease/SLC12A_dom.
    IPR002293. AA/rel_permease1.
    IPR004762. Amino_acid_permease_fungi.
    IPR004840. Amoino_acid_permease_CS.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF00324. AA_permease. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsi TIGR00913. 2A0310. 1 hit.
    PROSITEi PS00218. AMINO_ACID_PERMEASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yeast arginine permease: nucleotide sequence of the CAN1 gene."
      Ahmad M., Bussey H.
      Curr. Genet. 10:587-592(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular characterization of the CAN1 locus in Saccharomyces cerevisiae. A transmembrane protein without N-terminal hydrophobic signal sequence."
      Hoffmann W.
      J. Biol. Chem. 260:11831-11837(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae."
      Regenberg B., During-Olsen L., Kielland-Brandt M.C., Holmberg S.
      Curr. Genet. 36:317-328(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway."
      Shi Y., Stefan C.J., Rue S.M., Teis D., Emr S.D.
      Mol. Biol. Cell 22:4093-4107(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, RECYCLING, INTERACTION WITH RRT2.

    Entry informationi

    Entry nameiCAN1_YEAST
    AccessioniPrimary (citable) accession number: P04817
    Secondary accession number(s): D3DLI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3