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P04813

- CTR2_CANFA

UniProt

P04813 - CTR2_CANFA

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Protein

Chymotrypsinogen 2

Gene
CTRB1, CTRB
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Charge relay system
Active sitei120 – 1201Charge relay system
Active sitei213 – 2131Charge relay system

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Protein family/group databases

MEROPSiS01.152.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsinogen 2 (EC:3.4.21.1)
Cleaved into the following 3 chains:
Gene namesi
Name:CTRB1
Synonyms:CTRB
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 263245Chymotrypsinogen 2PRO_0000027634Add
BLAST
Chaini19 – 3113Chymotrypsin 2 chain APRO_0000027635Add
BLAST
Chaini34 – 164131Chymotrypsin 2 chain BPRO_0000027636Add
BLAST
Chaini167 – 26397Chymotrypsin 2 chain CPRO_0000027637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi19 ↔ 140 By similarity
Disulfide bondi60 ↔ 76 By similarity
Disulfide bondi154 ↔ 219 By similarity
Disulfide bondi186 ↔ 200 By similarity
Disulfide bondi209 ↔ 238 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029762.

Structurei

3D structure databases

ProteinModelPortaliP04813.
SMRiP04813. Positions 19-263.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 261228Peptidase S1Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00730000110306.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP04813.
KOiK01310.
OMAiITNLMVC.
OrthoDBiEOG7MKW6Q.
TreeFamiTF330455.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04813-1 [UniParc]FASTAAdd to Basket

« Hide

MAFLWLLSCF ALLGTAFGCG VPAIQPVLSG LSRIVNGEDA VPGSWPWQVS    50
LQDSTGFHFC GGSLISEDWV VTAAHCGVRT THQVVAGEFD QGSDAESIQV 100
LKIAKVFKNP KFNMFTINND ITLLKLATPA RFSKTVSAVC LPQATDDFPA 150
GTLCVTTGWG LTKHTNANTP DKLQQAALPL LSNAECKKFW GSKITDLMVC 200
AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSGTCST STPGVYARVT 250
KLIPWVQQIL QAN 263
Length:263
Mass (Da):27,787
Last modified:August 13, 1987 - v1
Checksum:i2A2F449D813B3961
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01173 mRNA. Translation: AAA30841.1.
PIRiA21195.
RefSeqiNP_001183984.1. NM_001197055.1.
UniGeneiCfa.40446.

Genome annotation databases

EnsembliENSCAFT00000036999; ENSCAFP00000032437; ENSCAFG00000020084.
GeneIDi479649.
KEGGicfa:479649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01173 mRNA. Translation: AAA30841.1 .
PIRi A21195.
RefSeqi NP_001183984.1. NM_001197055.1.
UniGenei Cfa.40446.

3D structure databases

ProteinModelPortali P04813.
SMRi P04813. Positions 19-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000029762.

Protein family/group databases

MEROPSi S01.152.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000036999 ; ENSCAFP00000032437 ; ENSCAFG00000020084 .
GeneIDi 479649.
KEGGi cfa:479649.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00730000110306.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P04813.
KOi K01310.
OMAi ITNLMVC.
OrthoDBi EOG7MKW6Q.
TreeFami TF330455.

Miscellaneous databases

NextBioi 20854798.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of cDNA clones encoding secretory isoenzyme forms: sequence determination of canine pancreatic prechymotrypsinogen 2 mRNA."
    Pinsky S.D., Laforge K.S., Luc V., Scheele G.
    Proc. Natl. Acad. Sci. U.S.A. 80:7486-7490(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCTR2_CANFA
AccessioniPrimary (citable) accession number: P04813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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