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P04813 (CTR2_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chymotrypsinogen 2

EC=3.4.21.1
Gene names
Name:CTRB1
Synonyms:CTRB
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Biological processDigestion
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdigestion

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Chain19 – 263245Chymotrypsinogen 2
PRO_0000027634
Chain19 – 3113Chymotrypsin 2 chain A
PRO_0000027635
Chain34 – 164131Chymotrypsin 2 chain B
PRO_0000027636
Chain167 – 26397Chymotrypsin 2 chain C
PRO_0000027637

Regions

Domain34 – 261228Peptidase S1

Sites

Active site751Charge relay system
Active site1201Charge relay system
Active site2131Charge relay system

Amino acid modifications

Disulfide bond19 ↔ 140 By similarity
Disulfide bond60 ↔ 76 By similarity
Disulfide bond154 ↔ 219 By similarity
Disulfide bond186 ↔ 200 By similarity
Disulfide bond209 ↔ 238 By similarity

Sequences

Sequence LengthMass (Da)Tools
P04813 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 2A2F449D813B3961

FASTA26327,787
        10         20         30         40         50         60 
MAFLWLLSCF ALLGTAFGCG VPAIQPVLSG LSRIVNGEDA VPGSWPWQVS LQDSTGFHFC 

        70         80         90        100        110        120 
GGSLISEDWV VTAAHCGVRT THQVVAGEFD QGSDAESIQV LKIAKVFKNP KFNMFTINND 

       130        140        150        160        170        180 
ITLLKLATPA RFSKTVSAVC LPQATDDFPA GTLCVTTGWG LTKHTNANTP DKLQQAALPL 

       190        200        210        220        230        240 
LSNAECKKFW GSKITDLMVC AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSGTCST 

       250        260 
STPGVYARVT KLIPWVQQIL QAN 

« Hide

References

[1]"Identification of cDNA clones encoding secretory isoenzyme forms: sequence determination of canine pancreatic prechymotrypsinogen 2 mRNA."
Pinsky S.D., Laforge K.S., Luc V., Scheele G.
Proc. Natl. Acad. Sci. U.S.A. 80:7486-7490(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K01173 mRNA. Translation: AAA30841.1.
PIRA21195.
RefSeqNP_001183984.1. NM_001197055.1.
UniGeneCfa.40446.

3D structure databases

ProteinModelPortalP04813.
SMRP04813. Positions 19-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000029762.

Protein family/group databases

MEROPSS01.152.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000036999; ENSCAFP00000032437; ENSCAFG00000020084.
GeneID479649.
KEGGcfa:479649.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00730000110306.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidP04813.
KOK01310.
OMAITNLMVC.
OrthoDBEOG7MKW6Q.
TreeFamTF330455.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20854798.

Entry information

Entry nameCTR2_CANFA
AccessionPrimary (citable) accession number: P04813
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: February 19, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries