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Protein

Chymotrypsinogen 2

Gene

CTRB1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Charge relay system
Active sitei120 – 1201Charge relay system
Active sitei213 – 2131Charge relay system

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Enzyme and pathway databases

ReactomeiREACT_174078. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Protein family/group databases

MEROPSiS01.152.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsinogen 2 (EC:3.4.21.1)
Cleaved into the following 3 chains:
Gene namesi
Name:CTRB1
Synonyms:CTRB
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 263245Chymotrypsinogen 2PRO_0000027634Add
BLAST
Chaini19 – 3113Chymotrypsin 2 chain APRO_0000027635Add
BLAST
Chaini34 – 164131Chymotrypsin 2 chain BPRO_0000027636Add
BLAST
Chaini167 – 26397Chymotrypsin 2 chain CPRO_0000027637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Disulfide bondi154 ↔ 219PROSITE-ProRule annotation
Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029762.

Structurei

3D structure databases

ProteinModelPortaliP04813.
SMRiP04813. Positions 19-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 261228Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP04813.
KOiK01310.
OMAiWIQEILA.
OrthoDBiEOG7MKW6Q.
TreeFamiTF330455.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLWLLSCF ALLGTAFGCG VPAIQPVLSG LSRIVNGEDA VPGSWPWQVS
60 70 80 90 100
LQDSTGFHFC GGSLISEDWV VTAAHCGVRT THQVVAGEFD QGSDAESIQV
110 120 130 140 150
LKIAKVFKNP KFNMFTINND ITLLKLATPA RFSKTVSAVC LPQATDDFPA
160 170 180 190 200
GTLCVTTGWG LTKHTNANTP DKLQQAALPL LSNAECKKFW GSKITDLMVC
210 220 230 240 250
AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSGTCST STPGVYARVT
260
KLIPWVQQIL QAN
Length:263
Mass (Da):27,787
Last modified:August 13, 1987 - v1
Checksum:i2A2F449D813B3961
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01173 mRNA. Translation: AAA30841.1.
PIRiA21195.
RefSeqiNP_001183984.1. NM_001197055.1.
UniGeneiCfa.40446.

Genome annotation databases

EnsembliENSCAFT00000036999; ENSCAFP00000032437; ENSCAFG00000020084.
GeneIDi479649.
KEGGicfa:479649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01173 mRNA. Translation: AAA30841.1.
PIRiA21195.
RefSeqiNP_001183984.1. NM_001197055.1.
UniGeneiCfa.40446.

3D structure databases

ProteinModelPortaliP04813.
SMRiP04813. Positions 19-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029762.

Protein family/group databases

MEROPSiS01.152.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000036999; ENSCAFP00000032437; ENSCAFG00000020084.
GeneIDi479649.
KEGGicfa:479649.

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP04813.
KOiK01310.
OMAiWIQEILA.
OrthoDBiEOG7MKW6Q.
TreeFamiTF330455.

Enzyme and pathway databases

ReactomeiREACT_174078. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Miscellaneous databases

NextBioi20854798.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of cDNA clones encoding secretory isoenzyme forms: sequence determination of canine pancreatic prechymotrypsinogen 2 mRNA."
    Pinsky S.D., Laforge K.S., Luc V., Scheele G.
    Proc. Natl. Acad. Sci. U.S.A. 80:7486-7490(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCTR2_CANFA
AccessioniPrimary (citable) accession number: P04813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: March 4, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.