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P04813

- CTR2_CANFA

UniProt

P04813 - CTR2_CANFA

Protein

Chymotrypsinogen 2

Gene

CTRB1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei75 – 751Charge relay system
    Active sitei120 – 1201Charge relay system
    Active sitei213 – 2131Charge relay system

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. digestion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Protein family/group databases

    MEROPSiS01.152.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chymotrypsinogen 2 (EC:3.4.21.1)
    Cleaved into the following 3 chains:
    Gene namesi
    Name:CTRB1
    Synonyms:CTRB
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 5

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Add
    BLAST
    Chaini19 – 263245Chymotrypsinogen 2PRO_0000027634Add
    BLAST
    Chaini19 – 3113Chymotrypsin 2 chain APRO_0000027635Add
    BLAST
    Chaini34 – 164131Chymotrypsin 2 chain BPRO_0000027636Add
    BLAST
    Chaini167 – 26397Chymotrypsin 2 chain CPRO_0000027637Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
    Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
    Disulfide bondi154 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000029762.

    Structurei

    3D structure databases

    ProteinModelPortaliP04813.
    SMRiP04813. Positions 19-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 261228Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00730000110306.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP04813.
    KOiK01310.
    OMAiITNLMVC.
    OrthoDBiEOG7MKW6Q.
    TreeFamiTF330455.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04813-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFLWLLSCF ALLGTAFGCG VPAIQPVLSG LSRIVNGEDA VPGSWPWQVS    50
    LQDSTGFHFC GGSLISEDWV VTAAHCGVRT THQVVAGEFD QGSDAESIQV 100
    LKIAKVFKNP KFNMFTINND ITLLKLATPA RFSKTVSAVC LPQATDDFPA 150
    GTLCVTTGWG LTKHTNANTP DKLQQAALPL LSNAECKKFW GSKITDLMVC 200
    AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSGTCST STPGVYARVT 250
    KLIPWVQQIL QAN 263
    Length:263
    Mass (Da):27,787
    Last modified:August 13, 1987 - v1
    Checksum:i2A2F449D813B3961
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01173 mRNA. Translation: AAA30841.1.
    PIRiA21195.
    RefSeqiNP_001183984.1. NM_001197055.1.
    UniGeneiCfa.40446.

    Genome annotation databases

    EnsembliENSCAFT00000036999; ENSCAFP00000032437; ENSCAFG00000020084.
    GeneIDi479649.
    KEGGicfa:479649.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01173 mRNA. Translation: AAA30841.1 .
    PIRi A21195.
    RefSeqi NP_001183984.1. NM_001197055.1.
    UniGenei Cfa.40446.

    3D structure databases

    ProteinModelPortali P04813.
    SMRi P04813. Positions 19-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000029762.

    Protein family/group databases

    MEROPSi S01.152.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000036999 ; ENSCAFP00000032437 ; ENSCAFG00000020084 .
    GeneIDi 479649.
    KEGGi cfa:479649.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00730000110306.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P04813.
    KOi K01310.
    OMAi ITNLMVC.
    OrthoDBi EOG7MKW6Q.
    TreeFami TF330455.

    Miscellaneous databases

    NextBioi 20854798.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of cDNA clones encoding secretory isoenzyme forms: sequence determination of canine pancreatic prechymotrypsinogen 2 mRNA."
      Pinsky S.D., Laforge K.S., Luc V., Scheele G.
      Proc. Natl. Acad. Sci. U.S.A. 80:7486-7490(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCTR2_CANFA
    AccessioniPrimary (citable) accession number: P04813
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3