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Protein

Chymotrypsinogen 2

Gene

CTRB1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay system1
Active sitei120Charge relay system1
Active sitei213Charge relay system1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processDigestion

Protein family/group databases

MEROPSiS01.152.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsinogen 2 (EC:3.4.21.1)
Cleaved into the following 3 chains:
Gene namesi
Name:CTRB1
Synonyms:CTRB
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000002763419 – 263Chymotrypsinogen 2Add BLAST245
ChainiPRO_000002763519 – 31Chymotrypsin 2 chain AAdd BLAST13
ChainiPRO_000002763634 – 164Chymotrypsin 2 chain BAdd BLAST131
ChainiPRO_0000027637167 – 263Chymotrypsin 2 chain CAdd BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Modified residuei93PhosphoserineBy similarity1
Disulfide bondi154 ↔ 219PROSITE-ProRule annotation
Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein, Zymogen

Proteomic databases

PaxDbiP04813.
PRIDEiP04813.

Expressioni

Gene expression databases

BgeeiENSCAFG00000020084.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000032437.

Structurei

3D structure databases

ProteinModelPortaliP04813.
SMRiP04813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 261Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP04813.
KOiK01310.
OMAiWILSCWA.
OrthoDBiEOG091G0AH5.
TreeFamiTF330455.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLWLLSCF ALLGTAFGCG VPAIQPVLSG LSRIVNGEDA VPGSWPWQVS
60 70 80 90 100
LQDSTGFHFC GGSLISEDWV VTAAHCGVRT THQVVAGEFD QGSDAESIQV
110 120 130 140 150
LKIAKVFKNP KFNMFTINND ITLLKLATPA RFSKTVSAVC LPQATDDFPA
160 170 180 190 200
GTLCVTTGWG LTKHTNANTP DKLQQAALPL LSNAECKKFW GSKITDLMVC
210 220 230 240 250
AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSGTCST STPGVYARVT
260
KLIPWVQQIL QAN
Length:263
Mass (Da):27,787
Last modified:August 13, 1987 - v1
Checksum:i2A2F449D813B3961
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01173 mRNA. Translation: AAA30841.1.
PIRiA21195.
RefSeqiNP_001183984.1. NM_001197055.1.
UniGeneiCfa.40446.

Genome annotation databases

EnsembliENSCAFT00000036999; ENSCAFP00000032437; ENSCAFG00000020084.
GeneIDi479649.
KEGGicfa:479649.

Similar proteinsi

Entry informationi

Entry nameiCTR2_CANLF
AccessioniPrimary (citable) accession number: P04813
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families