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Reviewed, UniProtKB/Swiss-Prot P04808 (REL1_HUMAN)

Last modified June 16, 2009. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Prorelaxin H1
Cleaved into the following 2 chains:
    1- Recommended name:
            Relaxin B chain
    2- Recommended name:
            Relaxin A chain
Gene names
Name: RLN1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.

Subunit structure

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Subcellular location

Secreted.

Tissue specificity

Prostate. Not expressed in placenta, decidua or ovary. Ref.5

Sequence similarities

Belongs to the insulin family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Molecular functionHormone
   PTMCleavage on pair of basic residues
Disulfide bond
Gene Ontology (GO)
   Biological processfemale pregnancy Ref.2

Non-traceable author statement. Source: ProtInc

signal transduction Ref.2

Non-traceable author statement. Source: ProtInc

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhormone activity Ref.2

Traceable author statement. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P04808-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P04808-2)

The sequence of this isoform differs from the canonical sequence as follows:
     71-117: EIVPSFINKD...SLPELQQYVP → GDFIQTVSLG...HPSSTKIQKL
     118-185: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Peptide23 – 5331Relaxin B chain By similarity
PRO_0000016076
Propeptide56 – 158103Connecting peptide By similarity
PRO_0000016077
Peptide163 – 18523Relaxin A chain By similarity
PRO_0000016078

Amino acid modifications

Disulfide bond35 ↔ 172Interchain (between B and A chains) By similarity
Disulfide bond47 ↔ 185Interchain (between B and A chains) By similarity
Disulfide bond171 ↔ 176 By similarity

Natural variations

Alternative sequence71 – 11747EIVPS…QQYVP → GDFIQTVSLGISPDGGKALR TGSCFTREFLGALSKLYHPS STKIQKL in isoform 2.
VSP_002709
Alternative sequence118 – 18568Missing in isoform 2.
VSP_002710
Natural variant281K → M: dbSNP rs618066.
VAR_011962

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: B318628ABFEC7142

FASTA18521,146
        10         20         30         40         50         60 
MPRLFLFHLL EFCLLLNQFS RAVAAKWKDD VIKLCGRELV RAQIAICGMS TWSKRSLSQE 

        70         80         90        100        110        120 
DAPQTPRPVA EIVPSFINKD TETIIIMLEF IANLPPELKA ALSERQPSLP ELQQYVPALK 

       130        140        150        160        170        180 
DSNLSFEEFK KLIRNRQSEA ADSNPSELKY LGLDTHSQKK RRPYVALFEK CCLIGCTKRS 


LAKYC 

« Hide

Isoform 2.

Checksum: 705E3AE6229DF3E4
Show »

FASTA11713,011

References

« Hide 'large scale' references
[1]"Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones."
Hudson P., John M., Crawford R., Haralambidis J., Scanlon D., Gorman J., Tregear G., Shine J., Niall H.
EMBO J. 3:2333-2339(1984) [PubMed: 6548702] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Structure of a genomic clone encoding biologically active human relaxin."
Hudson P., Haley J., John M., Cronk M., Crawford R., Haralambidis J., Tregear G., Shine J., Niall H.
Nature 301:628-631(1983) [PubMed: 6298628] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed: 15164053] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Prostate.
[5]"Expression of human relaxin genes: characterization of a novel alternatively-spliced human relaxin mRNA species."
Gunnersen J.M., Fu P., Roche P.J., Tregear G.W.
Mol. Cell. Endocrinol. 118:85-94(1996) [PubMed: 8735594] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
Tissue: Prostate.
[6]"Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes and their chromosomal localization on chromosome 9p24.1 by radiation hybrid and breakpoint mapping."
Garibay-Tupas J.L., Csiszar K., Fox M., Povey S., Bryant-Greenwood G.D.
J. Mol. Endocrinol. 23:355-365(1999) [PubMed: 10601981] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
+Additional computationally mapped references.

Cross-references

Sequence databases

X00949 mRNA. Translation: CAA25461.1.
V00578 Genomic DNA. Translation: CAA23839.1.
V00577 Genomic DNA. Translation: CAA23838.1.
AL135786 Genomic DNA. Translation: CAC04179.1.
BC005956 mRNA. Translation: AAH05956.1.
S83200 Genomic DNA. Translation: AAD14429.1.
AF104934 Genomic DNA. Translation: AAD21967.1.
IPIIPI00025853.
IPI00219641.
PIRA44559. B05092.
RefSeqNP_008842.1.
UniGeneHs.368996

3D structure databases

HSSPHSSP built from PDB template 6RLX based on UniProtKB P04090.
ModBaseSearch...

Proteomic databases

PRIDEP04808.

Genome annotation databases

EnsemblENSG00000107018. Homo sapiens. [Contig view]
GeneID6013.
KEGGhsa:6013.

Organism-specific databases

GeneCardsGC09M005324.
H-InvDBHIX0007898.
HGNCHGNC:10026. RLN1.
MIM179730. gene.
PharmGKBPA34399.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP04808.
HOVERGENP04808.

Gene expression databases

ArrayExpressP04808.
BgeeP04808.
CleanExHS_RLN1.
GermOnlineENSG00000107018. Homo sapiens.

Family and domain databases

InterProIPR004825. Ins/IGF/relaxin.
[Graphical view]
PfamPF00049. Insulin. 1 hit.
[Graphical view]
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio23459.
SOURCESearch...

Entry information

Entry nameREL1_HUMAN
AccessionPrimary (citable) accession number: P04808
Secondary accession number(s): Q99936, Q9UQJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 16, 2009
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents