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Protein

Prorelaxin H1

Gene

RLN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.

GO - Molecular functioni

  • hormone activity Source: ProtInc

GO - Biological processi

  • female pregnancy Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107018-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Prorelaxin H1
Cleaved into the following 2 chains:
Gene namesi
Name:RLN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:10026. RLN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6013.
OpenTargetsiENSG00000107018.
PharmGKBiPA34399.

Polymorphism and mutation databases

DMDMi132280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
PeptideiPRO_000001607623 – 53Relaxin B chainBy similarityAdd BLAST31
PropeptideiPRO_000001607756 – 158Connecting peptideBy similarityAdd BLAST103
PeptideiPRO_0000016078163 – 185Relaxin A chainBy similarityAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 172Interchain (between B and A chains)By similarity
Disulfide bondi47 ↔ 185Interchain (between B and A chains)By similarity
Disulfide bondi171 ↔ 176By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP04808.
PeptideAtlasiP04808.
PRIDEiP04808.

PTM databases

iPTMnetiP04808.
PhosphoSitePlusiP04808.

Expressioni

Tissue specificityi

Prostate. Not expressed in placenta, decidua or ovary.1 Publication

Gene expression databases

BgeeiENSG00000107018.
CleanExiHS_RLN1.
GenevisibleiP04808. HS.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

GO - Molecular functioni

  • hormone activity Source: ProtInc

Protein-protein interaction databases

IntActiP04808. 1 interactor.
STRINGi9606.ENSP00000223862.

Structurei

3D structure databases

ProteinModelPortaliP04808.
SMRiP04808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1BP. Eukaryota.
ENOG411169Y. LUCA.
GeneTreeiENSGT00510000048834.
HOGENOMiHOG000236342.
HOVERGENiHBG003234.
InParanoidiP04808.
KOiK05255.
OMAiCLIGCTK.
OrthoDBiEOG091G0SV7.
PhylomeDBiP04808.
TreeFamiTF333404.

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
IPR022421. Relaxin.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
PR02004. RELAXIN.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P04808-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRLFLFHLL EFCLLLNQFS RAVAAKWKDD VIKLCGRELV RAQIAICGMS
60 70 80 90 100
TWSKRSLSQE DAPQTPRPVA EIVPSFINKD TETIIIMLEF IANLPPELKA
110 120 130 140 150
ALSERQPSLP ELQQYVPALK DSNLSFEEFK KLIRNRQSEA ADSNPSELKY
160 170 180
LGLDTHSQKK RRPYVALFEK CCLIGCTKRS LAKYC
Length:185
Mass (Da):21,146
Last modified:August 13, 1987 - v1
Checksum:iB318628ABFEC7142
GO
Isoform 2 (identifier: P04808-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-117: EIVPSFINKD...SLPELQQYVP → GDFIQTVSLG...HPSSTKIQKL
     118-185: Missing.

Show »
Length:117
Mass (Da):13,011
Checksum:i705E3AE6229DF3E4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01196228K → M.Corresponds to variant rs618066dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00270971 – 117EIVPS…QQYVP → GDFIQTVSLGISPDGGKALR TGSCFTREFLGALSKLYHPS STKIQKL in isoform 2. CuratedAdd BLAST47
Alternative sequenceiVSP_002710118 – 185Missing in isoform 2. CuratedAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00949 mRNA. Translation: CAA25461.1.
V00578 Genomic DNA. Translation: CAA23839.1.
V00577 Genomic DNA. Translation: CAA23838.1.
AL135786 Genomic DNA. Translation: CAC04179.1.
BC005956 mRNA. Translation: AAH05956.1.
S83200 Genomic DNA. Translation: AAD14429.1.
AF104934 Genomic DNA. Translation: AAD21967.1.
CCDSiCCDS6462.1. [P04808-1]
PIRiB05092. A44559.
RefSeqiNP_008842.1. NM_006911.3. [P04808-1]
XP_016870498.1. XM_017015009.1. [P04808-2]
UniGeneiHs.368996.

Genome annotation databases

EnsembliENST00000223862; ENSP00000223862; ENSG00000107018. [P04808-1]
GeneIDi6013.
KEGGihsa:6013.
UCSCiuc003zjb.3. human. [P04808-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00949 mRNA. Translation: CAA25461.1.
V00578 Genomic DNA. Translation: CAA23839.1.
V00577 Genomic DNA. Translation: CAA23838.1.
AL135786 Genomic DNA. Translation: CAC04179.1.
BC005956 mRNA. Translation: AAH05956.1.
S83200 Genomic DNA. Translation: AAD14429.1.
AF104934 Genomic DNA. Translation: AAD21967.1.
CCDSiCCDS6462.1. [P04808-1]
PIRiB05092. A44559.
RefSeqiNP_008842.1. NM_006911.3. [P04808-1]
XP_016870498.1. XM_017015009.1. [P04808-2]
UniGeneiHs.368996.

3D structure databases

ProteinModelPortaliP04808.
SMRiP04808.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04808. 1 interactor.
STRINGi9606.ENSP00000223862.

PTM databases

iPTMnetiP04808.
PhosphoSitePlusiP04808.

Polymorphism and mutation databases

DMDMi132280.

Proteomic databases

PaxDbiP04808.
PeptideAtlasiP04808.
PRIDEiP04808.

Protocols and materials databases

DNASUi6013.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223862; ENSP00000223862; ENSG00000107018. [P04808-1]
GeneIDi6013.
KEGGihsa:6013.
UCSCiuc003zjb.3. human. [P04808-1]

Organism-specific databases

CTDi6013.
DisGeNETi6013.
GeneCardsiRLN1.
HGNCiHGNC:10026. RLN1.
MIMi179730. gene.
neXtProtiNX_P04808.
OpenTargetsiENSG00000107018.
PharmGKBiPA34399.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1BP. Eukaryota.
ENOG411169Y. LUCA.
GeneTreeiENSGT00510000048834.
HOGENOMiHOG000236342.
HOVERGENiHBG003234.
InParanoidiP04808.
KOiK05255.
OMAiCLIGCTK.
OrthoDBiEOG091G0SV7.
PhylomeDBiP04808.
TreeFamiTF333404.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107018-MONOMER.

Miscellaneous databases

GenomeRNAii6013.
PROiP04808.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107018.
CleanExiHS_RLN1.
GenevisibleiP04808. HS.

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
IPR022421. Relaxin.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
PR02004. RELAXIN.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREL1_HUMAN
AccessioniPrimary (citable) accession number: P04808
Secondary accession number(s): Q99936, Q9UQJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.