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Protein

Cytochrome P450 3A1

Gene

Cyp3a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi443Iron (heme axial ligand)1

GO - Molecular functioni

  • aromatase activity Source: UniProtKB-EC
  • demethylase activity Source: RGD
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • testosterone 6-beta-hydroxylase activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • drug metabolic process Source: RGD
  • oxidative demethylation Source: RGD
  • response to cadmium ion Source: RGD
  • response to drug Source: RGD
  • response to glucocorticoid Source: RGD
  • response to metal ion Source: RGD
  • response to nutrient Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.14.1. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A1 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA1
Cytochrome P450-PCN1
Gene namesi
Name:Cyp3a1
Synonyms:Cyp3a-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628626. Cyp3a1.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: RGD
  • intracellular membrane-bounded organelle Source: RGD
  • organelle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3323.
DrugBankiDB08834. Tauroursodeoxycholic acid.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517831 – 504Cytochrome P450 3A1Add BLAST504

Proteomic databases

PaxDbiP04800.
PRIDEiP04800.

PTM databases

iPTMnetiP04800.
PhosphoSitePlusiP04800.

Expressioni

Inductioni

By pregnenolone 16-alpha-carbonitrile (PNCN).

Interactioni

Protein-protein interaction databases

MINTiMINT-4570555.
STRINGi10116.ENSRNOP00000065082.

Chemistry databases

BindingDBiP04800.

Structurei

3D structure databases

ProteinModelPortaliP04800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP04800.
PhylomeDBiP04800.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLSALTLE TWVLLAVVLV LLYGFGTRTH GLFKKQGIPG PKPLPFFGTV
60 70 80 90 100
LNYYMGLWKF DVECHKKYGK IWGLFDGQMP LFAITDTEMI KNVLVKECFS
110 120 130 140 150
VFTNRRDFGP VGIMGKAVSV AKDEEWKRYR ALLSPTFTSG RLKEMFPIIE
160 170 180 190 200
QYGDILVKYL KQEAETGKPV TMKKVFGAYS MDVITSTSFG VNVDSLNNPK
210 220 230 240 250
DPFVEKTKKL LRFDFFDPLF LSVVLFPFLT PIYEMLNICM FPKDSIEFFK
260 270 280 290 300
KFVYRMKETR LDSVQKHRVD FLQLMMNAHN DSKDKESHTA LSDMEITAQS
310 320 330 340 350
IIFIFAGYEP TSSTLSFVLH SLATHPDTQK KLQEEIDRAL PNKAPPTYDT
360 370 380 390 400
VMEMEYLDMV LNETLRLYPI GNRLERVCKK DVEINGVFMP KGSVVMIPSY
410 420 430 440 450
ALHRDPQHWP EPEEFRPERF SKENKGSIDP YVYLPFGNGP RNCIGMRFAL
460 470 480 490 500
MNMKLALTKV LQNFSFQPCK ETQIPLKLSR QGLLQPTKPI ILKVVPRDEI

ITGS
Length:504
Mass (Da):57,918
Last modified:August 13, 1987 - v1
Checksum:iCFD5AC8C37E9CADB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti207T → A in strain: Wistar. 1
Natural varianti213F → I in strain: Wistar. 1
Natural varianti232I → V in strain: Wistar. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10161 mRNA. Translation: AAA41035.1.
X64401 mRNA. Translation: CAA45743.1.
M86850 Genomic DNA. Translation: AAA41780.1.
X62086 Genomic DNA. No translation available.
PIRiA22631.
UniGeneiRn.91120.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10161 mRNA. Translation: AAA41035.1.
X64401 mRNA. Translation: CAA45743.1.
M86850 Genomic DNA. Translation: AAA41780.1.
X62086 Genomic DNA. No translation available.
PIRiA22631.
UniGeneiRn.91120.

3D structure databases

ProteinModelPortaliP04800.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4570555.
STRINGi10116.ENSRNOP00000065082.

Chemistry databases

BindingDBiP04800.
ChEMBLiCHEMBL3323.
DrugBankiDB08834. Tauroursodeoxycholic acid.

PTM databases

iPTMnetiP04800.
PhosphoSitePlusiP04800.

Proteomic databases

PaxDbiP04800.
PRIDEiP04800.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi628626. Cyp3a1.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP04800.
PhylomeDBiP04800.

Enzyme and pathway databases

BRENDAi1.14.14.1. 5301.

Miscellaneous databases

PROiP04800.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP3A1_RAT
AccessioniPrimary (citable) accession number: P04800
Secondary accession number(s): Q64580
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.